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Hypophysitis induced by anti-programmed cell death protein 1 immunotherapy in non-small cell lung cancer:Three case reports

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World Journal of Clinical Cases 2022年第30期10卷 11049-11058页

作者： Yun Zheng chen-Yu Zhu Jing Lin wang-shan chen Yu-Jie wang Hong-Ye Fu Qiong Zhao Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310030Zhejiang ProvinceChina Department of Thoracic Oncology Shulan(Hangzhou)Hospital affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000Zhejiang ProvinceChina Zhejiang Chinese Medical University Hangzhou 311402Zhejiang ProvinceChina

BACKGROUND Hypophysitis induced by programmed cell death 1 protein(PD-1)immune checkpoint inhibitors is rare and poorly *** report three patients with non-small cell lung cancer who developed hypophysitis after anti-PD-1 *** SUMMARY Both case 1 and case 2 presented with common symptoms of fatigue,nausea,and ***,case 3 showed rare acute severe symptoms such as hoarse voice,bucking,and difficulty in breathing even when *** two cycles of immunotherapy in case 3,the above severe symptoms and pituitary gland enlargement were found on magnetic resonance imaging at the onset of *** symptoms were relieved after 10 d of steroid *** 3 was the first patient with these specific symptoms,which provided a new insight into the diagnosis of *** addition,we found that the clinical prognosis of patients with hypophysitis was related to the dose of steroid *** 3 was treated with high-dose hormone therapy and her pituitary-corticotropic axis dysfunction returned to normal after more than 6 mo of steroid *** 1 and 2 were treated with the low-dose hormone,and dysfunction of the pituitary-corticotropic axis was still present after up to 7 mo of steroid *** The clinical symptoms described in this study provide a valuable reference for the diagnosis and treatment of immune-related hypophysitis.

关键词： Programmed cell death protein 1 Immunotherapy Hypophysitis Lung cancer Case reports

Oxidative-damage effect of Fe3O4 nanoparticles on mouse hepatic and brain cells in vivo

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Frontiers in Biology 2013年第5期8卷 549-555页

作者： Yongli wang Nian QIN shan chen Jingyun ZHAO Xu YANG Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Science Central China Normal University Wuhan 430079 China

To assess the biological safety of Fe3O4 nanoparticles （NPs）, the oxidative-damage effect of these NPs was studied. Twenty-five Kunming mice were exposed to Fe3O4 NPs by intraperitoneai injection daily for 1 week at doses of 0, 10, 20, and 40 ***1. Five Kunming mice were also injected with 40 *** 1 ordinary Fe3O4 particles under the same physiological conditions. Biomarkers of reactive oxygen species （ROS）, glutathione （GSH）, and malondialdehyde （MDA） in the hepatic and brain tissues were detected. Results showed that no significant difference in oxidative damage existed at concentrations lower than 10 *** i for NPs compared with the control group. Fe3O4 NP concentration had obvious dose-effect relationships （P〈 0.05 or P 〈 0.01） with ROS level, GSH content, and MDA content in mouse hepatic and brain tissues at〉20 *** 1 concentrations. To some extent, ordinary Fe3O4 particles with *** -1 concentration also affected hepatic and brain tissues in mice. The biological effect was similar to Fe3O4 NPs at 10 mg. kg-1 concentration. Thus, Fe3O4 NPs had significant damage effects on the antioxidant defense system in the hepatic and brain tissues of mice, whereas ordinary Fe3O4 had less influence than Fe3O4 NPs at the same concentration.

关键词： Fe3O4 nanoparticle (NP) ordinary Fe3O4 particle oxidative damage reactive oxygen species (ROS) glutathione (GSH) malondialdehyde (MDA)

Failure evolution and disaster prediction of rock under uniaxial compression based on non-extensive statistical analysis of electric potential

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International Journal of Mining Science and Technology 2024年第7期34卷 975-993页

作者： Tiancheng shan Zhonghui Li Haishan Jia Enyuan wang Xiaoran wang Yue Niu Xin Zhang Dong chen shan Yin Quancong Zhang State Key Laboratory of Coal Mine Disaster Prevention and Control China University of Mining and TechnologyXuzhou 221116China National Engineering Research Center for Coal Gas Control China University of Mining and TechnologyXuzhou 221116China School of Safety Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China

Rock failure can cause serious geological disasters,and the non-extensive statistical features of electric potential(EP)are expected to provide valuable information for disaster *** this paper,the uniaxial compression experiments with EP monitoring were carried out on fine sandstone,marble and granite samples under four displacement *** Tsallis entropy q value of EPs is used to analyze the selforganization evolution of rock *** the influence of displacement rate and rock type on q value are explored by mineral structure and fracture modes.A self-organized critical prediction method with q value is *** results show that the probability density function(PDF)of EPs follows the q-Gaussian *** displacement rate is positively correlated with q *** the displacement rate increasing,the fracture mode changes,the damage degree intensifies,and the microcrack network becomes *** influence of rock type on q value is related to the burst intensity of energy release and the crack fracture *** q value of EPs can be used as an effective prediction index for rock failure like b value of acoustic emission(AE).The results provide useful reference and method for the monitoring and early warning of geological disasters.

