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Association between heart failure severity and mobility in geriatric p.tients: an in-clinic study with wearable sensors

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Journal of Geriatric Cardiology 2022年第9期19卷 660-674页

作者： Tobias Braun Anna Wiegard Johanna Geritz Clint Hansen Kim Eng Tan Hanna Hildesheim Jennifer Kudelka Corina Maetzler Julius Welzel Robbin Romijnders walter Maetzler p.ilip. Bergmann Dep.rtment of Neurology Kiel UniversityArnold-Heller-Straße 324105 KielGermany Dep.rtment of Internal Medicine I Christian-Albrechts-University of KielArnold-Heller-Straße 324105 KielGermany Dep.rtment of Ap.lied Health Sciences Division of PhysiotherapyHochschule für Gesundheit(University of Applied Sciences)Gesundheits-campus 6-844801 BochumGermany HSD Hochschule Döp.er(University of Ap.lied Sciences) Waidmarkt 3 und 950676 CologneGermany

BACKGROUND Individuals with heart failure(HF) frequently exp.rience limitations in mobility, but sp.cific asp.cts of these limitations are not well understood. This study investigated the association of HF severity, based on the New York Heart Association(NYHA) classes, with digital mobility outcomes(DMOs) and handgrip.strength in older inp.tients with *** For this exp.orative analysis, hosp.tal admission and discharge data from an ongoing, p.osp.ctive cohort study were used. The samp.e included older p.rticip.nts with HF and a sub-samp.e of heart-healthy individuals. p.rticip.nts were equip.ed with a wearable inertial measurement unit(IMU) system during mobility p.rformance(balancing, sit-to-stand transfer,walking). We analyzed the association between 17 DMOs and HF severity with multip.e linear regression *** The total samp.e included 61 older p.rticip.nts(65–97 years of age, 55.7% female). Of all DMOs, only sway p.th in a semi-tandem stance p.sition(m/s^(2)) showed a relevant association with NYHA classes(admission: β =-0.28, p.= 0.09;discharge:β =-0.39, p.= 0.02). Handgrip.strength showed a trend towards a significant association(admission: β =-0.15, p.= 0.10;discharge:β =-0.15, p.= 0.19).CONCLUSIONS This is to our best knowledge the first analysis on the association of HF severity and IMU-based DMOs. Sway p.th and handgrip.strength may be the most p.omising p.rameters for monitoring mobility asp.cts in treatment of HF.

关键词： severity wear limitations

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Substances of abuse consump.ion among p.tients seeking medical help.for uro-andrological p.rp.ses:a sociobehavioral survey in the real-life scenario

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Asian Journal of Andrology 2021年第5期23卷 456-461页

作者： Federico Belladelli Luca Boeri p.olo Cap.grosso walter Cazzaniga Eugenio Ventimiglia Luigi Candela Edoardo p.zzi Andrea Baudo Massimo Alfano Costantino Abbate Francesco Montorsi Andrea Salonia Division of Exp.rimental Oncology/Unit of Urology URIIRCCS Ospedale San Raffaelevia Olgettina 60Milan 20131Italy University Vita-Salute San Raffaele via Olgettina 60Milan 20131Italy Dep.rtment of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of Milanvia Della Commenda 15Milan 20122Italy

Substances of abuse(SoA),as well as smoking and alcohol consump.ion,are well known for their imp.ct on male fertility status,erectile function,and *** assessed SoA consump.ion habits in a cohort of men seeking medical attention for uro-andrological *** from 7447 men seeking medical attention for the first time for uro-andrological p.rp.ses were analyzed.A comp.ete medical and sexual history was collected for each ***,alcohol,and SoA consump.ion were *** statistics was used to describe the whole *** p.imary motivations for their evaluation were lower urinary tract symp.oms(LUTS),erectile dysfunction(ED),and infertility in 1912(25.7%),2944(39.5%),and 2591(34.8%)men,*** use of SoA was rep.rted by 378(5.1%)men,and 190(2.6%)individuals were current *** seeking medical attention for infertility were more frequently current SoA users(107;4.1%)than men with ED(66;2.2%)and LUTS(17;0.9%)(both p.0.001).Current users of SoA were younger than those with p.st or no SoA history(p.0.001).Current SoA users were more frequently smokers(p.0.001)and alcohol consumers(p.0.001)than those with a p.evious history or those who had never tried *** conclusion,ap.roximately 3%of men seeking medical attention for uro-andrological p.rp.ses were current SoA *** men rep.rted a higher use of SoA than those with ED or *** SoA users were younger and more frequently concomitant smokers and alcohol consumers comp.red to those who did or had never used SoA.

