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Hepatobiliary system and intestinal injury in new coronavirus infection(COvID-19):A retrospective study

World Journal of Clinical Cases 2023年第10期11卷 2226-2236页

作者： Konstantin v Kozlov Konstantin v Zhdanov Anna K Ratnikova vyacheslav A Ratnikov Artem v Tishkov vladimir Grinevich Yuriy A Kravchuk Panteley I Miklush Polina O Nikiforova vera v Gordienko Alexander F Popov Boris G Andryukov Department of Infectious Disease Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia Department of Admission Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Roentgenology Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Physics Mathematics and InformaticsFSBEI HE IP.Pavlov SPbSMU MOH RussiaSaint-Petersburg 197022Russia 2nd Department of Therapy(Advanced Medical Education) Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia School of Medicine Far Eastern Federal UniversityVladivostok 690922Russia

BACKGROUND An important area of effective control of the coronavirus disease 19(COvID-19)pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection,including those based on assessing the state of the intestinal microbiota and *** To study the clinical features of the new COvID-19 in patients with mild and moderate severity at the stage of hospitalization,to determine the role of hepatobiliary injury,intestinal permeability disorders,and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with *** The study was performed in 80 patients with COvID-19,with an average age of 45 years,19 of whom had mild disease,and 61 had moderate disease *** scope of the examination included traditional clinical,laboratory,biochemical,instrumental,and radiation studies,as well as original methods for studying microbiota and intestinal *** The clinical course of COvID-19 was studied,and the clinical and biochemical features,manifestations of systemic inflammation,and intestinal microbiome changes in patients with mild and moderate severity were *** permeability characteristics against the background of COvID-19 were evaluated by measuring levels of proinflammatory cytokines,insulin,faecal calprotectin,and *** This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COvID-19 severity.

关键词： Novel coronavirus infection COvID-19 SARS-Cov-2 Zonulin Faecal calprotectin Microbiota

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Identifying sex-specific injury predictors as a key factor in maintaining optimal physical activity levels

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World Journal of Orthopedics 2023年第3期14卷 146-154页

作者： Maria v Sankova vladimir N Nikolenko Marine v Oganesyan Andjela D vovkogon Aida N Gadzhiakhmedova Tatyana S Zharikova Yury O Zharikov Department of Human Anatomy and Histology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009Russia Department of Normal and Topographic Anatomy Lomonosov Moscow State UniversityMoscow 119991Russia European Osteopathic Clinical Center of the Moscow Branch of the“Medical Academy of Osteopathic Education” Saint Petersburg 199106Russia Institute of Clinical Medicine I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia

BACKGROUND Optimal physical activity is known to reduce cardiovascular,respiratory and endocrine system diseases and,as a consequence,improve quality of *** important risk factor for reinjuries during normal exercise is the initial connective tissue *** variety of clinical dysplastic manifestations significantly complicate the timely diagnosis of this *** To establish pathognomonic sex-specific dysplasia phenotypes that indicate a particular sensitivity to physical *** The study involved 117 participants with recurrent musculoskeletal injuries that occurred during normal *** were 67 women(57.26%)and 50 men(42.74%),which made it possible to compare the presence of the identified signs between sexes.A validated questionnaire was used to screen their connective tissue *** Ranking the most commonly revealed dysplasia signs depending on their clinical significance made it possible to establish pathognomonic sex-specific phenotypes that indicated a particular susceptibility to *** programs of optimal physical activity are necessary for men with chest deformities,flat-valgus feet,dolichostenomelia,arachnodactylia,hemorrhoids,abdominal muscle diastasis and recurrent *** women,special sensitivity to physical exertion was associated with a combination of signs such as asthenic body,joint hypermobility,overly soft auricles,thin hyperelastic skin,atrophic striae,telangiectasias and varicose *** particular importance were universal signs such as gothic palate,scoliosis,kyphosis,leg deformities,temporomandibular joint crunching,and moderate to high *** Participants’connective tissue condition should be considered when designing optimal physical activity *** the established sex-specific dysplasia phenotypes will allow timely optimization of training loads,thus reducing the risk of injury.

