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Simulation of Urban Land Expansion Under Ecological Constraints in Harbin-Changchun Urban Agglomeration,China

Chinese Geographical Science 2022年第3期32卷 438-455页

作者： GUO Rong WU Tong WU Xiaochen LUIGI Stendardo wang yueqin Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology Ministry of Industry and Information Technology/School of ArchitectureHarbin Institute of TechnologyHarbin 150006China Department of Civil Architectural and Environmental EngineeringPadova UniversityPadova 35131Italy School of Economics and Management Northeast Forestry UniversityHarbin 150040China

Under the demand of urban expansion and the constraints of China’s’National Main Functional Area Planning’policy,urban agglomerations are facing with a huge contradiction between land utilization and ecological protection,especially for HarbinChangchun urban agglomeration who owns a large number of land used for the protection of agricultural production and ecological *** alleviate this contradiction and provide insight into future land use patterns under different ecological constraints’scenarios,we introduced the patch-based land use simulation(PLUS)model and simulated urban expansion of the Harbin-Changchun urban *** verifying the accuracy of the simulation result in 2018,we predicted future urban expansion under the constraints of three different ecological scenarios in *** morphological spatial pattern analysis(MSPA)method and minimum cumulative resistance(MCR)model were also introduced to identify different levels of ecological security pattern(ESP)as ecological *** predicted result of the optimal protection(OP)scenario showed less proportion of water and forest than those of natural expansion(NE)and basic protection(BP)scenarios in *** conclusions are that the PLUS model can improve the simulation accuracy at urban agglomeration scale compared with other cellular automata(CA)models,and the future urban expansion under OP scenario has the least threat to the ecosystem,while the expansion under the natural expansion(NE)scenario poses the greatest threat to the *** with the MSPA and MCR methods,PLUS model can also be used in other spatial simulations of urban agglomerations under ecological constraints.

关键词： urban land expansion patch-based land use simulation(PLUS)model Harbin-Changchun urban agglomeration scenario simulation ecological constraints China

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RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling YRDC Translation in NSCLC Cells

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 850-865页

作者： Boyang Shi Ke An yueqin wang Yuhan Fei Caixia Guo Qiangfeng Cliff Zhang Yun-Gui Yang Xin Tian Quancheng Kan Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China MOE Key Laboratory of Bioinformatics Center for Synthetic and Systems BiologyBeijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

Epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)positively affect the initial control of non-small cell lung cancer(NSCLC).Rapidly acquired resistance to EGFR-TKIs is a major hurdle in successful ***,the mechanisms that control the resistance of EGFR-TKIs remain largely *** structures have widespread and crucial functions in many biological regulations;however,the functions of RNA structures in regulating cancer drug resistance remain ***,the psoralen analysis of RNA interactions and structures(PARIS)method is used to establish the higher-order RNA structure maps of EGFRTKIs-resistant and-sensitive cells of *** results show that RNA structural regions are enriched in untranslated regions(UTRs)and correlate with translation efficiency(TE).Moreover,yrdC N6-threonylcarbamoyltransferase domain containing(YRDC)promotes resistance to *** structure formation in YRDC 30 UTR suppresses embryonic lethal abnormal vision-like 1(ELAVL1)binding,leading to EGFR-TKI sensitivity by impairing YRDC translation.A potential therapeutic strategy for cancer treatment is provided using antisense oligonucleotide(ASO)to perturb the interaction between RNA and *** study reveals an unprecedented mechanism through which the RNA structure switch modulates EGFR-TKI resistance by controlling YRDC mRNA translation in an ELAVL1-dependent manner.

关键词： RNA structure EGFR-TKI resistance Non-small cell lung cancer YRDC ELAVL1

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NSUN2-mediated mRNA m^(5)C Modification Regulates the Progression of Hepatocellular Carcinoma

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 823-833页

作者： Dan Song Ke An Wenlong Zhai Luyao Feng Yingjie Xu Ran Sun yueqin wang Yun-Gui Yang Quancheng Kan Xin Tian Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Digestive Organ Transplantation of Henan Province Zhengzhou UniversityZhengzhou 450052China

RNA modifications affect many biological processes and physiological *** 5-methylcytosine(m^(5)C)modification regulates the progression of multiple ***,its characteristics and functions in hepatocellular carcinoma(HCC)remain largely ***,we found that HCC tissues had a higher m^(5)C methylation level than the adjacent normal *** analysis revealed that the hypermethylated genes mainly participated in the phosphokinase signaling pathways,such as the Ras and PI3K-Akt *** m^(5)C methyltransferase NSUN2 was highly expressed in HCC ***,the expression of many genes was positively correlated with the expression of NSUN2,including GRB2,RNF115,AATF,ADAM15,RTN3,and ***-time PCR assays further revealed that the expression of the mRNAs of GRB2,RNF115,and AATF decreased significantly with the down-regulation of NSUN2 expression in HCC ***,NSUN2 could regulate the cellular sensitivity of HCC cells to sorafenib via modulating the Ras signaling ***,knocking down NSUN2 caused cell cycle *** together,our study demonstrates the vital role of NSUN2 in the progression of HCC.

