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Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy

Stroke & Vascular Neurology 2022年第3期7卷 209-214页

作者： Matthew T Bender Thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy T Cushman webster h pilcher Curtis G Benesch Adam G Kelly Tarun Bhalla Department of Neurosurgery University of Rochester Medical CenterRochesterNew YorkUSA Department of Emergency Medicine University of Rochester Medical CenterRochesterNew YorkUSA Department of Neurology University of Rochester Medical CenterRochesterNew YorkUSA

Background The number of mobile stroke programmes has increased with evidence,showing they expedite intravenous *** questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical *** Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October *** reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical *** Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(phours to 4.5 hours since last known well and would likely have been outside the window with EMS *** thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(ET)at 133.0 min(±37.0)(p=0.0002).There was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal *** Mobile stroke care expedited both intravenous thrombolysis and endovascular *** is an ongoing need to show improved functional outcomes with MSU care.

关键词： intravenous throm endovascular

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Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment:evidence from a laboratory life-history trade-offs selection study

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Infectious Diseases of Poverty 2017年第1期6卷 988-998页

作者： Poppy h.L.Lamberton Christina L.Faust Joanne P.webster Institute for Biodiversity Animal Healthand Comparative Medicine&Wellcome Centre for Molecular ParasitologyCollege of MedicalVeterinary&Life SciencesUniversity of GlasgowG128QQGlasgowUK London Centre for Neglected Tropical Disease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonSt Mary’s CampusW21PGLondonUK Centre for Endemic Emerging and Exotic DiseasesThe Royal Veterinary CollegeUniversity of LondonLondon AL97TAUK

Background:Mass drug administration of praziquantel is the World health Organization’s endorsed control strategy for schistosomiasis.A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels,although‘hotspots’*** drug treatments place strong selective pressures on parasites,which may affect life-history traits that impact transmission *** drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing,maximise sustainable control programme success,and improve diagnostic ***:We performed a four-generation Schistosoma mansoni praziquantel selection experiment in mice and *** used three *** lines:a praziquantel-resistant isolate(R),a praziquantel-susceptible isolate(S),and a coinfected line(RS),under three treatment regimens:untreated,25 mg/kg praziquantel,or 50 mg/kg *** traits,including parasite adult-worm establishment,survival,reproduction(fecundity),and associated morbidity,were recorded in mice across all four *** variables were tested in a series of generalized linear mixed effects models to determine which factors had a significant influence on parasite life-history traits in definitive hosts under different selection ***:Praziquantel pressure significantly reduced adult-worm burdens across all generations and isolates,including within ***,previous drug treatment resulted in an increase in adult-worm establishment with increasing generation from P1 to *** highest worm numbers were in the co-infected RS *** treatment decreased adult-worm burden,but had a larger negative impact on the mean daily number of miracidia,a proxy for fecundity,across all three parasite ***:Our predicted cost of resistance was not supported by the traits we measured within the murine host.

关键词： Schistosoma mansoni Biomphalaria Mouse Praziquantel Resistance Establishment Survival Fecundity Trade-offs

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Spliceosomal genes in the *** genome:a comparison with those in ***,***,*** and ***

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Protein & Cell 2011年第5期2卷 395-409页

作者： Bing Yu Petra Fey Karen E.Kestin-pilcher Alexei Fedorov Ashwin Prakash Rex L.Chisholm Jane Y.Wu Department of Molecular and Clinical Genetics Royal Prince Alfred Hospital and Sydney Medical School(Central)the University of SydneyNSW 2006Australia dictyBase Center for Genetic MedicineNorthwestern UniversityChicagoIL 60611USA Department of Neurology and Lurie Comprehensive Cancer Center Center for Genetic MedicineNorthwestern University Feinberg Medical SchoolChicagoIL 60611USA Department of Medicine and Program in Bioinformatics and Proteomics/Genomics The University of ToledoToledoOH 43614USA