关键词： Electric potential Non-extensive statistical feature Displacement rate q-Gaussian distribution Precursor prediction Rock materials

Multi-scale Modeling and Finite Element Analyses of Thermal Conductivity of 3D C/SiC Composites Fabricating by Flexible-Oriented Woven Process

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 275-288页

作者： Zheng Sun Zhongde shan Hao Huang Dong wang wang wang Jiale Liu chenchen Tan Chaozhong chen Nanjing University of Aeronautics and Astronautics Nanjing 210016China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China CRRC Institute Corporation Limited Beijing 100070China

Thermal conductivity is one of the most significant criterion of three-dimensional carbon fiber-reinforced SiC matrix composites(3D C/SiC).Represent volume element(RVE)models of microscale,void/matrix and mesoscale proposed in this work are used to simulate the thermal conductivity behaviors of the 3D C/SiC *** entirely new process is introduced to weave the preform with three-dimensional orthogonal *** 3D steady-state analysis step is created for assessing the thermal conductivity behaviors of the composites by applying periodic temperature boundary *** RVE models of cuboid,hexagonal and fiber random distribution are respectively developed to comparatively study the influence of fiber package pattern on the thermal conductivities at the ***,the effect of void morphology on the thermal conductivity of the matrix is analyzed by the void/matrix *** prediction results at the mesoscale correspond closely to the experimental *** effect of the porosities and fiber volume fractions on the thermal conductivities is also taken into *** multi-scale models mentioned in this paper can be used to predict the thermal conductivity behaviors of other composites with complex structures.

关键词： 3D C/SiC composites Finite element analyses Multi-scale modeling Thermal conductivity

Assembling S-scheme heterojunction between basic bismuth nitrate and bismuth tungstate with promoting charges’separation for accelerated photocatalytic sulfamethazine degradation

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Journal of Materials Science & Technology 2024年第4期171卷 185-197页

作者： Wenhan chen Meng Dai Li Xiang shan Zhao Shuguang wang Zuoli He shandong Key Laboratory of Water Pollution Control and Resource Reuse Shandong Key Laboratory of Environmental Processes and HealthSchool of Environmental Science and EngineeringShandong UniversityQingdao 266237China CEDAR Knight Cancer InstituteSchool of MedicineOregon Health and Science UniversityPortlandOR 97201United States Weihai Research Institute of Industrial Technology of shandong University Shandong UniversityWeihai 264209China

The S-scheme heterojunction has garnered increasing attention due to its remarkable oxidation capacity and efficient separation of photogenerated *** this study,a one-pot glycerol-assisted hydrothermal process was utilized to successfully synthesize S-scheme heterojunction photocatalysts comprising basic bismuth nitrate(BBN)and bismuth tungstate(BWO).Interestingly,the BBN/BWO heterogeneous photo-catalysts exhibited the highest photocatalytic *** optimized product achieved the degradation of sulfamethazine(SMZ)within 1 h,with a kinetic constant(k)value of 0.05818 min^(−1).The degradation process was influenced significantly by·O^(2)−and h^(+)*** determine the degradation pathway of SMZ in the presence of BBN/BWO-0.6,liquid chromatography-mass spectrometry(LC-MS)analysis was performed,which revealed a decrease in the toxicity of intermediates and *** enhanced pho-tocatalytic activity can be attributed to the internal electric field(IEF)of the S-scheme heterojunction between BBN and BWO,effectively promoting the separation of photogenerated *** research presents a viable approach for developing S-scheme heterojunctions in SMZ photodegradation and other environmental applications.

关键词： Photocatalysis S-scheme Heterojunction Bi_(2)WO_(6) Sulfamethazine

Human influence on the duration of extreme temperature events in Asia's hotspot regions

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Advances in Climate Change Research 2024年第2期15卷 312-326页

作者： Zi-Meng wang Hong-Yun MA Wei LI Hai-shan chen Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Nanjing University of Information Science and TechnologyNanjing 210044China

Observations and models indicate that human activities exert a considerable impact on the frequency and intensity of extreme temperature events,which are associated with global ***,changes in the duration of extreme temperature events and their association with human influence have not been considered in most ***,the possible relationship between the observed changes in the warm and cold spell duration(WSDI and CSDI)in hotspot regions during 1960-2014 and human influence was investigated based on the NCEP/NCAR reanalysis version 1 and Coupled Model Inter-comparison Project Phase 6(CMIP6)*** projection based on these attribution results was also *** optimal fingerprinting technique was used to compare observed changes in WSDI and CSDI to simulated changes averaged across eight CMIP6 *** show that anthropogenic(ANT)forcing contributed to the observed increase in WSDI in the three hotspot regions(West Asia,South Asia and Southeast Asia),with the majority of the changes being attributed to greenhouse gas ***,a generally weak ANT signal can be observed in the decreasing trend of CSDI and can be detected in South and Southeast *** influence of aerosol forcing remains undetected in either WSDI or CSDI,which differs from the results for frequency and intensity of extreme *** attribution results revealed that the constrained projection of WSDI is lower than the raw projection for 2015-2100 in West Asia and Southeast ***,no differences in future CSDI changes are found in Southeast Asia between the constrained and raw projections.

