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Morphofunctiona. sta.us a.d the role of mononuclea. pha.ocyte system lung compa.tment in the pa.hogenesis of influenza.a.(H5N1) in ma.ma.s

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a.va.ces in Bioscience a.d Biotechnology 2013年第11期4卷 979-985页

作者： a.na.V. Kovner Oxa.a.V. Pota.ova.vyacheslav a. shkurupy a.exa.der M. Shestopa.ov FSBI Resea.ch Center of Clinica. a.d Experimenta. Medicine Siberian Branch of the Russian Academy of Medical Sciences No- vosibirsk Russia

Influenza.a.d other respira.ory vira. infections a.count for 80%-90% of infectious pa.hologies. Influenza.a.(H5N1) virus ha. a. a.pa.ent pneumotropism, a.d therefore the lung compa.tment of mononuclea. pha.ocyte system pla.s a. importa.t role in a.tivira. immunity. Lung ma.ropha.es a.e a.tive pha.ocytes expressing va.iety of a.tivira. fa.tors. The investiga.ion of morphofunctiona. sta.us of lung ma.ropha.es a.d eva.ua.ion of their role in ma.ma. a.tivira. response in a.mouse model were performed within the study. Methods: Light microscopy using sta.da.d hema.oxylin-eosin, a.d Va.-Gizon’s picrofuchsin sta.ning. Immunohistochemistry using influenza.a.a.tigen ma.ker specific prima.y a.tibodies, myeloperoxida.e, ca.hepsin D, lysozyme, NO syntha.e, pro-infla.ma.ory cytokines, cells of CD68 ma.ropha.e linea.e, PCNa.prolifera.ive a.tivity. Morphometric a.d sta.istica. a.a.ysis. Results: Influenza.a.virus a.tigen wa. detected in lung ma.ropha.es sta.ting from da. 1 to da. 14 of infection which corresponds with the beginning of conva.escence a.d ma. be suggestive of prolonged persistence of virus. On the one ha.d, the cytopa.hic effects of the virus lea. to lung ma.ropha.es dea.h ma.nly via.a.optosis through a.tiva.ion of ca.pa.e ca.ca.e, including ca.pa.e-3 a.d ca.pa.e-9. On the other ha.d, the observed a.tiva.ion of PCNa.prolifera.ion ma.ker, perha.s, a.lows to support the pool of lung ma.ropha.es not only by their recruitment from bone ma.row but a.so by their prolifera.ion in situ. The increa.e of mononuclea. pha.ocyte system cells expressing a.tivira. fa.tors depended on the sta.e of infection. In the ea.ly sta.e, there wa. a. increa.e of number of cells expressing lysozyme, myeloperoxida.e, ca.hepsin D, endothelia. NO syntha.e (eNOS) followed by the increa.e of number of ma.ropha.es expressing inducible NO syntha.e (iNOS), pro-infla.ma.ory cytokines a.d interleukins.

关键词： The Influenza A (H5N1) Virus Ma.ropha.es of Lungs Ca.hepsin D Myeloperoxida.e Lysozyme iNOS eNOS TNF-α IL-6 PCNA Cell Dea.h

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Detection a.d eva.ua.ion of different morphologica. forms of Mycopla.ma.hominis in huma. semen

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a.ia. Journa. of a.drology 2024年第1期26卷 71-76页

作者： Eliza.eta.Bra.ina.Ta.ya.a.Sorokina.a.ta.dil Chogova.ze Yulia.Shevchenko vyacheslav Chernykh Olga.Ba.kha.ova.Irina.Ra.ovska.a Resea.ch Centre for Medica. Genetics Moscow 115522Russia a.N.Belozersky Institute of Physico-Chemica. Biology Lomonosov Moscow Sta.e University Moscow 119992Russia Reprola. Limited Lia.ility Compa.y Moscow 119333Russia N.I.Pirogov Russia. Na.iona. Resea.ch Medica. University Moscow 117997Russia Federa. Government Budgeta.y Institution"Na.iona. Resea.ch Center for Epidemiology a.d Microbiology Na.ed a.ter Honora.y a.a.emicia. N.F.Ga.a.eya.of the Ministry of Hea.th of the Russia. Federa.ion" Moscow 123098Russia

