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Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

Petroleum Science 2024年第1期21卷 667-673页

作者： yan-Wen Lin Tong Li Yi Zhang wei-wei yan Xiao-Ming Chen Zhi-Sen Zhang Jian-yang Wu Department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research Lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical Lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings

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Effect of Cu Addition in Pipeline Steels on Microstructure,Mechanical Properties and Microbiologically Influenced Corrosion

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Acta Metallurgica Sinica(English Letters) 2017年第7期30卷 601-613页

作者： Xian-Bo Shi wei yan Mao-Cheng yan wei Wang Zhen-Guo yang Yi-Yin Shan Ke yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

In the present study, Cu-modified pipeline steels were fabricated to mitigate MIC by the antimicrobial ability of Cu element. The microstructure, mechanical properties and the antimircobial performance of the Cu-modified steel were systematically investigated. The Cu-modified steels showed good antimicrobial performance with remarkable strength enhancement by nanoscale Cu-rich precipitates and good impact toughness without changing the original base microstructures after the optimal aging treatment of 500 °C/1 h.

关键词： Pipeline steel Cu addition Mechanical properties Microstructure Antimicrobial performance

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PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway

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Biomedical and Environmental Sciences 2023年第3期36卷 241-252页

作者： WEN Shi Yuan LIU yan Tong wei Bing yan MA Jie Qiong CHEN yan yan College of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030000ShanxiChina School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanxi Key Laboratory of Experimental Animals and Animal Models for Human Diseases Laboratory Animal CenterShanxi Medical UniversityTaiyuan 030000ShanxiChina School of Medicine Jiangsu UniversityZhenjiang 212001JiangsuChina

Objective Programmed cell death 6(PDCD6), a Ca~(2+)-binding protein, has been reported to be aberrantly expressed in all kinds of tumors. The aim of this study was to explore the role and mechanism of PDCD6 in hepatocellular carcinomas(HCCs).Methods The expression levels of PDCD6 in liver cancer patients and HCC cell lines were analyzed using bioinformatics and Western blotting. Cell viability and metastasis were determined by methylthiazol tetrazolium(MTT) and transwell assays, respectively. And Western blotting was used to test related biomarkers and molecular pathway factors in HCC cell lines. LY294002, a PI3K inhibitor inhibiting AKT, was used to suppress the AKT/GSK3β/β-catenin pathway to help evaluate the role of this pathway in the HCC carcinogenesis associated with *** The analysis of The Cancer Genome Atlas Database suggested that high PDCD6 expression levels were relevant to liver cancer progression. This was consistent with our finding of higher levels of PDCD6 expression in HCC cell lines than in normal hepatocyte cell lines. The results of MTT, transwell migration, and Western blotting assays revealed that overexpression of PDCD6 positively regulated HCC cell proliferation, migration, and invasion. Conversely, the upregulation of PDCD6 expression in the presence of an AKT inhibitor inhibited HCC cell proliferation, migration, and invasion. In addition, PDCD6promoted HCC cell migration and invasion by epithelial-mesenchymal transition. The mechanistic investigation proved that PDCD6 acted as a tumor promoter in HCC through the AKT/GSK3β/β-catenin pathway, increasing the expression of transcription factors and cellular proliferation and *** PDCD6 has a tumor stimulative role in HCC mediated by AKT/GSK3β/β-catenin signaling and might be a potential target for HCC progression.

关键词： PDCD6 Hepatocellular carcinoma Proliferation Metastasis

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Climatic warming in Shanghai during 1873-2019 based on homogenised temperature records

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Advances in Climate Change Research 2022年第4期13卷 496-506页

作者： Ping LIANG Zhong-wei yan Zhen LI Key Laboratory of Cities'Mitigation and Adaptation to Climate Change in Shanghai Shanghai Regional Climate CenterShanghai 200030China Key Laboratory of Regional Climate-Environment for East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Xujahui(XJH)station in downtown Shanghai holds the longest continuous daily temperature series in China,which is unique for assessing modern climate change and impacts but must be *** present work established a set of homogenised monthly and daily surface air temperature(SAT)series during 1873-2019 at *** major inhomogeneous break points(around 1954 and 1993)were identified in the original SAT series,which had been overlooked in previous *** inhomogeneous biases were adjusted via the inter-station deviation *** adjusted SAT series shows a warming trend of 1.9℃ per century compared with 1.7℃ per century in the original *** multi-decadal variations of quasi-32-year and quasi-64-year periods are weaker in the adjusted series than in the original series,suggesting overestimated multi-decadal variability in the original data due to inhomogeneous *** to the early period 1873-1900,the recent decade(the 2010s)is warmer by 2.2℃.Urbanisation has been responsible for approximately 19.3%of the rapid warming since the *** high and low SAT extremes exhibit significant warming,especially after the *** trend in the low SAT extremes in the adjusted series is substantially larger than that in the original series,implying that previous studies might underestimate the warming in cold extremes.

