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Easy-to-perform organic-solvent-free synthesis of carbon dots with strong green photoluminescence

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Chinese Chemical Letters 2024年第3期35卷 373-378页

作者： Jiazhuang Guo yifeng Chen Pan Zhang Ge Li Xiaoning Yang Cai-Feng wang Su Chen State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China

Carbon dots(CDs)have been extensively studied owing to their fascinating optical properties and wide potential ***,we report an easy-to-perform and organic-solvent-free synthesis strategy for green-emissive CDs(G-CDs)possessing high photoluminescence(PL)quantum yield(QY).The G-CDs are synthesized by heating the homogeneous precursors of citric acid and cyanamide in an open vessel,circumventing the use of organic solvents,complex operations,high-pressure reactors,and expensive instruments in the synthesis *** effect of various reaction variables on the formation and the optical properties of G-CDs are systematically *** resultant G-CDs show bright PL emission at 521 nm with PL QY up to 73%.Then a white light-emitting diode(LED)with Commission Internationable de L'Eclairage(CIE)coordinates of(0.33,0.34)and color rendering index(CRI)of 92 is constructed based on G-CDs/thermoplastic polyurethane(TPU)***,a visual microfluidic detection platform is designed by using G-CDs as fluorescent probes for rapid quantitative detection of Fe^(3+),Cu^(2+),and Mn^(2+)metal ions,which can realize synchronized testing of multiple *** study might promote the development and preparation methods of high-performance CDs with various optical applications.

关键词： Carbon dots Efficient synthesis Green fluorescence Quantum yield White LEDs Microfluidic detection platform

Transplantation of mobilized peripheral blood mononuclear cells for peripheral arterial occlusive disease of the lower extremity

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Journal of Geriatric Cardiology 2006年第3期3卷 181-183页

作者： Xiaofeng YANG Yanxiang WU Hongmei wang yifeng XU Bo XU Xin LU Yibin ZANG Fa wang Yue ZHANG Cell Therapy Center The 463rd Hospital of Chinese PLAShenyang 110042Chinaa

Objectives To assess the clinical efficacy,safety,and feasibility of autologous transplantation of mobilized peripheral blood mononuclear cells(PBMNCs)for patients with peripheral arterial occlusive disease(PAOD)of the lower *** A total of 152 patients with PAOD of the lower extremity were enrolled into this non-controlled observational study from November 2003 to March *** patients received subcutaneous injections of recombinant human granulocyte colony-stimulating factor(G-CSF,450-600μg/day)for 5 days in order to mobilize stem/progenitor cells;their PBMNCs were collected and transplanted by multiple intramuscular injections into ischemic *** were followed up for at least 12 *** At 12 weeks,primary manifestations,including lower limb pain and coldness,were significantly improved in 137(90.1%)of the patients;limb ulcers improved or healed in 46(86.8%)of the 53 patients,while 25 of the 48(47.9%)patients with limb gangrene remained steady or ***-brachial index(ABI)improved in 33(22%)of the cases,and TcPO_(2) increased in 45(30%)of the *** before treatment,and at 12 weeks after treatment,was performed in 10 of the patients and showed formation of new collateral *** severe adverse effects or complications specifically related to cell transplantation were *** Autologous transplantation of G-CSF-mobilized PBMNCs might be a safe and effective treatment for lower limb ischemic disorder.