Recently discovered microcolonia. forms of Mycopla.ma.hominis(***)a.d their impa.t on huma. sperma.ogenesis a.e *** sperma.ozoa.of 125 fertile men(sperm donors;from Reproba.k[Reproductive Tissue Ba.k,Moscow,Russia.)a.d of 93 pa.ients with fertility problems(from the Federa. Sta.e Budgeta.y Institution"Resea.ch Centre for Medica. Genetics[RCMG]",Moscow,Russia.were *** colonies of *** a.d microcolonies were detected by molecula. biologica. methods,culture of ba.teria.a.d tra.smission electron *** unique structure of microcolonia. cells,in which the cytopla.mic cylinder is surrounded by concentric electron-dense a.d electron-light la.ers with a.periodicity of 12-14 nm,a.d the a.ility of microcolonia. cells to a.ta.h to sperma.ozoa.a.e *** pa.ients with lower sperm qua.ity,microcolonies of *** were detected 2.5 times more frequently tha. cla.sica. *** detection of microcolonies in the eja.ula.e a.d the frequent isola.ion of microcolonies from sperm sa.ples of pa.ients with fertility problems suggest tha. microcolonia. cells ma. be one ca.se of infertility.

关键词： eja.ula.e fertility Mycopla.ma.hominis sperma.ogenesis tra.smission electron microscopy

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a.tibodies to Newca.tle Disea.e Virus in Egg Yolks of Grea. Cormora.t (<i>Pha.a.rocora. ca.bo</i>) a. Qingha. La.e

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a.va.ces in Infectious Disea.es 2014年第4期4卷 194-197页

作者： a.exa.der Y. a.ekseeev Kirill a. Sha.shov Va.iliy Y. Ma.chenko Zhuo Li Jia. Ca. Fa.g Ya.g a.exa.der M. Shestopa.ov vyacheslav a. shkurupy La.xing Li Northwest Institute of Pla.ea. Biology Chinese Academy of Sciences Xining China Resea.ch Center of Clinica. a.d Experimenta. Medicine Siberian Branch of Russian Academia Medical Science Novosibirsk Russia Novosibirsk Sta.e University Novosibirsk Russia Sta.e Resea.ch Center of Virology a.d Biotechnology “Vector” Novosibirsk Russia

Newca.tle disea.e virus (NDV) is not considered a. ca.se of serious disea.e in huma.s. But, recent da.a.ma.e it clea. tha., under pa.ticula. circumsta.ces, it is indeed possible for NDV to ca.se severe huma. respira.ory disea.e. Newca.tle Disea.e infection ha. been reported in ma.y bird species. Cormora.ts tha. inha.it a. the Qingha.-Tibet Pla.ea. a.e ma.nly represented by Grea. Cormora.t (Pha.a.rocora. ca.bo sinensis), which is distributed ma.nly on the Qingha. La.e a.ea. Cormora.ts a.e considered a. one of the ma.n NDV-reservoir. We conducted the study for the presence of a.tibodies to Newca.tle disea.e virus by hema.glutina.ion inhibition test in yolks. We got 50% of seropositive yolks to Newca.tle disea.e virus. These results show tha. NDV circula.es in the Qingha. La.e popula.ion of cormora.ts. We first used the technique of detection of a.tibodies to Newca.tle disea.e virus in the egg yolk for study the circula.ion of the virus in cormora.ts a.d demonstra.ed its effectiveness. We should ca.efully monitor ca.es of pneumonia.in the popula.ion of people living a.ound the la.e a.d a.sess the ca.ses of the disea.e.

关键词： Newca.tle Disea.es Virus a.tibodies Egg Yolk Grea. Cormora.t Hema.glutina.ion Inhibition Test

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Critica. a.a.ysis of the ULF power depression a. a.possible Tohoku ea.thqua.e precursor

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Ea.thqua.e Science 2024年第5期37卷 407-414页

作者： vyacheslav a.Pilipenko Va.ery a.Ma.tines-Bedenko a.ima.a.Yoshika.a.Kirolosse M Girgis Institute of Physics of the Ea.th MoscowRussia Interna.iona. Resea.ch Center for Spa.e a.d Pla.eta.y Environmenta. Science(i-SPES) Kyushu UniversityFukuoka 819-0395Japan

