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Synthesis,Structure,and Ring-opening Metathesis Polymerization of η~5-Pentamethylcyclopentadienyl-(η~5-exo-tricyclo [5.2.1.0^(2,6)]deca-2,5,8-trien-6-yl) Iron

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Chemical Research in Chinese Universities 2009年第5期25卷 662-665页

作者： ZHAO Xi li bin xu shan-sheng song hai-bin wang bai-quan State Key Laboratory of Elemento-Organie Chemistry. College of Chemistry Nankai University Tianjin 300071 P. R. China

η^5-Pentamethylcyclopentadienyl-（η^5-exo-tricyclo[5.***.1.0^2,6]deca-2,5,8-trien-6-yl） iron（3） was synthesized and characterized by ^1H NMR, ^13C NMR, MS, elemental analysis, IR, UV and X-ray diffraction analysis. Compound 3 was polymerized with ring-opening metathesis polymerization（ROMP） initiator （PCy3）2Cl2Ru=CHPh. ^1H NMR and IR spectra revealed the presence of CH=CH units in the polymer and supported the ROMP mechanism. GPC analysis of the polymer showed that the weight-average molecular weights（Mw） was 5967, and the polydispersity index（PDl） was 1.16. The polymer was also investigated by UV and cyclic voltammetry.

关键词： Ferrocene Metathesis Ring-opening polymerization Cyclic voltammetry X-ray diffraction

1,1'-双(四甲基环戊二烯基)二茂铁与五羰基铁和三乙腈三羰基钼的反应

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高等学校化学学报 2000年第6期21卷 898-902页

作者：邓小斌徐善生王佰全周秀中南开大学化学系

配体 1 ,1 -双 (四甲基环戊二烯基 )二茂铁 1 ,1 -Fc( Me4Cp) 2 ( )与五羰基铁在二甲苯中回流反应 ,得二茂铁桥连双 (四甲基环戊二烯基 )四羰基二铁 1 ,1 -Fc[( Me4Cp) Fe( CO) ( μ-CO) ]2 ( 1 ) .化合物 1在氯仿中与单质碘反应 ,F... 详细信息

配体 1 ,1 -双 (四甲基环戊二烯基 )二茂铁 1 ,1 -Fc( Me4Cp) 2 ( )与五羰基铁在二甲苯中回流反应 ,得二茂铁桥连双 (四甲基环戊二烯基 )四羰基二铁 1 ,1 -Fc[( Me4Cp) Fe( CO) ( μ-CO) ]2 ( 1 ) .化合物 1在氯仿中与单质碘反应 ,Fe_ Fe键断裂 ,生成二茂铁桥连双铁碘化合物 1 ,1 -Fc[( Me4Cp) Fe( CO) 2 I]2 ( 2 ) .配体与正丁基锂作用生成二茂铁桥连双 (四甲基环戊二烯基负离子盐 ) ,后者随即与三乙腈三羰基钼反应形成 1 ,1 -二茂铁双 (四甲基环戊二烯基负离子盐 ) 1 ,1 -Fc[( Me4Cp) Mo( CO) 3- li+ ]2 ( ) .钼负离子与 CH3I作用在钼原子上发生甲基化 ,得到产物 1 ,1 -Fc[( Me4Cp) Mo( CO) 3Me]2 ( 3 ) . 与 Br CH2 CH2 Br反应 ,未得到预期的 Mo_ Mo键化合物 ,相反却得到少量亲核取代 -消除的双钼 -溴化合物 1 ,1 -Fc[( Me4Cp) Mo( CO) 3Br]2( 4) .经元素分析、IR及 1 H NMR表征化合物 1— 4的结构 ,并用 X射线衍射测定了化合物

