Sustained virological response in a predominantly hepatitis C virus genotype 4 infected population

作     者：Yaser Dahlan Hafiz-Mughees Ather Majid Al-ahmadi Faisal Batwa Waleed Al-hamoudi 

作者机构：Departement of MedicineKing Abdulaziz Medical cityJeddah 21423Saudi Arabia Departement of MedicineKing Saud UniversityPO Box 2925(59)Riyadh 11461Saudi Arabia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第35期

页      面：4429-4433页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Author contributions: The manuscript was written by Al- hamoudi W and Ather HM Data collection and analysis were conducted by Al-ahmadi M and Batwa F The final revision and approval was by Dahlan Y 

主　　题：Hepatitis C virus infection Sustained virological response Genotype 4 

摘      要：AIM:To assess sustained virological response(SVR) rates in a predominantly hepatitis C virus(HCV) genotype 4 infected population. METHODS:Between 2003-2007,240 patients who were treated for chronic hepatitis C infection at our center were *** data,viral genotypes,and treatment outcomes were evaluated in all treated *** with chronic renal failure, previous non-responders,and those who relapsed after previous treatment were excluded from the *** all patients,57%were treated with PEG-interferon(IFN)α-2a and 43%patients were treated with PEG-IFNα-2b;both groups received a standard dose of ribavirin. RESULTS:89.6%of patients completed the treatment with an overall SVR rate of 58%.The SVR rate was 54%in genotype 1,44%in genotype 2,73%in genotype 3,and 59%in genotype 4 *** was no statistical difference in the SVR rate between patients treated with PEG-IFNα-2a and PEG-IFNα-2b (61.5%vs 53%).Patients younger than 40 years had higher SVR rates than older patients(75%vs 51%,P =0.001).SVR was also statistically significantly higher when the HCV RNA load(pretreatment)was below 800.000(64%vs 50%,P=0.023),in patients with a body mass index(BMI)less than 28(65%vs 49%,P =0.01),and in patients who completed the treatment duration(64%vs 8%,P≤0.00001).CONCLUSION:The SVR rate in our study is higher than in previous *** with the standard duration of treatment,higher ribavirin dose,younger age,lower BMI,and low pretreatment RNA levels were associated with a higher virological response.