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Microstructural characterization of titanium matrix composite coatings reinforced by in situ synthesized TiB + TiC fabricated on Ti6Al4V by laser cladding

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Rare Metals 2010年第5期29卷 465-472页

作者： LI Jun YU Zhishui wang huiping LI Manping School of Materials Engineering Shanghai University of Engineering Science Shanghai 201620 China

Titanium-based composite coatings reinforced by in situ synthesized TiB and TiC particles between titanium and B4C were successfully fabricated on Ti6Al4V by laser cladding. Phase constituents of the coatings were predicted by thermodynamic calculations in the Ti-BnC-Al and Ti-B-C-Al systems, respectively, and were validated well by X-ray diffraction （XRD） analysis results. Microstructural and metallographic analyses were made by scanning electron microscopy （SEM） and electron probe micro-analysis （EPMA）. The results show that the coatings are mainly composed of α-Ti cellular dendrites and the eutecticum in which a large number of needle-shaped TiB and a few equiaxial TiC particles are embedded. C is enriched in α-Ti cellular dendrites and far exceeds the theoretical maximum dissolubility, owing to the extension of saturation during laser cladding. The coatings have a good metallurgical bond with the substrate due to the existence of the dilution zone, in which a great amount of lamella β-Ti grains consisting of a thin needle-shaped martensitic microstructure are present and grow parallel to the heat flux direction; a few TiB and TiC reinforcements are observed at the boundaries of initial β-Ti grains.

关键词： composite coatings laser cladding in situ synthesis microstructure thermodynamic calculation

C-terminal domain of Chk1 regulates its subcellular location and kinase activity for DNA repair

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Chinese Science Bulletin 2011年第30期56卷 3138-3147页

作者： NING LiFeng wang huiping SAN Dan SANG JianLi Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education College of Life Science Beijing Normal University Beijing 100875 China Department of Reproduction Immunology National Research Institute for Family Planning Beifing 100081 China

Effector kinase Chk1 is an evolutionarily conserved protein kinase. It is a key mediator linking the mechanisms that monitor DNA integrity to components of the cell cycle engine. In this study, recombinant vectors pEGFP-C1-Chk1/C 288/C 334/C 368 were constructed and transfected into HeLa cells to study the effect of the Chk1 regulatory domain on the regulation of subcellular Chk1 location in response to DNA damage. We found that DNA damage-induced nuclear accumulation is regulated by 34 amino acids (334–368) in the C-terminal regulatory domain. Recombinant vectors pXJ41-Chk1/C 288/C 334/C 368 were co-transfected with reporter plasmid pEGFP-N2 into HeLa cells to study the repair abilities of the different human Chk1 truncation mutants. In addition, recombinant vectors were transfected into HeLa cells to study the effects of the different truncation mutants on the cell cycle. Furthermore, to study the kinase activity of the different truncation mutants, Ser216 phosphorylation of Cdc25C was studied by Western blot analysis. We found that the enzymatic activity of C 368, missing the 108 C-terminal amino acids (368–476), was higher than that of full-length Chk1, and C 368 delayed the cell cycle progression. The enzymatic activity of C 334, missing the 142 C-terminal amino acids (334–476), was equivalent to that of full-length Chk1. C 288, missing the 188 C-terminal amino acids (288–476), had almost no enzymatic activity, suggesting that the regulatory domain contains both inhibitory and regulatory elements. This study provides useful information for further research on Chk1 function.

关键词：亚细胞定位激酶活性 DNA修复 HeLa细胞 DNA损伤细胞周期重组载体 blot分析

Development and Application of the CGP-2 Catalyst in the MIP-CGP Process

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China Petroleum Processing & Petrochemical Technology 2007年第4期9卷 25-32页

作者： Qiu Zhonghong Long Jun Tian huiping wang Peng Research Institute of Petroleum Processing Beijing 100083

The research and development of the CGP-2 catalyst, which was used in the MIP-CGP process for reducing the olefin and sulfur contents of FCC naphtha and enhancing the propylene yield, were introduced. A specific type of metal compound was added into the matrix to provide active centers for reactions including catalytic conversion and selective adsorption of sulfur containing compounds. The CGP-2 catalyst possessed excellent hydrothermal stability to meet the requirements of the 2rid reaction zone of the MIP-CGP process. The commercial test of the said catalyst at the SINOPEC Cangzhou refinery showed that in comparison with the base case （using the CGP-1Z catalyst） the CGP-2 catalyst could reduce the sulfur content of FCC naphtha by 30.32% and increase the propylene yield along with good coke selectivity. Thus, the naphtha produced by the MIP-CGP process at the Cangzhou refinery can meet the new gasoline standard enforced in July 2005.

