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Performance of American Society for Gastrointestinal Endoscopy guidelines for dyspepsia in Saudi population: Prospective observational study

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World Journal of Gastroenterology 2015年第2期21卷 637-643页

作者： Nahla A Azzam Majid A almadi Hessah Hamad alamar Lamis Atyah almalki Rehab Nawaf alrashedi Rawabi Saleh alghamdi waleed al-hamoudi Division of Gastroenterology King Khalid University Hospital King Saud University Riyadh 11461Saudi Arabia Division of Gastroenterology The Mc Gill University Health Center Montreal General Hospital Mc Gill UniversityMontreal H3A0G4Canada Division of Gastroenterology King Khalid University HospitalKing Saud UniversityRiyadh 11461Saudi Arabia Division of liver transplant King Faisal Specialist Hospital and Research CenterRiyadh 11461Saudi Arabia

AIM: To evaluate adherence of primary care physicians(PCPs) to international guidelines when referring patients for upper-gastrointestinal endoscopy(UGE), evaluate the importance of alarm symptoms and the performance of the American Society for Gastrointestinal Endoscopy(ASGE) guidelines in a Saudi ***: A prospective, observational cross-sectional study on dyspeptic patients undergoing UGE who were referred by PCPs over a 4 mo period. Refer-rals were classified as appropriate or inappropriate according to adherence to ASGE ***: Total of 221 dyspeptic patients was enrolled; 161 patients met our inclusion criteria. Mean age was 40.3 years(SD ± 18.1). Females comprised 70.1%. alarm symptoms included low hemoglobin level(39%), weight loss(18%), vomiting(16%), loss of appetite(16%), difficulty swallowing(3%), and gastrointestinal bleeding(3%). Abnormal endoscopy findings included gastritis(52%), duodenitis(10%), hiatus hernia(7.8%), features suggestive of celiac disease(6.5%), ulcers(3.9%), malignancy(2.6%) and gastroesophageal reflux disease(GERD: 17%). Among patients who underwent UGE, 63% met ASGE guidelines, and 50% had abnormal endoscopic findings. Endoscopy was not indicated in remaining 37% of patients. Among the latter group, endoscopy was normal in 54% of patients. There was no difference in proportion of abnormal endoscopic findings between two groups(P = 0.639).CONCLUSION: Dyspeptic patients had a low prevalence of important endoscopic lesions, and none of the alarm symptoms could significantly predict abnormalendoscopic findings.

关键词： Dyspepsia Primary care physician American Society

Sustained virological response in a predominantly hepatitis C virus genotype 4 infected population

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World Journal of Gastroenterology 2009年第35期15卷 4429-4433页

作者： Yaser Dahlan Hafiz-Mughees Ather Majid al-ahmadi Faisal Batwa waleed al-hamoudi Departement of Medicine King Abdulaziz Medical cityJeddah 21423Saudi Arabia Departement of Medicine King Saud UniversityPO Box 2925(59)Riyadh 11461Saudi Arabia

AIM:To assess sustained virological response(SVR) rates in a predominantly hepatitis C virus(HCV) genotype 4 infected population. METHODS:Between 2003-2007,240 patients who were treated for chronic hepatitis C infection at our center were *** data,viral genotypes,and treatment outcomes were evaluated in all treated *** with chronic renal failure, previous non-responders,and those who relapsed after previous treatment were excluded from the *** all patients,57%were treated with PEG-interferon(IFN)α-2a and 43%patients were treated with PEG-IFNα-2b;both groups received a standard dose of ribavirin. RESULTS:89.6%of patients completed the treatment with an overall SVR rate of 58%.The SVR rate was 54%in genotype 1,44%in genotype 2,73%in genotype 3,and 59%in genotype 4 *** was no statistical difference in the SVR rate between patients treated with PEG-IFNα-2a and PEG-IFNα-2b (61.5%vs 53%).Patients younger than 40 years had higher SVR rates than older patients(75%vs 51%,P =0.001).SVR was also statistically significantly higher when the HCV RNA load(pretreatment)was below 800.000(64%vs 50%,P=0.023),in patients with a body mass index(BMI)less than 28(65%vs 49%,P =0.01),and in patients who completed the treatment duration(64%vs 8%,P≤0.00001).CONCLUSION:The SVR rate in our study is higher than in previous *** with the standard duration of treatment,higher ribavirin dose,younger age,lower BMI,and low pretreatment RNA levels were associated with a higher virological response.

