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An overview of potential cardioprotective benefits of xanthophylls in atherosclerosis:an evidence-based review

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Food Science and Human Wellness 2024年第4期13卷 1739-1755页

作者： Yuting Su Feng Chen Jiehua Chen Mingfu wang Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Institution for Innovative Development of Food Industry Shenzhen UniversityShenzhen 518060China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Food Nutrition and Health Shenzhen UniversityShenzhen 518060China

Atherosclerosis,as the most prevalent form of cardiovascular disease,is characterized by oxidized lowdensity lipoprotein(ox-LDL)accumulation in the vascular wall,increased inflammation of the large arteries,dysfunction of the endothelial cells(ECs)and vascular smooth muscle cells(VSMCs),which may eventually lead to the formation of ***,one of the main groups of carotenoids,have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective ***,the underlying preventive mechanism of action of xanthophylls on the pathogenesis of atherosclerosis remains unclear,and clinical evidence of the effect of xanthophylls on atherosclerosis have not yet been summarized and critically *** this regard,we conducted a comprehensive literature search in four scientific databases(Pub Med,Google Scholar,Science Direct and Web of Science)and carefully analyzed the existing evidence to provide meaningful insights on the association between xanthophylls and atherosclerosis from various *** on the evidence from in vitro and in vivo studies,we explored several potential mechanisms,including antioxidant effect,anti-inflammatory effect,regulation of lipid metabolism,and modulation of ECs and VSMCs dysfunction,and we found that a clear picture of regulatory pathways of xanthophylls on atherosclerosis prevention and treatment is still *** addition,epidemiological studies suggested the possible relationship among high dietary intake of xanthophylls,high plasma/serum xanthophylls and a reduced risk of *** evidence from interventional studies investigating the effect of xanthophylls on atherosclerosis is very sparse,whilst indirect clinical evidence was only limited to astaxanthin and ***,well-designed long-term randomized controlled trials(RCTs)are highly recommended for future studies to investigate the effective dose of different

关键词： Atherosclerosis Xanthophylls Antioxidant Anti-inflammation Lipid metabolism

Multiscale Characteristics and Connection Mechanisms of Attraction Networks:A Trajectory Data Mining Approach Leveraging Geotagged Data

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Chinese Geographical Science 2024年第3期34卷 533-547页

作者： JIANG Hongqiang WEI Ye MEI Lin wang Zhaobo School of Resource and Environment Engineering Ludong UniversityYantai 264025China School of Geographical Sciences Northeast Normal UniversityChangchun 130024China Changchun University of Finance and Economics Changchun 130122China Jilin Jizhi City Architectural Design Co. LTDChangchun 130012China

Urban tourism is considered a complex system,and multiscale exploration of the organizational patterns of attraction networks has become a topical issue in urban tourism,so exploring the multiscale characteristics and connection mechanisms of attraction networks is important for understanding the linkages between attractions and even the future destination *** paper uses geotagging data to compare the links between attractions in Beijing,China during four different periods:the pre-Olympic period(2004–2007),the Olympic Games and subsequent‘heat period’(2008–2013),the post-Olympic period(2014–2019),and the COVID-19(Corona Virus Disease 2019)pandemic period(2020–2021).The aim is to better understand the evolution and patterns of attraction networks at different scales in Beijing and to provide insights for tourism planning in the *** results show that the macro,meso-,and microscales network characteristics of attraction networks have inherent logical relationships that can explain the commonalities and differences in the development process of tourism *** macroscale attraction network degree Matthew effect is significant in the four different periods and exhibits a morphological monocentric structure,suggesting that new entrants are more likely to be associated with attractions that already have high *** mesoscale links attractions according to the common purpose of tourists,and the results of the community segmentation of the attraction networks in the four different periods suggest that the functional polycentric structure describes their clustering effect,and the weak links between clusters result from attractions bound by incomplete information and distance,and the functional polycentric structure with a generally more efficient network of *** pattern structure at the microscale reveals the topological transformation relationship of the regional collaboration pattern,and the attraction network structure in the four diff

关键词： attraction network travel mobility polycentric structure network motif connectivity mechanism destination management organization(DMO) destination planning Beijing,China

氧化应激条件下CD200对MG炎性反应的调控作用

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热带医学杂志 2008年第10期8卷 999-1003页

作者：乔东访崔桐辉王慧君谭晓辉李艳红南方医科大学法医学系广州510515 广州从化市公安局从化510900

目的探讨氧化应激条件下CD200如何参与调控MG(小胶质细胞)激活后的炎性反应。方法对原代培养的MG进行氧化应激处理,并利用急性分离的皮质神经元进行干预。"对照组"和"H2O2组"分别采用生理盐水和H2O2(100μmol/L)进行处理,"H2O2+CD200组"... 详细信息

