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Beyond the Gut:The intratumoral microbiome’s influence on tumorigenesis and treatment response

Cancer Communications 2024年第10期44卷 1130-1167页

作者： Hao Zhang Li Fu Xinwen Leiliang Chunrun Qu wantao wu Rong Wen Ning Huang Qiuguang He Quan Cheng Guodong Liu Yuan Cheng Department of Neurosurgery The Second Affiliated HospitalChongqing Medical UniversityChongqingP.R.China Department of Gastroenterology The Second Affiliated HospitalChongqing Medical UniversityChongqingP.R.China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunanP.R.China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanP.R.China Department of Oncology Xiangya HospitalCentral South UniversityChangshaHunanP.R.China

The intratumoral microbiome(TM)refers to the microorganisms in the tumor tissues,including bacteria,fungi,viruses,and so on,and is distinct from the gut microbiome and circulating *** is strongly associated with tumorigenesis,progression,metastasis,and response to *** paper highlights the current status of *** sources,adjacent normal tissue,circulatory system,and concomitant tumor co-metastasis are the main origin of *** advanced techniques in TM analysis are comprehensively ***,TMis involved in tumor progression through several mechanisms,including DNA damage,activation of oncogenic signaling pathways(phosphoinositide 3-kinase[PI3K],signal transducer and activator of transcription[STAT],WNT/β-catenin,and extracellular regulated protein kinases[ERK]),influence of cytokines and induce inflammatory responses,and interaction with the tumor microenvironment(anti-tumor immunity,pro-tumor immunity,and microbial-derived metabolites).Moreover,promising directions of TM in tumor therapy include immunotherapy,chemotherapy,radiotherapy,the application of probiotics/prebiotics/synbiotics,fecal microbiome transplantation,engineered microbiota,phage therapy,and oncolytic virus *** inherent challenges of clinical application are also *** review provides a comprehensive landscape for analyzing TM,especially the TM-related mechanisms and TM-based treatment in cancer.

关键词： analysis methods immunotherapy intratumoral microbiome treatment application tumorpromotive and tumor-suppressive mechanisms

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Patient-derived xenograft models in cancer therapy:technologies and applications

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2209-2232页

作者： Yihan Liu wantao wu Changjing Cai Hao Zhang Hong Shen Ying Han Department of Oncology Xiangya HospitalCentral South UniversityChangshaHunan410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan410008P.R.China Department of Neurosurgery The Second Affiliated HospitalChongqing Medical UniversityChongqingChina

Patient-derived xenograft(PDX)models,in which tumor tissues from patients are implanted into immunocompromised or humanized mice,have shown superiority in recapitulating the characteristics of cancer,such as the spatial structure of cancer and the intratumor heterogeneity of ***,PDX models retain the genomic features of patients across different stages,subtypes,and diversified treatment *** PDX engraftment procedures and modern technologies such as multi-omics and deep learning have enabled a more comprehensive depiction of the PDX molecular landscape and boosted the utilization of PDX *** irreplaceable advantages make PDX models an ideal choice in cancer treatment studies,such as preclinical trials of novel drugs,validating novel drug combinations,screening drug-sensitive patients,and exploring drug resistance *** this review,we gave an overview of the history of PDX models and the process of PDX model ***,the review presents the strengths and weaknesses of PDX models and highlights the integration of novel technologies in PDX model ***,we delineated the broad application of PDX models in chemotherapy,targeted therapy,immunotherapy,and other novel therapies.

关键词： drugs replace treatment

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轻防腐水性钢结构防锈底漆的实验研究

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涂层与防护 2023年第11期44卷 53-56,65页

作者：徐小训查汪艺吴万涛安徽菱湖漆股份有限公司安徽安庆246000

以苯丙乳液为成膜物质,制备了一种钢结构轻防腐用的水性防锈底漆,符合HG/T5176—2017《钢结构用水性防腐涂料》的性能要求。研究了不同环境温度下成膜助剂的添加量对成膜效果的影响,以及不同防锈颜料对漆膜防锈性能的影响。研究表明,环... 详细信息

以苯丙乳液为成膜物质,制备了一种钢结构轻防腐用的水性防锈底漆,符合HG/T5176—2017《钢结构用水性防腐涂料》的性能要求。研究了不同环境温度下成膜助剂的添加量对成膜效果的影响,以及不同防锈颜料对漆膜防锈性能的影响。研究表明,环境温度在5℃时,成膜助剂添加量为乳液量的6%时,成膜效果最佳;608H磷酸锶黄的防腐性能最佳;FA179防闪锈剂和40%亚硝酸钠溶液使用量分别在0.5~1.0%和0.8%~1.0%时,防闪锈性能最佳;苯丙乳液的添加量为40%时,漆膜的早期耐水性、附着力和耐中性盐雾性能最佳。

