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山东济南优异农作物种质资源保护开发利用现状及建议

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中国种业 2024年第6期 66-68,72页

作者：王存凯亓翠玲央珍邢玉喜李修莲山东省济南市农业技术推广服务中心济南250002 山东省济南市章丘区农业发展服务中心济南250200 章丘市种业有限公司山东济南250200

济南市农作物种质资源丰富,拥有众多独具特色的地方资源,但近年来济南市地方种质资源消失风险加剧,给农作物种质资源保护开发利用工作带来极大的不利影响。截至目前,济南市第三次全国农作物种质资源普查与收集行动已基本结束,但种质资... 详细信息

济南市农作物种质资源丰富,拥有众多独具特色的地方资源,但近年来济南市地方种质资源消失风险加剧,给农作物种质资源保护开发利用工作带来极大的不利影响。截至目前,济南市第三次全国农作物种质资源普查与收集行动已基本结束,但种质资源保护开发利用工作任重而道远,不仅需要政策引导,还需要各相关单位积极配合。对济南市农作物种质资源基本情况进行介绍,深入剖析了莱芜生姜、章丘大葱、仲秋红大枣、灵岩御菊、李桂芬梨、黄金蜜桃等6个优异种质资源开发利用典型案例,提出了进一步推动优异种质资源开发利用的建议。

关键词：济南农作物种质资源保护开发利用

糖尿病肾病维持性血液透析患者皮肤瘙痒发生的影响因素分析

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中国实用医刊 2024年第11期51卷 49-52页

作者：王亭亭田兴张娟姚岚刘晓郑媛郑州大学第一附属医院肾脏内科郑州450000

目的探讨糖尿病肾病维持性血液透析患者皮肤瘙痒发生的影响因素。方法前瞻性抽取2021年5月至2023年5月于郑州大学第一附属医院接受维持性血液透析治疗的糖尿病肾病患者198例为研究对象,观察糖尿病肾病患者维持性血液透析期间皮肤瘙痒发... 详细信息

目的探讨糖尿病肾病维持性血液透析患者皮肤瘙痒发生的影响因素。方法前瞻性抽取2021年5月至2023年5月于郑州大学第一附属医院接受维持性血液透析治疗的糖尿病肾病患者198例为研究对象,观察糖尿病肾病患者维持性血液透析期间皮肤瘙痒发生情况,并根据结果分为发生组和未发生组。收集两组患者的一般资料和主要实验室指标检测结果,采用单因素和多因素Logistic回归分析检验糖尿病肾病患者维持性血液透析期间皮肤瘙痒发生的影响因素。结果198例行维持性血液透析治疗的糖尿病肾病患者中,发生皮肤瘙痒108例,发生率为54.55%,纳入发生组;90例未发生皮肤瘙痒的患者纳入未发生组。发生组与未发生组年龄、糖尿病病程、血液净化方式、空腹血糖(FBG)水平、尿素清除指数(Kt/v)水平比较差异均有统计学意义(P均1),Kt/v水平高是其保护因素(OR<1)。结论糖尿病肾病维持性血液透析患者并发皮肤瘙痒的风险高,可能与年龄、糖尿病病程、血液净化方式、FBG水平、Kt/v水平有关,临床应予以重视。

关键词：糖尿病肾病血液透析皮肤瘙痒

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Regenerative Biomaterials 2023年第1期10卷 377-385页

作者： Jianping Gao Zhenhu Guo Yang Zhang Yuying Liu Fangyu xing Junjie wang Xi Luo Yingjun Kong Guifeng Zhang National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China

The content of type I collagen(COL-I)and type III collagen(COL-III)and the ratio between them not only affect the skin elasticity and mechanical strength,but also determine the fibril *** this research,we investigated the age-related changes in COL-I/COL-III ratio with their formed fibril *** experimental result was obtained from high performance liquid chromatography-mass spectrometer,hydroxyproline determination,picrosirius red staining and transmission electron microscopes(TEM),*** result indicated that the COL-I/COL-III ratio in mouse skin increased with *** the 0th to 9th week,the COL-I/COLIII ratio increased from 1.3:1 to 4.5:*** the 9th to the 18th week,it remained between 4.5:1 and 4.9:*** total content of COL-I and COL-III firstly increased and then decreased with *** TEM result showed that the fibril diameter increased with *** the 0th to 9th week,the average fibril diameter increased from 40 to 112 nm;From the 9th to 18th weeks,it increased from 112 to 140 *** the 9th *** fibril diameter showed obvious uneven ***,the COL-I/COLIII ratio was proportional to the fibril diameter,but inversely proportional to the uniformity of fibril diameter.