关键词： peripheral blood stem cell transplantation peripheral arterial occlusive disease angiogenesis neovascularization diabetic foot

中药联合熊脱氧胆酸治疗老年女性原发性胆汁性肝硬化失代偿期的临床疗效

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上海中医药杂志 2024年第2期58卷 79-83页

作者：高司成柴海生杨海琳王一凤喻晓祝峻峰上海中医药大学附属岳阳中西医结合医院肝病科上海200437 上海中医药大学附属市中医医院肝病科上海200071 上海中医药大学附属龙华医院肝病科上海200032

目的观察中药联合熊脱氧胆酸(UDCA)治疗老年女性原发性胆汁性肝硬化(PBC)失代偿期患者的临床疗效。方法将收集的老年女性PBC失代偿期患者72例随机分为治疗组和对照组,每组36例。治疗组予失笑散合二至丸颗粒联合UDCA治疗,对照组予失笑... 详细信息

目的观察中药联合熊脱氧胆酸(UDCA)治疗老年女性原发性胆汁性肝硬化(PBC)失代偿期患者的临床疗效。方法将收集的老年女性PBC失代偿期患者72例随机分为治疗组和对照组,每组36例。治疗组予失笑散合二至丸颗粒联合UDCA治疗,对照组予失笑散合二至丸颗粒模拟剂联合UDCA治疗。疗程均为6个月,观察中医证候疗效及不良反应发生率,比较相关生化指标、肝硬度值(LSM)、蔡尔德-特科特-皮尤改良评分(CTP)的变化情况。结果 (1)最终完成试验者64例,治疗组32例、对照组32例。(2)治疗前与治疗6个月组内比较,两组总胆红素(TBil)、碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)、总胆汁酸(TBA)、白球比(A/G)水平差异有统计学意义(P0.05)。治疗前与治疗6个月组内比较,两组雌二醇(E2)水平差异有统计学意义(P0.05)。结论中药(失笑散合二至丸)联合UDCA治疗老年女性PBC,能改善患者的肝功能储备及临床症状,保肝利胆且不良反应较少。

关键词：肝硬化自身免疫性肝病中药熊脱氧胆酸老年女性肝功能

Analysis and Design of Distributed Pair Programming System

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Intelligent Information Management 2010年第8期2卷 487-497页

作者： Wanfeng Dou yifeng wang Sen Luo 不详

Pair Programming (PP) that has gained extensive focus within pedagogical and industrial environments is a programming practice in which two programmers use the same computer to work together on analysis, design, and programming of the same segment of code. Distributed Pair Programming (DPP) system is a programming system to aid two programmers, the driver and the navigator, to finish a common task such as analysis, design and programming on the same software from different locations. This paper first reviews the existing DPP tools and discusses the interaction and coordination mechanism in DPP process. By means of activity theory and language-action theory, some basic requirements of the DPP system are presented. Then, a design framework of such system and functions of each sub-system are deeply analyzed. Finally, a system prototype is implemented by plug-in style in Microsoft Visual Studio environment.

关键词： Pair Programming Distributed Pair Programming Software Engineering Extreme Programming

Experimental investigation of scrape-off layer blob high density transition in L-mode plasmas on EAST

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Plasma Science and Technology 2022年第7期24卷 129-136页

作者： Ping wang Guanghai HU Ning YAN Guosheng XU Lingyi MENG Zhikang LU Lin YU Manni JIA yifeng wang Liang CHEN Heng LAN Xiang LIU Mingfu WU Liang wang Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060People's Republic of China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060People's Republic of China Institute of Energy Hefei Comprehensive National Science CentreHefei 230031People's Republic of China

Lithium Beam Emission Spectroscopy systems in the outer midplane and divertor Langmuir probe arrays embedded in the divertor target plates,are utilized to investigate the scrape-off layer(SOL)blob transition and its relation with divertor detachment on *** blob transition in the near SOL is observed during the density ramp-up *** the plasma density,normalized to the Greenwald density limit,exceeds a threshold of f_(GW)~0.5,the blob size and lifetime increases by 2–3 times,while the blob detection rate decreases by about 2 *** addition,a weak density shoulder is observed in the near SOL region at the same density *** analysis indicates that the divertor detachment is highly correlated with the blob transition,and the density threshold of blob transition is consistent with that of the access to the outer divertor *** potential physical mechanisms are *** results could be useful for the understanding of plasma-wall interaction issues in future devices that will operate under a detached divertor and high density conditions(over the blob transition threshold).