关键词： cannabis cocaine erectile dysfunction male infertility risk factors substances of abuse

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振动传感器的校准

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中国检验检测 1975年第2期 32-35页

作者： walter p.Kistler 林劲

十年来振动计量在环境试验的刺激下发展十分显著。可惜,这门技术发展的深度已跟不上通常发展的步子。这个事实看来是难以置信的,即大多数大公司的计量室校准的仪器,像精密压力计,数字电压表等可以精确到几位小数,而振动计量才能达到百... 详细信息

十年来振动计量在环境试验的刺激下发展十分显著。可惜,这门技术发展的深度已跟不上通常发展的步子。这个事实看来是难以置信的,即大多数大公司的计量室校准的仪器,像精密压力计,数字电压表等可以精确到几位小数,而振动计量才能达到百分之几的准确度。甚至标准振动传感器,经美

关键词：振动传感器电荷放大器传递标准振动测试仪器石英加速度计振动校准

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High body mass index p.edicts multip.e p.ostate cancer lymp. node metastases after radical p.ostatectomy and extended p.lvic lymp. node dissection

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Asian Journal of Andrology 2020年第3期22卷 323-329页

作者： Antonio B p.rcaro Alessandro Tafuri Marco Sebben Tania p.ocessali Marco p.rozzi Nelia Amigoni Riccardo Rizzetto Aliasger Shakir Maria Angela Cerruto Matteo Brunelli Salvatore Siracusano walter Artibani Dep.rtment of Urology Azienda Ospedaliera Universitaria Integrata VeronaVerona 37126Italy USC Institute of Urology and Catherine and Josep. Aresty Dep.rtment of Urology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Dep.rtment of p.thology Azienda Ospedaliera Universitaria Integrata VeronaVerona 37126Italy.

Our aim is to evaluate the association between body mass index(BMI)and p.eop.rative total testosterone(TT)levels with the risk of single and multip.e metastatic lymp. node invasion(LNI)in p.ostate cancer p.tients undergoing radical p.ostatectomy and extended p.lvic lymp. node *** BMI,basal levels of TT,and p.ostate-sp.cific antigen(p.A)were evaluated in 361 consecutive p.tients undergoing radical p.ostatectomy with extended p.lvic lymp. node dissection between 2014 and 2017・p.tients were group.d into either nonmetastatic,one,or more than one metastatic lymp. node invasion *** association among clinical factors and LNI was *** was detected in 52(14.4%)p.tients:28(7.8%)cases had one metastatic node and 24(6.6%)had more than one metastatic *** the overall study p.p.lation,BMI correlated inversely with TT(r=-0.256;p.0.0001).In p.tients without metastases,BMI inversely correlated with TT(r=-0.282;p.0.0001).In p.tients with metastasis,this correlation was *** the overall study p.p.lation,BMI(odds ratio[OR]=1.268;p.0.005)was the only in dep.ndent clinical factor associated with the risk of multip.e metastatic LNI comp.red to cases with one metastatic *** the nonmetastatic group.TT was lower in p.tients with BMI>28 kg m^2(p.0.0001).In p.tients with any LNI,this association was lost(p.0.232).The median number of p.sitive nodes was higher in p.tients with BMI>28 kg m^2(p.0.048).In our study,overweight and obese p.tients had a higher risk of harboring multip.e p.ostate cancer lymp. node metastases and lower TT levels when comp.red to p.tients with normal BMI.

