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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao qi wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting Xu qi wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Study of thermal decoherence of harmonic oscillators

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原子与分子物理学报 2025年第5期42卷 108-114页

作者： LI Jian ZHOU Gao-Liang YAN Zheng-Xin LIU Wei wang Zhao-qi College of Science Xi’an University of Science and TechnologyXi’an 710054China

The thermal decoherence of harmonic oscillators is investigated *** quantum system presented here is a one-dimensional oscillator with angular frequency,which is surrounded by a thermal bath of environmental *** are various environmental oscillators with different angular frequency(below an ultraviolet cutoff).At the beginning,the quantum system is a pure state and the environmental oscillators are in thermodynamic equilibrium with *** a period,the system-environment interactions inspire significant decoherence of the quantum *** decoherence is displayed by explicit calculations of the purity and von Neumann entropy of the quantum *** is worth noting that the decoherence could be significant even in the weak coupling and low temperature case due to the large amount of environmental degrees of *** the decoherence process is inspired between the quantum system and an ordinary thermal environment here,the thermal decoherence result is quite general.

关键词： Quantum decoherence Grand canonical ensemble Oscillators

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弹目交会条件下爆炸驱动结构体的展开过程研究

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高压物理学报 2025年第1期39卷 1-16页

作者：宁建国汪齐栗建桥北京理工大学爆炸科学与安全防护全国重点实验室北京100081

复杂结构在爆炸驱动作用下的展开是展开型定向战斗部定向过程中的关键问题,对展开过程进行有效控制,有利于战斗部的起爆延时控制和破片利用率提高。针对复杂结构体的展开问题,基于JWL状态方程和第二类拉格朗日方程,从能量守恒出发推导... 详细信息

复杂结构在爆炸驱动作用下的展开是展开型定向战斗部定向过程中的关键问题,对展开过程进行有效控制,有利于战斗部的起爆延时控制和破片利用率提高。针对复杂结构体的展开问题,基于JWL状态方程和第二类拉格朗日方程,从能量守恒出发推导了考虑爆轰产物膨胀过程和对目标命中状态的爆炸驱动展开模型。将驱动展开模型计算结果与文献实验结果进行对比,验证了爆炸驱动展开模型计算结果的准确性。结果表明,基于该模型的理论计算结果与实验结果的一致性较好,能较为精确地预测不同装药量下结构的展开时间;将辅助装药1与辅助装药2的质量比控制在1.5~1.7,结构体展开可达最佳命中姿态,更有利于命中目标。研究成果可充实定向战斗部设计理论,为展开型定向战斗部的设计提供参考。

关键词：爆炸驱动展开姿态展开时间辅助装药定向战斗部

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电动拖拉机复合式振动馈能系统设计及试验

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农机化研究 2025年第4期47卷 230-235页

作者：王旭东王琪王威陈雨崔永杰西北农林科技大学机械与电子工程学院陕西杨凌712100 陕西省农业信息感知与智能服务重点实验室陕西杨凌712100 农业农村部农业物联网重点实验室陕西杨凌712100

为了回收和利用电动拖拉机行驶过程中产生的振动能量,基于浮动电池组提出了一种压电-机械电磁复合式振动馈能装置;然后,根据装置的电压输出特性构建了包含整流滤波、LM317稳压、超级电容储能和Boost升压模块的电能提取电路,以满足蓄电... 详细信息

为了回收和利用电动拖拉机行驶过程中产生的振动能量,基于浮动电池组提出了一种压电-机械电磁复合式振动馈能装置;然后,根据装置的电压输出特性构建了包含整流滤波、LM317稳压、超级电容储能和Boost升压模块的电能提取电路,以满足蓄电池充电需求;最后,进行了复合式振动馈能系统的实车试验。结果表明:电动拖拉机车速为4 km/h时,馈能装置的最大输出电压为34.80 V,平均输出功率为0.57 W;经过等效计算,由复合式馈能系统回收的电能可使电动拖拉机的续航时间延长0.784 7 h。研究结果可为我国电动拖拉机的电能补给和工作时间延长提供理论与技术支撑。

关键词：电动拖拉机振动能量回收复合式振动馈能装置电能提取电路

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电动拖拉机犁耕机组阻力自适应作业控制研究

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农机化研究 2025年第4期47卷 224-229页

作者：王琪王旭东王威张硕崔永杰西北农林科技大学机械与电子工程学院陕西杨凌712100 陕西省农业信息感知与智能服务重点实验室陕西杨凌712100 农业农村部农业物联网重点实验室陕西杨凌712100

犁耕质量和效率对粮食高产至关重要,而以往基于悬挂高度调整以适应阻力变化来控制犁耕机组耕作效率存在耕深不均匀的问题。为此,以重心可调电动拖拉机犁耕机组为对象,提出了调定耕深下考虑速度和滑转率的阻力自适应作业控制方法。首先,... 详细信息