关键词： collagen skin ratio fibril diameter

Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension

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Bioactive Materials 2022年第2期7卷 494-504页

作者： Chen wang Changyang xing Zhelong Li Yunnan Liu Qiaoying Li Yixiao wang Jiao Hu Lijun Yuan Guodong Yang Department of Ultrasound Diagnostics Tangdu HospitalFourth Military Medical UniversityXi’an710038People’s Republic of China State Key Laboratory of Cancer Biology Fourth Military Medical UniversityXi’an710032People’s Republic of China Department of Biochemistry and Molecular Biology Fourth Military Medical UniversityXi’an710032People’s Republic of China

Arterial stiffness due to the vessel remodeling is closely linked to raised blood pressure,and its physiopathologic mechanism is still not fully *** here aimed to explore whether extracellular vesicle(EV)mediated intercellular communication between endothelium and smooth muscle cell contribute to the blood vessel remodeling under *** here revealed that the arterial endothelial cells robustly secreted EV,which in turn could be circulated and/or directly taken up by the subendothelial smooth muscle cells(SMC).Under hypertension,the EV secretion increased and the miRNA profile changed significantly mainly due to the raised mechanical force and subsequent enhanced reactive oxygen species *** the miRNA cargos in the EV,miR-320d/423-5p were found increased most *** vivo delivery of miR-320d/423-5p mimics via engineered EV increased their expression in arterial vessels,recapitulating the phenotype in *** contrast,therapeutic delivery of miR-320d/423-5p inhibitors via engineered EV alleviated the phenotype in spontaneous hypertension rat ***,we have found that the injured endothelium due to the raised mechanical force in hypertension contributes to the arterial wall remodeling via the secreted *** study has not only provided novel insights on the mechanism of hypertension associated blood vessel wall remodeling,but also shed light on therapeutic intervention of hypertension associated vascular diseases.

关键词： Hypertension Extracellular vesicles Endothelial cell Smooth muscle cell Phenotype switch microRNA

SARS Patients-derived Human Recombinant Antibodies to S and M Proteins Efficiently Neutralize SARS-Coronavirus Infectivity

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Biomedical and Environmental Sciences 2005年第6期18卷 363-374页

作者： MI-FANG LIANG RUN -LEI DU JING-ZHI LIU CHUAN LI QUAN-FU ZHANG LU-LU HAN JIAN-SHI YU shu-MIN DUAN XIAO-FANG wang KONG-xing WU ZHAO-HUI XION QI JIN DE-XIN LI State Key Laboratory for Infectious Disease Control and Prevention Institute for Viral Disease Control and Prevention State Key Laboratory for Molecular Virology Chinese Center for Disease Control and Prevention 100 Yingxin Street Xuanwu District Beijing 100052 China

Objective To develop a specific SARS virus-targeted antibody preparation for emergent prophylaxis and treatment of SARS virus infection. Methods By using phage display technology, we constructed a naive antibody library from convalescent SARS patient lymphocytes. To obtain the neutralizing antibody to SARS virus surface proteins, the library panning procedure was performed on purified SARS virions and the specific Fab antibody clones were enriched by four rounds of repeated panning procedure and screened by highthroughput selection. The selected Fab antibodies expressed in the periplasma of E. coli were soluble and further purified and tested for their binding properties and antiviral function to SARS virus. The functional Fab antibodies were converted to full human IgG antibodies with recombinant baculovirus/insect cell systems and their neutralizing activities were further determined. Results After four rounds of the panning, a number of SARS-CoV virus-targeted human recombinant Fab antibodies were isolated from the SARS patient antibody library. Most of these were identified to recognize both natural and recombinant SARS spike （S） proteins, two Fab antibodies were specific for the virus membrane （M） protein, only one bound to SARS-CoV nucleocapsid protein. The SARS-CoV S and M protein-targeted Fab or IgG antibodies showed significant neutralizing activities in cytopathic effect （CPE） inhibition neutralization test, these antibodies were able to completely neutralize the SARS virus and protect the Vero cells from CPE after virus infection. However, the N protein-targeted Fab or IgG antibodies failed to neutralize the virus. In addition, the SARS N protein-targeted human Fab antibody reacted with the denatured N proteins, whereas none of the S and M protein specific neutralizing antibodies did. These results suggested that the S and M protein-specific neutralizing antibodies could recognize conformational epitopes which might be involved in the binding of virions t