目的探讨氧化应激条件下CD200如何参与调控MG(小胶质细胞)激活后的炎性反应。方法对原代培养的MG进行氧化应激处理,并利用急性分离的皮质神经元进行干预。"对照组"和"H2O2组"分别采用生理盐水和H2O2(100μmol/L)进行处理,"H2O2+CD200组"在H2O2(100μmol/L)处理之前30min采用急性分离的神经元(约含1×106细胞)进行预处理。于处理后第0.5h、1h、2h、3h和4h时,采用Western blotting法对MG内p-p38MAPK和IκB-α的蛋白表达量进行检测;以及第0h和72h时,采用ELISA法对培养介质内的TNF-α和IL-1β的含量进行检测。结果p-p38MAPK和IκB-α的蛋白表达:"对照组"各时间点均无明显变化;"H2O2组"和"H2O2+CD200组"0.5h时表达量亦基本相同;而3h时"H2O2组"p-p38MAPK蛋白表达量明显高于"H2O2+CD200组";4h时"H2O2组"IκB-α的蛋白表达量明显低于"H2O2+CD200组"。TNF-α和IL-1β含量:各组培养介质内0h时均未检出含有TNF-α和IL-1β;第72h时两细胞因子含量高低次序相同,即"对照组"<"H2O2+CD200"<"H2O2组"。结论氧化应激条件下,CD200分子通过抑制MG胞质内p38MARK的磷酸化,进而抑制了NF-κB的激活和炎性因子表达水平。

关键词：氧化应激小胶质细胞 CD200 p38 MAPK NF—κB 细胞因子

Compressed Least Squares Algorithm of Continuous-Time Linear Stochastic Regression Model Using Sampling Data

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Journal of Systems Science & Complexity 2024年第4期37卷 1488-1506页

作者： XIE Siyu ZHANG Shujun wang Ziming GAN Die School of Aeronautics and Astronautics University of Electronic Science and Technology of ChinaChengdu 611731China China Academy of Aerospace Science and Innovation Beijing 100176China Zhongguancun Laboratory Beijing 100094China

In this paper,the authors consider a sparse parameter estimation problem in continuoustime linear stochastic regression models using sampling *** on the compressed sensing(CS)method,the authors propose a compressed least squares(LS) algorithm to deal with the challenges of parameter *** each sampling time instant,the proposed compressed LS algorithm first compresses the original high-dimensional regressor using a sensing matrix and obtains a low-dimensional LS estimate for the compressed unknown ***,the original high-dimensional sparse unknown parameter is recovered by a reconstruction *** introducing a compressed excitation assumption and employing stochastic Lyapunov function and martingale estimate methods,the authors establish the performance analysis of the compressed LS algorithm under the condition on the sampling time interval without using independence or stationarity conditions on the system *** last,a simulation example is provided to verify the theoretical results by comparing the standard and the compressed LS algorithms for estimating a high-dimensional sparse unknown parameter.

关键词： Compressed excitation condition compressed sensing continuous-time model least squares linear stochastic regression parameter identification sampling data

哈尔滨市239名医护人员HBV职业暴露现况及原因分析

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中国公共卫生管理 2020年第3期36卷 411-413,431页

作者：段淑梅王惠君王岩温冬爱黑龙江省疾病预防控制中心黑龙江哈尔滨150030

目的探讨医护人员HBV职业暴露原因和采取的主动免疫和被动免疫措施,为HBV职业暴露后采取的预防措施提供依据。方法通过收集门诊病历资料和询问调查的方式,运用统计学方法回顾性分析239例医护人员HBV职业暴露原因和采取的防护措施。结果... 详细信息

目的探讨医护人员HBV职业暴露原因和采取的主动免疫和被动免疫措施,为HBV职业暴露后采取的预防措施提供依据。方法通过收集门诊病历资料和询问调查的方式,运用统计学方法回顾性分析239例医护人员HBV职业暴露原因和采取的防护措施。结果239例HBV职业暴露者均为临床一线医护人员,暴露源均为乙肝患者的血液或体液。其中医生61名,护士178名,二者占比差异有统计学意义(χ^2=6.70,P<0.05)。男性59例,年龄28~50岁;女性180例,年龄20~42岁,二者占比差异有统计学意义(χ^2=6.47,P<0.05)。暴露者中175例为血液感染,占比73.22%;64例为体液感染,占比26.78%(均为手术室医务人员),二者差异有统计学意义(χ^2=6.38,P<0.05)。暴露者中有76人明确知晓自己的乙肝五项情况,知晓率31.80%;101人对自己是否接种过乙肝疫苗不清楚;177例暴露者主动注射乙肝免疫球蛋白和接种乙肝疫苗,62例暴露者在其他医务人员提醒下注射乙肝免疫球蛋白和接种乙肝疫苗;239例暴露者均能在暴露后正确处置伤口。结论发生的职业暴露以护理人员和低年资医生为主,原因为防护意识淡薄,知识缺乏。在乙肝职业暴露发生前主动检测乙肝五项和接种乙肝疫苗,是减少医源感染HBV的有效方法。

关键词：职业暴露乙肝免疫球蛋白乙肝疫苗防护措施

Zero-Dynamics Attacks for Multi-Agent Systems Without Velocity Measurements

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Journal of Systems Science & Complexity 2024年第5期37卷 1809-1831页

