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Leveraging Robust Artificial Intelligence for Mechatronic Product Development—A Literature Review

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International Journal of Intelligence Science 2024年第1期14卷 1-21页

作者： Alexander Nüßgen René Degen Marcus Irmer Fabian Richter Cecilia Boström Margot Ruschitzka CAD CAM Center Cologne Institute of Automotive Engineering Cologne (IFK) Faculty of Automotive Systems and Production Cologne University of Applied Science Cologne Germany Division of Electricity Department of Electrical Engineering Uppsala University Uppsala Sweden

Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and softw.re engineering. The integration of artificial intelligence technologies is revolutionizing this domain, offering opportunities to enhance design processes, optimize performance, and leverage vast amounts of know.edge. How.ver, human expertise remains essential in contextualizing information, considering trade-offs, and ensuring ethical and societal implications are taken into account. This paper therefore explores the existing literature regarding the application of artificial intelligence as a comprehensive database, decision support system, and modeling tool in mechatronic product development. It analyzes the benefits of artificial intelligence in enabling domain linking, replacing human expert know.edge, improving prediction quality, and enhancing intelligent control systems. For this purpose, a consideration of the V-cycle takes place, a standard in mechatronic product development. Along this, an initial assessment of the AI potential is show. and important categories of AI support are formed. This is follow.d by an examination of the literature w.th regard to these aspects. As a result, the integration of artificial intelligence in mechatronic product development opens new.possibilities and transforms the w.y innovative mechatronic systems are conceived, designed, and deployed. How.ver, the approaches are only taking place selectively, and a holistic view.of the development processes and the potential for robust and context-sensitive artificial intelligence along them is still needed.

关键词： Artificial Intelligence Mechatronic Product Development Know.edge Management Data Analysis Optimization Human Experts Decision-Making Processes V-Cycle

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儿童肺部马尔尼菲篮状菌感染的诊治进展

中国实用儿科杂志 2024年第2期39卷 107-111,160页

作者：徐雪花卢根广州医科大学附属妇女儿童医疗中心呼吸科广东广州510623

马尔尼菲篮状菌是一种地方性机会致病真菌,主要流行于东南亚国家及中国南部。近年来,马尔尼菲篮状菌感染的发病率不断增加,在儿童中多见于免疫出生错误者。马尔尼菲篮状菌主要通过呼吸道入侵人体,感染可累及全身多组织器官,最常见的是... 详细信息

马尔尼菲篮状菌是一种地方性机会致病真菌,主要流行于东南亚国家及中国南部。近年来,马尔尼菲篮状菌感染的发病率不断增加,在儿童中多见于免疫出生错误者。马尔尼菲篮状菌主要通过呼吸道入侵人体,感染可累及全身多组织器官,最常见的是肺部受累。儿童马尔尼菲篮状菌感染缺乏特异性的临床表现,易导致误诊或诊断延迟,病死率高。该文主要介绍马尔尼菲篮状菌及其感染的致病机制、临床特点、诊断和治疗进展。

关键词：马尔尼菲篮状菌儿童肺部诊治

数字化转型如何影响企业可持续绩效——来自fsQCA的发现

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软科学 2024年第5期38卷 13-21页

作者：於军隋艮上海海事大学经济管理学院上海201306

基于双元理论,对302家企业进行模糊集定性比较分析(fsOCA),探索数字化转型的工具性因素(数字平台、客户体验、员工体验、运营和商业模式)和道德性因素(企业数字责任)对企业可持续绩效的组态效应。结果表明:(1)工具性和道德性因素的组合... 详细信息

基于双元理论,对302家企业进行模糊集定性比较分析(fsOCA),探索数字化转型的工具性因素(数字平台、客户体验、员工体验、运营和商业模式)和道德性因素(企业数字责任)对企业可持续绩效的组态效应。结果表明:(1)工具性和道德性因素的组合可以改善数字化转型企业的可持续绩效,其中企业数字责任起到了关键作用;(2)存在不同的组态可以实现不同维度的企业可持续绩效,且不同因素可以相互替代;(3)数字平台、客户体验、运营、商业模式和企业数字责任的组合能够同时实现数字化转型企业的经济、环境和社会绩效。

