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An Investigation of Molecular Targeting of MMP-9 for Endometriosis Using Algal Bioactive Molecules

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Phyton-International Journal of Experimental Botany 2022年第3期91卷 569-582页

作者： Farnaz Nabiya Anchana Devi Chenniappan Rajamiriyam Marichamy MubarakAli Davoodbasha jung-wan kim P.G.&Research Department of Biotechnology Women’s Christian CollegeChennai600006Tamil NaduIndia School of Life Sciences B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennai600048Tamil NaduIndia Division of Bioengineering Incheon National University119 Academy-roSongdo 1(il)-dongYeonsu-guIncheon22012Korea

Endometriosis is a chronic inflammatory disease that occurs due to the presence of endometrial tissue outside the uterine *** affects from 5%to 10%of women of reproductive *** levels of matrix metalloproteinase(especially MMP-9)have been observed in women suffering from ***,the aim of this study was to investigate the naturally anti-inflammatory compounds available from an algal source that can target the MMP-9 by various in silico *** target 1L6J(Crystal structure of human matrix metalloproteinase MMP-9)structure was retrieved from the PDB *** compounds such as Eckol,Sargafuran,Vitamin E,Docosahexaenoic acid,Fucoidan and Elagolix were selected based on‘Lipinski’s rule of five’using the PubChem *** pharmacokinetics,ADMET properties and biological activity of these compounds were predicted computationally using databases such as PreADME,SWISS-ADME,pkCSM and *** analysis of the bioactive compounds with the target was performed by AutoDock *** LigPlot v.2.2,the target residues interacting with the compounds were visualised in a 2D *** on the results,Eckol exhibited the highest binding energy value of−7.82 kcal/mol,whereas the Elagolix(control drug)showed a binding energy of−4.88 *** conclude that Eckol can be a potent inhibitor of target MMP-9 with least side effects when compared to the control ***,this compound can be effectively explored by further in vitro and in vivo studies to develop more effective treatments for Endometriosis.

关键词： Endometriosis matrix metalloproteinase anti-inflammatory PubChem AutoDock 4.2.6 LigPlot v.2.2 eckol

Changes in peak inspiratory flow rate and peak airway pressure with endotracheal tube size during chest compression

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World Journal of Emergency Medicine 2020年第2期11卷 97-101页

作者： jung wan kim Jin Woong Lee Seung Ryu jung Soo Park InSool Yoo Yong Chul Cho Hong Joon Ahn Department of Emergency Medicine Chungnam National University HospitalJung-guDaejeonRepublic of Korea Department of Emergency Medicine College of MedicineChungnam National UniversityJung-guDaejeonRepublic of Korea

BACKGROUND:Adequate airway management plays an important role in high-quality cardiopulmonary resuscitation(CPR).Airway management is usually performed using an endotracheal tube(ETT)during ***,no study has assessed the effect of ETT size on the fl ow rate and airway pressure during ***:We measured changes in peak inspiratory fl ow rate(PIFR),peak airway pressure(Ppeak),and mean airway pressure(Pmean)according to changes in ETT size(internal diameter 6.0,7.0,and 8.0 mm)and with or without CPR.A tidal volume of 500 mL was supplied at a rate of 10 times per minute using a mechanical *** compressions were maintained at a constant compression depth and speed using a mechanical chest compression device(LUCAS2,mode:active continuous,chest compression rate:102±2/minute,chest compression depth 2–2.5 inches).RESULTS:The median of several respiratory physiological parameters during CPR was significantly different according to the diameter of each ETT(6.0 vs.8.0 mm):PIFR(32.1 L/min[30.5–35.3]vs.28.9 L/min[27.5–30.8],P<0.001),Ppeak(48.84 cmH2O[27.46–52.11]vs.27.45 cmH2O[22.53–52.57],P<0.001),and Pmean(18.34 cmH2O[14.61–21.66]vs.13.66 cmH2O[8.41–19.24],P<0.001).CONCLUSION:The changes in PIFR,Ppeak,and Pmean were related to the internal diameter of ETT,and these values tended to decrease with an increase in ETT *** airway pressures were measured in the CPR group than in the no CPR group.

关键词： Cardiopulmonary resuscitation Intratracheal intubation Airway pressure

In situ infrared, Raman and X-ray spectroscopy for the mechanistic understanding of hydrogen evolution reaction

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Journal of Energy Chemistry 2024年第3期90卷 632-651,I0014页

作者： Andi Haryanto Kyounghoon jung Chan Woo Lee Dong-wan kim Department of Chemistry Kookmin UniversitySeoul 02707Republic of Korea School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea

Hydrogen production by water reduction reactions has received considerable attention because hydrogen is considered a clean-energy carrier,key for a sustainable energy *** methods have been widely used to study the reaction mechanism of the hydrogen evolution reaction(HER),but the calculation results need to be supported by experimental results and direct evidence to confirm the mechanistic *** this review,we discuss the fundamental principles of the in situ spectroscopic strategy and a theoretical model for a mechanistic understanding of the *** addition,we investigate recent studies by in situ Fourier transform infrared(FTIR),Raman spectroscopy,and X-ray absorption spectroscopy(XAS) and cover new findings that occur at the catalyst-electrolyte interface during *** spectroscopic strategies provide practical ways to elucidate catalyst phase,reaction intermediate,catalyst-electrolyte interface,intermediate binding energy,metal valency state,and coordination environment during HER.

