Synergistic Catalysis with Azomethine Ylides

作     者：Liang Wei Chun-Jiang Wang Liang Wei;Chun-Jiang Wang

作者机构：Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationCollege of Chemistry ond Molecular SciencesWuhan UniversityWuhanHubei 430072China State Key Laboratory of Elemento organic ChemistryNankoi UniversityTionjin 300071China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第1期

页      面：15-24页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：C.J.W.thanks the NSFC(Grants 21772147,21525207,21372180,21172176,20972117,20702039)for financial support the Program of Introducing Talents of Discipline to Universities of China(111 Project)is also appreciated 

主　　题：Azomethine ylides Synergistic catalysis Asymmetric synthesis N-Heterocycles α-Amino acids 

摘      要：Azomethine ylides are useful intermediates for the rapid construction of chiral N-containing ***,its synthetic potential has not been fully developed due to the limited reaction *** combination with synergistic catalysis and azomethine ylide chemistry,we have developed several types of novel catalytic system including Cu/Pd,Cu/Ir and PTC/Ir catalysis;which can convert readily-available azomethine ylides to various high-valued molecules such as unnatural a-amino acids,homoallylic amines and *** with the traditional mono-catalysis,the synergistic catalyst system exhibits enhanced catalytic efficiency and chiral induction ability in many *** addition,we have demonstrated that these strategies could be applied in the construction of bioactive compounds and natural products.