关键词： 5-methylcytosine Hepatocellular carcinoma NSUN2 Ras pathway Sorafenib

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An Imported Confirmed Case of COVID-19 Vaccinated in Brazil——Shanghai Municipality,China,March 17,2021

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China CDC weekly 2021年第30期3卷 650-652页

作者： Hongrang Zhou Xiaoling wang Guifu Li Sen wang Xiaoming wang yueqin wang Changpo Lin Jianguo Tian Junfeng Pan Ruifang Xu Ning Xiao Qingpu District Center for Disease Control and Prevention ShanghaiChina National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention/Chinese Center for Tropical Diseases Research/WHO Collaborating Centre for Tropical Diseases/National Center for International Research on Tropical DiseasesMinistry of Science and Technology/Key Laboratory of Parasitic and Vector BiologyNational Health Commission of China/The School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineHuangpuShanghaiChina Program in Public Health College of Health SciencesUniversity of California at IrvineIrvineUSA

On March 17,2021,a 42-year-old male returning from Brazil tested positive by Qingpu CDC for coronavirus disease 2019(COVID-19)during medical observation at a designated isolation *** was then sent to the Shanghai Public Health Clinical Center(SHPHCC)and confirmed again,and because he demonstrated no abnormal clinical signs(until the infection was controlled),he was diagnosed as an asymptomatic infection.

关键词： fir Brazil COV

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5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 187-199页

作者： Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu yueqin wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian Department of Pharmacy The First Affiliated Hospital of Zhengzhou University Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou University Sino-Danish College University of Chinese Academy of Sciences Physical Examination Center The First Affiliated Hospital of Zhengzhou University Department of Anesthesiology The First Affiliated Hospital of Zhengzhou University CAS Key Laboratory of Genomic and Precision Medicine School of Future Technology Beijing Institute of GenomicsChinese Academy of Sciences Institute of Stem Cell and Regeneration Chinese Academy of Sciences Department of Thoracic Surgery The First Affiliated Hospital of Zhengzhou University

Non-small-cell lung cancer （NSCLC）, the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymetbylcytosine （ShmC） signatures in circulating cell-free DNA （cfDNA） that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminat- ing tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here, we employed a sensitive and reliable method to map genome-wide 5hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identi- fied six potential biomarkers from 66 patients and 67 healthy controls （mean decrease accuracy 〉 3.2, P 〈 3.68E-19） using machine-learning-based tumor classifiers with high accuracy. Thus, the unique signature of 5hmC in tumor patient＇s cfDNA identified in our study may provide valuable information in facilitating the development of new diagnostic and therapeutic modalities for NSCLC.

关键词： 5-Hydroxymethylcytosine Lung cancer Cell-free DNA Biomarker 5hmC-Seal

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模拟体液中二氧化钛纳米管上沉积磷灰石

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生物医学工程学杂志 2008年第6期25卷 1354-1357页

作者：王月勤陶杰南京航空航天大学材料科学与技术学院南京210016

在NaF和H3PO4水溶液体系中,电化学阳极氧化法在钛板表面形成一层结构规整有序的高密度TiO2纳米管阵列。随后模拟体液(SBF)浸泡沉积出磷灰石涂层。扫描电镜(SEM)观察TiO2纳米管的微观结构,以及生成的磷灰石的形貌,X射线衍射仪(XRD)分析... 详细信息

在NaF和H3PO4水溶液体系中,电化学阳极氧化法在钛板表面形成一层结构规整有序的高密度TiO2纳米管阵列。随后模拟体液(SBF)浸泡沉积出磷灰石涂层。扫描电镜(SEM)观察TiO2纳米管的微观结构,以及生成的磷灰石的形貌,X射线衍射仪(XRD)分析了涂层的相组成,电化学工作站研究极化行为。试验结果表明:Ti金属表面制备的规整的TiO2管直径约100 nm左右。模拟体液浸泡试验表明二氧化钛纳米管上沉积了羟基磷灰石涂层。

