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Ethical frontiers in liver transplantation

world Journal of Transplantation 2024年第4期14卷 50-60页

作者： hoi Pong Nicholas wong Surya Varma Selvakumar Pei Yi Loh Jovan Yi Jun Liau Matthias Yi Quan Liau Vishalkumar Girishchandra Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Surgical Science Training Centre Tan Tock Seng HospitalSingapore 308433Singapore

Liver transplantation represents a pivotal intervention in the management of end-stage liver disease,offering a lifeline to countless *** significant strides in surgical techniques and organ procurement,ethical dilemmas and de-bates continue to underscore this life-saving *** the ethical terrain surrounding this complex procedure is hence *** the nuances of ethical principles of justice,autonomy and beneficence that underpin transplant protocols worldwide,we explore the modern challenges that plaques the world of liver *** investigate the ethical dimensions of organ transplantation,focusing on allocation,emerging technologies,and decision-making ***,Scopus,web of Science,Embase and Central were searched from database inception to February 29,2024 using the following key-words:“liver transplant”,“transplantation”,“liver donation”,“liver recipient”,“organ donation”and“ethics”.Information from relevant articles surrounding ethical discussions in the realm of liver transplantation,especially with regards to organ recipients and allocation,organ donation,transplant tourism,new age technologies and developments,were *** the definition of death to the long term follow up of organ recipients,liver transplantation has many ethical *** new transplant techniques,societal acceptance and perceptions also play a pivotal ***,religious and regional factors including but not limited to beliefs,wealth and accessibility are extremely influential in public at-titudes towards donation,xenotransplantation,stem cell research,and adopting artificial *** and addressing these perspectives whilst upholding bioethical principles is essential to ensure just distribution and fair allocation of *** regulatory oversight for ethical sourcing of organs,ensuring good patient selection and transplant techniques,and high-quality long-term surveillance to mitiga

关键词： “liver transplant” “transplan-tation” “liver donation” “liver recipient” “organ donation”and“ethics”

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A critical review:emerging bioeconomy and waste-to-energy technologies for sustainable municipal solid waste management

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waste Disposal and Sustainable Energy 2019年第3期1卷 151-167页

作者： To-hung Tsui Jonathan w.C.wong Department of Biology Institute of Bioresource and AgricultureSino-Forest Applied Research Centre for Pearl River Delta EnvironmentHong Kong Baptist UniversityKowloon TongHong KongChina

Municipal solid waste(MSw)management has emerged as probably the most pressing issue many governments nowadays are ***,waste-to-Energy(wtE)is mostly associated with incineration,but now,with the emergence of the bioeconomy,it embraces a broader definition comprising any processing technique that can generate electricity/heat or produce a waste-derived *** the ambit of the circular economy many nations are looking for,additional effort must be made to be sure of acquiring the most updated information and paving a sustainable path for managing MSw in such a *** this regard,we have undertaken a critical review of various technologies,with their updated progress,involved in the exploitation of MSw as a renewable resource,along with the critical advantages and limitations on energy and material cycling for sustainable MSw ***,the most widely used method,is nowadays difficult to further apply due to its dubious reputation and social ***,to address the organic fraction of MSw which currently is mostly unrecycled and causes disposal issues,the biological approach presents an attractive *** new emphasis of bioeconomy leads us to understand how environmental biotechnologies should be better connected/integrated for more sustainable MSw *** article is concluded with advances of future prospects,which can serve as a timely reminder to encourage competent authorities/researchers to work towards further improvement of the present MSw management system.

关键词： Municipal solid waste management Sustainability Circular economy Bioeconomy waste-to-energy Anaerobic digestion

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STRUCTURE AND SURFACE STUDIES OF Mg_xZn_(1-x)O FILMS GROwN BY PULSED LASER DEPOSITION

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 237-241页

作者： L.Zhuang K.h.wong DepartmentofAppliedPhysics TheHongKongPolytechnicUniversityKowloonHongKongChina

The structural and surface properties of high-quality epitaxial cubic MgxZn1-xO films deposited by pulsed laser deposition (PLD) were studied by X-ray diffracti on and atomic force microscopy respectively. For films of about 500nm thick, sca ns over a 30μm × 30μm area revealed a surface roughness Ra of about 100nm. Th is relatively large surface roughness is primarily attributed to the particulate and outgrowth during the PLD process. A good epitaxial growth on LaAlO3 (LAO ) (100) substrates, however has been obtained for composition x = 0.9, 0.7 and 0 .5 with the heteroepitaxial relationship of (100)■∥(100)LAO (out-of-plane) and (011)■∥(010)LAO (in-plane). These structural qualities suggest that cubic Mgx Zn1-xO alloys films have good potential in a variety of optoelectronic device ap plications.

