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Altered synaptic currents,mitophagy,mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention

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Journal of Pharmaceutical Analysis 2024年第3期14卷 348-370页

作者： Binbin Zhao Dongfeng Wei Qinghua Long Qingjie Chen fushun wang Linlin Chen Zefei Li Tong Li Tao Ma Wei Liu Linshuang wang Caishui Yang Xiaxia Zhang Ping wang Zhanjun Zhang State Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing100875China Institute of Gerontology Hubei University of Chinese MedicineWuhan430065China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Medical School Hubei Minzu UniversityEnshiHubei445000China HuBei University of Science and Technology XianningHubei437100China Institute of Brain and Psychological Science Sichuan Normal UniversityChengdu610066China Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription Ministry of EducationHubei University of Chinese MedicineWuhan430065China Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing100700China School of Systems Science Beijing Normal UniversityBeijing100875China BABRI Centre Beijing Normal UniversityBeijing100875China

Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial ***,the specific associations between these pathological changes remain *** this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro *** investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis,Nissl staining,thioflavin-S staining,enzyme-linked immunosorbent assay,Golgi-Cox staining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROS)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular *** results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD ***,intervention with Dengzhan Shengmai(DZSM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZSM intervention,which notably amplified the frequency and amplitude of synaptic *** cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular *** intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and ***,DZSM intervention led to favourable changes in mitochondrial parameters,including ROS expression,MMP and ATP contents,and mitochondrial *** conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZSM intervention.

关键词： Alzheimer's disease Synaptic currents Mitophagy Mitochondrial fusion and fission Dengzhan Shengmai capsules

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基于改进YOLO v8s的羊只行为识别方法

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农业机械学报 2024年第7期55卷 325-335,344页

作者：王旺王福顺张伟进刘红达王晨王超何振学河北农业大学信息科学与技术学院保定071001 河北省农业大数据重点实验室保定071001

羊只站立、行走、采食等日常行为与其健康状况密切相关,高效、准确的羊只行为识别有助于疾病检测,对实现羊只健康预警具有重要意义。针对目前羊只多行为识别检测大多基于传感器等接触式设备,羊只活动受限,行为具有局限性,且群体养殖环境... 详细信息

羊只站立、行走、采食等日常行为与其健康状况密切相关,高效、准确的羊只行为识别有助于疾病检测,对实现羊只健康预警具有重要意义。针对目前羊只多行为识别检测大多基于传感器等接触式设备,羊只活动受限,行为具有局限性,且群体养殖环境下,羊只行为多样、场景复杂、存在遮挡等造成的行为识别精度低等问题,提出了一种基于改进YOLO v8s的羊只行为识别方法。首先,引入SPPCSPC空间金字塔结构增强了模型的特征提取能力,提升了模型的检测精度。其次,新增P2小目标检测层,增强了模型对小目标的识别和定位能力。最后,引入多尺度轻量化模块PConv和EMSConv,在保证模型识别效果的同时,降低了模型参数量和计算量,实现了模型轻量化。实验结果表明,改进YOLO v8s模型对羊只站立、行走、采食、饮水、趴卧行为平均识别精度分别为84.62%、92.58%、87.54%、98.13%和87.18%,整体平均识别精度为90.01%。与Faster R-CNN、YOLO v5s、YOLO v7、YOLO v8s模型相比,平均识别精度分别提高12.03、3.95、1.46、2.19个百分点。研究成果可为羊只健康管理和疾病预警提供技术支撑。

关键词：羊行为识别 YOLO v8s 轻量化

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基于改进YOLO v8n-seg的羊只实例分割方法

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农业机械学报 2024年第8期55卷 322-332页

作者：王福顺王旺孙小华王超袁万哲河北农业大学信息科学与技术学院河北省农业大数据重点实验室河北软件职业技术学院数字传媒系河北农业大学动物医学院/中兽医学院

羊只实例分割是实现羊只识别和跟踪、行为分析和管理、疾病监测等任务的重要前提。针对规模化羊场复杂养殖环境中,羊只个体存在遮挡、光线昏暗、个体颜色与背景相似等情况所导致的羊只实例错检、漏检问题,提出了一种基于改进YOLO v8n-se... 详细信息

