检索结果-南通市图书馆

Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenomics 2022年第1期2卷 64-71页

作者： Yaoxi He Jun Li Tian Yue wangshan zheng Yongbo Guo Hui Zhang Li Chen Chunxia Li Hongyan Li Chaoying Cui Ouzhuluobu Xuebin Qi Bing Su State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Fukang Obstetrics Gynecology and Children Branch HospitalTibetan Fukang HospitalLhasa 850000China High Altitude Medical Research Center School of MedicineTibetan UniversityLhasa 850000China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesBeijing 100101China

Birth weight(BW)is a key determinant of infant *** studies have reported seasonal fluctuation of ***,the responsible environmental factors remain ***-altitude environment provides a great opportunity to test the current hypotheses due to its distinctive climate *** collected BW data of~9000 Tibetan singletons born at Lhasa(elevation:3660 m)from 2014 to *** regression models,we analyzed BW seasonality of highland *** models with meteorological factors as independent variables were employed to examine responsible environmental factors accounting for seasonal *** compared BW,low-BW prevalence and sex ratio between high-land and lowland populations,and we observed a significant seasonal pattern of BW in Tibetans,with a peak in winter and a trough in ***,there is a marked sex-biased pattern of BW seasonality(more striking in males than in females).Sunlight exposure in the 3rd trimester and barometric pressure exposure in the 2nd trimester are significantly correlated with BW,and the latter can be explained by seasonal change of oxygen partial *** particular,due to the male-biased BW seasonality,we found a more serious BW reduction and higher prevalence of low-BW in males,and a skewed sex ratio in *** infant BW of highland Tibetans has a clear pattern of *** winter BW is larger than the summer BW,due to the longer sunlight exposure during the *** infants are more sensitive to hypoxia than female infants during the 2nd trimester,leading to more BW reduction and higher mortality.

关键词： Birth weight Seasonality Sex-bias High altitude Tibetans

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2020年第2期7卷 391-402页

作者： Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao wangshan zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su High Altitude Medical Research Center School of Medicine Tibetan University Fukang Obstetrics Gynecology and Children Branch Hospital Tibetan Fukang Hospital State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Chinese Academy of Sciences Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and Health Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University Center for Disease Control Tibet Autonomous Region National Key Laboratory of High Altitude Medicine High Altitude Medical Research Institute Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Collaborative Innovation Center of Genetics and Development

Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence—a662-bp intronic insertion in the SCUBE2 gene—is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies.

关键词： long-read sequencing Tibetan structural variants genetic adaptation reference genome

Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2018年第4期5卷 516-529页

作者： Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai wangshan zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui State Key Laboratoryof Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences High Altitude Medical Research Center School of Medicine Tibetan University National Key Laboratory of High Altitude Medicine High Altitude Medical Research Institute Fukang International Medical Examination Center Fukang Obstetrics Gynecologyand Children Branch Hospital Tibetan Fukang Hospital 7. Yunnan Key Laboratory of Primate Biomedicine ResearchInstitute of PrimateTranslational MedicineKunming University of Science andTechnology

Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in ***, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct ***, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia.

关键词： adaptation high altitude Tibetan nitric oxide GCH1

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

青海藏猪与八眉猪遗传多样性研究

畜牧与兽医 2015年第7期47卷 9-12页

作者：赵生国汪文强郑王山郭永博权金强车陇杰李永青甘肃农业大学动物科学技术学院甘肃兰州730070

为调查青海藏猪与八眉猪遗传资源,本研究测定了青海藏猪与八眉猪线粒体DNA D环(mt DNA)高变区核苷酸序列。结果表明:青海藏猪与八眉猪mt DNA D-loop高变区存在14个多态位点,其中有5个单一多态位点和9简约信息位点,根据多态位点界定了14... 详细信息

为调查青海藏猪与八眉猪遗传资源,本研究测定了青海藏猪与八眉猪线粒体DNA D环(mt DNA)高变区核苷酸序列。结果表明:青海藏猪与八眉猪mt DNA D-loop高变区存在14个多态位点,其中有5个单一多态位点和9简约信息位点,根据多态位点界定了14个单倍型,其中6个是青海藏猪和八眉猪所共享,且各自有4个特有单倍型。由于自然条件下产生的突变类型积累的缘故,青海藏猪保持了相对较高的遗传多样性,而可能由于瓶颈效应与人工选择影响,八眉猪的遗传多样性较低。系统发育揭示八眉猪和藏猪是两次不同的驯化事件的结果。

关键词：青海藏猪八眉猪 mtDNA D-loop 遗传多样性

Synthesis of a new meso/microporous composite molecular sieve of MCM-41/mordenite

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2005年第12期50卷 1180-1184页

作者： wangshan DOUTao LIYuping ZHANGYing YANZichun LIXiaofeng InstituteofSpecialChemicals TaiyuanUniversityofTechnologyTaiyuan030024China InstituteofSpecialChemicals TaiyuanUniversityofTechnologyTaiyuan030024China//TheCNPCKeyLaboratoryofCatalysisUniversityofPetroleumBeijing102249China TheCNPCKeyLaboratoryofCatalysis UniversityofPetroleumBeijing102249China

An MCM-41/mordenite composite with two- fold porous structure and stepwise-distributed acidity was prepared for the first time by using zeolite mordenite as the silica-alumina source. The composite molecular sieve has been investigated and compared with a mechanical mixture of mordenite and MCM-41 for their structure, acidity and catalytic activity by means of XRD, N2 adsorption and desorption, HRTEM, DTG, NH3-TPD and catalytic reaction. The characterization results show that the structure and property of the composite molecular sieve are quite different from those of the mechanical mixture, which might be ascribed to the incorporation of secondary building units characteristic of zeolite mordenite into the mesoporous walls of the composite which gives rise to the thicker mesoporous walls, the higher hydrothermal stability and more strong acid sites. Furthermore, the new strategy could be used as a new general method for the preparation of catalysts for the reaction system with multifold large molecules, and the results were well confirmed by the dealkylation of C10+ aromatic hydrocarbon.

