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Twisted fiber microfluidics:a cutting-edge approach to 3d spiral devices

Microsystems & Nanoengineering 2024年第1期10卷 193-202页

作者： Shunsuke Kato daniel w.Carlson Amy Q.Shen Yuanyuan Guo department of Electrical Information and Physics EngineeringSchool of EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Micro/Bio/Nanofluidics Unit Okinawa Institute of Science and TechnologyOnnaKunigami-gun 904-0495 OkinawaJapan Frontier Research Institute for Interdisciplinary Sciences(FRIS) Tohoku UniversityAoba-kuSendai 980-0845 MiyagiJapan Graduate School of Biomedical Engineering Tohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan department of Physiology Graduate School of MedicineTohoku UniversityAoba-kuSendai 980-8575 MiyagiJapan

The development of 3d spiral microfluidics has opened new avenues for leveraging inertial focusing to analyze small fluid volumes,thereby advancing research across chemical,physical,and biological *** traditional straight microchannels rely solely on inertial lift forces,the novel spiral geometry generates dean drag forces,eliminating the necessity for external fields in fluid ***,fabricating 3d spiral microfluidics remains a labor-intensive and costly endeavor,hindering its widespread ***,conventional lithographic methods primarily yield 2d planar devices,thereby limiting the selection of materials and geometrical *** address these challenges,this work introduces a streamlined fabrication method for 3d spiral microfluidic devices,employing rotational force within a miniaturized thermal drawing process,termed as *** innovation allows for rapid prototyping of twisted fiber-based microfluidics featuring versatility in material selection and heightened geometric *** validate the performance of these devices,we combined computational modeling with microtomographic particle image velocimetry(uTPiM)to comprehensively characterize the 3d flow *** results corroborate the presence of a steady secondary flow,underscoring the effectiveness of our *** 3d spiral microfluidics platform paves the way for exploring intricate microflow dynamics,with promising applications in areas such as drug delivery,diagnostics,and lab-on-a-chip systems.

关键词： thereby straight twisted

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A perspective on greenhouse gas emission studies integrating arbuscular mycorrhiza

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Pedosphere 2024年第3期34卷 525-529页

作者： Stavros d.VERESOGLOU Junjiang CHEN State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityShenzhen 518107(China)

Climate change is a global *** is only possible to pace down global change through addressing the triggers of it,greenhouse gas *** commendable progress,we think that there is plenty of room to further make the studies addressing global change realistic,through integrating into them biotic *** make a case for this statement through a bibliometrics analysis on agricultural studies exploring greenhouse gas emissions that consider arbuscular *** show that even though mycorrhizal studies account right now for a small fraction of the agricultural literature,they get cited more *** further demonstrate that mycorrhizal studies are typically more descriptive in their nature,which we support through comparing the keywords they *** subsequently use the opportunity to identify shortcomings and opportunities to further integrate mycorrhiza into agricultural studies assaying greenhouse gas *** finally make a call to better integrate arbuscular mycorrhiza into global change studies.

关键词： bibliometric analysis biochemical models global change biology Glomeromycota sustainable agricultural intensification

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Nav1.7调节软骨细胞并作为骨关节炎的治疗靶点

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中国疼痛医学杂志 2024年第6期30卷 404-406页

作者： Fu w Vasylyev d Bi Y 戈家宜(译) 刘兴君(校) 不详南通大学药学院

骨关节炎(osteoarthritis,OA)是常见的关节疾病。目前还没有能够同时防止关节退化和减少疼痛的治疗方法。有证据表明软骨细胞中存在电压门控钠通道(voltage gated sodium channels,VGSCs),但它们在软骨细胞和OA中的表达和功能仍不清楚... 详细信息

