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Rapid testing methods for food contaminants and toxicants

Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： Jiachi Chiou Arthur Ho Hon leung Hang wai Lee Wing-tak Wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

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Helicobacter pylori associated gastric intestinal metaplasia:Treatment and surveillance

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World Journal of Gastroenterology 2016年第3期22卷 1311-1320页

作者： Kevin Sze-Hang Liu Irene Oi-Ling Wong wai K leung Department of Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina

Gastric cancer(GC) is one of the leading causes of cancer related death in the world, particularly in East Asia. According to the Correa's cancer cascade, noncardia GC is usually developed through a series of mucosal changes from non-atrophic gastritis to atrophic gastritis(AG), intestinal metaplasia(IM), dysplasia and adenocarcinoma. Atrophic gastritis and IM are therefore generally considered to be pre-neoplastic gastric lesions. Helicobacter pylori(H. pylori) infection is an important initiating and promoting step of this gastric carcinogenesis cascade. Emerging long-term data showed that eradication of H. pylori reduced the risk of subsequent cancer development. It however remains confusing whether eradication of the bacterium in individuals with pre-neoplastic gastric lesions could regress these changes as well as in preventing cancer. Whilst H. pylori eradication could likely regress AG, the presence of IM may be a point of no return in this cascade. Hence, surveillance by endoscopy may be indicated in those with extensive IM or those with incomplete IM, particularly in populations with high GC risk. The optimal interval and the best tool of surveillance endoscopy remains to be determined in future studies.

关键词： Helicobacter pylori Gastric cancer Intestinalmetaplasia Treatment Surveillance

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Development of a dual targeting scaffold of SET7/MLL inhibitor for castration-resistant prostate cancer treatment

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Genes & Diseases 2023年第6期10卷 2260-2262页

作者： Guodong Li Qi Huang Vincent Kam wai Wong Wanhe Wang Chung-Hang leung Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine University of MacaoMacao SAR 999078China Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Institute of Medical Research Northwestern Polytechnical UniversityXi'anShaanxi 710072China Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China Department of Biomedical Sciences Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China Zhuhai UM Science and Technology Research Institute ZhuhaiGuangdong 519000China

Histone methyltransferase enzyme SET7 and mixed-lineage leukemia protein(MLL)complex are crucial co-activators of androgen receptor(AR)and have recently emerged as potential therapeutic targets for advanced castration-resistant prostate cancer(CRPC).In this study,we described the identification of a rhodium-based hybrid complex(SM_1)as a potent blocker of AR activity via simultaneously inhibiting SET7 and MLL complex activity,which makes it a potential lead scaffold for CPRC drug development.

关键词： cancer inhibiting treatment

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Investigation on the Consumption Values of Hong Kong People on Tie Products

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Journal of Donghua University(English Edition) 2004年第2期21卷 52-59页

作者： Sarah Mei-yi leung Alice wai-ching Chu Kit-lun Yick Institute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong KongDrInstitute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong KongInstitute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong

This study aims at investigating the consumption values of Hong Kong people on necktie. Based on the Sheth-Newman-Gross Model of consumption values on consumers’ choice decision as conceptual framework, results from the focus group interview, a questionnaire was designed and adopted for conducting the survey. Data collected from 245 respondents were analysed using the Factor Analysis to review the important elements of consumers’ decision of purchasing tie products. Implications on the results on the Functional value were reviewed and discussed in details. Interesting elements such as fabric hand-feel were also identified as influential associated in Hong Kong consumers’ selection of necktie. Since, both fibre content and fabric handle were also found as major selection criteria for fabric materials, the study was focused on the analysis of functional value of the product and further extended to study the handle preference for Hong Kong customers, in which a subjective handle assessment of a wide range of tie fabrics being newly developed and introduced in the market was conducted and objective fabric physical and mechanical properties were measured. Important fabric handle attributes that influence the consumers’ preference on tie fabrics were identified and their objective translation by fabric physical and mechanical properties were also obtained. The investigation provides decision support to necktie manufacturers and retailers through scientific and quantitative recommendations for product development of tie products and material selection.