关键词： blobs divertor detachment L-mode EAST

脑电特征迁移方法预测帕金森病冻结步态的效果

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中国实用神经疾病杂志 2024年第10期27卷 1217-1222页

作者：张雪玲张伟王一峰林晓光杨丹丹孙威徐州医科大学附属宿迁医院江苏宿迁223800 徐州医科大学附属医院江苏徐州221000

目的观察脑电特征迁移方法预测帕金森病冻结步态(FOG)的效果。方法选取2022-06—2023-11在徐州医科大学附属宿迁医院诊断为帕金森病的80例患者为研究对象,PD+FOG+组(40例)伴冻结步态,PD+FOG-组(40例)不伴冻结步态。另选取基线资料与前2... 详细信息

目的观察脑电特征迁移方法预测帕金森病冻结步态(FOG)的效果。方法选取2022-06—2023-11在徐州医科大学附属宿迁医院诊断为帕金森病的80例患者为研究对象,PD+FOG+组(40例)伴冻结步态,PD+FOG-组(40例)不伴冻结步态。另选取基线资料与前2组一致的40例健康体检者作对照。比较3组基线资料,通过MMSE、帕金森综合评分量表(UPDRS)和冻结步态问卷(FOG-Q)评估患者的认知功能、日常生活及活动能力、冻结步态。进一步采用回归分析脑电特征与冻结步态的关联,评估脑电特征迁移方法预测帕金森病冻结步态的有效性。结果PD+FOG+组、PD+FOG-组与正常组间认知功能无统计学差异(P>0.05),PD+FOG+组活动能力更差(P<0.05)。PD+FOG+组对比正常组脑实质和脑电图均出现异常。进一步通过脑电图频段及FOG-Q评分与β频带的相关性分析发现两者呈线性相关。结论脑电特征与帕金森病冻结步态有一定的相关性。

关键词：帕金森病冻结步态 β频带冻结步态问卷脑电图

Comparison of natural grassy ELM behavior in favorable/unfavorable Bt in EAST

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Plasma Science and Technology 2021年第9期23卷 49-59页

作者： Genfan DING Qingquan YANG Guosheng XU Xin LIN Yang YE Ran CHEN Yumin wang Qing ZANG Heng LAN Liang CHEN Zhikang LU yifeng wang Lingyi MENG Liang wang Anhui University Hefei 230601People's Republic of China Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China Institute of Energy Hefei Comprehensive National Science CenterHefei 230031People's Republic of China

The properties of grassy edge-localized modes(ELMs)in EAST in the favorable and unfavorable Btare statistically *** analysis indicates that there is no systematical difference in the frequencies of grassy ELMs under the two different magnetic configurations in the similar parameter *** high-frequency grassy ELM(fELM>1 k Hz)in unfavorable Bt is dependent on the high poloidal betaβpand high triangularityδu,while the high-frequency grassy ELM(fELM>1k Hz)in favorable Btappears to rely on the high plasma density.A frequently occurring phenomenon in favorable Btdefined as‘clustered ELM’seems to be the most evident difference in ELM behavior between favorable and unfavorable *** analysis shows that larger plasma-wall outer gap,longer plasma elongation,lower low-hybrid wave heating power and electron cyclotron resonance heating power favor the occurrence of clustered grassy *** studies indicate that the generation of clustered grassy ELMs could be correlated with the lower electron temperature in the bulk plasma.