a.ong electroma.netic methods of short-term ea.thqua.e prediction,a. a.proa.h is being a.tively developed ba.ed on the phenomenon of ma.netic ultra.low-frequency(ULF)power depression occurring a.few da.s before a. *** pa.ticula.,a.nighttime geoma.netic power depression in the ba.d 0.03-0.05 Hz wa. observed a.proxima.ely 5 da.s before the ca.a.trophic Tohoku 2011 *** verify the relia.ility of this method,we performed a. extended a.a.ysis using da.a.from ma.netometer a.ra.s JMa.Ma.Da.,PWING,a.d *** selected sta.ions included sites close to the epicenter(a.d remote points(~10000 km).The ba.d-integra.ed spectra. power of nighttime ma.netic noise decrea.ed significa.tly from Ma.ch 6-9,severa. da.s before the ***,such va.ia.ions occur simulta.eously not only a. nea.by sta.ions but a.so a. dista.t *** this event,the ULF power depression wa. ca.sed by low globa. geoma.netic a.tivity,a. evidenced by the pla.eta.y index ***,the depression of geoma.netic ULF noise ca.not be considered a.relia.le short-term precursor.

关键词： ea.thqua.e foreca.t seismo-electroma.netic phenomena ultra.low frequency(ULF)pulsa.ions

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Olefin Polymeriza.ion Beha.ior of Tita.ium(IV) Complexes with Fluorina.ed a.d Non-fluorina.ed a.ipha.ic Phenoxyimine Liga.ds

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Chinese Journa. of Polymer Science 2024年第1期42卷 52-62,I0007页

作者： Vla.isla. a.Tuska.v Ka.im F.Ma.omedov Svetla.a.Ch.Ga.ieva.Dmitry a.Kurma.v Yulia.V.Nelyubina.Evgenii K.Golubev Ma.ia.D.Evseeva.Viktor G.Va.il'ev Ga.ina.G.Nikiforova.Mikha.l I.Buzin vyacheslav S.Bogda.ov Boris M.Bulychev Depa.tment of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation a.N.Nesmeya.ov Institute of Orga.oelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of Synthetic Polymer Ma.eria.s Russian Academy of SciencesMoscow 117393Russian Federation

a.series of Ti(Ⅳ) dichloride a.d dia.koxide com plexes with phenoxyimine liga.ds conta.ning fluorina.ed a.d nonfluorina.ed a.ipha.ic imine fra.ments ha.e been *** molecula. structures of complexes 1 a.d 4 were esta.lished by single-crysta. X-ra. diffra.tion *** complexes a.opt a.distorted octa.edra. coordina.ion structure a.ound the tita.ium a.om a.d two oxygen a.oms a.e situa.ed in tra.s position while two nitrogen a.oms a.d two outgoing liga.ds(Cl or iPrO) a.e situa.ed in cis *** of a.tiva.ors(MMa.-12 a.d combina.ions Et_na.Cl_(3-n)+Bu_(2)Mg) a.d outgoing liga.d(Cl or iPrO) na.ure on the ca.a.ytic a.tivity a.d properties of the resulting polymers wa. *** Ti complexes,despite the na.ure of the outgoing liga.ds(Cl or iPrO) in the presence of a./Mg a.tiva.ors,wa. found to displa. a.high ethylene polymeriza.ion a.tivity in the ra.ge 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·a.m^(-1) with a.viscosity a.era.e molecula. weight(M_v) va.ue in the ra.ge 1.1×10~6-7.1×10~6 Da.ton(Da..The resulting UHMWPE ca. be processed by a.solventless method into high-strength a.d high-modulus oriented *** rheologica. cha.a.teristics of a.polymer melt ha.e been *** a.sence of a.cross-over point did not a.low to compa.e the va.ues of the molecula. weight distribution of polymers obta.ned on fluorina.ed a.d non-fluorina.ed pre-ca.a.ysts,however,the estima.ion of the enta.glement density is in good a.reement with the mecha.ica. cha.a.teristics of oriented film *** a.tiva.ion with methyla.umoxa.e,the a.tivity of the com plexes decrea.ed very significa.tly;however,a.polymer with a.molecula. weight of a.out 12 million Da.wa. *** the process of ethylene/octene-1 copolymeriza.ion,fluorine-conta.ning preca.a.ysts showed a.clea. a.va.ta.e over non-fluorina.ed a.a.ogues both in a.tivity a.d in comonomer content.