关键词：二茂铁桥边双金属化合物富瓦烯晶体结构

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-bin ling Qiao-Nan shan xu-Yong Wei Rui wang Chang-Ku Jia li Zhuang Tian Shen li-min Ding Zhi-Dan xu Lai-Bang Luo li-Bo Sun Guang-ming li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su Zhi-hai Peng Ren Lang Tao Jiang Qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo liu-Gen Lan xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye min Tian Jian-Hua Shi Bo wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang lin Zhong Jing-sheng Ma Qi-Gen li sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang xuan wang Zi-Qiang li Mu-Jian Teng Jun-Jie li Wen-Tao Jiang Jian-Hua li quan-Bao Zhang Ning-Qi Zhu Zheng-Xin wang Kang He Qiang Xia Shao-Hua song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen Ying-Peng Zhao li li Ze-min Hu Qi-Jie Luo Zhong-Zhou Si bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU xue-qing liN Hong-li liU Jian XIE Ru-juan wang li-ning NI Zhao-hui liU Fu-you YIN Ai-ping XING Chang-ying wang li SHI Wei liU Jian-she HE Ya-ni DING Guo-hua li Wen-ge WU Guang-li MIAO li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong bai Yun-kai LUO Hui-min liN shan CHEN Meng-hua GONG li YANG Yi-bin YANG Xiao-ping li Ying WAN Jian-xin wang Nian-song li hai-ying XI Chun-sheng HAO li xu Yan FANG Jing-ai liU Bi-cheng li Rong-shan wang Rong ZHANG Jing-hong wang Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng liU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except Hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang xue-Zhong li Ya-Nan Sun li Shi min wang Xi-Cheng song Fu-quan Chen Xiao-Shu Zhang Hong-quan Wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao xu-Ping Xiao Xin Wei Zhi-Hong lin Feng-Hong Chen Chun-Guang shan Guang-Ke wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-lin wang Hua-bin li Feng liu Xiao-Bo Cui sheng-Nan Ye Zheng liu Yu xu Xiao Cai Wei Huang Ru-Xin Zhang Yu-lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-bing Xie Long-Gang Yu Ye-hai liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha bai Yu bai Yang bai Vipul bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen shanhong Chen shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen xun Chen xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

2019—2020年160例儿童肺炎链球菌脑膜炎临床流行病学多中心研究

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中国当代儿科杂志 2024年第2期26卷 131-138页

作者：王彩云许红梅刘钢刘静俞蕙陈必全郑帼舒敏杜丽君徐志伟黄丽素李海波汪东白松婷单庆文朱春晖田健美郝建华林爱伟林道炯吴谨准张新华曹清陶仲宾陈源朱国龙薛萍汤正珍苏学文曲政海赵仕勇庞琳邓慧玲舒赛男陈英虎浙江大学医学院附属儿童医院感染科浙江杭州310052 重庆医科大学附属儿童医院感染科重庆400014 首都医科大学附属北京儿童医院感染科北京100045 湖南省儿童医院感染科湖南长沙410007 复旦大学附属儿科医院感染科上海201102 安徽省儿童医院感染科安徽合肥230022 南京医科大学附属儿童医院神经科江苏南京210008 四川大学华西第二医院儿科四川成都610044 山西省儿童医院神经内科山西太原030006 温州医科大学附属第二医院/育英儿童医院普儿科浙江温州325027 上海交通大学医学院附属新华医院感染科上海200092 吉林大学第一医院儿科门诊吉林长春130061 西安交通大学附属儿童医院陕西西安710002 郑州大学第一附属医院儿科河南郑州450052 广西医科大学第一附属医院儿科广西南宁530021 江西省儿童医院感染科江西南昌330006 苏州大学附属儿童医院感染科江苏苏州215002 河南开封市儿童医院感染科河南开封475000 山东大学儿童院感染科山东济南250022 海南省妇幼保健院感染科海南海口571103 厦门大学附属妇女儿童医院儿科福建厦门361003 山西省儿童医院新生儿科山西太原030006 上海交通大学医学院附属上海儿童医学中心感染科上海200127 兰州大学第一医院儿科甘肃兰州730013 河北医科大学第二医院儿科河北石家庄050004 青海省妇女儿童医院感染消化科青海西宁810007 太原市妇幼保健院儿内科山西太原030012 遵义市第一人民医院儿科贵州遵义563099 内蒙古自治区人民医院儿科内蒙古呼和浩特750306 青岛大学附属医院儿科山东青岛266003 杭州市儿童医院感染科浙江杭州310005 首都医科大学附属北京地坛医院儿科北京100102 西安市中心医院儿科陕西西安710004 华中科技大学同济医学院附属同济医院儿科湖北武汉430030

