Chinese topical herbal medicine gives additive effect on pharmaceutical agent on fracture healing

作     者：Siu Wing Sum Shiu Hoi Ting Shum Wai Ting Ko Chun Hay Lau Clara Bik San Hung Leung Kim Leung Ping Chung 

作者机构：Institute of Chinese MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong China State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal PlantsThe Chinese University of Hong KongShatinNew TerritoriesHong Kong China Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongShatinNew TerritoriesHong Kong China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2019年第39卷第6期

页      面：853-860页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Health and Medical Research Fund of the Hong Kong Government(Ref:12130581) 

主　　题：Fracture healing Osteogenesis Bone resorption Medicine,Chinese Traditional Integrative medicine Strontium ranelate 

摘      要：OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture ***:An open fracture was created at the mid-shaft of the right tibia of rat.A herbal pastecalled CDR containing Honghua(Flos Carthami),Chuanxuduan(Radix Dipsaci Asperoidis)and Dahuang(Radix Et Rhizoma Rhei Palmati)was *** rats were treated with either CDR topically on the fracture site,or Sr R orally,or their *** turnover biochemical markers in serum were *** of the fracture was analyzed using micro-CT after 14 and 28 d,followed by histomorphometrical ***:Micro-computed tomography analysis revealed that the combined treatment of CDR with600 mg/g Sr R significantly increased the total callus density,mineralized callus volume fraction,mineralized callus mineral content and mineralized callus density of the callus after 28 d of *** result was consistent with the histomorphometrical analysis on the osteoid *** of biochemical markers showed that the combined treatments reduced the bone resorption that occurs temporarily after ***:This study demonstrated that the combined treatment of oral Sr R and topical CDR is effective to promote fracture healing by their additive effect on promoting bone formation and retarding bone resorption.