关键词： pulsed laser deposition thin film XRD MgxZn1-xO

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Effects of 2,3,7,8-TCDD and benzo[a]pyrene on modulating vitellogenin expression in primary culture of crucian carp (Carassius auratus) hepatocytes

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Chinese Science Bulletin 2004年第22期49卷 2372-2378页

作者： LIANGYong C.K.C.wong XUYing M.h.wong StateKeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China DepartmentofBiology HongKongBaptistUniversityKowloonTongHongKong StateKeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China

Vitellogenin (Vtg) is the precursor of yolk protein. Its expression and secretion are estrogen-regulated and are crucial for oocyte maturation. An in vitro xenoestro- gen screening model was established by measuring Vtg in- duction in cultured primary hepatocytes from crucian carp. Vtg production was detected by biotin-avidin sandwich ELISA method while Vtg and cytochrome P4501A1 (CYP1A1) mRNA induction were measured by semi- quan- titative PCR-primer dropping technique. Vtg and Vtg mRNA were dose-dependently induced by diethylstilbestrol (DES, 0.2—200 ng/mL) in hepatocytes of crucian carp. Co-treatment of the DES-induced hepatocytes with either 2,3,7,8-TCDD (TCDD, 0.1—4 pg/mL) or benzo[a]pyrene (B[a]P, 5—1000 ng/mL) resulted in a reduction of Vtg pro- duction and an increment of CYP1A1 mRNA expression both in a dose dependent manner, indicating the anti-estro- genic effects of the compounds. however, at lower tested concentrations, TCDD (0.1, 0.2 pg/mL), B[a]P (5 ng/mL) seemed to have a potentiating effect on Vtg expression and secretion, although by their own these compounds had no observable estrogenic effect on Vtg induction. Tamoxifen (a selective estrogen receptor modulators, 1 nmol/L—1 μmol/L), and β-naphtho-flavone (β-NF, an aryl hydrocarbon receptor inducing compounds, 2.5—1000 ng/mL) also were employed to study the possible interactions in DES-induced Vtg ex- pression. In co-treatment of the DES-induced hepatocytes with β-NF or tamoxifen, the decrease in Vtg production did parallel induction of CYP1A1 for β-NF, but tamoxifen inhib- ited Vtg induction did not parallel induced CYP1A1 expres- sion in all test concentrations. On the contrary, it was found that in co-treatment of the TCDD-induced hepatocytes with DES, TCDD induced CYP1A1 mRNA production was inhib- ited by DES also. These results implicated a possible cross talk between estrogen receptor- and aryl hydrocarbon re- ceptor-mediated pathways in the hepatocytes.

关键词： 2,3,7,8-TCDD 苯并[a]芘卵黄蛋白原鲫鱼鲤鱼肝细胞 CYP1A1 卵黄蛋白质异种雌激素

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Comprehensive Assessment of Anxiolytic Properties in 4-hPAA Derivatives: Bridging in Vivo Validation and Molecular Docking Analyses

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Open Journal of Medicinal Chemistry 2024年第3期14卷 29-44页

作者： Kawthar Alhussieni Rami Ayoub Jamal Jilani Qais Jarrar Othman Alhussinei Vetriselvan Subramaniyan Esra Nasraldin Khalil Sharafaldin harshini Muruganantham Jureerat Kijsomporn Ling Shing wong Department of Applied Pharmaceutical Sciences and Clinical Pharmacy Faculty of Pharmacy Isra University Amman Jordan Department of Pharmaceutical Chemistry Faculty of Pharmacy Universiti Malaya Kuala Lumpur Malaysia Department of Medicinal Chemistry and Pharmacognosy Faculty of Pharmacy Jordan University of Science and Technology Irbid Jordan Department of Allied Medical Sciences Zarqa Private University Zarqa Jordan Department of Medical Sciences School of Medical and Life Sciences Sunway University Bandar Sunway Malaysia Department of Clinical Pharmacy and Pharmacy Practice Faculty of Pharmacy Universiti Malaya Kuala Lumpur Malaysia Center for Global Research Saveetha Medical College Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India School of Nursing Metharath University Bangtoey Thailand Faculty of health and Life Sciences INTI International University Nilai Malaysia

