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Inflatable rock bolt bond strength versus rock mass rating (RMR)： A comparative analysis of pull-out testing data from underground mines in Nevada

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International Journal of Mining Science and Technology 2016年第1期26卷 19-22页

作者： Barnard Chase Kallu Raj R. warren sean Thareja Rahul Department of Mining Engineering University of Nevada Reno 89557 USA

The purpose of this paper is to establish confidence in anticipated minimum bond strength for inflatable rock bolts by comparing the bond strength to variable geotechnical conditions using the rock mass rating （RMR） system. To investigate a correlation between these parameters, the minimum bond strength of pull-out tested inflatable rock bolts was compared to the RMR of the rock in which these bolts were placed. Bond strength vs. RMR plots indicate that expected minimum bond strength is positively corre- lated with RMR; however, the correlation is not strong. Cumulative percent graphs indicate that 97~; of pull-out tests result in a minimum bond strength of 3.3 and 1.7 ton/m in RMR/〉 45 and 〈45, respectively. Although lower bond strengths are more commonly encountered in low RMR ground, high bond strengths are possible as well, yielding higher variability in bond strengths in low RMR ground. Bond strength of friction bolts relies on contact between the rock bolt and drill hole. Experience in Nevada indicates that RMR is known to affect both the quality and consistency of drill holes which likely affects bond strength. Drilling and bolting in low RMR ground is more sensitive to drilling and bolting practices, and strategies for maximizing bond strength in these conditions are discussed.

关键词： Rock mass ratingRMRRock boltPull-out testBond strength

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Human herpesvirus-8 positive iatrogenic Kaposi's sarcoma in the setting of refractory ulcerative colitis

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World Journal of Clinical Cases 2017年第12期5卷 423-427页

作者： Erica Duh sean Fine warren Alpert Medical School of Brown University Department of Inflammatory Bowel Disease Warren Alpert Medical School

Although Kaposi sarcoma(KS) has been more traditionally considered an AIDS-defining illness,it may also be seen in individuals on immunosuppresive *** report a case of a patient who presented to the hospital in the setting of increasingly refractory ulcerative *** tomography scan of the abdomen was consistent with sigmoid diverticulititis and blood cultures were positive for *** a course of antibiotics with resolution of infection,a colonoscopy was performed to evaluate his diverticulitis and incidentally revealed a new rectal *** showed the tumor was consistent with KS,with cells staining strongly positive for human *** case not only illustrates a rare case of KS found in an HIV-negative individual,but it also highlights the importance of considering an alternative diagnosis in a patient refractory to medical *** discuss the management and care of an ulcerative colitis patient diagnosed with KS on immunosuppressive therapy.

关键词： Kaposi sarcoma Colorectal cancer Ulcerative colitis Inflammatory bowel disease HIV/AIDS Human herpesvirus-8

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An automated multiwell plate reading flim microscope for live cell autofluorescence lifetime assays

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 99-113页

作者： Douglas J.Kelly sean C.warren Sunil Kumar Joao L.Lagarto Benjamin T.Dyer Anca Margineanu Eric W.-F.Lam Chris Dunsby Paul M.W.French Photonics Group Department of PhysicsImperial College London South Kensington CampusLondonSW72AZUK Institute of Chemical Biology Department of Chemistry Imperial College LondonSouth Kensington Campus LondonSWT 2AZUK National Heart&Lung Institute Imperial Centre for Eaperimental&Translational Medicine Du Cane Road LondonW12 ONNUK Department of Surgery and Cancer Imperial Cllege London Du Cane RoadLondonW12 ONNUK Centre for Histopathology Imperial College London Du Cane RoadLondonW120NNUK

Fluorescence lifetime imaging(FLIM)is increasingly used to read out cellular autofluorescenceoriginating from the coenzyme NADH in the context of investigating cell metabolic *** here an automated multiwell plate reading FLIM microscope optimized for UV illumi-nation with the goal of extending high content fluorescence lifetime asays to readouts ofmetabolism,We demonstrate its application to automated cellular autofluorescence lifetime imaging and discuss the key practical issues associated with its *** particular,weillustrate its capability to read out the NADH-lifetime response of cells to metabolic modulators,thereby illustrating the potential of the instrument for cytotoxicity studies,assays for drugdiscovery and stratified medicine.

关键词： High content analysis FLIM NADH metabolism cisplatin.

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Continued evidence for safety of endoscopic retrograde cholangiopancreatography during pregnancy

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World Journal of Gastrointestinal Endoscopy 2014年第8期6卷 352-358页

作者： sean Fine Joshua Beirne Silvia Delgi-Esposti Fadlallah Habr Department of Internal Medicine Warren Alpert School of Medicine Brown University Providence RI 02903 United States Department of Gastroenterology Santa Rosa Memorial Hospital and Sutter Medical Center Santa Rosa CA 95404 United States Department of Gastroenterology Warren Alpert School of Medicine Brown University Providence RI 02903 United States

AIM: To report the safety of continued use of endoscopic retrograde cholangiopancreatography(ERCP) during pregnancy at various maternal ***: A retrospective chart review of pregnant patients who underwent ERCP at a tertiary academic center was undertaken between 2002 and 2012. Pertinent past medical history and initial presenting laboratory data were collected. Review of the procedure note for each ERCP performed provided documentation of lead shielding, type of sedation, fluoroscopy time, and post-procedure complications. Patients' clinical courses were reviewed until the time of delivery and pregnancy complications with fetal outcomes were examined. Data was stratified based upon the mother's age at the time of ERCP: 18-21, 22-29, and ≥ 30 years of ***: Twenty pregnant patients who underwent ERCP between 2002 and 2012 were identified. The mean age at the time of ERCP was 26.4 years(18-38 years) and the average trimester was the second. The indications for ERCP were choledocholithiasis in 17 patients, gallstone pancreatitis in 2 patients, and cholangitis in 1 patient. The mean fluoroscopy time of ERCP was 3.8 min(0.3-23.6 min). Sphincterotomy was performed in 18 patients with therapeutic intent and not as a prophylactic measure to prevent recurrences. Clinical documentation of use of protective shielding was found in only 8 notes(40%). Post procedure complications were limited to two cases of post-ERCP pancreatitis(10%). Elective cholecystectomy was performed shortly after ERCP in 11 of the pregnant patients. Birth records were available for 16 patients, of which 15 had fullterm pregnancies. Cesarean sections were performed in 5(31%) patients. Term birth weight was greater than 2500 g in all cases except one in which the mother had a known hypercoagulable state. CONCLUSION: ERCP during pregnancy is both safe and efficacious regardless of maternal age or trimester.

关键词： Endoscopic retrograde cholangiopancreatography Pregnancy Choledocholithiasis Pancreatitis Cholecystectomy Caesarean section

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