关键词： Necktie Hand-feel Consumption Values and Consumer Behaviour

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Recent Trends in Sedentary Behaviors among Chinese Children According to Demographic and Social Characteristics

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Biomedical and Environmental Sciences 2021年第8期34卷 593-605页

作者： YANG Xi leung wai Yi CHEN Yuan Sheng OUYANG Yi Fei ZHAO Wen Hua Chinese Center for Disease Control and Prevention Beijing 102206China National Institution for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Chinese University of Hong Kong Hong Kong 999077China

Objective This study aims to explore trends in sedentary behavior among Chinese children aged 6–17 years per demographic and social *** A total of 4,341 children aged 6–17 years who participated in the China Health and Nutrition Survey from 2004 to 2015 were *** measures from mixed-effects models were applied to test trends in sedentary behaviors,which were further analyzed after applying stratification according to gender,age,urbanization level,residential area,and ***-effects ordinal regression models were used to examine the trends at sedentary *** From 2004 to 2015,sedentary time among children aged 6–17 years increased from 23.9±0.6 h/week to 25.7±0.6 h/week(P<0.001).Increases of 3.1 h/week(P<0.001),2.3 h/week(P=0.012),and 1.3 h/week(P=0.042)were found among the low-,medium-,and high-urbanization groups respectively and increased by 2.0 h/week(P<0.001)and 1.3 h/week(P=0.002)among rural and urban children,*** proportion of Chinese children with average daily screen time below 2 hours declined by 10.2%(OR=0.51,95%CI:0.42–0.63,P<0.001);a decreasing trend was observed in both boys and *** Sedentary time among Chinese children aged 6–17 years showed an upward trend from 2004 to 2015,especially among children residing in rural areas and regions with low urbanization levels.

关键词： Sedentary behaviors Child China Trends

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A newly discovered active contact binary in the field of NGC 1348

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Research in Astronomy and Astrophysics 2012年第1期12卷 93-103页

作者： Xiang-Song Fang Sheng-Hong Gu Ho-keung Hui Chi-Tai Kwok Bill Yeung Kam-Cheung leung National Astronomical Observatories / Yunnan Observatory Chinese Academy of SciencesKunming 650011 China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650011 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Hokoon Nature Education cum Astronomical Centre Sik Sik-Yuen Hong Kong China Hong Kong Astronomical Society Hong Kong China

We present a CCD photometry study of a newly discovered active eclipsing binary in the field of open cluster NGC 1348 based on the first time-series photometric observation. From the minimum times, we determined an orbital period of P = 0.691363 d. Among our datasets, the BV（.RI）c light curves obtained in November 2008 were analyzed using the Wilson-Devinney light curve modeling tech- nique. Because of the uncertainty of the membership of this binary in open cluster NGC 1348, we have analyzed the photometric data in two cases with different primary effective temperatures： Case A （T1 = 7750K） and Case B （T1 = 5250K）. Our anal- yses reveal that, for Case A, it is a deep （f 〉 70%）, very low mass ratio （q - 0.096） binary system, indicating that it is now in the late evolution stage of a contact binary; while for Case B, it is a red system with extraordinarily long orbital period with respect to the period-color relation for normal contact binaries, which suggests that this binary has evolved off the main sequence. The well known O＇Connell effect （e.g., AB 0.03 mag） was found in the dataset obtained in November 2008, which could be due to the existence of starspots on the components, therefore the corresponding spot properties （for Case A： hot spot; for Case B： dark spot） were determined using the Wilson-Devinney code. With the purpose of analyzing the dark spot activity for Case B, we compared the light curves derived in different observing runs, and found that a slight change appeared from November to December, 2008, which indicates the evolution of spot activity on at least one component over a time scale of about one month.

关键词： stars: binaries: close -- stars: binaries: eclipsing -- stars: spots

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Large-scale Circulation Control of the Occurrence of Low-level Turbulence at Hong Kong International Airport

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Advances in Atmospheric Sciences 2018年第4期35卷 435-444页

作者： Marco Y. T. leung Wen ZHOU Chi-Ming SHUN Pak-wai CHAN Guy Carpenter Asia-Pacific Climate Impact Center School of Energy and Environment City University of Hong Kong Hong Kong China Hong Kong Observatory Hong Kong China

This study identifies the atmospheric circulation features that are favorable for the occurrence of low-level turbulence at Hong Kong International Airport [below 1600 feet （around 500 m）]. By using LIDAR data at the airport, turbulence and nonturbulence cases are selected. It is found that the occurrence of turbulence is significantly related to the strength of the southerly wind at 850 hPa over the South China coast. On the other hand, the east-west wihd at this height demonstrates a weak relation to the occurrence. This suggests that turbulence is generated by flow passing Lantau Island from the south. The southerly wind also transports moisture from the South China Sea to Hong Kong, reducing local stability. This is favorable for the development of strong turbulence. It is also noted that the strong southerly wind during the occurrence of low-level turbulence is contributed by an anomalous zonal gradient of geopotential in the lower troposphere over the South China Sea. This gradient is caused by the combination of variations at different timescales. These are the passage of synoptic extratropical cyclones and anticyclones and the intraseasonal variation in the western North Pacific subtropical high. The seasonal variation in geopotential east of the Tibetan Plateau leads to a seasonal change in meridional wind, by which the frequency of low-level turbulence is maximized in spring and minimized in autumn.

