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Hypertransaminasemia in the course of infection with SARS-CoV-2:Incidence and pathogenetic hypothesis

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World Journal of Clinical Cases 2020年第8期8卷 1385-1390页

作者： Maddalena Zippi Sirio Fiorino Giuseppe Occhigrossi wandong hong Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRome 00157Italy Unit of Internal Medicine Maggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Department of Gastroenterology and Hepatology First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

In patients infected with severe acute respiratory syndrome coronavirus 2,the respiratory symptoms,such as fever,cough and dyspnea,are the most frequent clinical *** patients may also present with less well-defined symptoms like diarrhea,nausea,vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical *** a few cases,these symptoms may also present before the appearance of respiratory *** penetrate the body,Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors,which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver *** several cases,viral RNA is detectable in the stool of patients with coronavirus disease 2019(COVID-19).The liver damage seems to show a multifactorial *** 2%-11%of patients with COVID-19 have known underlying hepatic *** 14%-53%of COVID-19 cases,there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19,especially during hospitalization.

关键词： Coronavirus COVID-19 Hypertransaminasemia Liver Meta-analysis SARS-CoV-2

Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis

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World Journal of Clinical Cases 2021年第12期9卷 2763-2777页

作者： Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo wandong hong Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRome 00157Italy Unit of Internal Medicine Maggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Food Chemistry and Nutraceuticals Laboratory Department of Pharmacy and Biotechnology(FaBiT)Alma Mater StudiorumUniversity of BolognaBologna 40133Italy Experimental Diagnostic and Speciality Medicine DepartmentUniversity of BolognaBologna 40138Italy Department of Pharmacy and Biotechnology University of BolognaBologna 40138Italy Internal Medicine Unit Budrio Hospital Azienda USLBologna 40138Italy Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the *** consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these *** risks also appear to be linked to the duration and the *** the other hand,several studies have emerged with regard to the protective or therapeutic effects of these *** and more evidence underlines the immunomodulatory and anti-fibrotic role of *** addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host *** To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and *** A literature review was performed in November *** MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this *** search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and *** MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were *** tried to summarize and pool all the data if *** A total of 9 studies were found that described the use of PPIs,of which only 5

关键词： COVID-19 Proton pump inhibitors SARS-CoV-2,Severity Mortality

Evaluation of the risk factors for severe complications and surgery of intestinal foreign bodies in adults:a single-center experience with 180 cases

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Gastroenterology Report 2022年第1期10卷 420-429页

作者： Tingting Hu Jie Zhang Yang Liu Lifang Chen Wei Cen Wenzhi Wu Qingke Huang Xuecheng Sun Simon Stock Maddalena Zippi Vincent Zimmer Zarrin Basharat wandong hong Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangP.R.China Department of Otolaryngology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangP.R.China Department of Radiology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangP.R.China The First Clinical College Wenzhou Medical UniversityWenzhouZhejiangP.R.China Department of Surgery World Mate Emergency HospitalBattambangCambodia Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRomeItaly Department of Medicine II Saarland University Medical CenterSaarland UniversityHomburgGermany Jamil-ur-Rahman Center for Genome Research Dr.Panjwani Center for Molecular Medicine and Drug ResearchInternational Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan

Background Foreign bodies(FBs)lodged in the intestine or causing intestinal complications are uncommon in clinical practice but may pose diagnostic difficulties and prove *** study aimed to evaluate the risk factors for severe complications and surgery to aid clinicians in the diagnosis and management of intestinal *** We performed a retrospective analysis of patients in whom FBs were lodged in the intestine or caused complications from 2010 to 2020 in the First Affiliated Hospital of Wenzhou Medical University(Zhejiang,China).The characteristics of the patients and FBs,symptoms,imaging findings,diagnostics,treatment strategies,and clinical outcomes were ***,the risk factors for complications and surgery were *** In total,180 patients were included in our *** patients(76.1%)were unable to provide a history of *** were the most common FBs(35.6%).The FBs were mainly located in the duodenum(32.8%)and the ileum(27.8%).Surgical removal of FBs was successful in 89(49.4%)patients and endoscopic removal in 54(30.0%)*** with perforations were treated *** located in the jejunum or ileum were more likely to cause severe complications than those located in the *** located in the jejunum,ileum,or sigmoid colon were more likely to undergo surgery,and severe complications were an independent risk factor for *** Intestinal FBs,often localized in angulation,are likely to be misdiagnosed because most patients do not provide a history of FB *** and endoscopic therapy are the most commonly used treatment *** is not mandatory in clinically stable patients with small and contained *** located in the jejunum or ileum are risk factors for both complications and surgery.

