Patient-derived xenograft models in cancer therapy:technologies and applications
作者机构：Department of OncologyXiangya HospitalCentral South UniversityChangshaHunan410008China National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangshaHunan410008P.R.China Department of NeurosurgeryThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第5期
页 面：2209-2232页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from the National Key R&D Program of China (No.2018YFC1313300) National Natural Science Foundation of China (No.:81372629,81772627,81874073,81974384,82173342,and 82203015) key projects from the Nature Science Foundation of Hunan Province (No.:2021JJ31092&2021JJ31048) two projects from Beijing CSCO Clinical Oncology Research Foundation (No.Y-HR2019-0182&Y-2019Genecast-043)
摘 要：Patient-derived xenograft(PDX)models,in which tumor tissues from patients are implanted into immunocompromised or humanized mice,have shown superiority in recapitulating the characteristics of cancer,such as the spatial structure of cancer and the intratumor heterogeneity of ***,PDX models retain the genomic features of patients across different stages,subtypes,and diversified treatment *** PDX engraftment procedures and modern technologies such as multi-omics and deep learning have enabled a more comprehensive depiction of the PDX molecular landscape and boosted the utilization of PDX *** irreplaceable advantages make PDX models an ideal choice in cancer treatment studies,such as preclinical trials of novel drugs,validating novel drug combinations,screening drug-sensitive patients,and exploring drug resistance *** this review,we gave an overview of the history of PDX models and the process of PDX model ***,the review presents the strengths and weaknesses of PDX models and highlights the integration of novel technologies in PDX model ***,we delineated the broad application of PDX models in chemotherapy,targeted therapy,immunotherapy,and other novel therapies.
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