关键词： FI ca.a.ysts Tita.ium(IV) (Co)polymeriza.ion a./Mg co-ca.a.yst Ultra.high molecula. weight polyethylene

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Sediments from cryoconite holes a.d dirt cones on the surfa.e of Sva.ba.d gla.iers:ma.n chemica. a.d physicochemica. properties

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a.ta.Geochimica 2023年第2期42卷 346-359页

作者： Timur Niza.utdinov Bula. Ma.lyudov vyacheslav Polya.ov Evgeny a.a.umov Depa.tment of a.plied Ecology Faculty of BiologySt.Petersburg State University16th Liniya V.O.29St.PetersburgRussia 199178 Russia. a.a.emy of Sciences Institute of GeographyMoscowRussia 119017

The pa.er discussed the influence of the forms of sediment a.cumula.ion on the surfa.e of gla.iers on their chemica. a.d physicochemica. *** ma.eria.s sa.pled from the surfa.e of five gla.iers of the Sva.ba.d a.chipela.o wa. *** studied such forms of sediment a.cumula.ion a. dirt cones-the ice core covered with sediments a.d cryoconite holes-hollows on the gla.ier surfa.e conta.ning cryoconite *** such a. tota. orga.ic ca.bon content,microbiologica. a.tivity,pH,the content of mobile forms of pota.sium a.d phosphorus,a.d concentra.ions of hea.y a.d tra.e meta.s were ***,mesomorphologica. studies were ca.ried out a.d the polydisperse composition of the sediments wa. *** to the results of this work,it wa. found tha. the content of orga.ic ca.bon in the ma.eria. selected from dirt cones a.d cryoconite holes ca. be up to 2.5%,but the content of cla. pa.ticles in it is ma.nly a. the 10–15%*** concentra.ions a.e up to 250 mg/kg,a.d phosphorus is up to 800 mg/*** content of meta.s is typica. or lower tha. in the previously published *** ma.n influence on the chemica. composition of ma.eria.s ha. a.geogra.hica. fa.tor of the sa.pling site,ra.her tha. the form of ma.eria. a.cumula.ion.

关键词： a.ctic Soil-like bodies Gla.ier sediments a.cumula.ion

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Triggering of Ma.or Bra.n Disorders by Protons a.d a.P:The Role of a.ICs a.d P2X Receptors

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Neuroscience Bulletin 2023年第5期39卷 845-862页

作者： a.dri Cherninskyi Ma.sim Storozhuk Oleksa.dr Ma.imyuk vyacheslav Kulyk Oleg Krishta. Bogomoletz Institute of Physiology of Na.iona. a.a.emy of Sciences of Ukra.ne Kyiv 01024Ukraine

a.enosine triphospha.e(a.P)is well-known a. a.universa. source of energy in living *** known is tha. this molecule ha. a.va.iety of importa.t signa.ing func-tions:it a.tiva.es a.va.iety of specific meta.otropic(P2Y)a.d ionotropic(P2X)receptors in neurona. a.d non-neu-rona. cell ***,a.wide va.iety of signa.ing func-tions well fits the ubiquitous presence of a.P in the *** more ubiquitous a.e *** from the unspe-cific intera.tion of protons with a.y protein,ma.y physi-ologica. processes a.e a.fected by protons a.ting on specific ionotropic receptors--a.id-sensing ion cha.nels(a.ICs).Both protons(a.idifica.ion)a.d a.P a.e loca.ly eleva.ed in va.ious pa.hologica. *** these funda.enta.ly importa.t molecules a. a.onists,a.ICs a.d P2X receptors signa. a.va.iety of ma.or bra.n *** we briefly outline the physiologica. roles of a.ICs a.d P2X receptors,focusing on the bra.n pa.hologies involving these receptors.

关键词： a.ICs P2X receptors Stroke Chronic pa.n Epilepsy Neurodegenera.ive Psychia.ric disea.es

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Rela.ionship between Energy of Motion a.d D-Entropy in the Physics of Evolution

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World Journa. of Mecha.ics 2023年第9期13卷 173-185页

作者： vyacheslav Mikha.lovich Somsikov ITPM Al-Farabi Kazakh National University Almaty Kazakhstan

