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Metabolic Regulation of Mammary Gland Epithelial Cells of Dairy Cow by Galactopoietic Compound Isolated from Vaccariae segetalis

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Agricultural Sciences in China 2011年第7期10卷 1106-1116页

作者： tong Hui-li GAO Xue-jun LI Qing-zhang LIU Jie LI Nan wan Zhong-ying Key Laboratory of Dairy Science Ministry of Education/Life College Northeast Agricultural University Harbin 150030 P.R.China

In previous experiment, we isolated a compound dibutyl phthalate （DBP） from Vaccaria segetalis which had galactopoietic function on mammary gland epithelial cells of dairy cow （DCMECs）. In this experiment, we ascertained the metabolic regulation function of DBP on DCMECs. Many genes related to lactation including Stat5, AMPK, b-casein, Glut1, SREBP-1, PEPCK, and ACC were detected by real-time PCR. Furthermore, Stat5 and AMPK were detected by Western blot and immunofluorescence co-localization, respectively. The results showed that DBP stimulates the expression of Stat5 and p-Stat5, thus activates Stat5 cell signal transduction pathway and stimulates b-casein synthesis. DBP also raises the activities of Glut1 and AMPK to stimulate glucose uptake and glycometabolism and activates the expression of AMPK downstream target genes PEPCK and ACC and expression of SREBP-1 to stimulate milk fat synthesis. In addition, the activities of HK, G-6-PDH, ICDH, ATPase, and energy charges were stimulated by DBP to increase the energy metabolism level of DCMECs. The results showed DBP stimulates energy metabolism related to galactopoietic function in DCMECs.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cell metabolic regulation

The road to chirality-specific growth of single-walled carbon nanotubes

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National Science Review 2018年第3期5卷 310-312页

作者： Shuchen zhang Lianming tong Jin zhang Center for Nanochemistry Beijing Science and Engineering Center for Nanocarbons College of Chemistry and Molecular Engineering Peking University

Moore’s law has been declared to be eventually nearing its end after nearly five decades,with silicon being the main building block for all computing chips[1].The main roadblock in the development of transistors is the occurrence of the tunneling effect when the devices become small enough.A possible solution is finding alternative materials to fabricate a‘millivolt switch’,which is at least as fast as silicon counterparts and generates much less heat.

关键词： SWNTs Mo The road to chirality-specific growth of single-walled carbon nanotubes

Multistage Formation of Neoarchean Potassic Meta-Granites and Evidence for Crustal Growth on the North Margin of the North China Craton

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Journal of Earth Science 2023年第3期34卷 658-673页

作者： Xiaowei zhang Huafeng zhang Ying tong Laboratory of National Land Space Planning and Disaster Emergency Management of Inner Mongolia Chifeng UniversityChifeng 024000China Beijing SHRIMP Center Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Key Laboratory of Earthprobe and Geodynamics Chinese Academy of Geological SciencesBeijing 100037China

The North China Craton(NCC)is one of the most complex cratons in the *** underwent a series of tectonothermal events during the *** petrogenesis of potassic granitoids,the timing,and the style of Archean crustal growth are still *** field and petrological stdudies on the potassic meta-granites from the Guyang-Chayouzhongqi region were carried *** U-Pb ages,zircon Lu-Hf isotopic analyses,and whole-rock geochemical data were *** groups(~2.7 Ga and~2.5 Ga)of potassic meta-granites were ***~2.7 Ga meta-granites are mainly A2-type,with variableεHf(t)values(-8.4 to+3.3)and Archean one stage model ages(T_(DM)=~3.0 Ga),indicating that their source was derived from ancient anatectic TTG-like granite and depleted mantle,which suggests that thin crust had formed in the Guyang-Chayouzhongqi region by~3.0 *** to the K-rich granites in the NCC,most of the~2.5 Ga potassic meta-granites are typical of A1-type granite,and are enriched in Sm and Gd and depleted in Nb,Ta,P,and *** ages and isotopic data indicate that the~2.5 Ga meta-granites were generated from juvenile crustal sources with Neoarchean *** overall zircon U-Pb and Hf isotopic data furthermore suggested that the~2.7 Ga event is the most important stage of magmatic accretion in the NCC,similar to other *** contrast,reworking or metamorphic alteration was the main crustal process in the NCC at~2.5 Ga.

