Twisted fiber microfluidics:a cutting-edge approach to 3D spiral devices
作者机构：Department of ElectricalInformation and Physics EngineeringSchool of EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Micro/Bio/Nanofluidics UnitOkinawa Institute of Science and TechnologyOnnaKunigami-gun 904-0495 OkinawaJapan Frontier Research Institute for Interdisciplinary Sciences(FRIS)Tohoku UniversityAoba-kuSendai 980-0845 MiyagiJapan Graduate School of Biomedical EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Department of PhysiologyGraduate School of MedicineTohoku UniversityAoba-kuSendai 980-8575 MiyagiJapan
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2024年第10卷第1期
页 面：193-202页
核心收录：
学科分类：080704[工学-流体机械及工程] 080103[工学-流体力学] 08[工学] 0807[工学-动力工程及工程热物理] 0804[工学-仪器科学与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0801[工学-力学（可授工学、理学学位）]
基 金：supported by the OIST-SHINKA program and matching funds from Tohoku University.S.K.and Y.G.gratefully acknowledge funding from the JST FOREST,Grant No.JPMJFR205D D.W.C.and A.Q.S.acknowledge the support of the Okinawa Institute of Science and Technology Graduate University(OIST)with subsidy funding from the Cabinet Office,Government of Japan,along with funding from the Japan Society for the Promotion of Science(JSPS,Grant No.21K14080)
摘 要：The development of 3D spiral microfluidics has opened new avenues for leveraging inertial focusing to analyze small fluid volumes,thereby advancing research across chemical,physical,and biological *** traditional straight microchannels rely solely on inertial lift forces,the novel spiral geometry generates Dean drag forces,eliminating the necessity for external fields in fluid ***,fabricating 3D spiral microfluidics remains a labor-intensive and costly endeavor,hindering its widespread ***,conventional lithographic methods primarily yield 2D planar devices,thereby limiting the selection of materials and geometrical *** address these challenges,this work introduces a streamlined fabrication method for 3D spiral microfluidic devices,employing rotational force within a miniaturized thermal drawing process,termed as *** innovation allows for rapid prototyping of twisted fiber-based microfluidics featuring versatility in material selection and heightened geometric *** validate the performance of these devices,we combined computational modeling with microtomographic particle image velocimetry(uTPiM)to comprehensively characterize the 3D flow *** results corroborate the presence of a steady secondary flow,underscoring the effectiveness of our *** 3D spiral microfluidics platform paves the way for exploring intricate microflow dynamics,with promising applications in areas such as drug delivery,diagnostics,and lab-on-a-chip systems.
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