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Copy number variation profile-based genomic typing of premenstrual dysphoric disorder in Chinese

Journal of Genetics and Genomics 2021年第12期48卷 1070-1080页

作者： Hong Xue Zhenggang Wu Xi Long Ata Ullah Si Chen wai-kin Mat Peng Sun Ming-Zhou Gao Jie-Qiong Wang Hai-Jun Wang Xia Li Wen-Jun Sun Ming-Qi Qiao Shandong University of Traditional Chinese Medicine JinanShandong 250355China Division of Life Science and Applied Genomics Center Hong Kong University of Science and TechnologyHong KongChina School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsu 210009China HKUST Shenzhen Research Institute NanshanShenzhen 518057China Guangzhou HKUST Fok Ying Tung Research Institute Science and Technology BuildingNansha Information Technology ParkNanshaGuangzhou 511458China

Premenstrual dysphoric disorder(PMDD) affects nearly 5% of women of reproductive age. Symptomatic heterogeneity, together with largely unknown genetics, has greatly hindered its effective treatment. In the present study, analysis of genomic sequencing-based copy number variations(CNVs) called from 100 kb white blood cell DNA sequence windows by means of semisupervized clustering led to the segregation of patient genomes into the D and V groups, which correlated with the depression and invasion clinical types,respectively, with 89.0% consistency. Application of diagnostic CNV features selected using the correlation-based machine learning method enabled the classification of the CNVs obtained into the D group, V group, total patient group, and control group with an average accuracy of 83.0%. The power of the diagnostic CNV features was 0.98 on average, suggesting that these CNV features could be used for the molecular diagnosis of the major clinical types of PMDD. This demonstrated concordance between the CNV profiles and clinical types of PMDD supported the validity of symptom-based diagnosis of PMDD for differentiating between its two major clinical types, as well as the predominantly genetic nature of PMDD with a host of overlaps between multiple susceptibility genes/pathways and the diagnostic CNV features as indicators of involvement in PMDD etiology.

关键词： Clinical subtyping Genomic sequencing Machine learning Recurrent copy number variation Replication phase Semisupervized

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Science and prediction of monsoon heavy rainfall

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Science Bulletin 2019年第21期64卷 1557-1561页

作者： Yali Luo Liye Li Richard HJohnson Chih-Pei chang Lianshou Chen wai-kin Wong Jing Chen Kalli Furtado John LMcBride Ajit Tyagi Nanette Lomarda Thierry Lefort Esperanza O.Cayanan State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China HIWeather International Coordination Office Chinese Academy of Meteorological SciencesBeijing 100081China Colorado State University Fort CollinsCO 80523USA Naval Postgraduate School MontereyCA 93943USA Hong Kong Observatory.Hong Kong 999077 China Numerical Prediction Center China Meteorological AdministrationBeijing 100081China Met Office ExeterDevon EXI 3PBUK Bureau of Meteorology MelbourneVictoria 3001Australia India Meteorological Department Noida 201303India World Weather Research Division World Meteorological OrganizationGeneva 1211Switzerland Meteo-France Toulouse 31000France Philippine Atmospheric Geophysical and Astronomical Services Administration Quezon City 1100Philippines

With the increasing incidence of heavy rainfall events,particularly over the monsoon regions,the highly dense populations are more vulnerable[1].Research initiatives on observation,modeling,and prediction of monsoon heavy rainfall have been promoted actively by World Weather Research Programme's(WWRP)Working Group on Tropical Meteorology Research(WGTMR)of the World Meteorological Organization(WMO)since *** of monsoon-heavy-rainfall workshops were held in Beijing(2011),Petaling Jaya(2012),and New Delhi(2015)to benefit scientists worldwide and forecasters from the National Meteorological and Hydrological *** international Research and Development Project,namely,the Southern China Monsoon Rainfall Experiment(SCMREX)[2]was established in 2013 to coordinate field campaign experiments and to conduct scientific research on presummer(April-June)heavy rainfall processes in southern China.