关键词： Hydrogen evolution reaction Infrared spectroscopy Raman spectroscopy X-ray absorption spectroscopy Reaction mechanism

Plasma levels of acylated ghrelin in patients with functional dyspepsia

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World Journal of Gastroenterology 2012年第18期18卷 2231-2237页

作者： Yeon Soo kim Joon Seong Lee Tae Hee Lee Joo Young Cho Jin Oh kim wan jung kim Hyun Gun kim Seong Ran Jeon Hoe Su Jeong Department of Internal Medicine Hallym University College of MedicineChuncheon Sacred Heart HospitalGangwon-do 200-704South Korea Department of Internal Medicine Soonchunhyang University College of MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Anatomy and Cell Biology Hanyang University College of Medicine222 Wangsimni-roSeongdong-guSeoul 133-792South Korea

AIM:To investigate the relationship between plasma acylated ghrelin levels and the pathophysiology of functional ***:Twenty-two female patients with functional dyspepsia and twelve healthy volunteers were recruited for the *** functional dyspepsia patients were each diagnosed based on the Rome Ⅲ *** patients completed a questionnaire concerning the severity of 10 *** acylated ghrelin levels before and after a meal were determined in the study participants using a commercial human acylated enzyme immunoassay kit;electrogastrograms were performed for 50 min before and after a standardized 10-min meal containing 265 ***:There were no significant differences in plasma acylated ghrelin levels between healthy volunteers and patients with functional ***,in patients with functional dyspepsia,there was a negative correlation between fasting plasma acylated ghrelin levels and the sum score of epigastric pain(r =-0.427,P = 0.047) and a positive correlation between the postprandial/fasting plasma acylated ghrelin ratio and the sum score of early satiety(r = 0.428,P =0.047).Additionally,there was a negative correlation between fasting acylated ghrelin plasma levels and fasting normogastria(%)(r =-0.522,P = 0.013).Interestingly,two functional dyspepsia patients showed paradoxically elevated plasma acylated ghrelin levels after the ***:Abnormal plasma acylated ghrelin levels before or after a meal may be related to several of the dyspeptic symptoms seen in patients with functional dyspepsia.

关键词： Functional dyspepsia Acylated ghrelin Electrogastrogram Rome Ⅲ criteria Dyspeptic symptoms

A novel device for endoscopic submucosal dissection,the Fork knife

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World Journal of Gastroenterology 2008年第43期14卷 6726-6732页

作者： Hyun Gun kim Joo Young Cho Gene Hyun Bok Won Young Cho wan jung kim Bong Min Ko Jin Oh kim Joon Seong Lee Moon Sung Lee Chan Sup Shim Institute for Digestive Research Digestive Disease Research CenterSoonChunHyang University College of MedicineSeoul 140-743South Korea

AIM： To introduce and evaluate the efficacy and technical aspects of endoscopic submucosal dissection （ESD） using a novel device, the Fork knife. METHODS： From March 2004 to April 2008, ESD was performed on 265 gastric lesions using a Fork knife （Endo FS）（group A） and on 72 gastric lesions using a Flexknife （group B） at a single tertiary referral center. We retrospectively compared the endoscopic characteristics of the tumors, pathological findings, and sizes of the resected specimens. We also compared the en b/oc resection rate, complete resection rate, complications, and procedure time between the two groups. RESULTS： The mean size of the resected specimens was 4.27 ± 1.26 cm in group A and 4.29 ± 1.48 cm in group B. The en b/oc resection rate was 95.8% （254/265 lesions） in group A and 93.1% （67/72） in group B. Complete ESD without tumor cell invasion of the resected margin was obtained in 81.1% （215/265） of group A and in 73.6% （53/72） of group B. The perforation rate was 0.8% （2/265） in group A and 1.4% （1/72） in group B. The mean procedure time was 59.63 ± 56.12 min in group A and 76.65 ± 70.75 min in group B （P 〈 0.05）. CONCLUSION： The Fork knife （Endo FS） is useful for clinical practice and has the advantage of reducing the procedure time.