Little is known about pre-mRNA splicing in Dictyostelium discoideum although its genome has been completely *** analysis suggests that pre-mRNA splicing plays an important role in *** gene expression as two thirds of its genes contain at least one *** curation of the genome to date has revealed 40 genes in *** with clear evidence of alternative splicing,supporting the existence of alternative splicing in this unicellular *** identified 160 candidate U2-type spliceosomal proteins and related factors in *** based on 264 known human genes involved in *** small ribonucleoproteins(snRNPs),PRP19 complex proteins and late-acting proteins are highly conserved in *** and throughout the *** non-snRNP and hnRNP families,*** orthologs are closer to those in ***,*** and *** than to their counterparts in *** splicing regulators,including SR proteins and CUGbinding proteins,were found in ***,but not in *** comprehensive catalog of spliceosomal proteins provides useful information for future studies of splicing in *** where the efficient genetic and biochemical manipulation will also further our general understanding of pre-mRNA splicing.

关键词： pre-mRNA splicing spliceosomal genes Dictyostelium discoideum comparative genomics splicing regulators

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Fundamental motor skills,screen-time,and physical activity in preschoolers

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Journal of Sport and health Science 2019年第2期8卷 114-121页

作者： E.Kipling webster Corby K.Martin Amanda E.Staiano School ofKinesiology Louisiana State University Pennington Biomedical Research Center Louisiana State University

Purpose: To examine the associations among preschoolers fundamental motor skills, screen-time, physical activity(PA), and sedentary behavior(SB).Methods: Children ages 3à4 years were enrolled in a prospective observational trial of PA. Trained assessors conducted the Test of Gross Motor Development-3 rd edition(TGMD-3), and the Movement Assessment Battery for Children-2 nd edition, and parent-reported child screen-time and sociodemographic information. Children wore an accelerometer for 7 days to examine SB and total PA(TPA). TPA was further characterized as moderateto-vigorous PA(MVPA) or vigorous PA(VPA). Mixed linear models were calculated, controlling for age(for TGMD-3), sex, household income, and accelerometer wear time(for accelerometry models), with childcare center as a random effect. The primary analysis reported on the cross-sectional baseline data of 126 children with complete fundamental motor skill and screen-time data; a subanalysis included 88 children with complete accelerometry ***: Children were 3.4 § 0.5 years of age(54% girls; 46% white, 42% African American, 12% other). A total of 48% lived in households at or below the federal poverty level. Children engaged in 5.1 § 3.6 h/day of screen-time. Children's screen-time was inversely related to the Movement Assessment Battery for Children-2 nd edition, manual dexterity skills percentile(b(SE) = ?1.7(0.8), p = 0.049). In the accelerometry subsample,children engaged in 5.9 § 0.9 h/day of TPA of which 1.7 § 0.6 h/day was MVPA. Boys engaged in more MVPA and VPA and less SB compared with girls(all p higher TGMD-3, total score(b(SE) = 0.4(0.2), p = 0.017) and locomotor score(b(SE) = 0.7(0.3), p = 0.018) were associated with more VPA but not with TPA or MVPA. Screen-time and television in the bedroom were not related to SB, TPA, MVPA, or ***: Children's motor skills were positively related to VPA but inversely related to screen-time. Further inquiry into the implications of

关键词： Fundamental motor skills Physical activity Preschool Screen-time

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The Quantification of Intra-Fractional Tumour Motion Errors in Lung Stereotactic Ablative Radiotherapy Patients

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第2期6卷 105-110页

作者： Ibrahem h. Kanbayti Qamar Ghafoor Gareth webster Saddig Jastaniah Diagnostic Radiology Department King Abdulaziz University Jeddah KSA Queen Elizabieth hospital Oncology Center Birmingham UK Batterjee Medical College Jeddah KSA