羊只实例分割是实现羊只识别和跟踪、行为分析和管理、疾病监测等任务的重要前提。针对规模化羊场复杂养殖环境中,羊只个体存在遮挡、光线昏暗、个体颜色与背景相似等情况所导致的羊只实例错检、漏检问题,提出了一种基于改进YOLO v8n-seg的羊只实例分割方法。以YOLO v8n-seg网络作为基础模型进行羊只个体分割任务,首先,引入Large separable kernel attention模块以增强模型对实例重要特征信息的捕捉能力,提高特征的代表性及模型的鲁棒性;其次,采用超实时语义分割模型DWR-Seg中的Dilation-wise residual模块替换C2f中的Bottleneck模块,以优化模型对网络高层特征的提取能力,扩展模型感受野,增强上下文语义之间的联系,生成带有丰富特征信息的新特征图;最后,引用Dilated reparam block模块对C2f进行二次改进,多次融合从网络高层提取到的特征信息,增强模型对特征的理解能力。试验结果表明,改进后的YOLO v8n-LDD-seg对羊只实例的平均分割精度mAP_(50)达到92.08%,mAP_(50:90)达到66.54%,相较于YOLO v8n-seg,分别提升3.06、3.96个百分点。YOLO v8n-LDD-seg有效提高了羊只个体检测精度,提升了羊只实例分割效果,为复杂养殖环境下羊只实例检测和分割提供了技术支持。

关键词：羊只个体检测实例分割改进YOLO v8n-LDD-seg网络

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传统图像分割算法在农作物籽粒考种应用中的研究进展

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中国农机化学报 2024年第2期45卷 280-287页

作者：张伟进王福顺孙小华王军皓刘宏权王鑫鑫河北农业大学信息科学与技术学院河北保定071001 河北省农业大数据重点实验室河北保定071000 河北软件职业技术学院数字传媒系河北保定071000 河北农业大学城乡建设学院河北保定071001 河北省山区农业技术创新中心河北保定071001 国家北方山区农业工程技术研究中心河北保定071001

传统图像分割算法以时间、空间复杂度低等优点在农作物籽粒考种领域中有着广泛的应用。对传统分割算法在农作物表型获取过程中的应用进行研究,首先阐述Otsu、分水岭、边缘检测、SLIC算法以及凹点分析算法的算法原理,对种皮颜色灰度均匀... 详细信息

传统图像分割算法以时间、空间复杂度低等优点在农作物籽粒考种领域中有着广泛的应用。对传统分割算法在农作物表型获取过程中的应用进行研究,首先阐述Otsu、分水岭、边缘检测、SLIC算法以及凹点分析算法的算法原理,对种皮颜色灰度均匀、形状不同的农作物籽粒,以“问题—方法”的模式阐述不同算法在应用中存在的问题以及相应的解决方法;接着将算法基于阈值、区域、边缘、聚类、凹点整合为五大类,对算法的分割效果、优缺点及其适用范围进行比较研究;最后,剖析农作物籽粒图像分割应用研究存在农作物种类覆盖度不够宽泛、图像分割精度不高、技术通用性不高等问题,并从算法精度提高、重叠遮挡处理等方面对未来的研究进行展望,以期为农作物籽粒考种过程中的图像分割研究提供参考。

关键词：考种籽粒表型信息获取图像处理图像分割

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A decade of variation of COD in the Changjiang River (Yangtze River) and its variation trend analysis

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Chinese Journal Of Geochemistry 2007年第4期26卷 366-373页

作者： wang fushun wang Yuchun ZHANG Jing Institute of Applied Radiation School of Environmental and Chemical Engineering Shanghai University Shanghai 201800 China State Key Laboratory of Estuarine and Coastal Research East China Normal University Shanghai 200062 China Department of Wetter Environment China Institute of Water Resources and Hydroelectric Power Research （IWHR） Beijing 100038China

The average annual value of COD (chemical oxygen demand) fluxes of the Changjiang River (Yangtze River) and its main tributaries in the past decade (i.e., 1991–2000), has been evaluated. Based on the data from the Datong Hydrological Station (DHS), it was found that the Dongting Lake drainage basin contributed the greatest water discharge (35.8%) and COD flux (48.3%) among the main tributary drainage basins, followed by the Poyang Lake drainage basin with the contributions of 15.4% and 19.3%,respectively. By the end of the year of 2000, COD flux in the Changjiang River rose by almost 45% relative to that in the year of 1991, reaching about 1941000 ton/a at DHS. Statistical analysis revealed that industrial wastewater discharge, as well as COD in it, was found decreasing in the same period, due to the gradual reinforcement of environmental management. Moreover, correlation analysis indicated that non-point pollution from agriculture and increasing discharge of domestic sewages caused by rapid growth of population along the Changjiang River drainage valley should be responsible for the high COD. Furthermore, with the current trend of population growth and agricultural development in this basin, water quality of the Changjiang River, in terms of COD level, is going to deteriorate in the near future. Thus, the rational applications of fertilizers and pesticides in agriculture and the proper treatment of domestic sewages before they are discharged would be the most concerned controlling parameters.