关键词： complication foreign body intestine risk factor surgery

原发性渗出性淋巴瘤^18F—FDGPET／CT显像一例

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中华核医学与分子影像杂志 2017年第9期37卷 574-575页

作者：潘爽洪万东王宏清温州医科大学附属第一医院消化内二科 325000 温州医科大学附属第一医院放射影像科 325000

患者男，39岁，因＂腹痛、腹胀伴消瘦1周＂入院。既往无慢性病、肿瘤及传染病病史。体格检查：全身浅表淋巴结未触及，心、肺听诊无异常，腹部稍膨隆，腹软，无压痛及反跳痛，移动性浊音阳性。实验室检查（括号中为正常参考值范围）：WB... 详细信息

患者男，39岁，因＂腹痛、腹胀伴消瘦1周＂入院。既往无慢性病、肿瘤及传染病病史。体格检查：全身浅表淋巴结未触及，心、肺听诊无异常，腹部稍膨隆，腹软，无压痛及反跳痛，移动性浊音阳性。实验室检查（括号中为正常参考值范围）：WBC 10.1（3.5～9.5）×10^9/L，Hb 128（130～175） g/L，AST 14（15～40） U/L，ALT 70（9～50） U/L；肝炎标志物、EB病毒、HHV－8、HIV和肿瘤标志物均阴性，血红细胞沉降率2（0～15） mm/1 h。

关键词：原发性渗出性淋巴瘤 PET/CT显像 ^18F FDG 正常参考值范围肿瘤标志物红细胞沉降率浅表淋巴结

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胃底腺息肉与结直肠肿瘤关系的病例对照研究

中华消化内镜杂志 2015年第12期32卷 825-827页

作者：黄尔炯洪万东黄智铭温州医科大学附属第一医院消化内科浙江省温州市325000

目的探讨胃底腺息肉与结直肠肿瘤的相关性。方法回顾收集同时行胃镜和结肠镜检查的患者，经病理证实为胃底腺息肉且行结肠镜检查者65例为病例组，选取同期年龄与性别配对且胃镜检查未见胃底腺息肉者130例为对照组，对2组患者结肠镜结果... 详细信息

目的探讨胃底腺息肉与结直肠肿瘤的相关性。方法回顾收集同时行胃镜和结肠镜检查的患者，经病理证实为胃底腺息肉且行结肠镜检查者65例为病例组，选取同期年龄与性别配对且胃镜检查未见胃底腺息肉者130例为对照组，对2组患者结肠镜结果进行比较。结果病例组结直肠肿瘤检出率为18．5％（12／65），高于对照组结直肠肿瘤检出率6．2％（8／130），组间差异有统计学意义（P=0．008）。进一步分层分析，女性及〈50岁胃底腺息肉患者结直肠肿瘤的检出率均显著高于对照组（P=0．023，0．008）。结论胃底腺息肉与结直肠肿瘤风险紧密相关，应重视早期结直肠肿瘤的筛查。

关键词：胃镜检查结肠镜检查胃底腺息肉结直肠肿瘤

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留学生消化内科临床见习教学方法探讨

浙江医学教育 2011年第4期10卷 24-25,31页

作者：吴小丽陶利萍洪万东温州医学院附属第一医院浙江温州325000

随着医学教育模式的改变,既往的临床见习教学方法已不能满足现代留学生临床教学的要求,必须不断改革教学方法,才能适应培养高素质临床留学医学生的新要求。本文对消化内科留学生见习带教进行总结,对如何做好留学生临床见习教学工作并培... 详细信息

随着医学教育模式的改变,既往的临床见习教学方法已不能满足现代留学生临床教学的要求,必须不断改革教学方法,才能适应培养高素质临床留学医学生的新要求。本文对消化内科留学生见习带教进行总结,对如何做好留学生临床见习教学工作并培养高质量的临床留学医学生作初步探讨。

关键词：留学生消化内科临床见习

BISAP-HDL:BISAP评分联合HDL-C用于预测急性胰腺炎预后的临床价值

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中国现代医生 2022年第7期60卷 17-20页

作者：董乐妹金约朋洪万东温州医科大学附属第一医院消化内科浙江温州325000 温州医科大学附属第一医院肝胆外科浙江温州325000

目的根据2012亚特兰大急性胰腺炎分类标准,比较BISAP、HDL-C及BISAP联合HDL-C(BISAP-HDL)预测急性胰腺炎预后的临床价值。方法收集2013年1月至2014年4月在温州医科大学附属第一医院住院的急性胰腺炎患者资料,共402例患者符合入组条件并... 详细信息

