Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations

作     者：Yaoxi He Jun Li Tian Yue Wangshan Zheng Yongbo Guo Hui Zhang Li Chen Chunxia Li Hongyan Li Chaoying Cui Ouzhuluobu Xuebin Qi Bing Su 

作者机构：State Key Laboratory of Genetic Resources and EvolutionKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Fukang ObstetricsGynecology and Children Branch HospitalTibetan Fukang HospitalLhasa 850000China High Altitude Medical Research CenterSchool of MedicineTibetan UniversityLhasa 850000China Center for Excellence in Animal Evolution and GeneticsChinese Academy of SciencesKunming 650223China Kunming College of Life ScienceUniversity of Chinese Academy of SciencesBeijing 100101China 

出 版 物：《Phenomics》 (表型组学（英文）)

年 卷 期：2022年第2卷第1期

页      面：64-71页

学科分类：0302[法学-政治学] 03[法学] 030204[法学-中共党史(含：党的学说与党的建设)] 

基　　金：funded by grants from the National Natural Science Foundation of China(NSFC)(91631306 to B.S,3217040584 and 32000390 to Y.H.,32070578 to X.Q and 32170629 to H.Z.) the Youth Innovation Promotion Association of CAS(to Y.H.) the Science and Technology General Program of Yunnan Province(202001AT070110 to Y.H.) the Provincial Natural Science Foundation of Tibet Autonomous Region(XZ2018ZRG-130 to J.L.) Tibetan Fukang Hospital(2017-04 to J.L.) 

主　　题：Birth weight Seasonality Sex-bias High altitude Tibetans 

摘      要：Birth weight(BW)is a key determinant of infant *** studies have reported seasonal fluctuation of ***,the responsible environmental factors remain ***-altitude environment provides a great opportunity to test the current hypotheses due to its distinctive climate *** collected BW data of~9000 Tibetan singletons born at Lhasa(elevation:3660 m)from 2014 to *** regression models,we analyzed BW seasonality of highland *** models with meteorological factors as independent variables were employed to examine responsible environmental factors accounting for seasonal *** compared BW,low-BW prevalence and sex ratio between high-land and lowland populations,and we observed a significant seasonal pattern of BW in Tibetans,with a peak in winter and a trough in ***,there is a marked sex-biased pattern of BW seasonality(more striking in males than in females).Sunlight exposure in the 3rd trimester and barometric pressure exposure in the 2nd trimester are significantly correlated with BW,and the latter can be explained by seasonal change of oxygen partial *** particular,due to the male-biased BW seasonality,we found a more serious BW reduction and higher prevalence of low-BW in males,and a skewed sex ratio in *** infant BW of highland Tibetans has a clear pattern of *** winter BW is larger than the summer BW,due to the longer sunlight exposure during the *** infants are more sensitive to hypoxia than female infants during the 2nd trimester,leading to more BW reduction and higher mortality.