关键词：长江排水盆地水质量种群

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Carbon dioxide emissions from the Three Gorges Reservoir,China

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Acta Geochimica 2017年第4期36卷 645-657页

作者： Shuang Li fushun wang Wenyun Luo Yuchun wang Bing Deng School of Environmental and Chemical Engineering Shanghai University Department of Water Environment China Institute of Water Resources and Hydroelectric Power Research State Key Laboratory of Estuarine and Coastal Research East China Normal University

Carbon dioxide(CO_2) emission from the rivertype reservoir is an hotspot of carbon cycle within inland waters. However, related studies on the different types of reservoirs are still inadequate. Therefore, we sampled the Three Gorges Reservoir(TGR), a typical river-type reservoir having both river and lake characteristics, using an online system(HydroCTM/CO_2) and YSI-6600v2 meter to determine the partial pressure of carbon dioxide(pCO_2)and physical chemical parameters in 2013. The results showed that the CO_2 flux from the mainstream ranged from 26.1 to 92.2 mg CO_2/m^2h with average CO_2 fluxes of 50.0 mg/m^2h. The CO_2 fluxes from the tributary ranged from-10.91 to 53.95 mg CO_22/mh with area-weighted average CO_2 fluxes of 11.4 mg/m^2h. The main stream emits CO_2 to the atmosphere the whole year; however, the surface water of the tributary can sometimes act as a sink of CO_2 for the atmosphere. As the operation of the TGR, the tributary became more favorable to photosynthetic uptake of CO_2 especially in summer. The total CO_2 flux was estimated to be 0.34 and 0.03 Tg CO_2/year from the mainstream and the tributaries, respectively. Our emission rates are lower than previous estimates, but they are in agreement with the average CO_2 flux from temperate reservoirs estimated by Barros et al.(Nat Geosci 4(9):593–596, 2011).

关键词： C02 emissions Three Gorges Reservoir River-type reservoir

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Astrocytic modulation of potassium under seizures

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Neural Regeneration Research 2020年第6期15卷 980-987页

作者： fushun wang Xiaoming Qi Jun Zhang Jason HHuang Department of Neurosurgery Baylor Scott&White HealthTempleTXUSA Institute of Brain and Psychological Science Sichuan Normal UniversityChengduSichuan ProvinceChina Department of Neurosurgery PLA General HospitalBeijingChina Department of Surgery Texas A&M University College of MedicineTempleTXUSA

The contribution of an impaired astrocytic K^+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade.A defective K^+ regulation leads to an elevated extracellular K^+ concentration([K^+]o).When[K^+]o reaches peaks of 10-12 mM,it is strongly associated with seizure initiation during hypersynchronous neuronal *** the other hand,reactive astrocytes during a seizure attack restrict influx of K^+ across the membrane both passively and *** addition to decreased K^+ buffering,aberrant Ca^2+ signaling and declined glutamate transport have also been observed in astrogliosis in epileptic specimens,precipitating an increased neuronal discharge and induction of *** review aims to provide an overview of experimental findings that implicated astrocytic modulation of extracellular K^+ in the mechanism of epileptogenesis.

关键词： AQP4 Ca^2+ signaling cell volume connexins epilepsy K^+ buffering mi RNA NKCC pannexin TBI

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一种基于改进差分进化的K-Means聚类算法研究

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现代电子技术 2024年第18期47卷 156-162页

作者：刘红达王福顺孙小华张广辉王斌何振学河北农业大学信息科学与技术学院河北保定071000 河北省农业大数据重点实验室河北保定071000 河北软件职业技术学院河北保定071000

为改进传统K-Means聚类算法中因随机选取初始聚类中心而导致聚类结果不稳定且效率低的缺点,提出一种基于改进差分进化的K-Means聚类算法(AGDE-KM)。首先,设计自适应操作算子来提升算法前期的全局搜索能力和后期的收敛速度;其次,设计多... 详细信息

