Oxidative-damage effect of Fe3O4 nanoparticles on mouse hepatic and brain cells in vivo

作     者：Yongli WANG Nian QIN Shan CHEN Jingyun ZHAO Xu YANG 

作者机构：Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Science Central China Normal University Wuhan 430079 China 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2013年第8卷第5期

页      面：549-555页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 070602[理学-大气物理学与大气环境] 0706[理学-大气科学] 071002[理学-动物学] 

基　　金：This work was financially supported by a grant from the National Natural Science Foundation of China (Grant No. 50802032) 

主　　题：Fe3O4 nanoparticle (NP) ordinary Fe3O4 particle oxidative damage reactive oxygen species (ROS) glutathione (GSH) malondialdehyde (MDA) 

摘      要：To assess the biological safety of Fe3O4 nanoparticles （NPs）, the oxidative-damage effect of these NPs was studied. Twenty-five Kunming mice were exposed to Fe3O4 NPs by intraperitoneai injection daily for 1 week at doses of 0, 10, 20, and 40 ***1. Five Kunming mice were also injected with 40 *** 1 ordinary Fe3O4 particles under the same physiological conditions. Biomarkers of reactive oxygen species （ROS）, glutathione （GSH）, and malondialdehyde （MDA） in the hepatic and brain tissues were detected. Results showed that no significant difference in oxidative damage existed at concentrations lower than 10 *** i for NPs compared with the control group. Fe3O4 NP concentration had obvious dose-effect relationships （P〈 0.05 or P 〈 0.01） with ROS level, GSH content, and MDA content in mouse hepatic and brain tissues at〉20 *** 1 concentrations. To some extent, ordinary Fe3O4 particles with *** -1 concentration also affected hepatic and brain tissues in mice. The biological effect was similar to Fe3O4 NPs at 10 mg. kg-1 concentration. Thus, Fe3O4 NPs had significant damage effects on the antioxidant defense system in the hepatic and brain tissues of mice, whereas ordinary Fe3O4 had less influence than Fe3O4 NPs at the same concentration.