Anxiety is a significant mental health issue that substantially affects an individual’s quality of life. Feelings of uneasiness, irritability, and sleep disturbances characterize it. 4-hydroxyphenyl acetic acid (4-hPAA) is identified in brain cells as a physiological byproduct of tyramine. This study hypothesizes that 4-hPAA may regulate anxiety due to its anxiolytic properties, acting as a modulator of the GABAergic system, which plays a crucial role in the pathophysiology of anxiety disorders. Our study aims to enhance the anxiolytic effects of 4-hPAA through chemical modification to improve its pharmacokinetic properties. Three derivatives, namely Isopropyl-4-hydroxy-[phenyl] acetate (IhPA), Isopropyl-4-hydroxy-[phenyl] acetate (MPAA), and 4-methoxyphenyl acetate (MPhA), have been synthesized from 4-hPAA. This assessment will use well-established animal models, specifically the Elevated Plus-Maze (EPM) and Zero Maze (EZM) tests, selected for their validity in replicating anxiety-like symptoms in animals. Chronic caffeine administration via drinking water (0.3 g/l for 14 days) was employed to induce an anxiety state for testing purposes. IhPA and MPAA demonstrated significant anxiolyticactivity when tested in the EPM and EZM experiments. Molecular docking simulations using AutoDock Vina indicated that 4-hPAA derivatives had docking scores ranging from −5.8 to −4.8 kcal/mol, compared to the standard anxiolytic medication Diazepam, which scored −7.1 kcal/mol. These scores suggest a potential for 4-hPAA derivatives to interact effectively with the Gamma-aminobutyric acid (GABA_A) receptor. In conclusion, our in vivo and in silico analyses indicate a promising anxiolytic potential for 4-hPAA derivatives.

关键词： Anxiolytics 4-hPAA Molecular Docking Elevated Plus-Maze Zero Maze Tests

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音樂放鬆療法對改善結腸鏡檢查者疼痛的效果研究

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镜湖医学 2024年第1期24卷 75-77页

作者：黃家駒澳門鏡湖醫院護理部中国

目的用音樂療法作為放鬆的介入方式,以減輕結腸鏡檢查者術中的不適,促進結腸鏡檢查的進程及改善舒適度。方法2021年4月12日~5月18日,於澳門某醫院對104位結腸鏡檢查者進行研究,分為研究組及對照組(每組各52人)。研究組結腸鏡檢查者介入... 详细信息

目的用音樂療法作為放鬆的介入方式,以減輕結腸鏡檢查者術中的不適,促進結腸鏡檢查的進程及改善舒適度。方法2021年4月12日~5月18日,於澳門某醫院對104位結腸鏡檢查者進行研究,分為研究組及對照組(每組各52人)。研究組結腸鏡檢查者介入音樂療法,對照組予常規照護,比較兩組疼痛評分(numerical rating scale,NRS)、收縮壓、舒張壓、心率及結腸鏡檢查進鏡時間的差異。結果兩組研究參與者在NRS疼痛評分、術中及術後血壓及心率無差異;兩組結腸鏡檢查的進鏡時間均數沒有顯著差異;但進鏡時間≦10分鐘組(非困難腸鏡組)與>10分鐘組(困難腸鏡組)則存在組間差異,在非困難腸鏡組中,研究組進鏡時間為6.2±1.6分鐘,對照組進鏡時間為7.2±1.6分鐘(T=-2.075,P<0.05);困難腸鏡組則沒有顯著差異。結論音樂放鬆療法對結腸鏡檢查者的疼痛緩解、血壓及心率穩定沒有顯著作用,但仍可縮短“非困難腸鏡”的進鏡時間。

关键词：音樂療法結腸鏡檢查疼痛進鏡時間

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Computational Approaches for Traditional Chinese Painting: From the “Six Principles of Painting” Perspective

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Journal of Computer Science & Technology 2024年第2期39卷 269-285页

作者：张玮张建伟黄锦畦王懿芳封颖超杰王璐玮陈为 State Key Laboratory of CAD&CG Zhejiang UniversityHangzhou 310058China Department of Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong 999077China Kellogg School of Management Northwestern UniversityEvanston 60208U.S.A Laboratory of Art and Archaeology Image Zhejiang UniversityHangzhou 310058China

Traditional Chinese painting(TCP)is an invaluable cultural heritage resource and a unique visual art *** recent years,there has been a growing emphasis on the digitalization of TCP for cultural preservation and *** resulting digital copies have enabled the advancement of computational methods for a structured and systematic understanding of *** explore this topic,we conduct an in-depth analysis of 94 pieces of *** examine the current use of computer technologies on TCP from three perspectives,based on numerous conversations with ***,in light of the“Six Principles of Painting”theory,we categorize the articles according to their research focus on artistic ***,we create a four-stage framework to illustrate the purposes of TCP ***,we summarize the popular computational techniques applied to *** work also provides insights into potential applications and prospects,with professional opinion.