关键词： China. rainfall monsoon

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Topical application of adipose tissuederived mesenchymal stem cells(ADMSCs)reduced cerebral edema in experimental traumatic brain injury(TBI)-a preliminary study

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Chinese Neurosurgical Journal 2021年第2期7卷 131-136页

作者： Hui Ma Lian Xu Cui Ping Kuen Lam Cindy S.W.Tong kin K.Y.Lo George K.C.Wong wai Sang Poon Division of Neurosurgery Chow Tai Fook-Cheng Yu Tung Surgical Stem Cell Research CenterDepartment of SurgeryThe Chinese University of Hong KongShatinHong KongSARChina Division of Neurosurgery Department of SurgeryFo Shan First People’s HospitalFoshanGuangdongChina

Background:Our previous studies showed that topical application of mesenchymal stem cells(MSCs)improved functional recovery in rat traumatic brain injury(TBI)model,and hypoxic precondition further enhanced the therapeutic effects of *** was no previous study on the attenuation of cerebral edema by *** investigated whether topical application of normoxic and hypoxic MSCs could reduce cerebral edema in an experimental TBI ***:Two million normoxic(N=24)and hypoxic(N=24)MSCs were applied topically to exposed the cerebral cortex in a controlled cortical impact(CCI)*** MSCs were fixed in position with fibrin *** treatment was given to control animals(TBI only:n=24).After surgery,four animals in each group were sacrificed daily(day 1 to day 6)for edema *** animals without TBI were used as reference(n=4).The expressions of GFAP,AQP4,and MMP9 were also investigated by immunofluorescence staining and RT-PCR at day ***:The edema peaked within 3 days after *** with the control,hypoxic MSCs reduced brain water content significantly(p<0.05).Both hypoxic and normoxic MSCs downregulated the expression of MMP9 and normalized AQP4 distribution to astrocyte end ***:Our preliminary study showed that topical application of hypoxic MSCs suppressed both vasogenic and cytotoxic edema formation.

关键词： Topical MSCs Cerebral edema TBI

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Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities

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World Journal of Pediatrics 2018年第5期14卷 482-491页

作者： Kam Lun Hon Yan Min Bao Kate C.chan kin wai Chau Rong-Shan Chen Kun Tat Gary Cheok Wa Keung Chiu Li Deng Chun-Hui He kin Mui Ieong Jeng Sum C.Kung Ping Lam Shu Yan David Lam Qun Ui Lee So Lun Lee Ting Fan Leung Theresa N.H.Leung Lei Shi Ka Ka Siu Wei-Ping Tan Maggie Haitian Wang Tak wai Wong Bao-Jing Wu Ada Y.F.Yip Yue-Jie Zheng Daniel K.Ng Department of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Department ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hong Kong Society of P ediatric Respirology and Aller gy Hong K ong S ARChina Pediatric Respiratory andSleep Disorders Center Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Department of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of P ediatrics Kiang Wu HospitalMacaoChina Department of P ediatrics and A dolescent Medicine United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Department of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Department of P ediatrics and A dolescent Medicine Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Department of P ediatrics and A dolescent Medicine Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Department of P ediatrics and A dolescent Medicine The University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Department of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Department of P ediatrics and A dolescent Medicine Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Department of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescen

Background Asthma is a significant chronic health problem worldwide. Management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. Methods The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macao hos-pitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ). Acceptability of a treatment is graded as very good/good/fair/poor. Results Good asthma control was only reported in 80% subjects in Hong Kong, but higher in sister cities (85–94%, P<0.001). Allergic rhinitis, 'incense burning', and 'smoker in family' were prevalent among the four cities. Logistic regres-sion showed better control of asthma was associated with better PADQLQ (B=?0.029, P < 0.001), better acceptability of bronchodilator (B=?1.488, P = 0.025), negatively with 'smoker in family' (B=?0.83, P = 0.015) and various PADQLQ domains. Conversely, worse PADQLQ was associated with allergic rhinitis severity (B=4.77, P <0.001), poor control of asthma (B=7.56, P <0.001), increased frequency of traditional Chinese medicine use (B=1.7, P < 0.05), increased fre-quency of bronchodilator usage (B=1.05, P < 0.05), 'smoker in family' (B=4.05, P < 0.05), and incense burning at home (B=3.9, P < 0.05). Conclusions There are some clinical and cultural differences among the four southern Chinese cities within the Guangdong province. This study identifies potentially modifiable environmental and treatment factors associated with poor asthma control and QoL for health-care interventions. Having a smoker in the family is independently associated with poor asthma control and QoL.