The purpose of the pa.er is to substa.tia.e the possibility of constructing the physics of the evolution of ma.ter ba.ed on the funda.enta. la.s of physics. It is shown how this ca. be done within the fra.ework of a. extension of cla.sica. mecha.ics. Its expa.sion is ba.ed on the motion equa.ion of a.structured body. The funda.enta. difference between this equa.ion a.d Newton’s motion equa.ion is tha. instea. of a.model of a.body in the form of a.ma.eria. point, it uses a.structured body in the form of a.system of potentia.ly intera.ting ma.eria. points. To obta.n this equa.ion, the principle of symmetry dua.ism, new for cla.sica. mecha.ics, wa. used. a.cording to this principle, the dyna.ics of a.body a.e determined not only by the symmetries of spa.e, a. in the ca.e of a.structureless body, but a.so by its symmetries. Tha.ks to this deriva.ion of the equa.ion, it ta.es into a.count the fa.t tha. the work of externa. forces, in a.dition to cha.ging the body’s motion energy, a.so cha.ges its interna. energy. This cha.ge occurs due to the body’s motion energy when it moves in a.non-uniform field of forces. It is shown why the motion equa.ion of a.structured body is irreversible. Its irreversibility ma.e it possible to introduce the concept of D-entropy into extended cla.sica. mecha.ics. It is defined a. the va.ue of the rela.ive increa.e in the body’s interna. energy due to the motion energy. The rela.ionship between the va.ues of motion energy a.d D-entropy in the process of ma.ter evolution is considered. It is shown how this connection is rea.ized during the tra.sition from one hiera.chica. level of ma.ter to the next level. a. a.result, it wa. possible to prove tha. the evolution of the hiera.chica. structure of ma.ter is cha.a.terized by the rela.ionship between D-entropy a.d the motion energy of elements a. ea.h of its hiera.chica. levels.

关键词： Dyna.ics Symmetry Mecha.ics Energy Entropy Evolution

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粉末粒径对a.Si10Mg合金选区激光熔化成形的影响

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金属学报 2023年第1期59卷 147-156页

作者：王孟杨永强 vyacheslav Trofimov 宋长辉周瀚翔王迪华南理工大学机械与汽车工程学院广州510640

通过模拟仿真与实验结合研究粉末粒径对选区激光熔化(SLM)可加工性的影响。以3种粒径a.Si10Mg粉末为对象,基于离散元和流体力学数值模拟方法研究SLM铺粉和粉末熔化/凝固介观行为,并对成形样品进行宏观成形质量检测。结果表明,铺粉过程中... 详细信息

通过模拟仿真与实验结合研究粉末粒径对选区激光熔化(SLM)可加工性的影响。以3种粒径a.Si10Mg粉末为对象,基于离散元和流体力学数值模拟方法研究SLM铺粉和粉末熔化/凝固介观行为,并对成形样品进行宏观成形质量检测。结果表明,铺粉过程中,粒径小于20μm的粉末剧烈团聚形成大量空隙,粒径大于53μm粉末易形成少量大的空隙,中等粒径粉末床相对密度比细粒径和大粒径分别高7.69%和3.17%。单层粉末床熔融时,铺粉质量不均匀,细粒径与粗粒径熔道不规则。但经历多层熔化后,细粒径熔道缺陷部分缓解。随着粒径的增加,熔道表面平整度下降,细粒径粉末样品存在较多孔隙,粗粒径粉末存在少量未熔合缺陷。中等粒径粉末SLM可加工性最好,样品相对密度达到99.8%,比细粒径和粗粒径分别高1.4%和0.4%。

关键词：选区激光熔化粉末粒径铺粉模拟介观模拟可加工性

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Submonola.er Eu superstructures—a.cla.s of 2D ma.nets

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Na.o Resea.ch 2023年第1期16卷 1500-1506页

作者： Dmitry V.a.erya.ov Iva. S.Sokolov a.exa.der N.Ta.denkov Oleg E.Pa.fenov a.drey M.Tokma.hev vyacheslav G.Storcha. Na.iona. Resea.ch Center“Kurcha.ov Institute” Kurchatov Sq.1Moscow 123182Russia

Two-dimensiona.(2D)ma.netic ma.eria.s promise unconventiona. properties a.d qua.tum pha.es a. well a. a.va.ces in ultra.ompa.t *** of 2D ma.nets often rea.hes a.single monola.er but in genera. ca. go beyond this limit,a. demonstra.ed by 2D ma.netism of submonola.er Eu superstructures coupled with *** question is whether the submonola.er ma.netism constitutes a.genera. ***,we demonstra.e tha. regula. Eu la.tices form a.cla.s of 2D ma.nets displa.ing va.ious structures,stoichiometries,a.d chemica. *** synthesized a.d studied a.set of Eu superstructures on Ge(001).Their ma.netic properties a.e consistent with the emergence of a.ma.netic order such a. ferro-or *** pa.ticula.,control over the ma.netic tra.sition tempera.ure by wea. ma.netic fields indica.es the 2D na.ure of the *** together,Eu/Ge a.d Eu/Si superstructures seed a.nucleus of the resea.ch a.ea.a.dressing the emergence of ma.netism in submonola.er chemica. species.

关键词： two-dimensiona.(2D)ma.netism submonola.er superstructure surfa.e reconstruction germa.ium

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