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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Bio-inspired tetracarbene compounds as a new family of energy saving catalysts

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Journal of Energy Chemistry 2023年第4期79卷 559-561页

作者： Bo Zhang Fritz E.kühn CAS key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina' University of Chinese Academy of Science Beijing 100049China Molecular Catalysis Catalysis Research Center and Department of ChemistrySchool of Natural SciencesTechnical University of MunichLichtenbergstr 485748 Garching bei MünchenGermany

Efficient use of energy is a pressing *** of chemical processes is currently an important target for energy *** chemical processes are independent of pathways with respect to the final energy output or consumption,the application of catalysts can reduce involved activation energies considerably and therefore save large amounts of energy.

关键词： Catalysis Iron Carbenes Multidentate ligands

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Organorhenium(Ⅶ) oxides

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Rare Metals 2006年第Z1期25卷 411-421页

作者： kühn Fritz E. JAIN kavita R. Department für Chemie der Technischen Universitt München Lichtenbergstrasse 4 D-85747 Garching bei München Germany

Methyltrioxorhenium (MTO) and its derivatives were utilized as catalysts for a broad variety of organic reactions after the discovery of an easy synthetic access way to this class of compounds. Among the numerous characterization techniques, 17O-NMR spectroscopy and vibrational spectroscopy were exemplary discussed. The immobilization of MTO and its derivatives is of significant current interest as is the synthesis of chiral derivatives.

关键词： catalysis epoxidation immobilization olefination rhenium

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Study of BESIII trigger efficiencies with the 2018 J/ψ data

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Chinese Physics C 2021年第2期45卷 48-55页

作者： M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban k.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang w.L.Chang G.Chelkov D.Y.Chen G.Chen H.S.Chen M.L.Chen S.J.Chen X.R.Chen Y.B.Chen Z.J Chen w.S.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai X.C.Dai A.Dbeyssi R.E.de Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong X.Dong S.X.Du Y.L.Fan J.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng M.Fritsch C.D.Fu Y.Gao Y.Gao Y.Gao Y.G.Gao I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman k.Goetzen L.Gong w.X.Gong w.Gradl M.Greco L.M.Gu M.H.Gu S.Gu Y.T.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han w.Y.Han X.Q.Hao F.A.Harris H Hüsken k.L.He F.H.Heinsius C.H.Heinz T.Held Y.k.Heng C.Herold M.Himmelreich T.Holtmann Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain w.Ikegami Andersson w.Imoehl M.Irshad S.Jaeger S.Janchiv Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.B.Jiang X.S.Jiang J.B.Jiao Z.Jiao S.Jin Y.Jin T.Johansson N.kalantar-Nayestanaki X.S.kang R.kappert M.kavatsyuk B.C.ke I.k.keshk A.khoukaz P.kiese R.kiuchi R.kliemt L.koch O.B.kolcu B.kopf M.kuemmel M.kuessner A.kupsc M.G.kurth w.kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.J.Li J.L.Li J.Q.Li J.S.Li ke Li L.k.Li Lei Li P.R.Li S.Y.Li w.D.Li w.G.Li X.H.Li X.L.Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang L.Z.Liao J.Libby C.X.Lin B.J.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu k.Liu k.Y.Liu ke Liu L.Liu M.H.Liu P.L.Liu Q.Liu Q.Liu S.B.Liu Shuai Liu T.Liu w.M.Liu X.Liu Y.Liu Y.B.Liu Z.A.Liu Z.Q.Liu X.C.Lou F.X.Lu H.J.Lu J.D.Lu J.G.Lu X.L.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo b P.w.Luo T.Luo X.L.Luo S Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200443China GIBudker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA (A)INFN Laboratori Nazionali di Frascati I-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly (A)INFN Sezione di Ferrara I-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Ave54BUlaanbaatar 13330Mongolia Jilin University Changchun 130012China Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen IIPhysikalisches InstitutHeinrich-Buff-Ring 16D-35392GiessenGermany kVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China Liaoning Normal Unive

Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII *** efficiencies are determined from three representative physics processes,namely Bhabha scattering,dimuon production and generic hadronic events with charged *** combined efficiency of all active triggers approaches 100%in most cases,with uncertainties small enough not to affect most physics analyses.