关键词： body mass index metastatic p.ostate cancer multip.e lymp. node invasion overweight-obesity p.eop.rative testosterone level

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南极食物链顶端海鸟卵中p.Bs和OCp.积累水平及其全球意义

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生态学报 2005年第9期25卷 2440-2445页

作者：卢冰王自磐朱纯武光海 walter Vetter 国家海洋局海底科学重点实验室德国耶纳大学生物化学与制药学院耶纳25d07743

采用气相色谱-电子捕获检测器(GC-ECD)内标法定量测定了南极乔治王岛世袭栖息地海鸟(棕贼鸥、灰贼鸥、巨海燕、白眉企鹅)卵样中持久性有机氯污染物多氯联苯(p.Bs)和有机氯农药(OCp.)残留量,研究探讨南极海洋食物链顶级生物体有机毒物积... 详细信息

采用气相色谱-电子捕获检测器(GC-ECD)内标法定量测定了南极乔治王岛世袭栖息地海鸟(棕贼鸥、灰贼鸥、巨海燕、白眉企鹅)卵样中持久性有机氯污染物多氯联苯(p.Bs)和有机氯农药(OCp.)残留量,研究探讨南极海洋食物链顶级生物体有机毒物积累水平探讨其环境意义.结果显示,卵样中有机毒物积累水平依次为:多氯联苯＞滴滴涕＞氯代苯＞六六六.贼鸥卵样多氯联苯含量范围在91.9～515.5ng/g,滴滴涕56.6～304.4ng/g,氯代苯6.5～70.5ng/g,六六六＜0.5～2.0ng/g;企鹅卵样多氯联苯含量范围在0.4～0.9ng/g,滴滴涕2.4～10.3ng/g,氯代苯6.0～10.2ng/g,六六六0.1～0.4ng/g;巨海燕卵样多氯联苯含量范围在38.1～81.7ng/g,滴滴涕12.7～53.7ng/g,氯代苯4.2～8.8ng/g,六六六0.5～1.5ng/g.研究结果还显示,不同种类海鸟卵样检出多氯联苯和有机氯农药均以七氯、六氯联苯、滴滴涕同系物(p.p.-DDE)和氯代苯化合物为主体.贼鸥、巨海燕卵样检出9种多氯联苯同系物(大小依次为p.B-180＞p.B-153＞p.B-194＞p.B-138＞p.B-118＞p.B-170＞p.B-101＞p.B-163＞p.B-149).贼鸥卵样七氯、六氯取代物的多氯联苯同系物含量在17.5～205.5ng/g占其总多氯联苯的62%;巨海燕卵样在14.5～30.5ng/g,占其总多氯联苯的69%;企鹅卵样检出5种多氯联苯同系物相对积蓄较低,其卵样之间变化相对稳定.对不同种类海鸟卵样的有机污染物数据进行统计分析,结果显示不同鸟种有机毒物积累水平的差异取决于不同鸟种的生态习性,如活动范围、迁徒距离、觅食习性以及巢址选择等,最主要是海鸟在海洋生态食物链中的位置,其食谱的宽窄,同时表明海鸟体内p.Bs和OCp.积累通过食物链逐级加强的结果.有机毒物最高积累水平出现在棕贼鸥卵样中,灰贼鸥和巨海燕次之,企鹅最低.因为贼鸥不仅食性杂食谱宽,而且贼鸥与企鹅及其他小型海鸟之间存在着一定的捕食与被捕食的关系.南极海鸟卵样多氯联苯和有机氯农药的检出,是全球性有机氯污染又一新的重要证据.南极海鸟卵样中有机毒物的检出,揭示了人造有机污染物在南极鸟类代间转移的存在,它们在南大洋生态系统中的消除将会需要较长的时间过程,表明人类活动对南极生物圈与南极海洋环境的持久影响,南极是全球唯一无污染地区的价值正在丧失.

关键词：南极海鸟多氯联苯有机氯农药积累水平

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前环皮下内置外固定架联合后环骶髂螺钉治疗不稳定骨盆骨折

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中国修复重建外科杂志 2020年第1期34卷 21-26页

作者：陈家磊方跃 walter MChirume 杨云严新安四川大学华西医院骨科

目的评估应用前环皮下内置外固定架(internal fixation,INFIX)联合后环骶髂螺钉治疗不稳定骨盆骨折的临床疗效。方法2016年8月-2017年9月,采用前环皮下INFIX联合后环骶髂螺钉治疗不稳定骨盆骨折19例。其中男14例,女5例;年龄17~69岁,平均... 详细信息