关键词： SARS-CoV Phage display Human antibody

LNG储罐混凝土外罐施工期间温度裂缝预测及裂缝控制措施研究

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建筑技术开发 2024年第4期51卷 123-125页

作者：费振兴尹天王杨付伟杨翼鸣中国建筑第二工程局有限公司核电建设分公司广东深圳518000

大体积混凝土浇筑是LNG储罐基建筑的关键环节,其在养护期间会释放出大量的水泥水化热,并在内外环境的共同作用下形成巨大的拉伸拉应力,并伴随着与之相对应的混凝土的拉伸强度,导致结构的整体性、防水性及耐久性等性能降低。结合某公司... 详细信息

大体积混凝土浇筑是LNG储罐基建筑的关键环节,其在养护期间会释放出大量的水泥水化热,并在内外环境的共同作用下形成巨大的拉伸拉应力,并伴随着与之相对应的混凝土的拉伸强度,导致结构的整体性、防水性及耐久性等性能降低。结合某公司液化天然气储存与运输工程的贮罐地基工程,对其建造过程进行系统研究,并对所制订的施工方法进行科学、实用的检验,提出相应的防治对策,以期为我国未来的重大仓储、运输、储存等工程建设过程中的质量监控与管理工作奠定理论与实践基础。

关键词： LNG储罐混凝土裂缝预测裂缝控制

Optimized coagulation pretreatment alleviates ultrafiltration membrane fouling: The role of floc properties and slow-mixing speed on mechanisms of chitosan-assisted coagulation

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Journal of Environmental Sciences 2019年第8期31卷 82-92页

作者： Peng Du xing Li Yanling Yang Zhaoyang Su Hang Li Nan wang Tingting Guo Tingting Zhang Zhiwei Zhou College of Architecture and Civil engineering Beijing University of Technology

To alleviate ultrafiltration(UF) membrane fouling, the pre-coagulation of poly-aluminum chloride(PACl) with the aid of chitosan(CTS) was conducted for synthetic humic acid–kaolin water treatment. Pre-coagulation of three molecular weights(MW) CTSs(50–190 kDa(CTSL), 190–310 kDa(CTSM) and 310–375 kDa(CTSH)) was optimized with slow-mixing speeds of 30, 60 and 90 r/min, respectively. The removal efficiency and floc properties as well as membrane fouling were analyzed, and were compared to results obtained by conventional coagulation with PACl. Results showed that variations in floc properties could be ascribed to the coagulation mechanisms of CTS_L/CTS_M/CTS_H at different slow-mixing speeds, resulting in reduced UF membrane fouling. Specifically, at the low speed of 30 r/min, all three CTS types produced flocs with similar properties, while CTSLresulted in the lowest removal efficiency and aggravated irreversible fouling. At the appropriate speed of 60 r/min, CTSMgenerated the most compact flocs with the combined effects of bridging and path mechanisms. The compact cake layer formed could alleviate irreversible fouling,which was beneficial for prolonging the operation of the UF membrane. At the high speed of90 r/min, CTSHformed fragile flocs and aggravated irreversible membrane fouling. We considered membrane fouling to be affected by floc properties and the resultant removal efficiency, which was governed by the MW of the CTS used and the slow-mixing speed applied as well.