关键词： catalyst gasoline hydrogen transfer olefin sulfur content

Edge modes in finite-size systems with different edge terminals

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Chinese Physics B 2024年第10期33卷 381-387页

作者： huiping wang Li Ren Xiuli Zhang Liguo Qin School of Mathematics Physics and StatisticsShanghai University of Engineering ScienceShanghai 201620China

We investigate the behavior of edge modes in the presence of different edge terminations and long-range(LR)***,we mainly focus on such model crystals with two different types of structures(type I:“…-P-Q-P-Q-…”and type II:“…=P-Q=P-Q=…”),where P and Q represent crystal lines(CLs),while the symbols“-”and“=”denote the distance between the nearest neighbor(NN)*** on the lattice model Hamiltonian with LR hopping,the existence of edge modes is determined analytically by using the transfer matrix method(TMM)when different edge terminals are taken into *** findings are consistent with the numerical results obtained by the exact diagonalization *** also notice that edge modes can exhibit different behaviors under different edge *** result is helpful in solving novel edge modes in honeycomb crystalline graphene and transition metal dichalcogenides with different edge terminals.

关键词： edge modes long-range hopping different edge terminals

SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma

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BIOCELL 2024年第3期48卷 453-462页

作者： JIYU wang LIUYING YI KEKE HUANG YANGYANG wang huiping wang ZHIMIN ZHAI Department of Hematology The Second Affiliated Hospital of Anhui Medical UniversityHefei230601China Department of Hematology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China

Background:The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma(r/r B-NHL)is resistance to current therapies,and therapy-induced senescence(TIS)stands out as a crucial mechanism contributing to tumor drug ***,we analyzed SENEX/Rho GTPase Activating Protein 18(ARHGAP18)expression and prognostic signiﬁcance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients,investigating its target in B-NHL cell senescence and the effect of combining speciﬁc inhibitors on apoptosis resistance in B-NHL-TIS ***:Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector(Sh-SENEX)and the empty vector negative(NC)to construct a stable transfection cell line with knockdown of *** of SENEX-silencing on B-NHL-TIS formation,cell function and cell cycle-related pathways was *** doxorubicin(DOX)-inducible senescent B-NHL cells combined with the speciﬁc cyclin dependent kinase 4/6(CDK4/6)inhibitor Palbociclib to observe that blocking CDK4/6 effects on TIS *** expression of 21 B-NHL patients and 8 healthy controls were analyzed by qRT-PCR,and the correlation between its expression and clinical indicators were ***:The downregulation of SENEX expression promotes G1-S phase transition and apoptosis while inhibiting cell proliferation,collectively suppressing the formation of TIS in *** of CDK4/6 promotes the DOX-induced G1 phase arrest to enhance TIS formation in B-NHL cells which can reverse the regulatory effect of silencing SENEX on B-NHL cell cycle regulation and *** expression levels of SENEX were notably elevated in B-NHL patients compared to healthy controls,and Elevated expression levels of SENEX were associated with poor prognosis of B-NHL ***:SENEX enhances apoptosis resistance in B-NHL by inhibiting CDK4/6,thereby preventing G1-S phase transition and promoting TIS formation.

关键词： SENEX B-cell non-Hodgkin lymphoma CDK4/6 G1-S phase transition Therapy-induced senescence Apoptosis resistance

Edge states enhanced by long-range hopping:An analytical study

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Chinese Physics B 2021年第10期30卷 513-522页

作者： huiping wang Li Ren Liguo Qin Yueyin Qiu School of Mathematics Physics and StatisticsShanghai University of Engineering ScienceShanghai 201620China School of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China

We analyze the behavior of edge states in long-range(LR)interacting *** terms of lattice model Hamiltonian with the LR coupling,we determine analytically the condition of existence of edge states within the transfer matrix method(TMM).The expressions we obtain are general and hold for any choice of the LR *** reason why edge states can appear is the transfer matrix in the bulk different from that in the boundary *** predictions are in good agreement with numerical results by exact *** result is helpful in solving novel edge states in oneand two-dimensional(2D)superconductors with LR hopping and pairing.