关键词： Asthma Complementary and alternative medicine Control Inhaled bronchodilator Inhaled corticosteroid Pediatric Allergic Disease Quality of Life Questionnaire Smoking Traditional Chinese medicine

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Chronic ulcerative gastroduodenitis as a first gastrointestinal manifestation of Hermansky-Pudlak syndrome in a 10-year-old child

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World Journal of Gastroenterology 2008年第18期14卷 2939-2941页

作者： Anselm Chi-wai Lee kin-Hung Poon Wing-Hong Lo Lap-Gate Wong Department of Pediatrics & Adolescent Medicine Tuen Mun Hospital New Territories Hong Kong 999077 China Department of Clinical Pathology Tuen Mun Hospital New Territories Hong Kong 999077 China

A 10-year-old Chinese boy who had a history of congenital thrombocytopathy presented with severe iron deficiency anemia secondary to chronic gastric inflammation and duodenal ulcerations. Subtle oculocutaneous albinism led to the finding of diminished dense bodies in the platelets under electron microscopy, hence the diagnosis of Hermansky-Pudlak syndrome (HPS). Biopsies from the stomach and duodenum revealed a lymphocytic infiltration in the submucosa, but H pylori infection was absent. The gastroduodenitis responded to the treatment with omeprazole while iron deficiency anemia was corrected by oral iron therapy. HPS is a rare cause of congenital bleeding disorder with multisystemic manifestations. Upper gastrointestinal involvement is rare and should be distinguished from a mere manifestation of the bleeding diathesis.

关键词：白化病十二指肠溃疡肠炎并发症

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Cystic meconium peritonitis with jejunoileal atresia:Is it associated with unfavorable outcome?

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World Journal of Clinical Pediatrics 2017年第1期6卷 40-44页

作者： kin wai Edwin chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer wai Cheung Mou Yuk Him Tam Division of Paediatric Surgery and Paediatric Urology Department of Surgerythe Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM To compare the outcome between patients with jejunoileal atresia(JIA) associated with cystic meconium peritonitis(CMP) and patients with isolated JIA(JIA without CMP).METHODS A retrospective study was conducted for all neonates with JIA operated in our institute from January 2005 to January *** including the gestation age,sex,birth weight,age at operation,the presence of associated syndrome was *** outcome including the type of operation performed,operative time,the need for reoperation and mortality were *** demographics and the outcome between the 2 groups were *** During the study period,53 neonates had JIA underwent operation in our *** neonates(32%) were associated with *** was no statistical difference on the demographics in the two *** with CMP had earlier operation than patients with isolated JIA(mean 1.4 d vs 3 d,P = 0.038).Primaryanastomosis was performed in 16 patients(94%) with CMP and 30 patients(83%) with isolated JIA(P = 0.269).Patients with CMP had longer operation(mean 190 min vs 154 min,P = 0.004).There were no statistical difference the need for reoperation(3 vs 6,P = 0.606) and mortality(2 vs 1,P = 0.269) between the two *** Primary intestinal anastomosis can be performed in94% of patients with JIA associated with *** patients with CMP had longer operative time,the mortality and reoperation rates were low and were comparable to patients with isolated JIA.

关键词： Meconium Peritonitis Atresia Jejunoileal

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Laparoscopic excision of Meckel's diverticulum in children:What is the current evidence?

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World Journal of Gastroenterology 2014年第41期20卷 15158-15163页

作者： kin wai Edwin chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer wai Cheung Mou Yuk Him Tam Division of Paediatric Surgery and Paediatric Urology Department of SurgeryThe Prince of Wales HospitalThe Chinese University of Hong Kong

Complications aroused from Meckel's diverticulum tend to developed in *** presented with abdominal pain,intestinal obstruction,intussusception or gastrointestinal bleeding may actually suffered from complicated Meckel's *** the advancement of minimally invasive surgery(MIS) in children,the use of laparoscopy in the diagnosis and subsequent laparoscopic excision of Meckel's diverticulum has gained ***,single incision laparoscopic surgery(SILS) has emerged as a new technique in minimally invasive *** review offers the overview in the development of MIS in the management of children suffered from Meckel's *** current evidence in different laparoscopic techniques,including conventional laparoscopy,SILS,the use of special laparoscopic instruments,intracorporeal diverticulectomy and extracorporeal diverticulectomy in the management of Meckel's diverticulum in children were revealed.

关键词： Laparoscopy Meckel’s diverticulum Children

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私有公共空间与空间正义之博弈——以香港地区为例

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国际城市规划 2023年第3期38卷 73-82,98页

作者：简祎罗洁梅王安琪陈汉云陈蔚镇邵健伟香港理工大学设计学院中国香港香港理工大学中国香港同济大学浙江工业大学设计与建筑学院城乡规划系香港理工大学建筑及房地产学系中国香港同济大学建筑与城市规划学院景观学系香港理工大学公共设计研究室中国香港

私有公共空间作为增加城市公共空间存量、提升空间品质、激发城市活力的策略已日渐普遍。然而,私有公共空间被质疑是迎合了当下绅士化审美趋势的产物,是商业资本用以实现社会控制的排他性空间,引发了业界对空间不公的讨论。本研究通过... 详细信息