关键词： Hepatitis C virus infection Sustained virological response Genotype 4

Hemodynamics in the immediate post-transplantation period in alcoholic and viral cirrhosis

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World Journal of Gastroenterology 2010年第5期16卷 608-612页

作者： waleed K al-hamoudi Saleh alqahtani Puneeta Tandon Samuel S Lee Gastroenterology Unit(59) College of MedicineKing Saud UniversityPO Box 2925Riyadh 11461 Saudi Arabia Gastroenterology unit King Faisal Specialist Hospital&Research CenterJeddah 21499Saudi Arabia alberta Liver Transplantation Program University of AlbertaEdmontonAlbertaT6G 2X8 Canada Liver Unit University of CalgaryCalgary AlbertaT2N 4N1Canada

AIM:To study the hemodynamics in the immediate post transplant period and compare patients with alcoholic vs viral cirrhosis. METHODS:Between 2000-2003,38 patients were transplanted for alcoholic cirrhosis and 28 for postviral *** rate(HR),central venous pressure(CVP), mean arterial pressure(MAP),pulmonary capillary wedge pressure(PCWP),cardiac index(CI),systemic vascular resistance index(SVRI),pulmonary artery pressure(PAP),and pulmonary vascular resistance index(PVRI)were measured immediately and 24 h post transplantation. RESULTS:Hyperdynamic circulation persisted at 24 hfollowing transplantation with an elevated CI of 5.4± 1.3 L/(min×m 2 )and 4.9±1.0 L/(min×m 2 )in the viral and alcoholic groups,respectively,and was associated with a decreased *** the first 24 h, there was a significant decrease in HR and increase in MAP;the extent of the change was similar in both *** CVP,PCWP,and SVRI increased,and CI decreased in the viral patients,but not the alcoholic *** showed a lower PVRI(119±52 dynes/(cm 5 ×m 2 )vs 166±110 dynes/(cm5×m2),Pal group at 24 h. CONCLUSION:Hyperdynamic circulation persists in the immediate post-transplant period with a faster improvement in the viral *** patients have a more pronounced pulmonary vasodilatation.

关键词： Hemodynamics Cirrhosis alcohol Viral allograft

Day-of-surgery rejection of donors in living donor liver transplantation

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World Journal of Hepatology 2012年第11期4卷 299-304页

作者： Bassem Hegab Mohamed Rabei Abdelfattah Ayman Azzam Hazem Mohamed waleed al hamoudi Faisal Aba alkhail Hamad al Bahili Hatem Khalaf Mohammed al Sofayan Mohammed al Sebayel Department of Liver Trans-plantation and Hepatobiliary-Pancreatic Surgery King Faisal Specialist Hospital and Research Center Riyadh 11211 Saudi Arabia Department of Hepato-Biliary-Pancreatic Surgery and Liver Transplantation National Liver Institute University of Menoufiya Menoufiya 32714 Egypt Department of Hepato-Biliary and Pancreatic Surgery University of Alexan-dria Alexandria 21131 Egypt

AIM: To study diagnostic laparoscopy as a tool for excluding donors on the day of surgery in living donor liver transplantation (LDLT).METHODS: This study analyzed prospectively collected data from all potential donors for LDLT. all of the donors were subjected to a three-step donor evaluation protocol at our institution. Step one consisted of a clinical and social evaluation, including a liver profile, hepatitis markers, a renal profile, a complete blood count, and an abdominal ultrasound with Doppler. Step two involved tests to exclude liver diseases and to evaluate the donor’s serological status. This step also included a radiological evaluation of the biliary anatomy and liver vascular anatomy using magnetic resonance cholan-giopanc reatography and a computed tomography (CT) angiogram, respectively. A CT volumetric study was used to calculate the volume of the liver parenchyma. Step three included an ultrasound-guided liver biopsy. Between November 2002 and May 2009, sixty-nine potential living donors were assessed by open exploration prior to harvesting the planned part of the liver. Between the end of May 2009 and October 2010, 30 potential living donors were assessed laparoscopically to determine whether to proceed with the abdominal incision to harvest part of the liver for donation. RESULTS: Ninety-nine living donor liver transplants were attempted at our center between November 2002 and October 2010. Twelve of these procedures were aborted on the day of surgery (12.1%) due to donor findings, and eighty-seven were completed (87.9%). These 87 liver transplants were divided into the following groups: Group A, which included 65 transplants that were performed between November 2002 and May 2009, and Group B, which included 22 transplants that were performed between the end of May 2009 and October 2010. The demographic data for the two groups of donors were found to match; moreover, no significant difference was observed between the two groups of donors with res

关键词： Live donor Laparoscopic assessment Re-jected donors Day of surgery Fatty liver

Diabetes mellitus is not associated with worse short term outcome in patients older than 65 years old post-liver transplantation

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World Journal of Hepatology 2023年第2期15卷 274-281页