关键词： edge states transfer matrix method long-range hopping

Decreased CD10-positive granulocytes for the differential diagnosis of myelodysplastic syndrome

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BIOCELL 2020年第4期44卷 607-611页

作者： JIYU wang huiping wang YING PAN QIANSHAN TAO ZHIMIN ZHAI Department of Hematology The Second Hospital of Anhui Medical UniversityHefei230601China

Myelodysplastic syndromes(MDS)are highly heterogeneous myeloid neoplasms,and a large number of patients are difficult to diagnose and classify by blood and bone marrow *** a surface marker of granulocyte,studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS ***,whether it can be used for differential diagnosis of MDS and other hematological diseases remains *** explore the value of CD10 for differential diagnosis of MDS,60 newly diagnosed MDS,20 aplastic anemia(AA)patients,and 35 iron-deficient anemia(IDA)patients were selected for this *** marrow(BM)specimens were processed for surface marker analysis and labeled with pre-conjugated monoclonal *** cells were detected by flow *** results indicated that CD10-positive granulocytes were significantly decreased in BM of MDS patients than AA and IDA patients,and the level of CD10-positive mature granulocytes was not associated with the clinical stages of *** operating characteristic(ROC)areas under the curve(AUC)of CD10-positive granulocytes was 0.86 and 0.85,respectively,in MDS patients than the IDA group and AA group with good specificity and ***,CD10-positive granulocytes were increased after effective *** conclusion,we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS.

关键词： Myelodysplastic syndromes CD10 Granulocytes Flow cytometry Differential diagnosis

Anti-oxidative and immunological role of Cyclocarya paliurus polysaccharide on the liver injury of diabetic rats

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Journal of Traditional Chinese Medicine 2024年第6期44卷 1146-1152页

作者： XIA Xichao XUE Shipeng SONG Guoying LI Bin wang huiping QIU Ju wang Jihong LIU Qingchun MA Yuhong OUYANG Jingfeng Nursing College Pingdingshan UniversityPingdingshan 467000China Basic Medicine College of Nanyang Medical University Nanyang 473041China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE: To investigate the effects of Cyclocarya paliurus(C. paliurus) polysaccharide on the liver injury of diabetic rats. METHODS: Rats were divided into 6 groups, including normal group, model group, control group, low-dose group of C. paliurus polysaccharide treatment, middledose group of C. paliurus polysaccharide treatment and high-dose group of C. paliurus polysaccharide treatment. Histological analysis of liver was analyzed using hematoxilin and eosin. Levels of plasma biological parameters and anti-oxidative enzymes were determined by spectrophotometry. Nuclear factor kappa-B-p65(NF-κB p65), tumor necrosis factor-α(TNF-α), interleukins 6(IL-6), IL-1β were measured by real-time polymerase chain reaction and enzyme-linked immunosorbent assay. RESULTS: Compared with that of model group, the glucose level of plasma decreased 62.32%(P < 0.01), but glycogen and insulin level increased 1.51 times and 1.27 times in the high-dose group of C. paliurus polysaccharide treatment, respectively. Plasma alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP) level decreased 47.47%(P < 0.05), 43.65%(P < 0.05) and 50.51%(P < 0.05) in the high-dose group of C. paliurus polysaccharide treatment, respectively. Superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase level increased 1.16 times(P < 0.01), 71.28%(P < 0.05), 1.29 times(P < 0.01) and 87.46%(P < 0.05) in the high-dose group of C. paliurus polysaccharide treatment, respectively. Enzyme activities of NF-κB, TNF-α, IL-1β and IL-6 were decreased 39.29%(P < 0.05), 51.11%(P < 0.05), 37.42%(P < 0.05) and 36.50%(P < 0.05), respectively. CONCLUSIONS: Administration of C. paliurus polysaccharide may play a protecting role for liver injury of diabetic rats through lowering glucose, ALT, AST, ALP level, increasing glycogen and insulin level, enhancing the anti-oxidative ability and down-regulating the inflammatory factors expression.

关键词： Cyclocarya paliurus polysaccharide liver injury diabetic rats antioxidants inflammatory factors

Product Defect Management of Children's Toys Made in China——A renection on the two-year implementation of Children's toys recall system

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China Standardization 2009年第5期54卷 31-39页

作者： wang huiping Defective Product Administrative Center of AQSIQ

The Management Regulations on Recallof Children's Toys is a recall system based onthe Management Regulations on Recall of MotorVehicles in *** its two years,the children'stoy recall management system has helped toprevent and eliminate damage caused by defectivechildren's *** has also helped to protect children'shealth and safety,safeguard public safetyand interest,and improve toy manufacturers' productquality and safety ***,due tothe small scale of most Chinese toy manufacturers,and the low standard of management,more effort isneeded from government departments and thecommunity to improve the recall system.

关键词： toy recall quality and safety status analysis