私有公共空间作为增加城市公共空间存量、提升空间品质、激发城市活力的策略已日渐普遍。然而,私有公共空间被质疑是迎合了当下绅士化审美趋势的产物,是商业资本用以实现社会控制的排他性空间,引发了业界对空间不公的讨论。本研究通过梳理空间正义的相关理论,以香港地区商业公共空间为实证研究对象,探讨私有公共空间中空间正义的表达。从活动多样性、安全性与管理、邻近与可步行性、公共性和公众参与五个方面剖析其中公私权力的界限,理解私人所有权与空间正义间的冲突性生产关系和微妙的阈限性。挖掘私有公共空间在空间正义语境下作为缓解城市不公的中介效益,有助于实现公共空间的优化配置,缓解社会不公平现象。

关键词：私有公共空间空间正义可达性社会包容公共性多样性

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Planning and Implementation of a Strategic Link-Achieving Sustainability Through Environmental Impact Assessment

Planning and Implementation of a Strategic Link-Achieving Su...

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第四届粤港澳可持续发展研讨会

作者： Josh,LAM Kam-wai Richard,KWAN kin-Yan Executive Director ENSR Asia ENSR/MAUNSELL AECOM Group 11/F Grand Central PlazaTower 2 0138 Shatin Rural Committee RoadShatinHong Kong Manager-Environmental MTR Corporation Ltd 9 Lok king Street Fo TanShatinHong Kong

This paper presents the achievement of environmental sustainability in a strategic railway development through environmental impact assessment(EIA).The EIA process permeated all stages of the development,from planning and design to construction and operation,of the Lok Ma Chau Spur Line which provides a second rail link from Hong Kong in- to China’s *** was an initial environmental concern about its crossing ecologically important *** concern was effectively addressed in the EIA through ecological protec- tion and development of wetland compensatory measures,as a result of close collaboration of environmental and engineering professionals,as well as extensive stakeholder *** main sustainability outcomes were the protection of an ecologically important valley,as well as enhancement of a 37 ha wetland for long term *** wetland has since been widely used as a showcase for conservation and educational purposes,and is the site of a spectacular increase in endangered *** sustainability initiatives include wastewater manage- ment using reedbeds and effective noise control through a multi-plenum *** Spur Line case provides an important reference model for infrastructural projects with similar challen- ges,particularly for projects in culturally,economically and geographically similar contexts such as Guangdong and Macau.

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Effect of Initiation of Basal Insulin Glargine on Glycemic Control in Patients with Diabetes: Real Life Experience from Hong Kong

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Journal of Diabetes Mellitus 2017年第3期7卷 108-120页

作者： Chi-kin Yeung Fhkcp Fhkam Wilson wai-man Ngai Ip-tim Lau Department of Medicine Tseung Kwan O Hospital Hong Kong China Sanofi (Hong Kong) Ltd. Hong Kong China

Introduction: To assess the changes in glycemic control after initiating or switching to a basal insulin analogue in patients with diabetes mellitus. Methods: A retrospective, observational analysis was conducted using electronic data from a Hong Kong regional hospital. Data from adult patients with type 1 and 2 diabetes mellitus (T1DM and T2DM, respectively) who had been prescribed with basal insulin glargine in 2008-2010, with recorded HbA1c levels at the time of initiation, at 6 and 12 months thereafter, were analysed. Results: Data from 106 eligible patients were analysed. Substantial reduction in HbA1c and fasting sugar levels were reported in both T1DM (Δ HbA1c = 1.5%, Δ FBG = 1.3 mmol/L p < 0.05) and T2DM (Δ HbA1c = 1.2%, Δ FBG = 2.9 mmol/L p < 0.05) patients after 12 months of therapy. A total of 42% of T1DM and 26% of T2DM patients achieved HbA1c levels < 7.0%. After adjustment, T2DM patients who were insulin naive achieved a statistically greater HbA1c reduction (Δ = 1.7%) than those who previous treated with premixed or basal bolus insulin (Δ = 0.3%) (p < 0.05). Percentage of patients experiencing hypoglycaemia reduced from 69% to 62% in T1DM but increased from 26% to 36% in T2DM patients. All hypoglycaemic episodes recorded were either asymptomatic or mild and self-limiting. Only 4% of the patients discontinued treatment at the end of 12 months. Conclusions: In real life clinical practice, a single daily basal insulin analogue therapy provided effective glycemic control with an acceptable risk of mild hypoglycaemia.

关键词： Glycemic Control Insulin Initiation Insulin Glargine Type 1 Diabetes Mellitus Type 2 Diabetes Mellitus Hong Kong

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