作者： Saad alghamdi Shaden alamro Dhari alobaid Elwy Soliman ali albenmousa Khalid Ibrahim Bzeizi Saleh alabbad Saleh A alqahtani Dieter Broering waleed al-hamoudi Liver and Small Bowel Health Centre Department KFSHRCRiyadh 11211Saudi Arabia Department of Medicine KFSHRCRiyadh 11211Saudi Arabia Department of Internal Medicine Minia UniversityMinya 61519Egypt Division of Gastroenterology and Hepatology Johns Hopkins UniversityBaltimoreMD 21287United States Liver Disease Research Center Department of MedicineCollege of MedicineKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUND Non-alcoholic fatty liver disease is a global health care challenge and a leading indication of liver transplantation(LT).Hence,more patients with diabetes mellitus(DM)are undergoing LT,especially,above the age of *** To evaluate the impact of DM on short-term outcomes post-LT in patients over the age of *** We collected data of patients who underwent LT from January 2001 until December 2019 using our electronic medical *** assessed the impact of DM on short-term outcomes,one-year,post-LT based on the following variables:Survival at one year;acute cellular rejection(ACR)rates;intensive care unit(ICU)and hospital length of stay;and *** Total of 148 patients who are 65 year or older underwent LT during the study *** mean age is 68.5±3.3 years and 67.6%were *** median Model for End-stage Liver Disease score at time of transplantation was 22(6-39),39%of patients had hepatocellular carcinoma and 77.7%underwent living donor *** one-year survival was similar between DM patients and others,91%.ACR occurred in 13.5%of patients(P=0.902).The median ICU stay is 4.5-day P=*** rates of ICU and 90-d readmission were similar(P=0.821)and(P=0.194),*** The short-term outcome of elderly diabetic patients undergoing LT is similar to *** presence of DM in elderly LT candidates should not discourage physicians from transplant consideration in this cohort of patients.

关键词： Acute cellular rejection Diabetes mellitus Elderly Graft survival Liver transplantation

Liver transplantation for hepatitis B virus: Decreasing indication and changing trends

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World Journal of Gastroenterology 2015年第26期21卷 8140-8147页

作者： waleed al-hamoudi Hussien Elsiesy Abdulrahman Bendahmash Nasser al-masri Safiyya ali Naglaa allam Mohammed al Sofayan Hamad al Bahili Mohammed al Sebayel Dieter Broering Sammy Saab Faisal Abaalkhail Gastroenterology Unit Department of MedicineCollege of MedicineKing Saud University Department of Liver Transplantation and Hepatobiliary Surgery King Faisal Specialist Hospital and Research Center National Liver Institute Menoufeya University David Geffen School of Medicine UCLA

AIM: To evaluate the indication and outcome of hepatitis B virus(HBV)-related liver transplantation(LT) in the era of newer antiviral ***: We collected data on all patients who underwent transplantation at King Faisal Specialist Hospital and Research *** data included demographic,perioperative and long-term postoperative follow-up data including viral serological markers,HBV DNA,and repeated liver *** January 1990 and January 2012,133 patients(106 males and 27 females) underwent LT for HBV-related cirrhosis at our *** patients were followed up frequently during the first year following transplantation,according to our standard protocol; follow-up visits occurred every 3-6 mo *** infection was definedas re-emergence of HBV-DNA or hepatitis B surface antigen(HBs Ag) while on *** patients transplanted prior to 1992 did not receive immediate posttransplant anti-HBV prophylaxis; all other patients were treated with HBIG and at least one nucleos(t)ide ***: One hundred and thirty-three patients underwent LT for HBV and were followed for a median of 82 mo(range: 1-274).The rates of post-LT survival and HBV recurrence during the follow-up period were 89% and 11%,*** following factors were associated with disease recurrence: younger age(44.3 ± 16.2 years vs 51.4 ± 9.9 years,P = 0.02),positive pretransplant hepatitis B e antigen(HBe Ag)(60% vs 14%,P al of 64 transplants were performed,including 46(72%) for decompensated HBV cirrhosis,12(19%) for decompensated cirrhosis complicated by HCC and 6(10%) for compensated cirrhosis complicated by ***

关键词： Hepatitis B Hepatitis C Non-alcoholicsteatohepatitis Liver transplantation Hepatocellularcarcinoma

Extraction of cobalt(Ⅱ) from aqueous solution by N,N'-carbonyl difatty amides

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Chinese Chemical Letters 2011年第4期22卷 469-472页

作者： Emad A.Jaffar al-Mulla Khalid waleed S.al-Janabi Department of Chemistry College of ScienceUniversity of KufaAnNajafIraq Department of Chemistry College of EducationBaghdad UniversityBaghdadIraq