This work aims at quantifying intra-fractional motion errors and evaluating the appropriateness of a Planning Target Volume (PTV) margin for Queen Elizabeth (QE) hospital’s patients. Intra-fractional motion errors were quantified for 29 patients who underwent lung Stereotactic Ablative Radiotherapy (SABR) treatment at the cancer centre of QE hospital. One hundred thirty post-Cone Beam Computed Tomography (CBCT) scans were collected to calculate these errors. In terms of the adequacy of a PTV margin, the intra-fractional motion errors that were calculated are combined with other geometric errors which were taken from historical audit studies. Then, the combined outcome was compared with the common PTV margin that is delineated by most United Kingdom (UK) oncology centres. The findings of this study showed that the systematic component of intra-fractional motion error is equal to 0.08, 0.08 and 0.08 cm in right/left, superior/anterior and anterior/posterior directions, respectively, While the random component of this error is equal to 0.11, 0.13 and 0.14 cm. In addition to that, a PTV margin of 0.5 cm is the appropriate margin for QE hospital’s patients and this volume is compatible with the common PTV margin that is delineated by the most UK oncology centres. This work concluded that A PTV margin of 0.5 cm is the suitable volume for lung SABR patients at QE hospital.

关键词： SABR Geometric Errors Lung Cancer

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Predicting numerically the large increases in extra pressure drop when boger fluids flow through

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Natural Science 2010年第1期2卷 1-11页

作者： h. R. Tamaddon-Jahromi M. F. webster K. Walters 不详

Recent numerical studies on pressure-drops in contraction flows have introduced a variety of constitutive models to compare and contrast the competing influences of extensional vis-cosity, normal stress and shear-thinning. Early work on pressure-drops employed the constant viscosity Oldroyd-B and Upper Convected Max- well (UCM) models to represent the behavior of so-called Boger fluids in axisymmetric contrac-tion flows, in (unsuccessful) attempts to predict the very large enhancements that were ob-served experimentally. In more recent studies, other constitutive models have been employed to interpret observed behavior and some pro-gress has been made, although finding a (re-spectable) model to describe observed contrac-tion-flow behavior, even qualitatively, has been frustratingly difficult. With this in mind, the present study discusses the ability of a well- known FENE type model (the so-called FENE- CR model) to describe observed behavior. For various reasons, an axisymmetric (4:1:4) con-traction/expansion geometry, with rounded corners, is singled out for special attention, and a new hybrid finite element/volume algo-rithm is utilized to conduct the modeling, which reflects an incremental pressure-correction time-stepping structure. New to this algo-rithmic formulation are techniques in time discretization, discrete treatment of pressure terms, and compatible stress/velocity-gradient representation. We shall argue that the current simulations for the FENE-CR model have re-sulted in a major improvement in the sort-for agreement between theory and experiment in this important bench-mark problem.

关键词： Contraction Flows Extra Pressure Drop Numerical Simulation Extensional Viscosity Normal Stress Differences

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测定淬火槽对流强度的热流速仪探头的优化设计(英文)

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金属热处理 2002年第7期27卷 39-44页

作者： h.M.Tensi A.haas K.Lainer G.E.Totten G.M.webster Department of Materials and Processing Technical University of MunichDepartment of Materials and ProcessingTechnical University of MunichDepartment of Materials and ProcessingTechnical University of MunichThe Dow Chemical CompanyTarrytownThe Dow Ch

淬火槽中复杂的液流形态会明显影响淬硬结果 ,因此开发一套结构紧凑的液流测量装置就显得很重要了。一个典型的淬火过程包括把已奥氏体化了的钢浸没在淬火槽中 ,这一过程势必影响液流的循环 ,使其形成不均匀的液流和热波动 ,由此而引起... 详细信息

淬火槽中复杂的液流形态会明显影响淬硬结果 ,因此开发一套结构紧凑的液流测量装置就显得很重要了。一个典型的淬火过程包括把已奥氏体化了的钢浸没在淬火槽中 ,这一过程势必影响液流的循环 ,使其形成不均匀的液流和热波动 ,由此而引起传热变化 ,导致零件的不均匀淬火。

关键词：测定淬火槽对流强度热流速仪探头优化设计

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工业淬火槽中的液流传感器—文献综述(英文)

