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The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi Jin Suyu Wang Yujia Yao Qin jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu Lijie Yang Wanrong jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu Dong Zhouhua jiang Shuyang Du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

AQDS Enhances Degradation of BDE-47 by Promoting Shewanella oneidensis MR-1-mediated Fenton Reaction with Fe(III)-containing Minerals

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Journal of Earth Science 2025年

作者： Yongguang jiang Siqi Zhu Zhou jiang Yiran Dong Liang Shi School of Environmental Studies， China University of Geosciences State Key Laboratory of Biogeology and Environmental Geology， China University of Geosciences Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science， China University of Geosciences State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution， Ministry of Ecology and Environment， China University of Geosciences(Wuhan)

Electron shuttles are widespread in the environments and play important role in microbe-mineral interaction. This study investigated the effects of a model electron shuttle (i.e.， anthraquinone-2， 6-disulfonate， AQDS) on Shewanella oneidensis MR-1-mediated Fenton reaction and subsequent degradation of 2， 2′， 4， 4′-tetrabrominated diphenyl ether (BDE-47). Three Fe(III)-containing minerals， namely， ferrihydrite， goethite and nontronite， were used as electron acceptors and Fe(II) sources. With each mineral， additions of 0.01 – 1 mM AQDS in the reactions significantly enhanced Fe(III) reduction by S. oneidensis MR-1 and increased the amounts of Fe(II) produced in anoxic phase. As a result， the amounts of cumulative ·OH formed in oxic phase were increased by 10% – 287%. Regression analysis revealed that ·OH cumulation has significant linear correlation with sorbed Fe(II) but not aqueous and structural Fe(II). This finding may be ascribed to the higher reactivity of sorbed Fe(II) in oxygenation than the latter two types of Fe(II). With more ·OH， the degradation efficiency of BDE-47 was elevated by 31% – 173%. Collectively， AQDS enhances ·OH formation and BDE-47 degradation by promoting production of Fe(II)， particularly sorbed Fe(II) in S. oneidensis MR-1-mediated Fenton reaction with Fe(III)-containing minerals.

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Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou wei-Jin jiang Ji Yu Mao-Jun Yao Yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

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石耳属ITS条形码物种的快速鉴定

菌物学报 2011年第6期30卷 938-943页

作者：郑方圆曹叔楠张涛刘川鹏周启明魏江春哈尔滨工业大学理学院生命科学与工程系哈尔滨150001 中国科学院微生物研究所真菌地衣系统学重点实验室北京100101

生物DNA条码是利用一个短的DNA标记进行生物的快速鉴定。以真菌界的石耳目、石耳科中的石耳属地衣的部分种类为材料,应用地衣共生菌的rDNA-ITS序列,对29种石耳属地衣进行鉴定,并初步探究其中部分种类特异的微型条码,为石耳属地衣的快速... 详细信息

生物DNA条码是利用一个短的DNA标记进行生物的快速鉴定。以真菌界的石耳目、石耳科中的石耳属地衣的部分种类为材料,应用地衣共生菌的rDNA-ITS序列,对29种石耳属地衣进行鉴定,并初步探究其中部分种类特异的微型条码,为石耳属地衣的快速鉴定提供依据。

关键词：地衣地衣型真菌微型条码物种鉴定树 ITS

Synergistic Catalysis with Azomethine Ylides

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Chinese Journal of Chemistry 2021年第1期39卷 15-24页

作者： Liang wei chun-jiang Wang Engineering Research Center of Organosilicon Compounds&Materials Ministry of EducationCollege of Chemistry ond Molecular SciencesWuhan UniversityWuhanHubei 430072China State Key Laboratory of Elemento organic Chemistry Nankoi UniversityTionjin 300071China

Azomethine ylides are useful intermediates for the rapid construction of chiral N-containing ***,its synthetic potential has not been fully developed due to the limited reaction *** combination with synergistic catalysis and azomethine ylide chemistry,we have developed several types of novel catalytic system including Cu/Pd,Cu/Ir and PTC/Ir catalysis;which can convert readily-available azomethine ylides to various high-valued molecules such as unnatural a-amino acids,homoallylic amines and *** with the traditional mono-catalysis,the synergistic catalyst system exhibits enhanced catalytic efficiency and chiral induction ability in many *** addition,we have demonstrated that these strategies could be applied in the construction of bioactive compounds and natural products.