关键词：双元理论企业数字责任企业可持续绩效数字化转型 fsQCA

基于NSGA-Ⅱ算法的五连杆悬架硬点优化分析

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机械设计与研究 2024年第2期40卷 45-50页

作者：李根代迪沃尔沃汽车技术(上海)有限公司上海201800

在探讨五连杆悬架的硬点结构中,利用MATLAB分析各个硬点坐标的灵敏度,从而确定其中的重要因子,将其纳入五连杆悬架的结构优化设计中,通过NSGA-Ⅱ算法进行多目标优化,使悬架具有最佳的运动学性能。对平行轮跳过程中的各个参数进行优化后... 详细信息

在探讨五连杆悬架的硬点结构中,利用MATLAB分析各个硬点坐标的灵敏度,从而确定其中的重要因子,将其纳入五连杆悬架的结构优化设计中,通过NSGA-Ⅱ算法进行多目标优化,使悬架具有最佳的运动学性能。对平行轮跳过程中的各个参数进行优化后,五连杆悬架的跳动转向、外倾梯度和侧倾中心高度的变化都能够达到预期的状态,从而达到最佳的性能表现。

关键词：五连杆悬架运动学特性硬点灵敏度分析 NSGA-Ⅱ

Clinical application of the endometrial microbiota test combined w.th personalized treatment in patients w.th repeated implantation failure

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Reproductive and Developmental Medicine 2024年第1期8卷 18-23页

作者： Rou-Zhu Chen Yan-Fang w.ng Pei-gen Chen Cong Fang Ting-Ting Li Reproductive Medicine Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Guangdong Engineering Technology Research Center of Fertility Preservation Guangzhou 510655China

Objective:The objective of this study w.s to investigate the clinical value of the endometrial microbiota test(EMT)combined w.th personalized treatment in patients w.th repeated implantation failure(RIF).Methods:From March 2019 to August 2022,the clinical data of patients w.th RIF at the Reproductive Medicine Research Center of the Sixth Affiliated Hospital of Sun Yat-sen University w.re retrospectively analyzed.A total of 356 patients underw.nt the EMT using 16S rRNA sequencing and w.re included in the EMT *** SPSS statistical softw.re propensity score w.s set at 1:1 to match the age,anti-Müllerian hormone(AMH),antral follicle count(AFC),years of infertility,and body mass index(BMI)of the w.men w.o had not undergone the EMT;subsequently,354 patients w.re classified in the non-EMT *** compared the clinical characteristics of the tw. groups and analyzed the clinical pregnancy outcomes after personalized ***:The clinical pregnancy rate(CPR)of the EMT group w.s significantly higher than that of the non-EMT group(47.81%vs.13.38%,Pw.o underw.nt the EMT,55 patients(15.45%)in group A w.th normal endometrial microbiota composition did not test positive for the pathogenic bacteria causing chronic endometritis,34 patients(9.55%)in group B w.th abnormal endometrial microbiota composition did not test positive for the pathogenic bacteria causing chronic endometritis,35 patients(9.83%)in group C w.th normal endometrial microbiota composition tested positive for the pathogenic bacteria causing chronic endometritis,and 232 patients(65.17%)in group D w.th abnormal endometrial microbiota composition tested positive for the pathogenic bacteria causing chronic *** administration of probiotics or antibiotic plus probiotics treatment,the pregnancy rates of groups C and D w.re higher than those of group A(44.00%vs.20.00%and 55.03%vs.20.00%,respectively;bothPw.th personalized treatment in

关键词： Endometrial microbiota test Assisted reproductive technology Repeated implantation failure Personalized treatment

Analysis of standardization development of TCM in Sichuan

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China Standardization 2024年第5期129卷 59-61页

作者： Li gen Sichuan Institute of Standardization

Sichuan province is home to rich traditional Chinese medicine(TCM)*** years have seen unremitting efforts of TCM standardization in the *** analyzing the measures and existing problems,this paper provides recommendati... 详细信息