关键词：苯丙乳液钢结构水性防锈底漆

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湛江乌石油田群海上溢油污染风险防控

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中国海事 2024年第4期 45-47页

作者：许万涛喻亮吴迪湛江海事局广东湛江524001

2024年3月17日,湛江乌石17-2/23-5油田群联合开放项目三座海上平台全部安装完成,预计2024年6月30日前正式投产。该项目作为广东省首个近浅海油气上岸项目,对保障国家能源安全、促进地区经济发展具有重要战略意义。同时,近浅海油气开发... 详细信息

2024年3月17日,湛江乌石17-2/23-5油田群联合开放项目三座海上平台全部安装完成,预计2024年6月30日前正式投产。该项目作为广东省首个近浅海油气上岸项目,对保障国家能源安全、促进地区经济发展具有重要战略意义。同时,近浅海油气开发也给海洋生态环境带来较大污染风险。针对乌石油田群海上溢油污染风险,提出防治对策与溢油应急能力建设等建议,为乌石油田群的安全绿色可持续开发提供有力支撑。

关键词：溢油污染防控

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基于可爆性分区方法的露天矿炸药单耗预测模型

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金属矿山 2024年第5期 102-109页

作者：于庆磊李友李万涛吴嘉伟王宇恒金日杰东北大学资源与土木工程学院辽宁沈阳110819 河北钢铁集团滦县司家营铁矿有限公司河北唐山063701

露天矿山爆破作业要求矿岩爆破块度均匀,对岩体可爆性进行评价与应用是优化爆破设计、改善爆破效果的重要依据。在总结分析岩体可爆性主要影响因素的基础上,对司家营铁矿15个爆区矿岩物理力学参数和节理裂隙参数进行了聚类分析和相关分... 详细信息

露天矿山爆破作业要求矿岩爆破块度均匀,对岩体可爆性进行评价与应用是优化爆破设计、改善爆破效果的重要依据。在总结分析岩体可爆性主要影响因素的基础上,对司家营铁矿15个爆区矿岩物理力学参数和节理裂隙参数进行了聚类分析和相关分析。结果表明:可以采用抗拉强度、岩石密度、岩体完整性系数和平均节理间距4个指标对岩体可爆性进行评价;同时用蚁群算法优化BP神经网络对评价指标进行赋权,提出了基于加权聚类分析的露天矿岩体可爆性分区方法;然后结合钻孔信息与地质模型,使用距离幂次反比法插值得到矿岩可爆性分区块体模型;利用多元回归分析方法,建立了基于可爆性分区指标的炸药单耗预测数学模型,可为后续类似工况爆区矿岩爆破设计提供参考,对优化爆破设计工作具有指导意义。

关键词：矿山爆破可爆性分区加权聚类分析块体模型炸药单耗

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Long and Covalently Conjugated Branched DNA Structures for in Situ Gelation in Vivo

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CCS Chemistry 2023年第9期5卷 2125-2139页

作者： Xuehe Lu Hong Wang Ruofan Chen Tiantian wu Xiaohui wu Yingxu Shang Yuang Wang wantao Tang Dongsheng Liu Jianbing Liu Baoquan Ding CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijing 100190 School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001 Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 University of Chinese Academy of Sciences Beijing 100049

DNA nanotechnology has been widely employed for biomedical ***,most DNA nanomaterials rely on noncovalent complementary base pairing of short single-stranded DNA ***,we describe a general strategy to construct a long and covalently conjugated branched DNA structure for fast and in situ gelation in *** our design,a short and covalently conjugated branched DNA structure can normally be employed as the DNA primer in the terminal deoxynucleotidyl transferase-dependent enzymatic polymerization *** enzymatic extension,the DNA aptamer-modified branched DNA structures with the sequences of poly T or poly A can immediately coassemble for in situ encapsulation of the target protein and tumor *** fast and in situ gelation system can function in a murine model of local tumor recurrence for targeting residual tumor cells to achieve long-term drug release for efficient tumor inhibition in *** rationally developed DNA self-assembly strategy provides a new avenue for the development of multifunctional DNA nanomaterials.

关键词： DNA material self-assembly nucleic acidmodification DNA polymerization in situ gelation

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循经点穴联合气交灸防治青少年轻中度单纯性近视的应用研究

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国际医药卫生导报 2024年第14期30卷 2423-2426页

作者：曾伟娇郭先桂曾婉桃林少芬吴儒林乔妹徐琳广东药科大学附属第一医院中医科广州510080

目的探讨循经点穴联合气交灸防治青少年轻中度单纯性近视的应用效果。方法选取2023年1—6月于广东药科大学附属第一医院中医科护眼门诊就诊的30例10~19周岁青少年为研究对象,其中男16例,年龄(14.31±3.14)岁;女14例,年龄(13.00±2.86)岁... 详细信息

