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Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： fang JIANG Tian MAO Jin-Song wang Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan JIA Tianfang wang National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue wang Shijie su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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基于危险理论的动态垃圾邮件过滤模型

计算机工程与应用 2008年第14期44卷 159-162页

作者：王素芳王小伟焦作师专计算机与信息工程系河南焦作454001 郑州大学体育学院现代教育技术中心郑州450052

基于危险理论,建立了一个垃圾邮件过滤模型DTDEF,对过滤垃圾邮件具有一定的动态性、学习的自适应性和分类的有效性,给出了该模型的基本架构及其具体实现算法,并通过与Bayes算法比较,表明该模型相对Bayes方法在邮件过滤时具有更好的动态... 详细信息

基于危险理论,建立了一个垃圾邮件过滤模型DTDEF,对过滤垃圾邮件具有一定的动态性、学习的自适应性和分类的有效性,给出了该模型的基本架构及其具体实现算法,并通过与Bayes算法比较,表明该模型相对Bayes方法在邮件过滤时具有更好的动态性和有效性。

关键词：人工免疫系统实时黑白名单危险理论邮件过滤

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Experimental Probe to the Isospin-Dependent Properties of Hot Nuclei in Reactions ^(40)Ar+^(112,124)Sn at 30 MeV/u

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Chinese Physics Letters 2001年第8期18卷 1037-1039页

作者： XIAO Zhi-Gang JIN Gen-Ming WU He-Yu WEI Zhi-Yong wang Hong-Wei DUAN Li-Min LIU Yong-Ying LI Zu-Yu ZHANG Bao-Guo ZHU Yong-Tai wang su-fang LU Zhao-Hui ZHU Hai-Dong HU Rong-Jiang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000

Protons are emitted much more affluently in neutron-deficient system ^(40)Ar+^(112)Sn while triton emissions are greater in a neutron-rich system ^(40)Ar+^(124)Sn at incident energy of 30 MeV/*** to neutron,proton emission provied a dominant contribution to neutralize the system N/Z in the decay process of the hot *** emission of hydrogen isotopes with high energies is much enhanced in the ^(112)Sn *** original temperature of the hot nuclei in the ^(40)Ar+^(112)Sn reaction is 5.8±0.3 MeV,about 0.7 MeV higher than 5.1±0.3 MeV as in the ^(40)Ar+^(124)Sn reaction.

关键词： reaction. system Probe

在关系中呈现人性的复杂性——铁凝小说中的父女关系

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石家庄职业技术学院学报 2005年第1期17卷 51-56页

作者：汪素芳河北省文联文艺理论研究室河北石家庄050000

分析了铁凝笔下较为敏感的父女关系这种代际异性关系,并把它与弗洛伊德的“恋父情结”理论作了比较,指出铁凝笔下的父女关系是一种血缘之爱和基于灵魂相通的异性之情的结合。

关键词：铁凝小说父女关系

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng wang Hao Nian Yan-fang wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

Isobaric enzymatic assays reveal depth-dependent variation in microbial ectoenzyme activities in the deepest ocean on Earth

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Science China Earth Sciences 2025年第1期68卷 185-194页

作者： Junwei CAO Jiahua wang Hongge ZHANG Junhao DENG Binbin PAN Jiawang CHEN Li ZHANG Jiasong fang College of Oceanography and Ecological Science Shanghai Ocean University Ocean College Zhejiang University Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology

Microbial ectoenzymes play essential roles in the transformation and mineralization of organic matter in the ***, conventional methods for measuring microbial ectoenzyme activities(MEAs) in the deep ocean under atmospheric conditions can misrepresent the metabolic activities of indigenous microbial communities. To overcome this limitation, we measured the activities of three microbial ectoenzymes(aminopeptidase, α-glucosidase, and β-glucosidase) under both atmospheric and in situ pressure conditions in seawater collected using pressure-retaining and non-pressure-retaining samplers in the Challenger Deep, Mariana Trench. In the case of aminopeptidase and α-glucosidase, the highest isobaric MEAs were observed in the surface layer(50 m), followed by those at abyssopelagic depths(4,000–6,000 m) for aminopeptidase, hadal realm(10,903 m)for α-glucosidase, while β-glucosidase activity exhibited the highest value at 10,903 m. Furthermore, the isobaric MEAs in hadal waters were commonly found to be higher than the decompressed counterparts, highlighting the importance of pressure-retaining sampling and isobaric enzymatic assays. The half-saturation constant(Km) showed a general decreasing trend with depth,suggesting that the deep ocean microbes might have adapted to the high-pressure and oligotrophic environment by increasing their ectoenzyme's affinity to substrate. Furthermore, particle-free MEAs contribute more to the total MEAs in the deep ocean than particle-associated MEAs, suggesting the significance of cell-associated and dissolved ectoenzymes in ocean *** study provides a foundation for future investigations of MEAs in the ocean and has important implications for understanding the dynamics of microbially mediated biogeochemical cycling in marine ecosystems.

关键词： Pressure-retaining sampling Microbial ectoenzyme activity Deep-sea microbes High pressure Mariana Trench

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基于DSGE模型的影子银行与信贷传导研究

预测 2017年第2期36卷 44-50页

作者：王苏生赵芳陈刚哈尔滨工业大学深圳研究生院广东深圳518055

本文以新凯恩斯主义理论为基础,构建了一个包含影子银行和商业银行两种类型金融中介的动态随机一般均衡模型(DSGE),在市场出清的条件下,通过数理建模与脉冲响应分析了影子银行金融中介对货币政策传导有效性的影响。研究结果表明:通过影... 详细信息

本文以新凯恩斯主义理论为基础,构建了一个包含影子银行和商业银行两种类型金融中介的动态随机一般均衡模型(DSGE),在市场出清的条件下,通过数理建模与脉冲响应分析了影子银行金融中介对货币政策传导有效性的影响。研究结果表明:通过影响银行资产负债表,紧缩性的货币政策显著地影响银行金融中介的净资产和融资资本,进而影响银行贷款的筛选水平。

关键词：影子银行金融中介信贷渠道 DSGE模型