关键词： Homogenised temperature series Long-term climate warming Effect of urbanisation Muli-decadal variability

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EMPIRICAL VERIFICATION OF ANISOTROPIC HYDRODYNAMIC TRAFFIC MODEL IN TRAFFIC ANALYSIS AT INTERSECTIONS IN URBAN AREA

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Journal of Hydrodynamics 2007年第2期19卷 230-235页

作者： wei yan-fang GUO Si-ling XUE Yu Institute of Physics Science and Engineering Guangxi University Nanning 530004 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China Department of Physics and Information Science Guangxi Yulin Normal University Yulin 537000 China

In this article, the traffic hydrodynamic model considering the driver＇s reaction time was applied to the traffic analysis at the intersections on real roads. In the numerical simulation with the model, the pinch effect of the right-turning vehicles flow was found, which mainly leads to traffic jamming on the straight lane. All of the results in accordance with the empirical data confirm the applicability of this model.

关键词： traffic flow hydrodynamic traffic model,intersection pinch effect

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A novel molecular mechanism for nitrated α-synuclein-induced cell death

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Journal of Molecular Cell Biology 2011年第4期3卷 239-249页

作者： yanying Liu Min Qiang yan wei Rongqiao He State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China Key Laboratory of Mental Health Institute of PsychologyChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China

Although previous studies have demonstrated the involvement of nitrated a-synuclein in neurodegenerative disorders(synucleinopathies),the effects of nitrated α-synuclein and the molecular mechanisms underlying its toxicity are still *** the present study,nitrated α-synuclein with four 3-nitrotyrosines(Tyr^(39),Tyr^(125),Tyr^(133),and Tyr^(136))was obtained non-enzymatically by incubation with *** nitrated protein existed as a mixture of monomers,dimers,and polymers in *** nitrated a-synuclein could induce cell death in a time-and concentration-dependent manner when SH-SY5Y cells(a human neuroblastoma cell line)were incubated with the dimers and *** with anti-integrin α5β1 antibody partially rescued the SH-SY5Y cells from the cell *** blotting and immunoprecipitation revealed that the nitrated protein bound to integrin on the cell *** of nitric oxide(NO)and calcium-independent inducible NO synthase(iNOS)activity increased during the initial stages of the *** expression of phosphorylated focal adhesion kinase(FAK)decreased in the ***,an increase in caspase 3 activity was observed in SH-SY5Y *** results demonstrate that activation of iNOS and inhibition of FAK may both be responsible for the cell death induced by nitrated α-*** data suggest that the cytotoxicity of nitrated a-synuclein is mediated via an integrin-iNOS/-FAK signaling pathway,and that the nitration of α-synuclein plays a role in neuronal degeneration.

关键词： nitric oxide nitration neuronal death toxicity focal adhesion kinase calcium-independent inducible nitric oxide synthase

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Innovative developments in lunar and planetary science promoted by China's lunar exploration

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Science China Earth Sciences 2023年第11期66卷 2399-2418页

作者： Chunlai LI wei yan Jianjun LIU Ziyuan OUyanG Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Institute of Geochemistry Chinese Academy of SciencesGuiyang 550002China

As the only natural satellite of the earth, the Moon has always been the first choice for human exploration of the solar system. China's lunar exploration project(Chang'e project) was launched in 2004. At present, it has created a perfect end to the three phases of “orbiting, landing and returning”. A series of remarkable research achievements have been made on the basic issues of current lunar scientific research, such as the Earth-Moon space environment, lunar surface material, morphology,geological structure, lunar subsurface and internal structure, and the origin and evolution of the Moon, further deepening the human understanding of the Moon. This paper briefly reviews the development process of China's lunar exploration project,summarizes the main research results and scientific understanding, and finally prospects to the future development of China's lunar and planetary exploration.