关键词： LIDAR temperate cyclone and anticyclone western North Pacific subtropical high seasonal cycle topography effect

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Chinese topical herbal medicine gives additive effect on pharmaceutical agent on fracture healing

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Journal of Traditional Chinese Medicine 2019年第6期39卷 853-860页

作者： Siu Wing Sum Shiu Hoi Ting Shum wai Ting Ko Chun Hay Lau Clara Bik San Hung leung Kim leung Ping Chung Institute of Chinese Medicine The Chinese University of Hong KongShatinNew TerritoriesHong Kong China State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongShatinNew TerritoriesHong Kong China Department of Orthopaedics and Traumatology The Chinese University of Hong KongShatinNew TerritoriesHong Kong China

OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture ***:An open fracture was created at the mid-shaft of the right tibia of rat.A herbal pastecalled CDR containing Honghua(Flos Carthami),Chuanxuduan(Radix Dipsaci Asperoidis)and Dahuang(Radix Et Rhizoma Rhei Palmati)was *** rats were treated with either CDR topically on the fracture site,or Sr R orally,or their *** turnover biochemical markers in serum were *** of the fracture was analyzed using micro-CT after 14 and 28 d,followed by histomorphometrical ***:Micro-computed tomography analysis revealed that the combined treatment of CDR with600 mg/g Sr R significantly increased the total callus density,mineralized callus volume fraction,mineralized callus mineral content and mineralized callus density of the callus after 28 d of *** result was consistent with the histomorphometrical analysis on the osteoid *** of biochemical markers showed that the combined treatments reduced the bone resorption that occurs temporarily after ***:This study demonstrated that the combined treatment of oral Sr R and topical CDR is effective to promote fracture healing by their additive effect on promoting bone formation and retarding bone resorption.

关键词： Fracture healing Osteogenesis Bone resorption Medicine,Chinese Traditional Integrative medicine Strontium ranelate

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Soft Computing Based Procurement Planning of Time-variable Demand in Manufacturing Systems

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International Journal of Automation and computing 2007年第1期4卷 80-87页

作者： Kai leung Yung wai Hung Ip Ding-Wei Wang Department of Industrial and Systems Engineering Hong Kong Polytechnic University Hung Horn Kowloon Hong Kong PRC School of Information Science and Engineering Northeastern University Shenyang 110004 PRC

Procurement planning with discrete time varying demand is an important problem in Enterprise Resource Planning （ERP）. It can be described using the non-analytic mathematical programming model proposed in this paper. To solve the model we propose to use a fuzzy decision embedded genetic algorithm. The algorithm adopts an order strategy selection to simplify the original real optimization problem into binary ones. Then, a fuzzy decision quantification method is used to quantify experience from planning experts. Thus, decision rules can easily be embedded in the computation of genetic operations. This approach is applied to purchase planning problem in a practical machine tool works, where satisfactory results have been achieved.

关键词： Purchase planning Enterprise Resource Planning (ERP) soft computing genetic algorithm fuzzy decision inventory control.

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Mimotope-based allergen-specific immunotherapy: ready for prime time?

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Cellular & Molecular Immunology 2019年第11期16卷 890-891页

作者： Nicki Y.H.leung Christine Y.Y.wai Ka Hou Chu Patrick S.C.leung Department of Paediatrics The Chinese University of Hong KongShatinHong KongChina School of Life Sciences The Chinese University of Hong KongShatinHong KongChina Division of Rheumatology/Allergy School of MedicineUniversity of CaliforniaDavisCA 95616USA

INTRODUCTION Allergen-specific immunotherapy(AIT)is a therapeutic strategy to restore the normal immune response by suppressing inflammatory effector cells and inducing regulatory cells specific to the culprit ***,AIT is achieved by administering escalating doses of allergen over a long treatment ***,the use of unmodified allergens for AIT often results in severe anaphylactic side effects,and alternative approaches such as hypoallergens and T-cell epitopes with enhanced safety have been *** use of mimotopes in AIT is a relatively new concept,but earlier proof-ofconcept studies showed promising results for mimotopes,with decent safety profiles and immunomodulatory *** the treatment of cancer with mimotope-based immunotherapy has already been tested in clinical trials2,mimotope-based AIT remains largely in the preclinical ***,we revisit the pros and cons of mimotope-based AIT and describe recent findings concerning the use of mimotopes in AIT.

关键词： immunotherapy doses treatment

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