关键词： Extreme temperature events Duration Detection attribution Constraint projection Hotspot regions

Atomic layer deposition in advanced display technologies:from photoluminescence to encapsulation

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International Journal of Extreme Manufacturing 2024年第2期6卷 65-82页

作者： Rong chen Kun Cao Yanwei Wen Fan Yang Jian wang Xiao Liu Bin shan State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China

Driven by the growing demand for next-generation displays,the development of advanced luminescent materials with exceptional photoelectric properties is rapidly accelerating,with such materials including quantum dots and phosphors,***,the primary challenge preventing the practical application of these luminescent materials lies in meeting the required durability *** layer deposition(ALD)has,therefore,been employed to stabilize luminescent materials,and as a result,flexible display devices have been fabricated through material modification,surface and interface engineering,encapsulation,cross-scale manufacturing,and *** addition,the appropriate equipment has been developed for both spatial ALD and fluidized ALD to satisfy the low-cost,high-efficiency,and high-reliability manufacturing *** strategic approach establishes the groundwork for the development of ultra-stable luminescent materials,highly efficient light-emitting diodes(LEDs),and thin-film ***,this significantly enhances their potential applicability in LED illumination and backlighted displays,marking a notable advancement in the display industry.

关键词： atomic layer deposition display luminescent encapsulation

A whole-net cooperative positioning method based on CDGNSS and inter-vehicle ranging

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Chinese Journal of Aeronautics 2024年第2期37卷 401-416页

作者： shan HU Hongbo ZHAO chen ZHUANG School of Electronics and Information Engineering Beihang UniversityBeijing 100191China

Relative positioning is recognized as an important issue for vehicles in urban ***-vehicle Cooperative Positioning(CP)techniques which fuse the Global Navigation Satellite System(GNSS)and inter-vehicle ranging have attracted attention in improving the performance of baseline estimation between ***,current CP methods estimate the baselines separately and ignore the interactions among the positioning information of different *** interactions are called’information coupling’.In this work,we propose a new multivehicle precise CP framework using the coupled information in the network based on the Carrier Differential GNSS(CDGNSS)and inter-vehicle *** demonstrate the benefit of the coupled information by deriving the Cramer-Rao Lower Bound(CRLB)of the float estimation in *** fully use this coupled information,we propose a Whole-Net CP(WN-CP)method which consists of the Whole-Net Extended Kalman Filter(WN-EKF)as the float estimation filter,and the Partial Baseline Fixing(PBF)as the ambiguity resolution *** WN-EKF fuses the measurements of all baselines simultaneously to improve the performance of float estimation,and the PBF strategy fixes the ambiguities of the one baseline to be estimated,instead of full ambiguity resolution,to reduce the computation load of ambiguity *** tests involving four vehicles were conducted in urban *** results show that the proposed WN-CP method can achieve better performance and meanwhile maintain a low computation load compared to the existing methods.

关键词： GNSS Cooperative positioning Baseline Ambiguity resolution Information coupling

Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms

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Journal of Environmental Sciences 2024年第1期135卷 449-473页

作者： Jianwei Zhang Zhao chen Dan shan Yang Wu Yue Zhao chen Li Yue Shu Xiaoyu Linghu Baiqi wang Department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Medical Tianjin Stomatological HospitalSchool of MedicineNankai UniversityTianjin 300041China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China National Demonstration Center for Experimental Preventive Medicine Education(Tianjin Medical University) Tianjin 300070China

Particulate pollution is a global risk factor that seriously threatens human *** particles(FPs)and ultrafine particles(UFPs)have small particle diameters and large specific surface areas,which can easily adsorb metals,microorganisms and other *** and UFPs can enter the human body in multiple ways and can be easily and quickly absorbed by the cells,tissues and *** the body,the particles can induce oxidative stress,inflammatory response and apoptosis,furthermore causing great adverse *** studies mainly take the population as the research object to study the distribution of diseases and health conditions in a specific population and to focus on the identification of influencing ***,the mechanism by which a substance harms the health of organisms is mainly demonstrated through toxicological *** epidemiological studies with toxicological studies will provide a more systematic and comprehensive understanding of the impact of PM on the health of *** this review,the sources,compositions,and morphologies of FPs and UFPs are briefly introduced in the first *** effects and action mechanisms of exposure to FPs and UFPs on the heart,lungs,brain,liver,spleen,kidneys,pancreas,gastrointestinal tract,joints and reproductive system are systematically *** addition,challenges are further pointed out at the end of the *** work provides useful theoretical guidance and a strong experimental foundation for investigating and preventing the adverse effects of FPs and UFPs on human health.

关键词： Fine particles Ultrafine particles Organs Adverse effect