骨关节炎(osteoarthritis,OA)是常见的关节疾病。目前还没有能够同时防止关节退化和减少疼痛的治疗方法。有证据表明软骨细胞中存在电压门控钠通道(voltage gated sodium channels,VGSCs),但它们在软骨细胞和OA中的表达和功能仍不清楚。该研究发现,Nav1.7作为一个与OA相关的VGSCs,人OA软骨细胞以0.1~0.15个/μm2和350~525个通道/细胞的密度表达功能性Nav1.7。在通过基因操作抑制Nav1.7的一系列小鼠模型上发现,表达在背根神经节(dorsal root ganglion,dRG)神经元中的Nav1.7参与疼痛的调控,而表达在软骨细胞中的Nav1.7调节OA进程。使用选择性或临床常用的泛Nav通道阻断剂,可显著改善结构性关节损伤,并减轻OA疼痛。Nav1.7阻断剂调节细胞内Ca2+信号和软骨细胞的分泌组,进而影响软骨细胞生物学和OA进程。该研究证实,Nav1.7为一个新发现的、在软骨细胞表达的OA相关VGSCs,可作为具有双重靶点特性的用于治疗OA和镇痛的非阿片类镇痛药。

关键词：骨关节炎软骨细胞关节疾病基因操作背根神经节治疗靶点关节损伤电压门控钠通道

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Quaternionic Monge–Ampère Measure on Pluripolar Set

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1431-1457页

作者： Hichame AMAL Saïd ASSERdA Fadoua BOUKHARI department of Mathematics Laboratory LaREAMIRegional Centre of Trades of Education and TrainingKenitraMorocco Ibn Tofail University Faculty of SciencesDepartment of MathematicsPO 242 KenitraMorroco

In this paper, we prove that in a hyperconvex domain Ω in H^(n), if a non-negative Borel measure is dominated by a quaternionic Monge–Ampère measure, then it is a quaternionic Monge–Ampère measure of a function i... 详细信息

关键词： Quaternion space Monge-Amp`ere operator plurisubharmonic function

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Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： d.LEE S.CHANG J.LEE department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea School of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random *** method consists of a generalized polynomial chaos expansion(GPCE)for statistical moment and reliability analyses associated with the stochastic output and a static reanalysis method to generate the input-output data *** the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random *** allows for avoiding repeated computations of invariant substructures while generating the input-output data *** substructuring with static condensation further improves the computational efficiency of the reanalysis without losing ***,the GPCE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional *** numerical results obtained from a simple structure indicate that the proposed method for UQ produces accurate solutions more efficiently than the GPCE using full finite element analyses(FEAs).we also demonstrate the efficiency and scalability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPCE) static reanalysis method static condensation substructuring

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Organic stabilization in earthen plaster:Eco-compatible architecture and ancient techniques in Tata Somba homes

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Frontiers of Architectural Research 2024年第3期13卷 625-638页

作者： d.Ben Ghida department of Architecture University of Naples FedericoⅡNaplesItaly

The study of organic stabilization is crucial for understanding its impact on the durability and effectiveness of earthen *** natural admixtures’effects on plaster properties provides insights that aid in optimizing plaster composition and application for desired *** addition of biopolymers,known to enhance plaster performance,necessitates further investigation to understand their role in earthen plaster *** study focuses on Tata Somba homes in Benin and Togo,recognized as UNESCO world Heritage *** unique architectural examples embody“architecture without architects”,relying solely on local traditional *** objective is to explore and revive Tata Somba’s ancient eco-technology for earth plaster *** shows that biopolymers’combined stabilization and application techniques can improve earthen plaster *** promising bio-stabilizers were identified,suggesting their potential as sustainable,effective options for CO_(2) mitigation in *** findings not only deepen our understanding of earthen architecture but also underscore the potential of merging traditional,eco-friendly building methods with modern scientific insights to create sustainable solutions for cultural heritage preservation and contemporary built environments.

关键词： Vernacular architecture Cultural heritage preservation Sustainable architecture Biopolymer Earth architecture Earth stabilization

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A dynamic Network Game of the Fintech Industry

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Journal of the Operations Research Society of China 2024年第1期12卷 5-33页

作者： david w.K.Yeung Leon A.Petrosyan Ying-Xuan Zhang SRS Consortium for Advanced Study in Cooperative dynamic Games Shue Yan UniversityHong KongChina Center of Game Theory St Petersburg State UniversitySaint PetersburgRussia department of Finance Asia UniversityTaichung CityTaiwanChina Faculty of Applied Mathematics-Control Processes and Center of Game Theory St Petersburg StateUniversitySaint PetersburgRussia

Economies of scale,economies of scope,and technology spillover are decisive eco-nomic elements that are crucial to the development in the Fintech *** externalities are often realized through network *** this paper,we presenta dynamic network ofﬁnancialﬁrms which exhibits these decisive *** game equilibria are characterized.A Pareto efﬁcient solution involving col-laboration of allﬁrms is *** obtain a fair-share distribution of cooperativegains,the Shapley value is adopted as the sharing *** distributionmechanisms which guarantee the fulﬁlment of the Shapley value distribution in eachstage of the cooperation duration are derived.

