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Secondary electron yield suppression using millimeter-scale pillar array and explanation of the abnormal yield–energy curve

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Chinese Physics B 2019年第7期28卷 479-485页

作者： Ming Ye Peng Feng Dan wang Bai-Peng Song Yong-Ning He wan-zhao cui School of Electronic and Information Engineering Xi'an Jiaotong University Xi'an 710049 China Key Laboratory for Physical Electronics and Devices of the Ministry of Education School of Electronic and Information Engineering Xi'an Jiaotong University Xi'an 710049 China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical Engineering Xi'an Jiaotong University Xi'an 710049 China National Key Laboratory of Science and Technology on Space Microwave China Academy of Space Technology Xi'an 710100 China

The phenomenon of secondary electron emission is of considerable interest in areas such as particle accelerators and on-board radio frequency(RF) *** secondary electron yield(TSEY) is a parameter that is frequently used to describe the secondary electron emission capability of a *** has been widely recognized that the TSEY *** electron energy curve has a single-hump ***, the TSEY–energy curve with a double-hump shape was also observed experimentally-this anomaly still lacks *** this work, we explain this anomaly with the help of a millimetre-scale(mm-scale) silver pillar array fabricated by three-dimensional(3 D) printing *** TSEY–energy curve of this pillar array as well as its flat counterpart is obtained using sample current *** measurement results show that for the considered primary electron energy(40–1500 eV), the pillar array can obviously suppress TSEY,and its TSEY–energy curve has an obvious double-hump *** Monte Carlo simulations and electron beam spot size measurements, we successfully attribute the double-hump effect to the dependence of electron beam spot size on the primary electron *** observations of this work may be of help in determining the TSEY of roughened surface with characteristic surface structures comparable to electron beam spot *** also experimentally confirms the TSEY suppression effect of pillar arrays.

关键词： secondary electron emission pillar array total secondary electron yield suppression

Analysis of secondary electron emission using the fractal method

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Chinese Physics B 2021年第1期30卷 537-544页

作者： Chun-Jiang Bai Tian-Cun Hu Yun He Guang-Hui Miao Rui wang Na Zhang wan-zhao cui National Key Laboratory of Science and Technology on Space Science China Academy of Space Technology(Xi’an)Xi’an 710100China

Based on the rough surface topography with fractal parameters and the Monte–Carlo simulation method for secondary electron emission properties, we analyze the secondary electron yield(SEY) of a metal with rough surface topography. The results show that when the characteristic length scale of the surface, G, is larger than 1 × 10^(-7), the surface roughness increases with the increasing fractal dimension D. When the surface roughness becomes larger, it is difficult for entered electrons to escape surface. As a result, more electrons are collected and then SEY decreases. When G is less than 1 × 10^(-7),the effect of the surface topography can be ignored, and the SEY almost has no change as the dimension D increases. Then,the multipactor thresholds of a C-band rectangular impedance transfer and an ultrahigh-frequency-band coaxial impedance transfer are predicted by the relationship between the SEY and the fractal parameters. It is verified that for practical microwave devices, the larger the parameter G is, the higher the multipactor threshold is. Also, the larger the value of D,the higher the multipactor threshold.

关键词： secondary electron emission yield the fractal method multipactor

An improved secondary electrons energy spectrum model and its application in multipactor discharge

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Chinese Physics B 2018年第3期27卷 502-507页

作者： wan-zhao cui Heng Zhang Yun Li Yun He Qi wang Hong-Tai Zhang Hong-Guang wang Jing Yang National Key Laboratory of Science and Technology on Space Microwave China Academy of Space Technology(Xi'an)Xi'an 710100China School of Electronic and Information Engineering Xi'an Jiaotong UniversityXi'an 710049China

Secondary electron emission(SEE)of metal and dielectric materials plays a key role in multipactor discharge,which is a bottle neck problem for high-power satelliate *** of both the secondary electron yield(SEY)and the secondary electron energy spectrum(SES)are performed on metal samples for an accurate description of the real SEE *** order to simplify the fitting process and improve the simulation efficiency,an improved model is proposed for the description of secondary electrons(SE)emitted from the material surface,including true,elastic,and inelastic *** the novel SES model into the electromagnetic particle-in-cell method,the electronic resonant multipactor in microwave components is simulated successfully and hence the discharge threshold is *** results of the SES variation in the improved model demonstrate that the multipactor threshold is strongly dependent on *** addition,the mutipactor simulation results agree quite well with the experiment for the practical microwave component,while the numerical model of SEY and SES fits well with the sample data taken from the microwave component.

关键词： secondary electron energy spectrum multipactor simulation vaccum breakdown satellite application

Effects of O_(2)adsorption on secondary electron emission properties

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Chinese Physics B 2023年第4期32卷 663-669页

作者：杨兆伦杨晶何鋆胡天存王新波张娜陈泽煜苗光辉张雨婷崔万照 College of Aeronautics Nanjing University of Aeronautics and AstronauticsNanjing 211106China National Key Laboratory of Science and Technology on Space Microwave China Academy of Space Technology(Xi’an)Xi’an 710100China

The surface adsorption of gas molecules is a key factor limiting the secondary electron yield(SEY)of a material in many areas of applied *** influence of O_(2)adsorption on the SEY of metallic Ag is investigated in this *** account for the particle distribution,we propose a BET theory based on multilayer O_(2)physisorption ***,based on the phenomenological model of secondary electron(SE)emission and by taking into account the different scattering processes between electrons and particles in the adsorbed layer,we develop a numerical model of SEY in the adsorbed state using Monte Carlo *** relationships among O_(2)adsorption,adsorption layer thickness,and SEY variation characteristics are then examined through a series of *** 12-h exposure to O_(2),the clean samples increases12%-19%of the maximum value of SEY and 2.3 nm in thickness of the adsorbed *** results are also compared with the results from the MC model to determine whether the model is accurate.

关键词： multilayer adsorption model secondary electron Monte Carlo simulation gas adsorption experiments

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei zhao Donghong cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui wan Meng zhao Jiaqi wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun cui Chenmeng Qiao Weijiang zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Modified constitutive models for Inconel 718 considering current density and temperature in electrically assisted forming process

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Chinese Journal of Aeronautics 2024年第2期37卷 524-540页

作者： Xuan cui Rui zhao Min wan School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Jiangxi Research Institute of Beihang University Jiangxi 330000China

Electrically Assisted Forming(EAF)technology has obvious advantages in material *** develop an effective constitutive model considering electrical effects,room temperature and electrically assisted quasi-static uniaxial tensile tests were conducted using ultrathin nickelbased superalloy plates with a thickness of 0.25 *** research focused on the two most widely recognized effects:the Joule thermal and the electric athermal *** mechanism of current action can be divided into two scenarios:one considering the Joule thermal effect only,and the other considering both effects *** basic constitutive models,namely the Modified-Hollomon model and the Johnson-Cook(J-C)model,were selected to be optimized through the classification of two different situations,and four optimized constitutive models were *** was found that the J-C model with simultaneous consideration of the Joule thermal effect and electric athermal effect had the best prediction effect by comparing the results of these four ***,the accuracy of the optimization model was verified by finite element simulation of the electrically assisted stretching optimization *** results show that the constitutive model can effectively predict the temperature effect caused by the Joule heat effect and the athermal effect of current on the material.

关键词： Joule heating Elastoplasticity Plastic deformation Superalloys Constitutive models