作者： GAO Jinming wang Yijing ZUO Zhiqiang ZHANG Wentao Tianjin Key Laboratory of Intelligent Unmanned Swarm Technology and System School of Electrical and Information Engineering Tianjin University Continental-NTU Corporate Lab School of Electrical and Electronic Engineering Nanyang Technological University

This paper studies the periodic zero-dynamics attacks(ZDAs) in multi-agent systems without velocity measurements under directed graph. Specifically, two types of attack modes are addressed,i.e., infinite number and finite number of zero-dynamics attacks. For the former case, the authors show that the consensus of the considered system cannot be guaranteed. For the latter case, the dynamic evolution of the agents is investigated and it is found that only attacking the rooted agents can destroy the consensus. Then, a sufficient condition which quantifies whether or not the consensus value is destroyed is given, revealing the relationship among parameters of system model, filter and attack ***, simulations are carried out to verify the effectiveness of the theoretical findings.

关键词： Consensus directed graph multi-agent systems zero-dynamics attacks

An mmWave Dual-Band Integrated Substrate Gap Waveguide Single Cavity Filter with Frequency Selectivity

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China Communications 2024年第1期21卷 188-199页

作者： Qiuhua Lin Dongya Shen Lihui wang Zhiyong Luo School of Electronics and Communication Engineering Sun Yat-sen UniversityShenzhen 518107China School of Information Science and Engineering Yunnan UniversityKunming 650091China Pengcheng Laboratory Shenzhen 518107China Shenzhen Key Laboratory of Navigation and Communication Integration Shenzhen 518107China

A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling *** cavity is designed to control the number of modes,and then the ports are determined by analyzing the coupling relationship between these selected *** synthesizing the coupling matrix of the filter,a nonresonating node(NRN)structure is introduced to flexibly tune the frequency of modes,which gets a dualband and quad-band filtering response from a tri-band filter no the ***,a frequency selective surface(FSS)has been newly designed as the upper surface of the cavity,which significantly improves the bad out-of-band suppression and frequency selectivity that often exists in most traditional cavity filter designs and *** results show that its two center frequencies are f01=27.50 GHz and f02=32.92GHz,*** with the dual-band filter that there is no the FSS metasurface,the out-of-band suppression level is improved from measured 5 dB to18 dB,and its finite transmission zero(FTZ)numbers is increased from measured 1 to 4 between the two designed *** with the tri-band and quadband filter,its passband bandwidth is expanded from measured 1.17%,1.14%,and 1.13% or 1.31%,1.50%,0.56%,and 0.57% to 1.71% and 1.87%.In addition,the filter has compact,small,and lightweight characteristics.

关键词： coupling topology frequency selectivity non-resonating node(NRN) out-of-band suppression single ISGW cavity filter

Covalent Triazine Framework Nanosheets:Synthesis and Energy Conversion and Storage

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Chinese Journal of Chemistry 2024年第3期42卷 301-316页

作者： Zhao Liu Congxu wang Wenjing Yuan Yuxi Xu School of Materials Science & Engineering Hebei University of TechnologyTianjin300130 China School of Engineering Westlake UniversityHangzhouZhejiang310024 China

Covalent triazine framework nanosheets (CTF NSs),an emerging class of two-dimensional nanomaterials,have received great attention due to their abundant active sites,permanent porosity,molecular structural diversity,superior chemical/thermal stability,and short charge diffusion path,enabling technological breakthroughs in a myriad of applications. The forefront developments and applications of CTF NSs as photocatalysts and electrochemical electrodes have conferred superior performance and made great impact in the field of energy and advanced catalysis. This forward-looking review aims to summarize the research trends,synthesis,properties of CTF NSs and their CTF counterpart,and highlight their progress in applications with respect to energy storage and conversion devices. Finally,the current challenges and future perspectives for CTF NSs are also presented.

关键词： Covalent triazine framework Nanosheets Photocatalysis Energy storage Charge transfer

An Ontology-based Approach to Security Pattern Selection

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International Journal of Automation and computing 2016年第2期13卷 168-182页

作者： hui Guan Hongji Yang jun wang School of Computer Science and Technology Shenyang University of Chemical Technology Centre for Creative Computing Bath Spa University

Usually, the security requirements are addressed by abstracting the security problems arising in a specific context and providing a well proven solution to them. Security patterns incorporating proven security expertise solution to the recurring security problems have been widely accepted by the community of security engineering. The fllndamental challenge for using security patterns to satisfy security requirements is the lack of defined syntax, which makes it impossible to ask meaningful questions and get semantically meaningful answers. Therefore, this paper presents an ontological approach to facilitating security knowledge mapping from security requirements to their corresponding solutions security patterns. Ontologies have been developed using Web Ontology Language （OWL） and then incorporated into a security pattern search engine which enables sophisticated search and retrieval of security patterns using the proposed algorithm. Applying the introduced approach allows security novices to reuse security expertise to develop secure software system.

关键词： Security pattern ontology security requirement risk analysis security engineering