关键词：发光沸石合成分子网 MCM.41 二级建筑

在线全文

学校读者我要写书评

暂无评论

福建省数字内容产业发展问题研究

中共福建省委党校学报 2008年第12期 95-102页

作者：雷弯山中共福建省委党校福建福州350001

福建省拥有丰富的文化资源,但数字内容产业存在"数字鸿沟",必须从体制机制的层面来解决福建省发展数字内容产业面临的问题:前提是明确产业、关键是整合资源、重点是突出个性、基础是创新教育,即由传承教育转向创意教育、数字技术转向创... 详细信息

福建省拥有丰富的文化资源,但数字内容产业存在"数字鸿沟",必须从体制机制的层面来解决福建省发展数字内容产业面临的问题:前提是明确产业、关键是整合资源、重点是突出个性、基础是创新教育,即由传承教育转向创意教育、数字技术转向创意思维、授之以鱼转向授之以渔。

关键词：数字内容产业发展困境对策研究

在线全文

学校读者我要写书评

暂无评论

应用逻辑是逻辑应用的元逻辑

中共福建省委党校学报 2005年第5期 41-46页

作者：雷弯山福建省委党校福建福州350001

应用逻辑是逻辑理论应用于特定领域所形成的逻辑理论,是国内外公认的一门逻辑分支学科。应用逻辑不是逻辑的应用,也不是逻辑哲学,更不能把任何科学都作为应用逻辑。应用逻辑是逻辑应用中逻辑的逻辑、理论的理论、元逻辑。

关键词：应用逻辑逻辑应用次元逻辑

基于ASP及SQL Server技术的长治市特色农产品电子商务平台构建研究

在线全文

学校读者我要写书评

暂无评论

基于ASP及SQL Server技术的长治市特色农产品电子商务平台构建研究

作者：王珊成都理工大学

学位级别：硕士

近年来,我国农业有了长足的发展,农业结构也有了较大的变化,信息对农业的影响越来越大,电子商务这一交易模式作为全新的交易模式,也促使农产品交易发生了新的变化。在这样一个契机下,发展农产品电子商务也就成为了必然的选择。长治市作... 详细信息

近年来,我国农业有了长足的发展,农业结构也有了较大的变化,信息对农业的影响越来越大,电子商务这一交易模式作为全新的交易模式,也促使农产品交易发生了新的变化。在这样一个契机下,发展农产品电子商务也就成为了必然的选择。长治市作为山西省的重点农业城市之一,农业产业有比较不错的基础,各项数据在全省都名列前茅。然而由于习惯使然,一家一户的小农习惯,以及城市农村分化,使得农业在长治市依然处于弱势的地位。因此,要想方设法加强农业建设,提高农民收入。特色农产品电子商务,作为地区特色产品的展销途径,可以较好地占据市场,以销量带动生产力,促进农业产业经济发展。长治市的特色农产品电子商务现今还只是在最初始的层面,无法与南方一些经济发达的城市比较。特色农产品电子商务会受很多方面的影响,电子商务平台就是其中重要的一个部分。有相关专家从多个方向对其进行了研究,并获得了一些结论。论文阐述了课题的研究背景和意义,论述了长治市农产品电子商务发展现状及存在问题,分析了电子商务平台对长治市电子商务发展的影响。简要说明了本文开发的农产品电子商务交易平台所用到的一些基本理论和相关技术工具。在此基础上,给出了系统分析和总体设计方案以及数据库的设计。对本系统的前台购物和后台管理主要功能模块的设计进行了详细分析与研究。论文分析了长治市特色农产品电子商务的现状以及存在的问题,对前人的研究进行了学习,运用问卷调查的途径进行数据的采集,总结出对电子商务发展有着巨大影响的几个方面,并对长治市特色农产品电子商务的发展状况进行了分析。论文将长治市农业信息化的情况及特色农产品交易的现状与之前的研究结果结合,利用ASP技术及SQL数据库的特点,设计出一个集合了产品发布,在线交易,个性服务,用户管理等功能的地区性特色农产品电子商务平台。该平台除具有传统电商的功能以外,增加了个性化的预定及高端订制功能,这是该平台与传统电商的不同之处,也是亮点所在。如若实现必将能组织引导更多的长治市的农业相关企业、社区农业合作社及个体农户发展农产品电子商务,让当地的特色农产品更大限度地得到宣传,使农企更快更及时更准确地了解市场上农产品的供求信息,推进长治市农业现代化的进程。

关键词：长治市特色农产品电子商务平台设计

Individual stimuli can improve the score of Functional Object Use in CRS-R in DOC patients

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Individual stimuli can improve the score of Functional Objec...