关键词：模拟体液羟基磷灰石纳米管

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广东LED产业技术学习影响因素实证研究

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科技管理研究 2013年第3期33卷 71-76页

作者：王月琴华中科技大学管理学院湖北武汉430074

以215家广东LED企业为样本,采用结构方程模型检验知识的缄默性、复杂性对产业技术学习绩效的影响,以及网络属性对知识的缄默性、复杂性与产业技术学习绩效关系的调节效应。研究结果显示,(1)知识的缄默性、复杂性对广东LED产业技术学习... 详细信息

以215家广东LED企业为样本,采用结构方程模型检验知识的缄默性、复杂性对产业技术学习绩效的影响,以及网络属性对知识的缄默性、复杂性与产业技术学习绩效关系的调节效应。研究结果显示,(1)知识的缄默性、复杂性对广东LED产业技术学习绩效具有显著的负向影响;(2)尽管广东LED企业充分利用了网络中心性的有利位置去获取缄默性较高的外部技术知识,但是对于复杂程度较高的外部技术知识,网络中心性没有起到明显的调节作用;(3)广东LED企业与外部创新资源的强关系有利于其尽快掌握外部LED产业技术中的缄默性知识以及复杂程度较高的核心产业技术。

关键词： LED产业技术学习结构方程模型

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钛基材上羟基磷灰石生物活性研究

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南京航空航天大学学报 2007年第5期39卷 659-664页

作者：王月勤陶杰王玲何娉婷孙涛南京航空航天大学材料科学与技术学院南京210016

考察了电沉积时添加双氧水(H2O2)与不添加H2O2对羟基磷灰石涂层在模拟体液(Simulated body fluid,SBF)和柠檬酸修饰的磷酸缓冲液(Citric acid-containing phosphate buffer solutions,CPBS)中浸泡时生物活性的影响。扫描电镜(SEM)观察了涂层的形貌,X射线衍射仪(XRD)与傅里叶变换红外吸收光谱测试仪(FTIR)对涂层的物相组成、结构进行了分析。SBF浸泡试验表明涂层具有良好的生物活性;CPBS浸泡试验表明电沉积时加入H2O2的涂层的溶解性降低。本项工作对研制钛基材上高生物活性、长效性的羟基磷灰石涂层有积极意义。

关键词：羟基磷灰石钛生物活性涂层

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技术创新发展阶段对广东技术发展战略的约束

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科技管理研究 2005年第6期25卷 10-12,15页

作者：王月琴张鹏广东省经贸委产业技术处广东广州510030 华南理工大学工商管理学院广东广州510640

本文探讨了广东技术创新发展阶段、R&D资源结构对广东科技战略转变的约束,并就如何突破这些约束条件提出了建议主张。

关键词：技术创新发展战略发展阶段 R&D资源结构

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教育减负、家庭教育投入与教育不平等

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管理世界 2022年第9期38卷 83-95页

作者：张川川王玥琴浙江大学经济学院浙江大学财税大数据与政策研究中心浙江大学共享与发展研究院四川大学经济学院

在教育减负思潮的推动下,中小学生在校时长不断缩短,在课堂内外产生了广泛影响,也引发了针对家庭教育负担和教育公平的广泛争论。本文使用中国教育追踪调查数据考察了在校时长对家庭教育负担和教育不平等的影响,以期为平息政策争论和完... 详细信息

在教育减负思潮的推动下,中小学生在校时长不断缩短,在课堂内外产生了广泛影响,也引发了针对家庭教育负担和教育公平的广泛争论。本文使用中国教育追踪调查数据考察了在校时长对家庭教育负担和教育不平等的影响,以期为平息政策争论和完善教育减负政策提供学术上的借鉴。本文的实证分析表明:(1)初中生在校时长与其课外学习投入之间存在统计上显著的替代关系,但经济显著性有限;(2)学生在校时长的减少导致父母在子女养育上的时间投入增加,对较低学历的父母影响更大,并且导致他们的就业率下降;(3)由于在家庭经济条件较好、非农户口的学生中,在校时长减少导致的学生课外学习投入和父母在子女养育上的时间投入增加的更多,在校时长的减少导致同一班级、年级内学生成绩的离散程度显著上升;(4)除了在校时长外,学生家庭背景、父母对子女教育的焦虑程度等诸多因素也与家庭教育投入息息相关。本文的研究表明通过缩短在校时长所实现的教育减负在减轻学生课外学习负担方面的作用较为有限,且加重了教育不平等,从减轻父母对子女教育的焦虑程度等其他角度入手可能更有助于降低家庭教育负担。

关键词：教育减负在校时长家庭教育投入教育不平等

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