关键词： zircon U-Pb age Lu-Hf isotope geochemistry potassic meta-granite crustal growth North China Craton

Spectra of seismic force reduction factors of MDOF systems normalized by two characteristic periods

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Earthquake Engineering and Engineering Vibration 2020年第1期19卷 53-69页

作者： Li Xiao tong Genshu zhang Lei Department of Civil Engineering Zhejiang University

Seismic force reduction factor(SFRF) spectra of shear-type multi-degree-of-freedom(MDOF) structures are investigated. The modified Clough model, capable of considering the strength-degradation/hardening and stiffnessdegradation, is adopted. The SFRF mean spectra using 102 earthquake records on a typical site soil type(type C) are constructed with the period abscissa being divided into three period ranges to maintain the peak features at the two sitespecific characteristic periods. Based on a large number of results, it is found that the peak value of SFRF spectra may also exist for MDOF, induced by large high-mode contributions to elastic base shear, besides the mentioned two peak values. The variations of the stiffness ratio λk and the strength ratio λF of the top to bottom story are both considered. It is found that the SFRFs for λF ≤λk are smaller than those for λF > λk. A SFRF modification factor for MDOF systems is proposed with respect to SDOF. It is found that this factor is significantly affected by the story number and ductility. With a specific λF(= λk0.75), SFRF mean spectra are constructed and simple solutions are presented for MDOF systems. For frames satisfying the strong column/weak beam requirement, an approximate treatment in the MDOF shear-beam model is to assign a post-limit stiffness 15%-35% of the initial stiffness to the hysteretic curve. SFRF spectra for MDOF systems with 0.2 and 0.3 times the post-limit stiffness are remarkably larger than those without post-limit stiffness. Thus, the findings that frames with beam hinges have smaller ductility demand are explained through the large post-limit stiffness.

关键词： seismic force reduction factor multi-degree of freedom modifi ed Clough model characteristic period highmode eff ect post-limit stiff ness analysis

Generalized Fronts in Reaction-Diffusion Equations with Bistable Nonlinearity

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Acta Mathematica Sinica,English Series 2012年第8期28卷 1633-1646页

作者： Ya Qin SHU wan tong LI Nai Wei LIU School of Mathematics and Statistics Chongqing University of Technology School of Mathematics and Statistics Lanzhou University School of Mathematics and Informational Science Yantai University

In this paper, we first study the existence of transition fronts （generalized traveling fronts） for reaction-diffusion equations with the spatially heterogeneous bistable nonlinearity. By constructing sub-solution and super-solution we then show that transition fronts are globally exponentially stable for the solutions of the Cauchy problem. Furthermore, we prove that transition fronts are unique up to translation in time by using the monotonicity in time and the exponential decay of such transition fronts.

关键词： Reaction-diffusion equation transition fronts uniqueness bistable nonlinearity stability

Advancements in Humanoid Robots: A Comprehensive Review and Future Prospects

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 301-328页

作者： Yuchuang tong Haotian Liu Zhengtao zhang IEEE CAS Engineering Laboratory for Intelligent Industrial Vision Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

This paper provides a comprehensive review of the current status, advancements, and future prospects of humanoid robots, highlighting their significance in driving the evolution of next-generation industries. By analyzing various research endeavors and key technologies, encompassing ontology structure,control and decision-making, and perception and interaction, a holistic overview of the current state of humanoid robot research is presented. Furthermore, emerging challenges in the field are identified, emphasizing the necessity for a deeper understanding of biological motion mechanisms, improved structural design,enhanced material applications, advanced drive and control methods, and efficient energy utilization. The integration of bionics, brain-inspired intelligence, mechanics, and control is underscored as a promising direction for the development of advanced humanoid robotic systems. This paper serves as an invaluable resource, offering insightful guidance to researchers in the field,while contributing to the ongoing evolution and potential of humanoid robots across diverse domains.