关键词： traditional Chinese painting(TCP) digital humanities cultural heritage computer vision deep learning

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Effect of Earthworm(Pheretimasp.) Density on Revegetation of Lead/zinc Metal Mine Tailings Amended with Soil

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Chinese Journal of Population,Resources and Environment 2008年第2期6卷 43-48页

作者： Cheng Jiemin Ming h wong College of Population Resources and Environment Shandong Normal University Jinan Shandong 210014 China Croucher Institute for Environmental Sciences Department of Biology Hong Kong Baptist University Hong Kong China

The objective of this study was to investigate the ef- fects of earthworm density on the availability of nutrients and heavy metals in metal contaminated ***/Zn mine tailings were mixed throughly with a red yellow podzolic soil at the ratio (w/w) of 75:*** (Pheretima sp.) were introduced to the mixture at four different densities,zero,three,six and nine individuals per pot planted with ryegrass (Loliun multiflorum). The results indicated that earthworm activity significantly en- hanced ryegrass shoot ***,as denser earthworm population was introduced,shoot biomass tended to decrease. Earthworm activity significantly increased soil ph and availability of N,P and K in the tailings and soil *** was a general tendency that uptake of Zn by ryegrass increased after earthworm inoculation,although the increase in extractable Zn in tailings and soil mixture was not *** the contrary,there seemed to be a lower uptake of Pb by ryegrass under earthworm inoclation, despite the fact that higher extractable Pb concentrations were *** present project indicated that the improved growth of ryegrass was due to improved nutrient availability and other soil conditions,by inoculation of earthworms at an appropriate *** studies are needed to illustrate the relationship be- tween metal availability and earthworm activity in the field.

关键词： lead zinc nitrogen phosphorus phytostabilization Pb/Zn mine tailings

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A case of secretory breast carcinoma with ETV6-NTRK3 fusion gene during childhood

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镜湖医学 2024年第1期24卷 62-63,F0004页

作者： TAI wai Meng ChAN Kin Iong wong Peng hong XU De Li wEN Jian Ming Department of Pathology Kiang Wu HospitalMacao SARChina Department of Surgery Kiang Wu HospitalMacao SARChina

Secretory carcinoma is a rare breast *** report a case of secretory carcinoma occurred in childhood.A 7-year-old girl had a history of a mass in the breast for 4 *** tumor grew slowly and well circumscribed,mimicking benign lesions on *** breast lumpectomy,a diagnosis of secretory carcinoma was made based on its histological morphology,immunohistochemical reaction,and molecular ***,we report the process of diagnosis,and treatment of this rare case.

关键词： diagnosis carcinoma lesions

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探本溯源——夏含夷《〈周易〉的起源与早期演变》英文版导读

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国际儒学（中英文） 2024年第1期4卷 160-170,189,190页

作者：王嘉宝北京师范大学—香港浸会大学联合国际学院通识教育学院珠海519087

《〈周易〉的起源与早期演变》展示了夏含夷四十年来治易的成果,此书可谓英文学界《周易》古经研究中的里程碑著作。在内容上,此书结合出土材料与传世文献,系统地考辨公元前800—前500年《周易》的起源及其演变。在方法上,夏含夷持有严... 详细信息

《〈周易〉的起源与早期演变》展示了夏含夷四十年来治易的成果,此书可谓英文学界《周易》古经研究中的里程碑著作。在内容上,此书结合出土材料与传世文献,系统地考辨公元前800—前500年《周易》的起源及其演变。在方法上,夏含夷持有严格的经传分观,以《周易》为筮占之书,以《易经》及易学著作为以传释经的哲理智慧之书。此书强调《周易》文本的形成只有放回到“筮占情境”当中,方可探求文本的本来意涵。夏含夷始终从“筮占情境”出发,对《周易》文本形成的诸种细节进行剖析,反对由哲学路径解读《周易》。

关键词：夏含夷卜筮《〈周易〉的起源与早期演变》

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