关键词： Network game Network equilibria Shapley value Pareto efﬁcientcooperation

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Strategies for dissecting the Genetic driving of Conserved Noncoding-Elements for Evolutionary development of the Corpus Callosum

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Neuroscience Bulletin 2024年第7期40卷 1025-1027页

作者： Yaxin Ye Boxing Jin Hao w.Zhang Nengyin Sheng State Key Laboratory of Genetic Resources and Evolution Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan ProvinceKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650201China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650201China

with the efforts in developmental biology and neuroscience during the past several decades,our knowledge has been significantly advanced about the genetic,cellular,and molecular mechanisms underlying brain development and ***,we should keep in mind that the human brain is the product of complex evolutionary processes,and there is a trade-off between brain evolution and neurological disorders[1].

关键词： function. neurological knowledge

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Carbene chemistry for unnatural biosynthesis

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Science China(Life Sciences) 2024年第1期67卷 204-207页

作者： Jing Huang Jay d.Keasling department of Chemical and Biomolecular Engineering University of CaliforniaBerkeley 94720USA Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryville 94608USA Biological Systems and Engineering division Lawrence Berkeley National LaboratoryBerkeley 94720USA Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKongens Lyngby 2800Denmark department of Bioengineering University of CaliforniaBerkeley 94720USA Synthetic Biochemistry Center Institute for Synthetic BiologyShenzhen Institutes for Advanced TechnologiesShenzhen 518055China

Previously,chemists working in synthesis were jealous of biologists since the enzymes found in nature usually exhibited great catalytic properties(e.g.,high catalytic efficiency,excellent selectivity such as substrate selectivity,regioselectivity and stereoselectivity).However,biological systems lack many counterparts of reactions widely used in chemical synthesis.

关键词： synthesis selectivity catalytic

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Liver transplantation as an alternative for the treatment of intrahepatic cholangiocarcinoma: Past, present, and future directions

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Hepatobiliary & Pancreatic diseases International 2024年第2期23卷 129-138页

作者： Sudha Kodali Ashton A Connor Souhail Thabet Elizabeth w Brombosz R Mark Ghobrial Sherrie and Alan Conover Center for Liver disease and Transplantation Houston Methodist HospitalHoustonTX 77030USA JC walter Jr Transplant Center Houston Methodist HospitalHoustonTX 77030USA department of Medicine Weill Cornell Medical CollegeNew YorkNYUSA department of Surgery Houston Methodist HospitalHoustonTX 77030USA department of Surgery Weill Cornell Medical CollegeNew YorkNYUSA School of Medicine New Giza UniversityGizaEgypt

Intrahepatic cholangiocarcinoma(iCCA)is a rare biliary tract cancer with high mortality *** resection of the iCCA lesion is the first choice of treatment,with good prognosis after margin-negative ***,only 12%-40% of patients are eligible for resection at presentation due to cirrhosis,portal hypertension,or large tumor *** transplantation(LT)offers margin-negative iCCA extirpation for patients with unresectable ***,iCCA was a contraindication for LT until size-based selection criteria were introduced to identify patients with satisfied post-LT *** studies have shown that tumor biology-based selection can yield high post-LT survival in patients with locally advanced *** selection criterion is the tumor response to neoadjuvant *** with response to neoadjuvant therapy have better outcomes after LT compared with those without tumor response to neoadjuvant *** index that helps predict the treatment outcome is the *** survival outcomes have also opened the door for living donor LT for *** undergoing LT for iCCA now have statistically similar survival rates as patients undergoing *** combination of surgery and locoregional and systemic therapies improves the prognosis of iCCA patients.

关键词： Liver transplantation Cholangiocarcinoma Hepatectomy Transplant oncology Liver neoplasm

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