Hypertransaminasemia in the course of infection with SARS-CoV-2:Incidence and pathogenetic hypothesis

作     者：Maddalena Zippi Sirio Fiorino Giuseppe Occhigrossi Wandong Hong 

作者机构：Unit of Gastroenterology and Digestive EndoscopySandro Pertini HospitalRome 00157Italy Unit of Internal MedicineMaggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Department of Gastroenterology and HepatologyFirst Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第8期

页      面：1385-1390页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Coronavirus COVID-19 Hypertransaminasemia Liver Meta-analysis SARS-CoV-2 

摘      要：In patients infected with severe acute respiratory syndrome coronavirus 2,the respiratory symptoms,such as fever,cough and dyspnea,are the most frequent clinical *** patients may also present with less well-defined symptoms like diarrhea,nausea,vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical *** a few cases,these symptoms may also present before the appearance of respiratory *** penetrate the body,Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors,which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver *** several cases,viral RNA is detectable in the stool of patients with coronavirus disease 2019(COVID-19).The liver damage seems to show a multifactorial *** 2%-11%of patients with COVID-19 have known underlying hepatic *** 14%-53%of COVID-19 cases,there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19,especially during hospitalization.