目的探讨循经点穴联合气交灸防治青少年轻中度单纯性近视的应用效果。方法选取2023年1—6月于广东药科大学附属第一医院中医科护眼门诊就诊的30例10~19周岁青少年为研究对象,其中男16例,年龄(14.31±3.14)岁;女14例,年龄(13.00±2.86)岁,均予以循经点穴联合气交灸治疗,选取面部、耳部、膀胱经、督脉的穴位进行点按,此外在神阙穴进行气交灸治疗,每周3次,每2次间隔1 d,共治疗12周。观察患者治疗前后的裸眼视力及眼局部症状。采用配对t检验。结果治疗前,患者左眼视力(4.410±0.220)、右眼视力(4.373±0.160);治疗后,患者左眼视力(4.707±0.187)、右眼视力(4.700±0.137);治疗后双眼视力均较治疗前上升,差异均有统计学意义(t=137.549、188.652,均P<0.001)。治疗后,眼局部症状视物不持久、干涩、异物感、眼球酸胀、畏光流泪评分均低于治疗前[(1.367±0.490)分比(2.300±0.466)分、(1.367±0.490)分比(2.333±0.479)分、(1.400±0.498)分比(2.267±0.450)分、(1.167±0.379)分比(2.200±0.407)分、(1.333±0.479)分比(2.333±0.479)分],差异均有统计学意义(t=27.028、26.655、27.603、29.618、26.655,均P<0.001)。结论循经点穴联合气交灸可以提高轻中度单纯性近视青少年患者的双眼视力,缓解眼局部症状,效果显著,值得推广。

关键词：近视循经点穴气交灸青少年

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Chemically modified DNA nanostructures for drug delivery

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The Innovation 2022年第2期3卷 38-48页

作者： Yuang Wang Xuehe Lu Xiaohui wu Yan Li wantao Tang Changping Yang Jianbing Liu Baoquan Ding School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001China CAS Key Laboratory of Nanosystemand Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Based on predictable,complementary base pairing,DNA can be artificially pre-designed into versatile DNA nanostructures of well-defined shapes and *** excellent addressability and biocompatibility,DNA nanostructures have been widely employed in biomedical research,such as biosensing,bio-imaging,and drug *** the development of the chemical biology of nucleic acid.

关键词： DNA versatile pairing

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Dysregulated miR-363 affects head and neck cancer invasion and metastasis by targeting podoplanin

Dysregulated miR-363 affects head and neck cancer invasion a...

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第八届全国医学生物化学与分子生物学第五届全国临床应用生物化学与分子生物学2013华东六省一市生物化学与分子生物学联合学术研讨会

作者： Qiang Sun Jianjun Zhang Wei Cao Xu Wang Qin Xu Ming Yan Xiangbing wu wantao Chen Department of Oral and Maxillofacial-Head & Neck Oncology Ninth People's HospitalShanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology

Head and neck squamous cell carcinoma(HNSCC) is characterised by an elevated capacity for tumour invasion and lymph node metastasis and the cause remains to be *** studies suggest that microRNAs can regulate the evolution of malignant behaviours by regulating multiple target *** this study,we have first confirmed that miR-363 is down-regulated in HNSCC tissues with lymph node metastasis and cell lines with highly invasive *** used bioinformatics,cellular and molecular methods to predict and prove that miR-363 directly targeted to podoplanin(PDPN) and caused up-regulation of PDPN in *** assay showed that DNA promoter methylation was involved in silencing the miR-363 in ***,we provided evidence to demonstrate that PDPN dysregulation caused by down-regulation of miR-363 contributes to HNSCC invasion and *** data reveal a key role of miR-363-PDPN in HNSCC metastasis and support biological and clinical links between miR-363-PDPN and HNSCC.

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Nu A4 and Hos3/Rpd3-mediated histone H4 lysine 8 2-hydroxyisobutyrylation is regulated by glucose homeostasis in S. cerevisiae

Nu A4 and Hos3/Rpd3-mediated histone H4 lysine 8 2-hydroxyis...

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第九届中国模式真菌研讨会

作者： Jing Huang Zhouqing Luo wantao Yin Peng Xu Fangyi Li Qichen Cao Junkai Dong Chao wu Jian Wang Qingyu wu Zhucheng Chen Yingming Zhao Xiaohong Qian Junbiao Dai MOE Key laboratory of Bioinformatics MOE Key laboratory of Biocatalysis Centre for Synthetic and Systems Biology School of Life Sciences Tsinghua University State Key Laboratory of Proteomics National Protein Science Center-Beijing Beijing Proteome Research Center Beijing Institute of Radiation Medicine Department of Pharmacology and Pharmaceutical Sciences School of Medicine Tsinghua University Ben May Department of Cancer Research University of Chicago

New types of lysine modifications keep ***,their functional impacts and regulatory mechanisms remain largely ***,H4K82-hydroxyisobutyrylation(H4K8)was identified as a new evolutionary conserved

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