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金属热处理 2002年第5期27卷 27-32页

作者： G.E.Totten 1,h.M.Tensi 2,and G.M.webster 1 (1 The Dow Chemical Company,Tarrytown,NY USA 2 Technical University of Munich,Munich,Germany) The Dow Chemical Company 美国 Tarrytown Technical University of Munich 德国 Munich

造成淬火后工件硬度不均匀、热应力增加、畸变和开裂 ,主要是因为淬火槽内整个淬火区的液流不均匀。在淬火过程中 ,液流是控制淬火烈度的关键。因此 ,如何测量在淬火过程发生的液流特性很重要。迄今为止 ,市场上还没有一种可用于热处理... 详细信息

造成淬火后工件硬度不均匀、热应力增加、畸变和开裂 ,主要是因为淬火槽内整个淬火区的液流不均匀。在淬火过程中 ,液流是控制淬火烈度的关键。因此 ,如何测量在淬火过程发生的液流特性很重要。迄今为止 ,市场上还没有一种可用于热处理生产设备的设计合理、具有足够灵敏度并经久耐用的液流传感器。本文对不同传感器的各种测量原理进行了概括 ,并描述了几种最近开发的可用于淬火槽中测量液流传感器。

关键词：工业淬火槽液流传感器测量原理

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Merriam-webster's Collegiate Dictionary, 11th Edition 11th ed.

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2003年

作者： Inc. Merriam-webster

ISBN: (数字)0877798095

ISBN: (纸本)9780877798095

Merriam webster is proud to announce the arrival of its most famous dictionary, now completely revised and updated. The features of the dictionary now include: 225,000 clear and precise definitions More than 40,000 word-use examples More than 7500 phrases and idions The Merriam webster Collegiate is a great learning too: It features a comprehensive coverage of all fields of knowledge 165,000 entries with correct spellings and pronunciations More than 700 illustrations, tables and diagrams for at-a-glance information The CD edition comes complete with the book and a free one year subscription to *** new Eleventh Edition of America's best-selling dictionary merges print, CD-ROM, and Internet-based formats to deliver unprecedented accessibility and flexibility at one affordable price. Fully revised print content features more than 225,000 clear and precise definitions and more than 10,000 words and meanings. Includes easily installable CD-ROM and free one-year subscription to new Collegiate Web *** first Merriam-webster's Collegiate Dictionary (M-W) was published in 1898, and the tenth edition had a copyright date of 1993. The eleventh edition brings many new words, a CD-ROM, and a free one-year subscription to Merriam-webster ***, which includes the text of the dictionary as well as the Collegiate Thesaurus, Collegiate Encyclopedia, and Merriam-webster's Spanish-English *** for the numbers. M-W has a paper file of 15,700,000 citations from which their lexicographers chose 10,000 new words, for a total of 165,000 entries and 225,000 definitions. There are 100,000 "changes" from the tenth edition. Users asked for more usage examples and idioms and phrases, so there are now 40,000 examples and a "significant" increase in idioms. There are 91,000 pronunciations, 33,000 etymologies, 2,700 illustrative quotations, 650 foreign words and phrases, and 700 *** the world rushes on, so does the time taken for w

关键词： English language

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The Language of Early Childhood: Volume 4

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丛书名： Collected Works of M.A.K. halliday

2004年

作者： M.A.K. halliday Jonathan J. webster

ISBN: (数字)9781847144041

ISBN: (纸本)9780826458704

For nearly half a century, Professor M. A. K. halliday has been enriching the discipline of linguistics with his keen insights into the social semiotic phenomenon we call language. This ten-volume series presents the seminal works of Professor halliday. This fourth volume contains sixteen papers that look at the development of early childhood language. They are presented in three parts: infancy and protolanguage; the transition from child tongue to mother tongue; and early language and learning. The sociolinguistic account of the early development of the mother tongue presented by Professor halliday is based on his intensive study of the language of one particular child, Nigel, for the period from nine- to eighteen months.

关键词： Language acquisition.

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