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嗅觉系统神经网络模型字符识别中的应用

复旦学报（自然科学版） 2004年第5期43卷 710-713页

作者：郭宏记李光李绪汪乐史嘉凝 walter j.freeman 浙江大学物理系杭州310027 浙江大学生物医学工程与仪器系杭州310027 美国加州大学伯克力分校分子和细胞生物学系 ca947203200

freeman在大量神经生理实验的基础上建立了生物嗅觉系统的非线性神经网络模型,即K系列模型.其中,KIII模型是一种混沌神经网络,它的模式识别机制与以往的人工神经网络完全不同,更接近实际生物神经系统的工作模式.研究通过对26个英文字符... 详细信息

freeman在大量神经生理实验的基础上建立了生物嗅觉系统的非线性神经网络模型,即K系列模型.其中,KIII模型是一种混沌神经网络,它的模式识别机制与以往的人工神经网络完全不同,更接近实际生物神经系统的工作模式.研究通过对26个英文字符的学习、识别研究得出,系统相对于传统的神经网络有着很强的学习能力,学习5～6次就能有很好的识别能力,在10次达到最优学习效果,并与真实神经系统学习过程中的倒"U"曲线相对应.

关键词：字符识别生物神经系统混沌神经网络模式识别神经网络模型 K系列人工神经网络学习效果学习过程实际

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非线性嗅觉生理模型在一维序列识别中的应用

系统仿真学报 2004年第3期16卷 564-569页

作者：汪乐李光郭宏记李绪 walter j.freeman 浙江大学生物医学工程系杭州310027 浙江大学物理系杭州310027 Department of Molecular & CellBiology UC Berkeley

Water j.freeman教授在生理实验的基础上建立了一套基于嗅觉系统的神经网络模型。这套模型运用非线性动力学的方法较好的模拟了人体的嗅觉系统,并能够产生类似脑电的非周期背景信号。利用这个的基于嗅觉系统而建立的模型--K系列模型可... 详细信息

Water j.freeman教授在生理实验的基础上建立了一套基于嗅觉系统的神经网络模型。这套模型运用非线性动力学的方法较好的模拟了人体的嗅觉系统,并能够产生类似脑电的非周期背景信号。利用这个的基于嗅觉系统而建立的模型--K系列模型可以实现模式识别。本文首先从原理上介绍了K系列模型的拓扑结构和数学基础,然后通过实际的计算机数值模拟介绍了KII网络和KIII模型在实现一维序列识别时的方法和结果,简单说明了这个模型在模式识别上的特点。

关键词：神经嗅觉系统混沌模式识别

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模拟生物嗅觉神经系统的混沌神经网络及应用

计算机仿真 2003年第9期20卷 124-127页

作者：李绪李光汪乐 walter j.freeman 浙江大学生物医学工程与仪器系浙江杭州310027 加州大学伯克力分校分子和细胞生物学系 ca947203200

以神经生物学实验结果为基础,根据生物嗅觉神经系统的信息处理机制,freeman建立了非线性神经网络模型-K系列模型。KIII模型在模拟神经系统方面具有突出的优点,同时也具有一定的模式识别的能力,它的仿生特点代表了一种新型的神经网络模... 详细信息

以神经生物学实验结果为基础,根据生物嗅觉神经系统的信息处理机制,freeman建立了非线性神经网络模型-K系列模型。KIII模型在模拟神经系统方面具有突出的优点,同时也具有一定的模式识别的能力,它的仿生特点代表了一种新型的神经网络模型。因此,KIII模型在解释人脑的认知机制和处理比较复杂的模式识别问题中有着广泛的实际应用价值。该文应用KIII模型在图像模式识别方面的应用做了初步探索,并将该模型应用于具体的简单图像模式识别中,取得了良好的效果。这一探索拓展了KIII模型模式识别应用范围,为该模型在图像模式识别方面的广泛应用建立了基础。

关键词：混沌神经网络模拟生物嗅觉神经系统信息处理 KIII模型

基于混沌神经网络和支持向量机的7500米高空缺氧脑电分析

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基于混沌神经网络和支持向量机的7500米高空缺氧脑电分析

A chaotic neural network mimicking an olfactory system and its application on image recognition

中国力学学会学术大会'2009

作者：胡萌李交杰郑远哲缪育平 walter j.freeman 胡萌浙江大学控制系杭州空军疗养院杭州展望科技有限公司美国加州大学伯克利分校神经生物学系

利用支持向量机对现有的一种混沌神经网络(KⅢ模型)进行了改进,并应用到基于脑电技术的高空缺氧检测研究中。采用小波包分解对采集的所有通道的脑电信号进行预处理,并且提取空间特征向量。利用支持向量机改进了KⅢ模型中原有的识别模块... 详细信息