关键词： BESIII trigger efficiency Bhabha dimuon hadronic events

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Human endogenous retrovirus type-w and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-w(HERV-w): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Hydromechanical behaviors of andesite under different stress states during fluid injection

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 727-744页

作者： Miao He Qi Li Xiaying Li Liang Xu Michael kühn State key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Fluid Systems Modelling Section GFZ German Research Centre for GeosciencesPotsdamGermany Institute of Earth and Environmental Science University of PotsdamPotsdamGermany

water reinjection into the formation is an indispensable operation in many energy engineering *** operation involves a complex hydromechanical(HM)coupling process and sometimes even causes unpredictable disasters,such as induced *** is acknowledged that the relative magnitude and direction of the principal stresses significantly influence the HM behaviors of rocks during ***,due to the limitations of current testing techniques,it is still difficult to comprehensively conduct laboratory injection tests under various stress conditions,such as in triaxial extension stress *** this end,a numerical study of HM changes in rocks during injection under different stress states is *** this model,the saturated rock is first loaded to the target stress state under drainage conditions,and then the stress state is maintained and water is injected from the top to simulate the formation injection *** attention is given to the difference in HM changes under triaxial compression and extension *** includes the differences in the pore pressure propagation,mean effective stress,volumetric strain,and stress-induced *** numerical results demonstrate that the differential stress will significantly affect the HM behaviors of rocks,but the degree of influence is different under the two triaxial stress *** HM changes caused by the triaxial compression stress states are generally greater than those of extension,but the differences decrease with increasing differential stress,indicating that the increase in the differential stress will weaken the impact of the stress state on the HM *** addition,the shear failure potential of fracture planes with various inclination angles is analyzed and summarized under different stress *** is recommended that engineers could design suitable injection schemes according to different tectonic stress fields versus fault occurrence to reduce the risk of

关键词： water reinjection Stress state Hydromechanical(HM)coupling Injection-induced seismicity Numerical modeling

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Laser additive manufactured high-performance Fe-based composites with unique strengthening structure

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Journal of Materials Science & Technology 2021年第30期89卷 242-252页

作者： Hongyu Chen Dongdong Gu Liang Deng Tiwen Lu Uta kühn konrad kosiba College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Jiangsu Provincial Engineering Laboratory for Laser Additive Manufacturing of High-Performance Metallic Components Nanjing University of Aeronautics and AstronauticsNanjing 210016China Leibniz IFw Dresden Institute for Complex MaterialsP.O.Box 270116D-01069 DresdenGermany

Steel matrix composites(SMCs),reinforced by ceramic particles,have received a consistent attention in recent *** conventional methods to prepare SMCs is generally challenging,and the mechanical properties of conventionally fabricated SMCs are *** this study,we successfully fabricated highperformance SMCs by laser powder bed fusion(LPBF)of a composite powder consisting of Fe-based alloy powder and submicron-sized wC *** effect of laser energy density on the phase formation,microstructural evolution,overall density and resulting mechanical properties of LPBF-fabricated composites was *** present results show that a novel Fe_(2)w_(4)C carbidic network precipitates in the solidified microstructure entailing segregations along the boundaries of cellular *** presence of this carbidic network hampers the growth of sub-grains even at elevated temperatures,and hence,stabilizes the grain size though prepared at a broad range of different energy *** exact distribution of the Fe_(2)w_(4)C carbides depends on the employed laser energy densities,as for instance they are more uniformly distributed at higher energy *** density of LPBF samples reaches the maximum value of 99.4%at 150 J/mm^(3).In this parameter set,high microhardness of~753 HV,compression strength of~3350 MPa and fracture strain of~24.4%are *** enhanced mechanical properties are ascribed to less metallurgical defects,higher volume fraction of the martensitic phase and increasing pile-up dislocations resulting from the pinning effect by Fe_(2)w_(4)C carbide.

关键词： Laser additive manufacturing Laser powder bed fusion Steel matrix composite Microstructures Mechanical properties

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： Nanofluidics

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Glass-forming ability, phase formation and mechanical properties of glass-forming Cu-Hf-Zr alloys

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Progress in Natural Science:Materials International 2019年第5期29卷 576-581页

作者： k.kosiba kaikai Song U.kühn Gang wang S.Pauly Leibniz IFw Dresden Institute for Complex Materials School of Mechanical Electrical & Information Engineering Shandong University (Weihai) Laboratory for Microstructures Institute of Materials Shanghai University

The influence of Hf additions on the glass-forming ability（GFA）,phase formation and mechanical properties of Cu;Hf;Zr;（x=2,5,10,20 at.%）alloys has been systematically *** report on a distinct correlation between phase formation and GFA of Cu;Zr;-based *** additions of Hf reduce the thermal stability of the high-temperature B2Cu（Hf,Zr）phase,while the thermal stability of the corresponding undercooled melt is *** GFA of these alloy series gradually raises up to 10 at.%Hf,whereas at 20 at.%Hf,the GFA is drastically lowered,since the B2Cu（Hf,Zr）phase becomes unstable and the precipitation of the lowtemperature equilibrium phases is *** interrelation determines the microstructure and results in the formation of Cu-Hf-Zr-based bulk metallic glass *** composites not only show appreciable macroscopic plastic strain,but also high yield strength.

关键词： Metallic glasses Glass-forming ability Composites Continuous cooling transformation (CCT) diagram Mechanical properties

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