关键词： Sichuan TCM standardization

PBX/Knotted 1 homeobox-2(PKNOX2)is a novel regulator of myocardial fibrosis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2231-2249页

作者： Liang Chen Haotong Li Xiaorui Liu Ningning Zhang Kui w.ng Anteng Shi Hang Gao Deniz Akdis Ardan MSaguner Xinjie Xu Elena Osto w.llem Van de Veen Guangyu Li Antoni Bayés-genís Firat Duru Jiangping Song Xiangjie Li Shengshou Hu State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Statistics and Data Science Nankai UniversityTianjinChina Department of Cardiology University Heart CenterUniversity Hospital Zurich and University of ZurichZurichSwitzerland Institute for Clinical Chemistry University Hospital Zurich and University of ZürichZurichSwitzerland Sw.ss Institute of Allergy and Asthma Research(SIAF) University of ZurichDavosSwitzerland Heart Institute Hospital Universitari Germans Trias i PujolBadalonaCIBERCVSpain

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA ***,the cardiac transcriptional regulation netw.rks have not been systematically described because of the limitations in detecting transcription *** this study,w. optimized a pipeline for isolating nuclei and conducting single-nucleus RNA sequencing targeted to detect a higher number of cell signal genes and an optimal number of transcription *** this unbiased protocol,w. characterized the cellular composition of healthy human hearts and investigated the transcriptional regulation netw.rks involved in determining the cellular identities and functions of the main cardiac cell *** in fibroblasts,a novel regulator,PKNOX2,w.s identified as being associated w.th physiological fibroblast activation in healthy *** validate the roles of these transcription factors in maintaining homeostasis,w. used single-nucleus RNA-sequencing analysis of transplanted failing hearts focusing on fibroblast *** trajectory analysis suggested that PKNOX2 w.s abnormally decreased from fibroblast activation to pathological myofibroblast *** gain-and loss-of-function in vitro experiments demonstrated the inhibitory role of PKNOX2 in pathological fibrosis ***,fibroblast-specific overexpression and knockout of PKNOX2 in a heart failure mouse model induced by transverse aortic constriction surgery significantly improved and aggravated myocardial fibrosis,*** summary,this study established a high-quality pipeline for single-nucleus RNA-sequencing analysis of heart *** this optimized protocol,w. described the transcriptional regulation netw.rks of the main cardiac cell subtypes and identified PKNOX2 as a novel regulator in suppressing fibrosis and a potential therapeutic target for future translational studies.

关键词： NOX2 homeostasis fibrosis

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia w. w.i w.n Xiuqin Rao Yue Lin gen w.i Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review.outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow.hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, w. summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, w. discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new.ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Machine learning-based prediction of pregnancy outcomes in couples w.th non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study

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Reproductive and Developmental Medicine 2024年第1期8卷 24-31页

作者： Lei Jia Pei-gen Chen Li-Na Chen Cong Fang Jing Zhang Pan-Yu Chen Reproductive Medicine Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China GuangDong Engineering Technology Research Center ofFertility Preservation The Sixth Affiliated HospitalSun Yatsen UniversityGuangzhou 510275China Biomedical Innovation Center The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510275China

Objective:To develop a clinically applicable tool for predicting clinical pregnancy,providing individualized patient counseling,and helping couples w.th non-obstructive azoospermia(NOA)decide w.ether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction(mTESE).Methods:A total of 240 couples w.th NOA w.o underw.nt mTESE-ICSI w.re divided into tw. groups based on the type of spermatozoa used for intracytoplasmic sperm injection(ICSI):the fresh and cryopreserved *** evaluating several machine learning algorithms,logistic regression w.s *** LASSO regression and 10-fold cross-validation,the factors associated w.th clinical pregnancy w.re ***:The area under the curves(AUCs)for the fresh and cryopreserved groups in the Logistic Regression-based prediction model w.re 0.977 and 0.759,*** w.th various modeling algorithms,Logistic Regression outperformed machine learning in both groups,w.th an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved ***:The model accurately predicted clinical pregnancies in NOA couples.

关键词： Cryopreserved spermatozoa Fresh spermatozoa Logistic regression Microdissection testicular sperm extraction