为改进传统K-Means聚类算法中因随机选取初始聚类中心而导致聚类结果不稳定且效率低的缺点,提出一种基于改进差分进化的K-Means聚类算法(AGDE-KM)。首先,设计自适应操作算子来提升算法前期的全局搜索能力和后期的收敛速度;其次,设计多变异策略并引入权重系数,在算法的不同进化阶段发挥不同变异策略的优势,平衡算法的全局和局部搜索能力,加快算法的收敛速度;最后,提出一种基于当前种群最佳个体的高斯扰动交叉操作,为个体提供更优进化方向的同时保持种群在“维”上的多样性,避免算法陷入局部最优。将算法停止执行时输出的最优解作为初始聚类中心替代传统K-Means随机选取的聚类中心。将提出算法在UCI公共数据库中的Vowel、Iris、Glass数据集和合成数据集Jcdx上进行对比实验,误差平方和(SSE)相对于传统K-Means分别减小5.65%、19.59%、13.31%、6.1%,聚类时间分别减少83.03%、81.33%、77.47%、92.63%。实验结果表明,提出的改进算法具有更快的收敛速度和更好的寻优能力,显著提升了聚类的效果、效率和稳定性。

关键词： K-Means聚类算法差分进化算法多变异策略高斯扰动 UCI数据库聚类中心优化

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Optimization of extraction method for quantitative analysis of Si/Al in soil phytoliths

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Acta Geochimica 2023年第6期42卷 1007-1016页

作者： Yongsheng Chu Yue Xia Xiaoying Li fushun wang School of Environmental and Chemical Engineering Shanghai University99 Shangda RoadBaoshanP.O.Box 144Shanghai 200433China

Elemental information carried by phytoliths plays a crucial indicative role in geochemical *** instance,it serves as an indicator of the carbon pool effect in phytoliths and aids in the elucidation of silicon ***,early extraction methods for soil phytoliths primarily focused on obtaining their morphological and quantitative information,lacking efficient techniques for quantitative elemental *** this study,we aimed to extract Si/Al information from soil *** the need for complete extraction of phytolith,six extraction methods were developed and further by alkaline dissolution to determine Si/*** methods were compared in terms of enrichment capacity,the weight of extracted phytoliths,and Si/Al *** results indicated that the addition of Ammonia-Catechol in the commonly used heavy liquid flotation method effectively improved phytolith extraction capability and the accuracy of Si/Al ***,the inclusion of an acetic acid step before alkaline dissolution further removed surface-adsorbed impurities and enhanced the analytical quality of Si/Al in *** comparison of the data in this study with other published data shows that our method is relatively *** improved method proposed in this study can provide a new idea for the quantitative analysis of other elements in soil phytoliths.

关键词： Soil phytolith Extraction method Silica–aluminum ratio Ammonia–Catechol

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Flux of organic carbon burial and carbon emission from a large reservoir: implications for the cleanliness assessment of hydropower

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Science Bulletin 2019年第9期64卷 603-611页

作者： fushun wang Yunchao Lang Cong-Qiang Liu Yong Qin Ningxiao Yu Baoli wang School of Environmental and Chemical Engineering Shanghai University Institute of Surface-Earth System Sciences Tianjin University

Accurately quantifying the budget of carbon sources and sinks in hydropower reservoirs is important for evaluating the cleanliness of hydroelectricity. However, current research on carbon emissions from reservoirs has rarely taken into account the organic carbon(OC) buried in sediment. Only greenhouse gas emissions from the water-air interface at reservoirs have been examined, which would result in an overestimation of the greenhouse effect of reservoirs. In November 2017, this study investigated the distribution of sediment in the Hongfeng Reservoir(HFR) in southwest China, a typical large hydropower reservoir, by using an underwater seismology monitoring system. We estimated the flux of OC into sediment using the results of a sediment survey and a dataset compiled from references. Our results show that, the HFR retained 200,715 t of OC in the sediment since its impounding after dam construction to the sampling year of 2017, when the average burial flux was 3,521 t-C aà1(106 g C aà1) and the modern burial flux was 5,449 t-C aà1. After excluding the exogenous OC, the modern valid carbon sink of the sediment was 4,632 t per year. Under the current state of the reservoir, taking the modern valid carbon sink value, the carbon emissions from the reservoir's surface, and the discharge water from the dam into consideration, the net carbon sink of the HFR is found to be 1,098.9 t-C aà1. If the hydroelectricity generated by the reservoir is converted to a carbon sink, then the total net carbon sink becomes 12,972.9 t-C aà*** work argues that both reservoir sediment and hydroelectricity are important carbon sinks and both should be included in assessments of the greenhouse effects of reservoirs.

关键词： The Hongfeng Reservoir Sediment Carbon sink Underwater seismology method

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