关键词： grassy ELM favorable and unfavorable Bt clustered ELM EAST

OsbZIP72 Is Involved in Transcriptional Gene-Regulation Pathway of Abscisic Acid Signal Transduction by Activating Rice High-Affinity Potassium Transporter OsHKT1;1

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Rice science 2021年第3期28卷 257-267页

作者： wang Baoxiang LIU Yan wang yifeng LI Jingfang SUN Zhiguang CHI Ming XING Yungao XU Bo YANG Bo LI Jian LIU Jinbo CHEN Tingmu FANG Zhaowei LU Baiguan XU Dayong Babatunde Kazeem BELLO Lianyungang Institute of Agricultural Sciences Collaborative Innovation Center for Modern Crop ProductionLianyungang 222006China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China

We created CRISPR-Cas9 knock-out and overexpressing OsbZIP72 transgenic rice plants to gain a better understanding of the role and molecular mechanism of OsbZIP72 gene in stress tolerance,which has remained largely ***72 was expressed and integrated into rice transgenic plant genomes,and the OsbZIP72 transcript in overexpression lines was elicited by salinity,abscisic acid(ABA)and drought ***72 overexpressing plants showed higher tolerance to drought and salinity stresses,while knock-out transgenic lines showed higher sensitivity to these *** differentially expressed genes(DEGs)from RNA-sequencing data encompassed several abiotic stress genes,and the functional classification of these DEGs demonstrated the robust transcriptome diversity in *** one-hybrid,along with luciferase assay,indicated that OsbZIP72 acted as a transcriptional ***,electrophoresis mobility assay revealed that OsbZIP72 bound directly to the ABAresponsive element in the OsHKT1;1 promoter region and activated its ***,our findings revealed that OsbZIP72 can act as a transcriptional modulator with the ability to induce the expression of OsHKT1;1 in response to environmental stress through an ABA-dependent regulatory pathway,indicating that OsbZIP72 can play a crucial role in the ABA-mediated salt and drought tolerance pathway in rice.

关键词： abscisic acid basic leucine zipper drought stress high-affinity potassium transporter rice salinity stress transgenic plant

基于cAMP-PKA途径研究茶碱影响核盘菌菌核形成的相关机制

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陕西农业科学 2024年第7期70卷 7-11页

作者：赵帅杨大群马常瑜王一峰白伊玲吕蕊花陕西中医药大学医学技术学院陕西咸阳712046

【目的】菌核在核盘菌生活史中占据核心地位,茶碱可作用于cAMP-PKA途径中的PDEs而影响生物体生长发育,本研究通过外源添加茶碱,研究茶碱对于核盘菌菌核的产生及其通路中相关因子的影响,其结果可为新型杀菌剂的开发提供参考。【方法】首... 详细信息

【目的】菌核在核盘菌生活史中占据核心地位,茶碱可作用于cAMP-PKA途径中的PDEs而影响生物体生长发育,本研究通过外源添加茶碱,研究茶碱对于核盘菌菌核的产生及其通路中相关因子的影响,其结果可为新型杀菌剂的开发提供参考。【方法】首先,通过外源添加不同浓度的茶碱,检测其对核盘菌菌丝生长抑制率及菌核形成情况的影响,其次,通过试剂盒检测茶碱对核盘菌菌丝体内cAMP含量的影响,最后,通过qRT-PCR方法检测外源添加茶碱对于核盘菌cAMP-PKA通路中相关因子的变化。【结果】外源添加终浓度为1~2.5 mmol/L的茶碱,对于核盘菌菌丝生长速率和菌核的形成均有抑制作用,而茶碱终浓度为0.5 mmoI/L对菌丝生长速率几乎没有影响。外源添加的茶碱主要是在菌核原基形成的S4期及菌核成熟的S5阶段提升胞内cAMP含量,而在S1~S3阶段和对照组胞内cAMP含量无差异。茶碱通过抑制PDE2的表达水平使得胞内cAMP含量升高,而下游基因PKA和RAS的表达量也相应减少,外源添加茶碱后ATG8的表达量显著上升。【结论】一定浓度的茶碱对于核盘菌菌丝生长速率和菌核的产生均有抑制作用,外源添加茶碱可通过抑制PDE2的表达而提高胞内cAMP含量,使得下游基因表达量相应减少。

关键词：核盘菌茶碱 cAMP含量菌核形成