Decreased CD10-positive granulocytes for the differential diagnosis of myelodysplastic syndrome
作者机构：Department of HematologyThe Second Hospital of Anhui Medical UniversityHefei230601China
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2020年第44卷第4期
页 面：607-611页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：the National Natural Science Foundation of China(81670179) Research Fund Project of Anhui Medical University(No.2018xkj026) National Natural Science Foundation Incubation Project of the Second Hospital of Anhui Medical University(Grant No.2019GQFY11)
主 题：Myelodysplastic syndromes CD10 Granulocytes Flow cytometry Differential diagnosis
摘 要：Myelodysplastic syndromes(MDS)are highly heterogeneous myeloid neoplasms,and a large number of patients are difficult to diagnose and classify by blood and bone marrow *** a surface marker of granulocyte,studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS ***,whether it can be used for differential diagnosis of MDS and other hematological diseases remains *** explore the value of CD10 for differential diagnosis of MDS,60 newly diagnosed MDS,20 aplastic anemia(AA)patients,and 35 iron-deficient anemia(IDA)patients were selected for this *** marrow(BM)specimens were processed for surface marker analysis and labeled with pre-conjugated monoclonal *** cells were detected by flow *** results indicated that CD10-positive granulocytes were significantly decreased in BM of MDS patients than AA and IDA patients,and the level of CD10-positive mature granulocytes was not associated with the clinical stages of *** operating characteristic(ROC)areas under the curve(AUC)of CD10-positive granulocytes was 0.86 and 0.85,respectively,in MDS patients than the IDA group and AA group with good specificity and ***,CD10-positive granulocytes were increased after effective *** conclusion,we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS.
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