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿... 详细信息

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿的临床信息、实验室资料和微生物学资料。结果160例PM患儿中,男103例,女57例;年龄15 d至15岁,其中3月龄至<3岁109例(68.1%)。脑脊液培养分离SP菌株95例(59.4%),血培养分离SP菌株57例(35.6%)。脑脊液宏基因组二代测序和脑脊液SP抗原检测阳性率分别为40%(35/87)、27%(21/78)。55例(34.4%)患儿存在1个或多个化脓性脑膜炎高危因素;113例(70.6%)患儿有1个或多个颅外感染病灶;18例(11.3%)有明确基础疾病。临床症状以发热最常见(147例,91.9%),其次是精神萎靡(98例,61.3%)、呕吐(61例,38.1%)等。69例(43.1%)患儿住院期间发生颅内并发症,常见并发症为硬膜下积液和/或积脓(43例,26.9%)、脑积水(24例,15.0%)、脑脓肿(23例,14.4%)、脑出血(8例,5.0%)。硬膜下积液和/或积脓和脑积水主要发生在<1岁患儿,分别为91%(39/43)、83%(20/24)。SP菌株对万古霉素(100%,75/75)、利奈唑胺(100%,56/56)、厄他培南(100%,6/6)完全敏感;对左氧氟沙星(81%,22/27)、莫西沙星(82%,14/17)、利福平(96%,25/26)和氯霉素(91%,21/23)敏感率高;对青霉素(16%,11/68)、克林霉素(6%,1/17)敏感率低;对红霉素完全耐药(100%,31/31)。痊愈和好转出院率分别为22.5%(36/160)、66.2%(106/160);18例(11.3%)出现不良结局。结论儿童PM多见于3月龄至<3岁婴幼儿,颅内并发症多发生在<1岁患儿,发热是PM患儿最常见的临床表现,硬膜下积液和/或积脓、脑积水是最常见的并发症。脑脊液非培养检测方法有助于提高病原菌检出率。超过10%PM患儿出现不良结局。SP菌株对万古霉素、利奈唑胺、厄他培南、左氧氟沙星、莫西沙星、利福平、氯霉素敏感率高。

关键词：肺炎链球菌脑膜炎流行病学多中心研究儿童

新型冠状病毒感染者脊柱外科急诊手术的围手术期管理专家共识

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脊柱外科杂志 2020年第6期18卷 361-368页

作者：华文彬郜勇李危石仉建国朱泽章王冰李方财何达马真胜魏欣杨磊任东平张雪松李利吴继功徐宝山宁广智武汉杨群戈朝晖康学文夏磊高延征刘新宇刘浩初同伟熊伟夏平陈雄生白玉树殷国勇王向阳刘向阳杨军林万勇董健文丁文元陶惠人王迎松吴星火张宇坤郑东潘海涛吴永超曾宪林李锋邵增务杨述华邱海波王征杨操华中科技大学同济医学院附属协和医院骨科武汉430022 北京大学第三医院骨科北京100191 北京协和医院骨科北京100032 南京大学医学院附属鼓楼医院骨科南京210008 中南大学湘雅二医院骨科长沙410011 浙江大学医学院附属第二医院骨科杭州310056 北京积水潭医院骨科北京100035 空军军医大学西京医院骨科西安710032 华中科技大学同济医学院附属协和医院麻醉科武汉430022 华中科技大学同济医学院附属协和医院手术室武汉430022 中国人民解放军总医院骨科北京100853 中国人民解放军战略支援部队特色医学中心骨科北京100010 天津医院骨科天津300211 天津医科大学总医院骨科天津300052 吉林大学中日联谊医院骨科长春130033 大连医科大学附属第一医院骨科大连116011 宁夏医科大学总医院骨科银川750004 兰州大学第二医院骨科兰州730000 郑州大学第一附属医院骨科郑州450052 河南省人民医院骨科郑州450003 山东大学齐鲁医院骨科济南250012 四川大学华西医院骨科成都610041 陆军军医大学新桥医院骨科重庆400037 华中科技大学同济医学院附属同济医院骨科武汉430030 武汉市第一医院骨科武汉430022 海军军医大学附属长征医院骨科上海200003 海军军医大学附属长海医院骨科上海200433 南京医科大学第一附属医院骨科南京210029 温州医科大学附属第二医院骨科温州325000 湖南省人民医院骨科长沙410002 上海交通大学医学院附属新华医院骨科上海200092 中山大学附属第一医院骨科广州510080 中山大学附属第三医院骨科广州510630 河北医科大学第三医院骨科石家庄050091 深圳大学总医院骨科深圳518055 昆明医科大学附属第二医院骨科昆明650031 东南大学附属中大医院重症医学科南京210009

自2019年12月以来,已有200余个国家和地区相继报道了新型冠状病毒感染病例,世界卫生组织(WHO)于2020年3月12日宣布新型冠状病毒全球大流行,截至6月18日,全球已累计有824万余人感染,44万余人死亡,对全世界医疗、政治和经济领域影响巨大[1... 详细信息

自2019年12月以来,已有200余个国家和地区相继报道了新型冠状病毒感染病例,世界卫生组织(WHO)于2020年3月12日宣布新型冠状病毒全球大流行,截至6月18日,全球已累计有824万余人感染,44万余人死亡,对全世界医疗、政治和经济领域影响巨大[1-2]。WHO将其命名为“2019冠状病毒感染性疾病”(COVID-19),病原体被命名为重症急性呼吸综合征冠状病毒2(SARS-CoV-2)[3-6]。按照《中华人民共和国传染病防治法》,COVID-19被纳入乙类传染病,采取甲类传染病的预防控制措施[7]。

关键词：脊柱疾病冠状病毒感染肺炎,病毒性急诊处理外科手术