利用支持向量机对现有的一种混沌神经网络(KⅢ模型)进行了改进,并应用到基于脑电技术的高空缺氧检测研究中。采用小波包分解对采集的所有通道的脑电信号进行预处理,并且提取空间特征向量。利用支持向量机改进了KⅢ模型中原有的识别模块,并且把它应用与缺氧脑电空间特征向量的识别。实验结果表明,利用支持向量机改进的KⅢ模型可以有效的识别脑电信号中的缺

关键词：混沌神经网络支持向量机脑电分析缺氧

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journal of Bionic Engineering 2004年第3期1卷 191-198页

作者： walter j. freeman Department of Molecular & Cell Biology UCB LSA 142 Berkeley CA 94720-3200 USA

Based on the research of a biological olfactory system, a novel chaotic neural network model - K set model has been es- tablished. This chaotic neural network not only simulates the real brain activity of an olfactory system, but also presents a novel chaotic concept for signal processing and pattern recognition. The characteristics of the K set models are investigated and show that a KIII model can be used for image pattern classification.

关键词： olfactory system pattern recognition neural networks image classification

Inhibition of tumor autophagy: a strategy to improve antitumorimmunity?

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Signal Transduction and Targeted Therapy 2021年第1期6卷 3-4页

作者： Andrew jfreeman Emily jLelliott jane Oliaro Cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVIC 3000Australia Sir Peter MacCallum Department of Oncology The University of MelbourneParkvilleVIC 3010Australia Department of Immunology and Pathology Monash UniversityMelbourneVIC 3004Australia

In a study recently published in Nature,Lawson et *** several pathways previously implicated in tumor cell sensitivity to cytotoxic T lymphocytes(CTLs),and identify autophagy as an additional pathway involved in mediating tumor immune evasion.1 Autophagy is a regulated and conserved multistep process that enables cells to degrade and recycle intracellular components and is critical for cellular *** has recently been associated with tumor immune evasion in pancreatic ductal adenocarcinoma,2 whereby this process selectively targeted the degradation of major histocompatibility complex I(MHC-I),limiting recognition,and anti-tumor responses by ***,Lawson et *** an additional role for autophagy in tumor immune evasion,by mediating resistance to cytokine-mediated cell death.

关键词： immunity homeostasis limiting

Ground-based and additional science support for SMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： j.A.Carter M.Dunlop C.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.C.Fear D.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams j.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock M.P.freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-j.Hu M.K.james L.juusola K.Kauristie E.A.Kronberg M.Lester j.Manuel j.Matzka I.McCrea Y.Miyoshi j.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh C.Wang j.Weygand j.Wild j.Yan j.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ German Research Centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

Pancreatic endocrine and exocrine changes in celiac disease

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World journal of Gastroenterology 2007年第47期13卷 6344-6346页

作者： Hugh j.freeman Department of Medicine (Gastroenterology) University of British ColumbiaVancouverBCCanada

Although there is a great deal of information on celiac disease and associated involvement of other non-intestinal sites,data on concomitant changes in the structure and function of the pancreas is limited. The present review critically examines pancreatic endocrine changes that have been well documented in the literature,including insulin-dependent diabetes mellitus. Pancreatic exocrine alterations may also occur,and if severe,marked malnutrition with pancreatic failure and ductal calcification have been observed. Finally,other pancreatic disorders have been recorded with celiac disease.

关键词： Celiac disease Gluten-sensitive enteropathy Diabetes mellitus Chronic pancreatitis Pancreatic function

Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction

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World journal of Gastroenterology 2005年第33期11卷 5245-5247页

作者： Hugh j.freeman Department of Medicine (Gastroenterology) University of British Columbia Vancouver BC V6T 1W5 Canada Correspondence to:Dr.Hugh J FreemanGastroenterologyUBC Hospital2211 Wesbrook MallVancouverBCV6T 1W5

A 69-year-old male with chronic lymphocytic leukemia presented with iron deficiency anemia and post-prandial abdominal fullness. Endoscopy showed a large polyp on a stalk, protruding through the pylorus into the duodenum causing intermittent gastric outlet obstruction. While prolapsing gastric antral polyps are usually benign and hyperplastic, inflammatory or regenerative in type, excisional snare polypectomy here led to complete resolution of his symptoms, but showed a malignant polyp.

关键词： Gastric adenoma Gastric carcinoma Endoscopic polypectomy Neoplastic gastric polyps