关键词： Fork knife Novel device Endoscopic submucosal dissection Flexknife Procedure

A comprehensive review on the resynthesis of ternary cathode active materials from the leachate of Li-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 446-463,I0010页

作者： Dongwoo kim Hyeoncheol Joo Chanmin kim Seoa kim wan-Yi kim Sangwoo Han Joongkil Park Soyeon Park Heechul jung Sanghyuk Park Kyungjung Kwon Department of Energy and Mineral Resources Engineering Sejong UniversitySeoul 05006Republic of Korea LIB Recycling Research Group LIB Materials R&D CenterPOSCO HoldingsPohang 37859Republic of Korea Department of Future Energy Convergence Seoul National University of Science&Technology232 Gongreung-roNowon-guSeoul 01811Republic of Korea Autonomous Intelligent Unmanned Flying Vehicles Institute Sejong UniversitySeoul 05006Republic of Korea

This review highlights the importance of recovering valuable metals from spent Li-ion battery(LIB)cathodes through the resynthesis of cathode active materials(CAMs).The resynthesis process of CAMs,a promising recycling method that directly produces CAM precursors from LIB leachate,is *** process encompasses six key steps,including pretreatment,leaching,purification,adjustment of metal concentrations,precursor synthesis,and *** review also investigates the potential introduction of impurity elements during CAM resynthesis and provides tolerance levels for these impurities based on thorough reference ***,it addresses challenges related to the commercialization of the resynthesis ***,this review represents the first comprehensive assessment of CAM resynthesis,including the systematic evaluation of 12 impurity elements(Fe,Li,Al,Cu,C,P,F,Na,Cl,S,Mg,and Zn).Overall,this comprehensive review is poised to support the commercial development of resynthesized CAMs by offering valuable guidelines for managing impurities and streamlining the purification process.

关键词： Li-ion battery Recycling Resynthesis Leachate Impurity

Clinical characteristics and prognosis of patients with ulcerative colitis that shows rectal sparing at initial diagnosis

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World Journal of Gastrointestinal Endoscopy 2021年第9期13卷 407-415页

作者： Yong-Sung Choi Jong-Kyu kim wan-jung kim Department of Internal Medicine Daehang HospitalSeoul 06699South Korea Department of Gastroenterology Daehang HospitalSeoul 06699South Korea

BACKGROUND Ulcerative colitis(UC)is characterised by mucosal inflammation from the rectum to its proximal area in a symmetric and continuous ***,although uncommon,we encounter cases of UC with rectal sparing in the initial *** To evaluate the clinical characteristics and clinical course for rectal sparing UC compared with typical *** We looked at records from 2004 to 2015,and selected patients who were newly diagnosed with UC,and who could be followed up for at least 5 years in our *** then retrospectively analysed the medical records and endoscopic findings of those *** compare the clinical course and prognosis,we matched each patient with rectal sparing UC 1:3 with controls by age,sex,and disease *** Of 619 UC patients,24(3.9%)showed rectal sparing at *** the follow-up period(median 8 years),in two(8.3%)of the 24 patients,rectal sparing remained through follow-up inspections;but for the other 22(91.7%)patients,obvious rectal inflammation was found at follow-up *** the 24 patients,8(33.3%)were initially misdiagnosed with infectious *** diagnosis was changed to Crohn’s *** uses of corticosteroid or biologic agents,hospitalisation rate,and colectomy rates were not different between the rectal sparing UC group and typical UC *** Some patients with UC can reveal atypical patterns of disease distribution,such as rectal sparing in its initial stage;but despite this,the clinical course and prognosis may not differ from those of typical UC patients.

关键词： Ulcerative colitis Rectal sparing Clinical characteristics Prognosis At diagnosis Adult

Boosted Lithium-Ion Transport Kinetics in n-Type Siloxene Anodes Enabled by Selective Nucleophilic Substitution of Phosphorus

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Nano-Micro Letters 2024年第10期16卷 618-637页

作者： Se In kim Woong-Ju kim Jin Gu Kang Dong-wan kim School of Civil Environmental and Architectural EngineeringKorea University02841 SeoulSouth Korea Nanophotonics Research Center Korea Institute of Science and Technology02792 SeoulSouth Korea

Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy ***,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-SX),are employed as Li-ion battery *** thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(SX)without compromising its 2D layered morphology and unique Kautsky-type crystal ***,selective nucleophilic substitution occurs,with only Si atoms being replaced by P atoms in the O_(3)≡Si-H *** resulting n-SX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in Si sites and(ii)H *** doping concentrations are varied by controlling the amount of precursors or their mean free *** at 2000 mA g^(-1),the n-SX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 *** improvements originate from the enhanced kinetics of charge transport processes,including electronic conduction,charge transfer,and solid-state *** approach proposed herein offers an unprecedented route for engineering SX anodes to boost Li-ion storage.

关键词： Li-ion battery Two-dimensional N-type siloxene Doping mechanism Kinetics

Intelligent structured nanocomposite adhesive for bioelectronics and soft robots

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Nano Research 2024年第2期17卷 534-549页

作者： Yeon Soo Lee Min-Seok kim Da wan kim Changhyun Pang School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Mechanical Metrology Group Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Electronic Engineering Korea National University of TransportationChungbuk 27469Republic of Korea Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced *** review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological *** underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft *** addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.

关键词： biomimetics bio-adhesive switchable adhesion bioelectronics nanocomposite soft robotics