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Mode Control of Quasi-PT Symmetry in Laterally Multi-Mode Double Ridge Semiconductor Laser

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Chinese Physics Letters 2020年第4期37卷 67-70页

作者： Ting Fu Yu-Fei wang Xue-You wang Xu-Yan Zhou wan-hua zheng Laboratory of Solid State Optoelectronics Information technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083 College of Future Technology University of Chinese Academy of SciencesBeijing 101408 Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049 State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083

In traditional semiconductor lasers, it is usual to obtain single lateral mode operation by narrowing the ridge of waveguide, which is sensitive to fabrication inaccuracies. To overcome this shortcoming, a quasi-PT(parity-time)symmetric double ridge semiconductor laser is proposed to reach single lateral mode operation for an intrinsic multi-mode stripe laser. The coupled mode theory is used to analyze the non-Hermitian modulation of the gain(or loss) of the PT symmetric double ridge laser to obtain the coupling coefficient between the two ridge waveguides. Finally, the mode field distributions of the quasi-PT symmetric double ridge laser are simulated before and after the spontaneous PT symmetry breaking, which keep the laser operating in single lateral mode.

关键词： waveguide mode double

High-Brightness Low-Divergence Tapered Lasers with a Narrow Taper Angle

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Chinese Physics Letters 2019年第8期36卷 43-46页

作者： Zhong-Hao Chen Hong-Wei Qu Xiao-Long Ma Ai-Yi Qi Xu-Yan Zhou Yu-Fei wang wan-hua zheng State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing100083 Laboratory of Solid State Optoelectronics Information Technology Institute of SemiconductorsChinese Academy of SciencesBeijing100083 College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing1000494College of Future TechnologyUniversity of Chinese Academy of SciencesBeijing101408

High-brightness tapered lasers with photonic crystal structures are designed and fabricated.A narrow taper angle is designed for the tapered *** device delivers an output power of 3.3 W and a maximum wall-plug efficiency of 43%.The vertical beam divergence is around 110 at different *** diffraction-limited beam qualities for the vertical and lateral directions are *** lateral beam quality factor M2 is below 2.5 and the vertical M2 value is around 1.5 across the whole operating current *** maximum brightness is 85 MW·*** the current is above 3.3 A,the brightness is still above 80 MW·cm-2sr-1.

关键词： profile High-Brightness Narrow Taper Angle

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da wan Shuwei Tang Shulin Bai Xiaodong Li Peng Ai wanrong Guo Tuo zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu huang Qiuyu Pang Lexin zheng Jiaxi Lin Hanxi Li Lingbo wan Tao wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

基于成桥荷载试验的武汉青山长江公路大桥主桥有限元模型修正

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世界桥梁 2021年第6期49卷 85-89页

作者：朱江华张晨万正华田碧鹏中南安全环境技术研究院股份有限公司湖北武汉430040

武汉青山长江公路大桥主桥为主跨938 m双塔双索面全飘浮体系斜拉桥。该桥成桥静载试验3个典型测试工况校验系数不在常值范围,动载自振特性试验未能测出主梁一阶计算纵向飘移频率。为反映大桥的实际受力状态,分析典型异常工况实测数据和... 详细信息

武汉青山长江公路大桥主桥为主跨938 m双塔双索面全飘浮体系斜拉桥。该桥成桥静载试验3个典型测试工况校验系数不在常值范围,动载自振特性试验未能测出主梁一阶计算纵向飘移频率。为反映大桥的实际受力状态,分析典型异常工况实测数据和计算值,确定支座摩阻力是影响试验结果的主要原因。成桥荷载试验前计算有限元模型是基于理想状态建立,未考虑支座摩阻力的影响,导致静载试验及自振特性试验测试结果异常。采用施加外荷载的方法模拟支座摩阻力,对初始有限元模型进行修正及试算。结果表明:修正后的有限元模型计算值与实测值吻合较好,校验系数满足规范要求,修正后的结果可更真实地反映结构的实际受力特性。

关键词：斜拉桥全飘浮体系荷载试验校验系数自振特性支座摩阻力有限元模型修正

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing Xuyun hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong zheng He wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng Wu Wen-Jia Chen Xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

山区高速公路宽幅厚层水泥稳定碎石基层施工技术

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交通标准化 2014年第15期42卷 140-145页

作者：彭韬万正华叶华何文华宗炜湖北省谷竹高速公路建设指挥部湖北十堰442100 湖北省交通规划设计院湖北武汉430051 中交二公局萌兴工程有限公司陕西西安710119

通过研究山区高速公路宽幅厚层水泥稳定碎石基层施工技术,总结出一套可行的施工技术方案。研究发现:采用双缸串联拌和能够有效改善水泥稳定碎石混合料的拌和均匀性;大功率宽幅厚层抗离析摊铺机的使用能够解决普通摊铺机容易产生的纵向... 详细信息

通过研究山区高速公路宽幅厚层水泥稳定碎石基层施工技术,总结出一套可行的施工技术方案。研究发现:采用双缸串联拌和能够有效改善水泥稳定碎石混合料的拌和均匀性;大功率宽幅厚层抗离析摊铺机的使用能够解决普通摊铺机容易产生的纵向两机搭接离析;对比不同水泥稳定碎石基层碾压方案,采用大吨位大激振力的振动压路机能够保证宽幅厚层基层压实度满足规范要求。

关键词：宽幅厚层水泥稳定碎石基层双缸串联拌和离析压实

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