目的根据2012亚特兰大急性胰腺炎分类标准,比较BISAP、HDL-C及BISAP联合HDL-C(BISAP-HDL)预测急性胰腺炎预后的临床价值。方法收集2013年1月至2014年4月在温州医科大学附属第一医院住院的急性胰腺炎患者资料,共402例患者符合入组条件并入组,分为轻症急性胰腺炎(MAP)组,中度重症急性胰腺炎(MSAP)组和重症急性胰腺炎(SAP)组。收集入选患者的人口学特征、入院时的BISAP评分、HDL-C值,制作BISAP评分、HDL-C及BISAP-HDL预测急性胰腺炎进展为重症急性胰腺炎的受试者工作特征曲线(ROC),分别取最佳cutoff值计算其预测结局的敏感度、特异度及曲线下面积(AUROC)。结果BISAP、HDL-C及BISAP-HDL预测重症急性胰腺炎的曲线下面积(AUROC)分别为0.8686,0.7030,0.9036(P<0.05)。当cutoff值取2时,BISAP-HDL的预测准确性最高,敏感度和特异度分别为90.00%和77.15%。结论BISAP-HDL预测重症急性胰腺炎的敏感度和特异度均优于BISAP。

关键词：急性胰腺炎 BISAP HDL-C BISAP-HDL

人工神经网络在肝硬化食管大静脉曲张预测中的应用

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医学研究杂志 2013年第2期42卷 156-159页

作者：董乐妹洪万东吴建胜温州医学院附属第一医院消化内科 325000

目的利用人工神经网络模型(ANN模型)预测肝硬化食管大静脉曲张。方法共纳入309例肝硬化患者,根据胃镜结果将患者分为食管无或小静脉曲张组和食管大静脉曲张组,记录年龄、生化指标、脾脏厚度等14个参数。先经单变量分析筛选出与食管大静... 详细信息

目的利用人工神经网络模型(ANN模型)预测肝硬化食管大静脉曲张。方法共纳入309例肝硬化患者,根据胃镜结果将患者分为食管无或小静脉曲张组和食管大静脉曲张组,记录年龄、生化指标、脾脏厚度等14个参数。先经单变量分析筛选出与食管大静脉曲张相关的指标,后用这些指标构建ANN模型。结果单变量分析显示血小板计数、凝血酶原时间、脾脏厚度、腹腔积液、门静脉宽度与食管大静脉曲张相关.以这5指标构建ANN模型预测肝硬化食管大静脉曲张的敏感度为94.27%,特异性达75.00%,诊断的准确率达到84.79%。结论 ANN模型在非侵入性预测肝硬化食管大静脉曲张方面有一定临床意义。

关键词：肝硬化食管大静脉曲张人工神经网络预测

Post-COVID-19 cholangiopathy:A systematic review

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World Journal of Meta-Analysis 2023年第1期11卷 29-37页

作者： Maddalena Zippi Sirio Fiorino wandong hong Dario de Biase Claudio Giuseppe Gallo Alfonso Grottesi Annamaria Centorame Pietro Crispino Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRome 00157Italy Unit of Internal Medicine Maggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Department of Pharmacy and Biotechnology University of BolognaBologna 40126Italy Unit of Internal Medicine Emilian Physiolaser Therapy CenterBologna 40024Italy Unit of General Surgery Sandro Pertini HospitalRome 00157Italy Department of Nursing Sciences University of FoggiaFoggia 71122Italy Unit of Emergency Medicine Santa Maria Goretti HospitalLatina 04100Italy

BACKGROUND The recent and still ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entailed various long-term complications,including post-infectious *** To identify the available studies concerning post-coronavirus disease 2019(COVID-19)*** An extensive bibliographical search was carried out in PubMed and in Cochrane Library to identify the articles(retrospective and prospective studies,cohort studies,case series and case reports)published between January 1,2020 and August 22,2022,using both MeSH terms and free-language keywords:cholangiopathy;COVID-19;post-COVID-19 cholangiopathy;*** Thirteen studies fulfilled the inclusion criteria,which included 64 patients suffering from this *** patients were male in 82.8%of *** transplant was executed in 6 patients and scheduled in 7 patients,while 2 patients refused the surgical *** in 23.4%of the cases,performing this procedure appeared to be *** This review has revealed that generally the involvement of the liver in the course of SARS-CoV-2 infection is mild and transient,inducing cholestasis of cholangiocytes but can also be severe enough to cause organ failure in some cases.

关键词： Cholangiopathy COVID-19 Post-COVID-19 cholangiopathy SARS-CoV-2 Transplantation