关键词： Azomethine ylides Synergistic catalysis Asymmetric synthesis N-Heterocycles α-Amino acids

脱落酸对盐藻SZ-05药理活性成分积累的影响

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解放军药学学报 2007年第1期23卷 13-16页

作者：赵艳霞郑维发魏江春河北大学生命科学学院河北保定071002 徐州师范大学江苏省药用植物生物技术重点实验室河北保定071002 不详

目的阐明脱落酸对盐藻SZ-05药理活性成分积累的影响。方法以脱落酸加入盐藻SZ-05培养体系,在盐胁迫条件下检测盐藻SZ-05药理活性成分。其中β-胡萝卜素用HPLC法检测,多糖用硫酸-蒽酮法检测。结果脱落酸明显的促进了盐藻的生长,使盐藻SZ... 详细信息

目的阐明脱落酸对盐藻SZ-05药理活性成分积累的影响。方法以脱落酸加入盐藻SZ-05培养体系,在盐胁迫条件下检测盐藻SZ-05药理活性成分。其中β-胡萝卜素用HPLC法检测,多糖用硫酸-蒽酮法检测。结果脱落酸明显的促进了盐藻的生长,使盐藻SZ-05的生物量提高了16.94%,β-胡萝卜素提高了11.16%;多糖提高了22.31%,其中胞外多糖的增长量为8.01%。结论脱落酸能显著提高盐藻SZ-05药理活性物质的积累并能显著降低藻细胞在胁迫条件下的脂质过氧化,提高氧化酶的活性。

关键词：盐藻脱落酸 β-胡萝卜素多糖药理活性成分

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苦参根中化学成分及其体外抗肿瘤活性研究

中草药 2022年第4期53卷 978-984页

作者：龙国清王东东胡高升魏江春王安华贾景明沈阳药科大学中药学院辽宁沈阳110016

目的研究苦参Sophora flavescens根的化学成分及其体外抗肿瘤活性。方法利用大孔树脂柱色谱、硅胶柱色谱、ODS柱色谱及半制备型HPLC等进行分离纯化,结合理化性质及波谱数据鉴定化合物的结构;评估了从苦参根提取物中分离得到的11个化合... 详细信息

目的研究苦参Sophora flavescens根的化学成分及其体外抗肿瘤活性。方法利用大孔树脂柱色谱、硅胶柱色谱、ODS柱色谱及半制备型HPLC等进行分离纯化,结合理化性质及波谱数据鉴定化合物的结构;评估了从苦参根提取物中分离得到的11个化合物对人乳腺鳞状癌HCC1806细胞,人乳腺癌MCF-7细胞,宫颈癌HeLa细胞,肺癌A549、H1299和H460细胞和人肝癌HepG2细胞的体外抑制活性。结果从苦参根70%乙醇提取物中分离得到17个化合物,分别鉴定为8-(3,3-dimethylallyl)isorhamnetin(1)、6-lavandulyl-7,4-dimethoxy-5,2-dihydroxylflavanone(2)、sophoraflavanone B(3)、5-methyl-sophoraflavanone B(4)、苦参酮(5)、苦参醇U(6)、去甲脱水淫羊藿黄素(7)、槐果碱(8)、9α-羟基槐果碱(9)、槐胺碱(10)、臭豆碱(11)、胡椒酸(12)、1-(4-ethylphenyl)-1,2-ethanediol(13)、丁香酸(14)、1,2,4-苯三酚(15)、阿魏酸(16)、羟苄基酒石酸(17)。其中化合物5对H1299和H460细胞的体外半数抑制浓度(median inhibition concentration,IC50)分别为(22.6±1.2)、(13.6±0.5)μmol/L,其抑制效果强于阳性药顺铂。此外,化合物4对A549细胞和化合物5对MCF-7细胞的抑制效果与阳性药相当。结论化合物1为新的天然产物,化合物2、12~15首次从该属中分离得到;化合物5对H1299细胞和H460细胞具有较好的抑制活性。苦参中的异戊烯基黄酮在抗肿瘤药物开发与应用上有良好的发展前景。

关键词：苦参抗肿瘤活性苦参酮异戊烯基黄酮胡椒酸丁香酸 8-(3,3-dimethylallyl)isorhamnetin