The development of economic and environmentally friendly extractants to recover cobalt metal is required due to the increasing demand for this *** this study,solvent extraction of Co（Ⅱ） from aqueous solution using a mixture of N,N＇-carbonyl difatty amides（CDFAs） synthesised from palm oil as the extractant was carried *** effects of various parameters such as acid,contact time,extractant concentration,metal ion concentration and stripping agent and the separation of Co（Ⅱ） from other metal ions such as Fe（Ⅱ）,Ni（Ⅱ）,Zn（Ⅲ） and Cd（Ⅱ） were *** was found that the extraction of Co（Ⅱ） into the organic phase involved the formation of 1：1 ***（Ⅱ） was successfully separated from commonly associated metal ions such as Fe（Ⅱ）,Ni（Ⅱ）,Zn（Ⅲ） and Cd（Ⅱ）.Co（Ⅱ） stripping from the loaded organic phase was studied in aqueous *** results are useful to recover Co（Ⅱ） from aqueous solution utilising（CDFAs） as an extractant.

关键词： N N'-Carbonyl difatty amides Solvent extraction Co(Ⅱ)

Direct and Reverse Carleson Conditions on Generalized Weighted Bergman-Orlicz Spaces

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Analysis in Theory and Applications 2017年第3期33卷 287-300页

作者： waleed al-Rawashdeh Department of Mathematical Sciences Montana Tech of The University of MontanaMontana 59701USA

Let D be the open unit disk in the complex plane C. For a〉 -1, let dAa（z）=（1 ＋a）（1 -｜z}^2） ^a da（z）be the weighted Lebesgue measure on ]D. For a positive function ω ∈ L^1（D,dAa）, the generalized weighted Bergman-Orlicz spaceA^ψω（D,dAa）is｜｜f｜｜ω^ψ=∫Dψ｜F（z）｜ω（z）dA^（z）〈 ∞,where q; is a strictly convex Orlicz function that satisfies other technical hypotheses. Let G be a measurable subset of D, we say G satisfies the reverse Carleson condition for A^ψω （D, dAa） if there exists a positive constant C such that ∫Gψ（f（z））ω（z）dAa（z）≥C∫Dψ（｜f（z）dAa（z）.for all f ∈ .A^ψω （D,dAa）. Let μ be a positive Borel measure, we say μ satisfies the direct Carleson condition if there exists a positive constant M such that for all f∈Aψ^ω （D,dAa）,∫Dψ（｜f（z）｜）dμ（z）≤M∫Dψ（｜f（z）｜）ω（z）dAa（a）.In this paper, we study the direct and reverse Carleson condition on the generalized weighted Bergman-Orlicz space Aω^ψ（D,dAa）.We present conditions on the set G such that＇the reverse Carleson condition＇holds. ＂Moreover, we give a sufficient condition for the finite positive Borel measure μ to satisfy the direct carleson condition on the generalized weighted Bergman-Orlicz spaces.

关键词： Orlicz function global ?2-condition reverse Carleson condition Direct Carleson condition closed range Pseudohyperbolic disks Orlicz spaces weighted Bergman spaces generalized weighted Bergman-Orlicz spaces

Improving Prediction Efficiency of Machine Learning Models for Cardiovascular Disease in IoST-Based Systems through Hyperparameter Optimization

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Computers, Materials & Continua 2024年第9期80卷 3485-3506页

作者： Tajim Md.Niamat Ullah Akhund waleed M.al-Nuwaiser Department of Computer Science and Engineering(CSE) Daffodil International UniversityDhaka1216Bangladesh Graduate School of Science and Engineering Saga UniversitySaga8408502Japan Computer Science Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11623Saudi Arabia

This study explores the impact of hyperparameter optimization on machine learning models for predicting cardiovascular disease using data from an IoST(Internet of Sensing Things)*** distinct machine learning approaches were implemented and systematically evaluated before and after hyperparameter *** improvements were observed across various models,with SVM and Neural Networks consistently showing enhanced performance metrics such as F1-Score,recall,and *** study underscores the critical role of tailored hyperparameter tuning in optimizing these models,revealing diverse outcomes among *** Trees and Random Forests exhibited stable performance throughout the *** enhancing accuracy,hyperparameter optimization also led to increased execution *** representations and comprehensive results support the findings,confirming the hypothesis that optimizing parameters can effectively enhance predictive capabilities in cardiovascular *** research contributes to advancing the understanding and application of machine learning in healthcare,particularly in improving predictive accuracy for cardiovascular disease management and intervention strategies.

关键词： Internet of sensing things(IoST) machine learning hyperparameter optimization cardiovascular disease prediction execution time analysis performance analysis wilcoxon signed-rank test