犁耕质量和效率对粮食高产至关重要,而以往基于悬挂高度调整以适应阻力变化来控制犁耕机组耕作效率存在耕深不均匀的问题。为此,以重心可调电动拖拉机犁耕机组为对象,提出了调定耕深下考虑速度和滑转率的阻力自适应作业控制方法。首先,建立了机组动力学模型并分析了阻力变化下机组的动态特性;然后,采用模糊神经网络控制算法调节驱动电机转矩和电池组位移,使牵引附着性能自动适应阻力变化,以实现速度和滑转率的联合控制;最后,进行了实车测试平台搭建和犁耕试验。结果表明:耕速最大偏差仅为0.48 km/h,相比于控制前滑转率降低了21.42%,牵引效率提高了7.76%。在恒定耕深下机组作业稳定性和效率得以提高,为电动拖拉机的自动化和智能化精准作业提供了技术支持。

关键词：电动拖拉机犁耕作业自适应控制牵引效率

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On a Lotka-Volterra Competition Diffusion Model with Advection

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Chinese Annals of Mathematics,Series B 2021年第6期42卷 891-908页

作者： qi wang College of Science University of Shanghai for Science and TechnologyShanghai 200093China

In this paper,the author focuses on the joint effects of diffusion and advection on the dynamics of a classical two species Lotka-Volterra competition-diffusion-advection system,where the ratio of diffusion and advection rates are supposed to be a positive *** comparison purposes,the two species are assumed to have identical competition abilities throughout this *** results explore the condition on the diffusion and advection rates for the stability of former ***,an asymptotic behavior of the stable coexistence steady states is obtained.

关键词： Competition-diffusion-advection Stability Dynamics

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Rock dynamics in deep mining

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International Journal of Mining Science and Technology 2023年第9期33卷 1065-1082页

作者： Manchao He qi wang State Key Laboratory for Geo-mechanics and Deep Underground Engineering China University of Mining&Technology-BeijingBeijing 100083China

Rock mass dynamics disasters caused by excavations and mining occur frequently in deep *** order to establish a theoretical system and control technologies for such disasters,we first classify and define dynamic disasters,such as rock bursts,coal bursts,mine pressure bumps,and mine *** to the occurrence mechanism of different types of dynamic disasters,we establish a compensation control theory based on excavation and mining *** the basis,we propose three key technologies:high prestress compensation technology for the roadway,pressure relief technology using directional roof cutting,and the goaf filling technology using broken rock *** three technologies constitute the compensation control method for dynamic disasters in deep ***,this method was successfully applied in a deep coal mine with high stress,with monitored results suggesting its *** work provides a new concept and control method for the prevention of rock dynamic disasters in deep mines.

关键词： Rock burst Coal burst Mine pressure bump Mine earthquake Excavation compensation control Mining compensation control

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Numerical Solutions of Fractional Boussinesq Equation

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Communications in Theoretical Physics 2007年第3期47卷 413-420页

作者： wang qi School of Mathematical Sciences Fudan University Shanghai 200433 China Key Laboratory of Mathematics Mechanizations the Chinese Academy of Sciences Beijing 100080 China

Based upon the Adomian decomposition method, a scheme is developed to obtain numerical solutions of a fractional Boussinesq equation with initial condition, which is introduced by replacing some order time and space derivatives by fractional derivatives. The fractional derivatives are described in the Caputo sense. So the traditional Adomian decomposition method for differential equations of integer order is directly extended to derive explicit and numerical solutions of the fractional differential equations. The solutions of our model equation are calculated in the form of convergent series with easily computable components.

关键词： fractional Boussinesq equation Adomian decomposition method

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Bidirectional Partial Generalized Synchronization in Chaotic and Hyperchaotic Systems via a New Scheme

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Communications in Theoretical Physics 2006年第6期45卷 1049-1056页

作者： wang qi Department of Applied Mathematics Dalian University of Technology Dalian 116024 China Key Laboratory of Mathematics Mechanization the Chinese Academy of SciencesBeijing 100080 China

In this paper, a bidirectional partial generalized （lag, complete, and anticipated） synchronization of a class of continuous-time systems is defined. Then based on the active control idea, a new systematic and concrete scheme is developed to achieve bidirectional partial generalized （lag, complete, and anticipated） synchronization between two chaotic systems or between chaotic and hyperchaotic systems. With the help of symbolic-numerical computation, we choose the modified Chua system, Lorenz system, and the hyperchaotic Tamasevicius Namajunas-Cenys system to illustrate the proposed scheme. Numerical simulations are used to verify the effectiveness of the proposed scheme. It is interesting that partial chaos synchronization not only can take place between two chaotic systems, but also can take place between chaotic and hyperchaotic systems. The proposed scheme can also be extended to research bidirectional partial generalized （lag, complete, and anticipated） synchronization between other dynamical systems.

关键词： bidirectional partial generalized (lag complete and anticipated) synchronization modified Chua system Lorenz system hyperchaotic Tamasevicius-Namajunas-Cenys system numerical simulation

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