关键词： Future trends and challenges humanoid robots human-robot interaction key technologies potential applications

Repetitive transcranial magnetic stimulation improves consciousness disturbance in stroke patients A quantitative electroencephalography spectral power analysis

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Neural Regeneration Research 2012年第31期7卷 2465-2472页

作者： Ying Xie tong zhang Capital Medical University School of Rehabilitation Medicine Department of Rehabilitation Electric Power Teaching Hospital of CapitalMedical University Beijing 100073 China Department of Neurology and Rehabilitation Capital Medical University School of Rehabilitation Medicine China Rehabilitation ResearchCenter Beijing 100068 China

Repetitive transcranial magnetic stimulation is a noninvasive treatment technique that can directly alter cortical excitability and improve cerebral functional activity in unconscious patients. To investigate the effects and the electrophysiological changes of repetitive transcranial magnetic stimulation cortical treatment, 10 stroke patients with non-severe brainstem lesions and with disturbance of consciousness were treated with repetitive transcranial magnetic stimulation. A quantitative electroencephalography spectral power analysis was also performed. The absolute power in the alpha band was increased immediately after the first repetitive transcranial magnetic stimulation treatment, and the energy was reduced in the delta band. The alpha band relative power values slightly decreased at 1 day post-treatment, then increased and reached a stable level at 2 weeks post-treatment. Glasgow Coma Score and JFK Coma Recovery Scale-Revised score were improved. Relative power value in the alpha band was positively related to Glasgow Coma Score and JFK Coma Recovery Scale-Revised score. These data suggest that repetitive transcranial magnetic stimulation is a noninvasive, safe, and effective treatment technology for improving brain functional activity and promoting awakening in unconscious stroke patients.

关键词： repetitive transcranial magnetic stimulation consciousness disturbance stroke quantitative electroencephalography nervous excitation consciousness neuroregenerative disease regeneration neural regeneration

Functional Amphiphilic Poly(2-oxazoline)Block Copolymers as Drug Carriers:the Relationship between Structure and Drug Loading Capacity

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Chinese Journal of Polymer Science 2021年第7期39卷 865-873页

作者： Si Dong Sheng Ma Zhi-Lin Liu Li-Li Ma Yu zhang Zhao-Hui Tang Ming-Xiao Deng wan-tong Song College of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Poly(2-oxazoline)(POx)is a kind of polymeric amides that can be viewed as conformational isomers of polypeptides with excellent cyto-and hemo-compatibility,and is promising to be used as drug ***,the drug loading capacity(DLC)of POx for many drugs is still low except several hydrophobic ones including paclitaxel(PTX).Herein,we prepared a series of amphiphilic POx block copolymers with various functional groups,and investigated the relationship between functional structures and the *** POxs with benzyl,carboxyl,and amino groups in the side-chain were synthesized based on a poly(2-methyl-2-oxazoline)-block-poly(2-buty1-2-oxazoline-co-2-buteny1-2-oxazoline)(PMeOx-P(nBuOx-co-ButenOx),PMBEOx)precursor,followed by click reaction between vinyl and the 2-phenylethanethiol,thioglycolic acid and *** thin-film hydration method,eight commonly used drugs with various characteristics were encapsulated within these functional POx *** found that amine-containing drugs were more easily encapsulated by POx with carboxyl groups,while amine functionalities in POx enhanced the loading capacity of drugs with carboxyl *** addition,n-n interactions resulted in enhanced DLC of most drugs,except several hydrophobic drugs with aromatic to total carbon ratios less than *** general,we could successfully encapsulate all the selected drugs with a DLC%over 10%using properly selected functional *** above results confirm that the DLC of polymeric carriers can be adjusted by modifying the functional groups,and the prepared series of functional POxs provide an option for various drug loadings.

关键词： Poly(2-oxaozoline) Polymeric micelles Drug loading π-πInteraction Electrostatic interaction

Study on Catalytic Wet Oxidation of H_2S into Sulfur on Fe/Cu Catalyst

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Journal of Natural Gas Chemistry 2006年第1期15卷 63-69页

作者： Junfeng zhang Zhiquan tong Environmental Engineering Department of Xiangtan University Xiangtan 411105 China

A wet catalytic oxidation at room temperature was investigated with solution containing ferric, ferrous and cupric ions for H2S removal. The experiments were carried out in a two step process, and the results obtained show that the removal efficiency of H2S can always reach 100% in a 300 mm scrubbing column with four sieve plates, and the regeneration of ferric ions in 200 mm bubble column can match the consumed ferric species in absorption. Removal of H2S, production of elemental sulfur and regeneration of ferric, cupric ions can all be accomplished at the same time. No raw material is consumed except O2 in flue gas or air, the process has no secondary pollution and no problem of catalyst degradation and congestion.

关键词： wet oxidation H2S catalytic sulfur ferric ion ferrous ion cupric ion