关键词： Coagulation–ultrafiltration Membrane fouling Floc properties Chitosan Slow-mixing speed

Surface superconductivity in the type Ⅱ Weyl semimetal TaIrTe4

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National Science Review 2020年第3期7卷 579-587页

作者： Ying xing Zhibin Shao Jun Ge Jiawei Luo Jinhua wang Zengwei Zhu Jun Liu Yong wang Zhiying Zhao Jiaqiang Yan David Mandrus Binghai Yan Xiong-Jun Liu Minghu Pan Jian wang Department of Materials Science and Engineering College of New Energy and Materials China University of Petroleum International Center for Quantum Materials School of Physics Peking University School of Physics and Information Technology Shaanxi Normal University School of Physics Huazhong University of Science and Technology Wuhan National High Magnetic Field Center Huazhong University of Science and Technology Center of Electron Microscopy State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Department of Materials Science and Engineering University of Tennessee Department of Physics and Astronomy University of Tennessee Materials Science and Technology Division Oak Ridge National Laboratory Department of Condensed Matter Physics Weizmann Institute of Science CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences Beijing Academy of Quantum Information Sciences Collaborative Innovation Center of Quantum Matter

The search for unconventional superconductivity in Weyl semimetal materials is currently an exciting pursuit, since such superconducting phases could potentially be topologically non-trivial and host exotic Majorana modes. The layered material TaIrTe4is a newly predicted time-reversal invariant type Ⅱ Weyl semimetal with the minimum number of Weyl points. Here, we report the discovery of surface superconductivity in Weyl semimetal Ta Ir Te4. Our scanning tunneling microscopy/spectroscopy(STM/STS) visualizes Fermi arc surface states of TaIrTe4that are consistent with the previous angle-resolved photoemission spectroscopy results. By a systematic study based on STS at ultralow temperature, we observe uniform superconducting gaps on the sample surface. The superconductivity is further confirmed by electrical transport measurements at ultralow temperature, with an onset transition temperature(Tc) up to 1.54 K being observed. The normalized upper critical field h*(T/Tc) behavior and the stability of the superconductivity against the ferromagnet indicate that the discovered superconductivity is unconventional with the p-wave pairing. The systematic STS, and thickness-and angular-dependent transport measurements reveal that the detected superconductivity is quasi-1 D and occurs in the surface states. The discovery of the surface superconductivity in TaIrTe4provides a new novel platform to explore topological superconductivity and Majorana modes.

关键词： surface superconductivity Weyl semimetal topological superconductivity

Efficacy and safety of albumin-bound paclitaxel in treating recurrent advanced non-small-cell lung cancer

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Chinese Journal of Cancer Research 2013年第2期25卷 200-205页

作者： Pu-Yuan xing Jun-Ling Li Yan wang Xue-Zhi Hao Bin wang Lin Yang Yuan-Kai Shi Xiang-Ru Zhang Cancer Institute and Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective： To observe the efficacy and safety of albumin-bound paclitaxel （ABP） monotherapy in treating recurrent advanced non-small-cell lung cancer （NSCLC）. Methods： We retrospectively analyzed the short-term efficacy and toxicities of ABP monotherapy in treating 21 patients who had previously undergone multiple cycles of therapy for their advanced NSCLC in our hospital since 2010. The treatment-related survival was also analyzed. Results： Of these 21 patients, the best overall response was partial response （PR） in 6 patients （28.6%）, stable disease （SD） in I0 patients （47.6%）, and progressive disease （PD） in 5 patients （23.8%）. The overall response rate （ORR） was 28.6% and the disease control rate （DCR）（PR ＋ SD） was 76.2%. The median progression-flee survival （PFS） was 4.0 months （95% CI, 5.0-7.0 months）. The main grade 3/4 toxicities included neutropenia （11.1%）, peripheral nerve toxicity （5.6%）, muscle and joint aches （5.6%）, and fatigue （5.6%）. Conclusions： The ABP monotherapy can achieve good objective response in advanced NSCLC patients who have previously received multiple cycles of treatment and be well tolerated.

关键词： Albumin-bound paclitaxel paclitaxel advanced non-small cell lung cancer chemotherapy