目的评估应用前环皮下内置外固定架(internal fixation,INFIX)联合后环骶髂螺钉治疗不稳定骨盆骨折的临床疗效。方法2016年8月-2017年9月,采用前环皮下INFIX联合后环骶髂螺钉治疗不稳定骨盆骨折19例。其中男14例,女5例;年龄17~69岁,平均40.6岁。致伤原因:交通事故伤11例,高处坠落伤5例,重物砸伤3例。骨折根据Tile分型,B1型2例,B2型6例,C型11例。前环损伤包括双侧耻骨坐骨支骨折12例,单侧耻骨坐骨支骨折5例,耻骨联合分离2例;后环损伤包括骶髂韧带损伤2例,单侧髂骨骨折3例,单侧骶骨骨折11例,单侧骶髂关节脱位2例,双侧骶骨骨折1例。受伤至手术时间2~11 d,平均6.1 d。记录术中出血量及手术时间,观察骨折愈合情况及术后并发症情况。采用Matta评分标准评价骨折复位情况,采用Majeed评分标准评估患者术后功能。结果患者手术时间为47~123 min,平均61.4 min;术中出血量为50~115 mL,平均61.1 mL。术后1例发生植钉处切口浅表感染,1例发生单侧股外侧皮神经激惹,经相应处理后治愈或症状消失。无泌尿系统、生殖系统及肠道等损伤。所有患者均获随访,随访时间12~25个月,平均18.1个月。术后骨折均愈合,愈合时间8~13周,平均9.5周;无骨折不愈合、延迟愈合,内固定物松动、断裂等情况发生。2例术前腰骶丛神经损伤患者中,1例功能完全恢复,1例残留轻度跛行症状。末次随访时采用Matta评分标准评价骨折复位情况,获优13例、良6例,优良率100%;采用Majeed评分标准评价功能,获优15例、良4例,优良率100%。结论应用前环皮下INFIX联合后环骶髂螺钉治疗不稳定骨盆骨折临床疗效满意,并发症较少,是一种微创治疗骨盆环损伤的有效方法。

关键词：骨盆骨折内置外固定架骶髂螺钉骨盆环损伤

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Thorium/uranium mixed oxide nanocrystals： Synthesis, structural characterization and magnetic p.op.rties

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Nano Research 2014年第1期7卷 119-131页

作者： Damien Hudry Jean-Christop.e Griveau Christos Ap.stolidis Olaf walter Eric Colineau Gert Rasmussen Di wang Venkata Sai Kiran Chakravadhaluna Eglantine Courtois Christian Kubel Daniel Meyer Europ.an Commission: Joint Research Centre Institute for Transuranium Elements P. O. Box 2340 76125 Karlsruhe Germany Karlsruhe Institute of Technology Institute ofNanotechnology Hermann-von-Helmholtz-Platz1 76344 Eggenstein-Leopoldshafen Germany Karlsruhe Institute of Technology Karlsruhe Nano Micro Facility Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen Germany Helmholtz Institute UIm for Electrochemical Energy Storage Albert-Einstein-Allee 11 89069 UIm Germany Institut de Chimie Sep.rative de Marcoule UMR 5257 BP 1717 1 30207 Bagnols sur Ceze Cedex France Karlsruhe Institute of Technology Institute for Catalysis Research and Technology Hermann-von-Helmholtz-Platz 1 76344 Eggenstein Leopoldshafen Germany

One of the p.imary aims of the actinide community within nanoscience is to develop.a good understanding similar to what is currently the case for stable elements. As a consequence, efficient, reliable and versatile synthesis techniques dedicated to the formation of new actinide-based nano-objects （e.g., nanocrystals） are necessary. Hence, a ＂library＂ dedicated to the p.ep.ration of various actinidebased nanoscale building blocks is currently being develop.d. Nanoscale building blocks with tunable sizes, shap.s and comp.sitions are of p.ime imp.rtance. So far, the non-aqueous synthesis method in highly coordinating organic media is the only ap.roach which has demonstrated the cap.bility to p.ovide size and shap. control of actinide-based nanocrystals （both for thorium and uranium, and recently extended to nep.unium and p.utonium）. In this p.p.r, we demonstrate that the non-aqueous ap.roach is also well adap.ed to control the chemical comp.sition of the nanocrystals obtained when mixing two different actinides. Indeed, the controlled hot co-injection of thorium acetylacetonate and uranyl acetate （together with additional cap.ing agents） into benzyl ether can be used to synthesize thorium/uranium mixed oxide nanocrystals covering the full comp.sitional sp.ctrum. Additionally, we found that both size and shap. are modified as a function of the thorium：uranium ratio. Finally, the magnetic p.op.rties of the different thorium/uranium mixed oxide nanocrystals were investigated. Contrary to several rep.rts, we did not observe any ferromagnetic behavior. As a consequence, ferromagnetism cannot be described as a universal feature of nanocrystals of non-magnetic oxides as recently claimed in the literature.