关键词： Lunar exploration Lunar science Chang'e project Scientific achievements Future prospects

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A comparison of the toxicity of landfill leachate exposure at the seed soaking and germination stages on Zea mays L.(maize)

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Journal of Environmental Sciences 2017年第5期29卷 206-213页

作者： Guangke Li Junyan Chen wei yan Nan Sang College of Environment and Resource Shanxi University Taiyuan 030006 China

To compare the toxicity of landfill leachate exposure at the early stages of seed soaking and germination on maize,a field experiment was conducted to evaluate the physiological aspects of growth,yield and potential clastogenicity of root-tip cells. The maizes were treated with leachate at levels of 2%,10%,20%,30% or 50%（V/V）. First,the change of physiological indexes,including chlorophyll（Chl）,Malondialdehyde（MDA）and Reactive oxygen species（ROS）levels,combined with yield all showed that soaking with leachate,but not germination,generated a greater ecological risk on maize. After a soaking treatment of maize with 50% leachate,the Chl,MDA and ROS levels during a vigorous growth period were 47.3%,149.8% and 309.7%,respectively,of the control,whereas the yield decreased to 68.6% of the control. In addition,our results demonstrated that the leachate at lower levels could promote growth. This is mainly embodied in that the yield of maize treated with 10%leachate at the soaking stage increased to 116.0% of the control. Moreover,the cytological analysis experiment also demonstrated that the ecological risk of leachate still exists in both cases. Furthermore,the gray relational analysis showed that the ear row number and tassel branch number were the major factors affecting the yield of maize treated with 50%leachate at the stages of soaking and germination,respectively. In general,these results are helpful in understanding the phytotoxicity of leachate,which provides additional reference data for risk assessment and management of leachate.

关键词： Landfill leachate Maize Phytotoxicity Seed soaking Germination

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磁共振成像在评估膝关节退行性骨关节病患者软骨改变中的价值探究

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中国医疗器械信息 2025年第2期31卷 123-125页

作者：邓文睿韦菊临韦艳生柳城县人民医院放射科广西柳州545299

目的:探究磁共振成像在评估膝关节退行性骨关节病患者软骨改变中的价值。方法:回顾柳城县人民医院2020年1月~2023年6月收治的50例膝关节退行性骨关节病患者资料,所有患者均接受磁共振成像PDWI-FS-TSE、T1WI-TSE检查,以关节镜为金标准,... 详细信息

目的:探究磁共振成像在评估膝关节退行性骨关节病患者软骨改变中的价值。方法:回顾柳城县人民医院2020年1月~2023年6月收治的50例膝关节退行性骨关节病患者资料,所有患者均接受磁共振成像PDWI-FS-TSE、T1WI-TSE检查,以关节镜为金标准,探究各序列诊断软骨损伤的效能及判断损伤分级的准确率。结果:50例患者检查软骨234处,包括正常软骨145处,损伤软骨89处,损伤分级包括:Ⅰ级11处,Ⅱ级21处,Ⅲ级22处,Ⅳ级35处。磁共振成像诊断软骨损伤,特异度:联合诊断>PDWI-FS-TSE>T1WI-TSE,灵敏度:联合诊断=T1WI-TSET1WI-TSE。结论:磁共振成像在诊断膝关节退行性骨关节病患者软骨损伤中与关节镜诊断结果具有良好一致性,存在较高损伤分级诊断准确率和特异度。

关键词：磁共振成像膝关节退行性骨关节病软骨损伤影像学

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Degradation and Self-recovery of Polycrystalline Silicon TFT CMOS Inverters Under NBTI Stress

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Chinese Journal of Electronics 2019年第4期28卷 884-888页

作者： GUO Jian YU Zhinong yan wei SHI Dawei XUE Jianshe XUE wei School of Optics and Photonics and Beijing Engineering Research Center of Mixed Reality and Advanced Display Beijing Institute of Technology

Degradation and self-recovery of polycrystalline Silicon(poly-Si) Thin film transistor(TFT) by using complementary metal oxide semiconductor(CMOS)inverter were investigated. Under DC stress, degradation mechanisms were clarified by comparing the Voltage transfer characteristics(VTC) of fresh and stressed inverters. It is determined that Negative bias temperature instability(NBTI) of p-TFT dominates the degradation of the inverter under zero bias DC stress. After removing the stress, the VTC continues to be degraded, because the interface trap-states and the grain boundary trapstates increase due to hydrogen species diffusion. It is found out that the VTC is shifted to its right side severely with negative bias stress of VIN. The NBTI of p-TFT is enhanced and the NBTI of n-TFT also plays a role on the degradation. When removing the negative bias stress, the self-recovery of NBTI of nTFT and the continuing degradation of NBTI of p-TFT become competing mechanisms, together controlling the VTC after-stress behavior. Consequently, the continuing degradation of NBTI of p-TFT is restrained by selfrecovery of NBTI of n-TFT.

关键词： Negative bias temperature instability(NBTI) Self-recovery Inverter Polycrystalline silicon Voltage transfer characteristics(VTC)

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