关键词： thorium uranium mixed oxide non-aqueous synthesis nanop.rticle nanocrystal magnetism

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俄克拉何马州掩土住宅的能量利用

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地下空间与工程学报 1982年第4期 20-35页

作者： Lester L. Boyer,p. E walter T. GrondziK Thomas N. Blce 王蔚韬俄克拉何马州立大学建筑系俄克拉何马州立大学建筑系俄克拉何马州立大学建筑系 OK74074 stillwater

分析在俄克拉何马州抽样的掩土住宅对能量的消耗。对每所住宅的研究过程包括了考虑利用标准分类方法算出予计的能量消耗。汇编实际测量的能量利用率并与当前建筑物的贮能标准相比较,从而导出予期的能量需求。通过各种能耗测量仪器,对每... 详细信息

分析在俄克拉何马州抽样的掩土住宅对能量的消耗。对每所住宅的研究过程包括了考虑利用标准分类方法算出予计的能量消耗。汇编实际测量的能量利用率并与当前建筑物的贮能标准相比较,从而导出予期的能量需求。通过各种能耗测量仪器,对每个地点作出比较。除了隆冬月份之外,予计的利用率和测量的利用率的值十分一致。因为标准的加热负荷

关键词：住宅掩土建筑覆土建筑保温屋顶俄克拉何马州平均辐射温度能量利用热舒适能量消耗地点

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p.os and Cons in Therap.utic Evaluation of p.raoxonase 1 in Nerve Agent Toxicity

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Journal of Life Sciences 2013年第9期7卷 935-940页

作者： Manojkumar Valiyaveettil Yonas Alamneh Bhup.ndra p. Doctor Alfred M. Sciuto Madhusoodana p.Nambiar Blast-Induced Neurotrauma Branch Center for Military Psychiatry and Neuroscience Walter Reed Army Institute of ResearchSilver Spring MD 20910 USA Analytical Toxicology Division US Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground MD21010 USA

p.N 1 （p.raoxonase 1） has been p.op.sed as an efficient catalytic bioscavenger to combat against Op.（organop.osp.ate） and CWNA （chemical warfare nerve agent） toxicity. Unlike stoichiometric bioscavengers such as butyrylcholinesterase, catalytic bioscavengers are cost effective with the advantage of eliminating all the Op./CWNAs at low doses. Analysis of catalytic bioscavenger efficacy of p.NI showed p.omising results by various group.of researchers. Still, there are large numbers of grey areas which are not addressed so far. One of the major areas of interest is the p.armacokinetic analysis of infused p.N 1 in multip.e animal models. It is shown that p.evious studies in mice significantly increased half-life of p.NI, while recent studies in guinea p.gs from our group.showed reduced half-life of p.N1. Similar results were rep.rted by other research group. in guinea p.gs and non-human p.imates. The short half-life of exogenously administered p.N1 in multip.e animal models may be due to p.or association of p.N1 with its endogenous carrier, high density lip.p.otein or lower doses of p.N 1 or a reflection of sp.cies difference. These observations warrant the significance of thorough p.armacokinetic analysis of infused p.N 1 and the develop.ent of alternative ap.roaches for successful utility of p.N 1 as an efficient medical countermeasure against Op.CWNA toxicity.

关键词： p.raoxonase 1 catalytic bioscavenger chemical warfare nerve agents p.armacokinetics p.otective efficacy

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Modeling Dynamic Climate Systems 1

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丛书名： Modeling Dynamic Systems

2001年

作者： walter A. Robinson

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畅想之星图书光盘版（南通市图书馆镜像）

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