关键词： Injury risk Physical activity Connective tissue condition Sex-specific dysplasia phenotypes Clinical dysplastic manifestations

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Provenance of Precambrian Fe- and Al-rich Metapelites in the Yenisey Ridge and Kuznetsk Alatau, Siberia: Geochemical Signatures

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Acta Geologica Sinica(English Edition) 2007年第3期81卷 409-423页

作者： Igor I. LIKHANOv vladimir v. REvERDATTO Institute of Geology and Mineralogy Siberian Branch Russian Academy of SciencesPr. Acad. Koptyuga3Novosibirsk630090Russian Federation

Major, trace and rare earth element contents of Fe- and Al-rich metapelites from the Korda （Yenisey Ridge） and Amar （Kuznetsk Alatau） formations were determined to examine the nature, origin and evolution of their protoliths. Results indicate that these rocks are the redeposited and metamorphosed products of Precambrian kaolinitic weathering crusts, while the geochemical distinctions between the studied metapelites are determined by different weathering conditions in the source area and tectonic settings. The protolith of the Korda Formation metapelites was produced by erosion products of the post-Archean granitoid rocks, which accumulated under humid climate conditions in shallow-water basins along the continental margin. The geochemical characteristics of the deeper primary deposits of the Amar Formation suggest that volcanogenic material of mafic composition derived from an island-arc environment had a major role in supplying the erosion zone. These results agree with lithofacies data and with the geodynamic reconstruction of the evolution of the Yenisey Ridge and Kuznetsk Alatau during the Mesoproterozoic and Neoproterozoic, respectively. It was shown that REEs had limited mobility during contact metamorphism. The coherent mobility of REEs during collisional metamorphism may be attributed both to mineral reactions responsible for modal changes and to local chemical heterogeneity inherited from the initial protolith.

关键词： geochemistry protolith pelitic schists Kuznetsk Alatau Yenisey Ridge Russia

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Role of the Rossiter-McLaughlin effect in the study of close binaries

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Research in Astronomy and Astrophysics 2019年第3期19卷 21-30页

作者： Galina N.Dryomova vladimir v.Dryomov Russian Federal Nuclear Centre

This paper is devoted to binary stars belonging to the class of eclipsing-variable *** and spectroscopic analysis of eclipses allows us to determine geometric parameters of the orbit and physical characteristics of stellar components as well as inclinations of stellar equators to the orbital plane. Estimations of inclinations can be obtained from measurement of the Rossiter-McLaughlin effect, which is discussed using examples of some eccentric binaries with an anomalous apsidal effect. Our task is to find the complete spectrum of solutions of the equation of apsidal motion, depending on the inclinations of the polar axes of the components to the orbital one for these systems, based on their individual spectroscopic and photometric observational data. The matrix of solutions allows us to select those pairs of polar inclinations that provide agreement with the observational apsidal period.

关键词： Rossiter-McLaughlin effect: eclipsing-variable stars apsidal effect individual binaries: AI Hya,NY Cep,EW Ori,DI Her,AS Cam

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Plasma transport simulation under different conditions and optimization analysis of dual-stage grid ion thruster

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Chinese Journal of Aeronautics 2023年第7期36卷 388-399页

作者： Yajie HAN Guangqing XIA Bin SUN Chang LU Junjun ZHANG vladimir A.SAETCHNIKOv State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China Key Laboratory of Advanced Technology for Aerospace vehicles of Liaoning Province Dalian University of TechnologyDalian 116024China Collaborative Innovation Center of Micro&Nano Satellites of Hebei Province North China Institute of Aerospace EngineeringLangfang 065000China Physics and Aerospace Technology Department Belarusian State UniversityMinsk 220030Belarus

In order to study the extraction and acceleration mechanism of the dual-stage grid,a three-dimensional model based on the Particle-In-Cell/Monte Carlo Collision(PIC/MCC)method is ***-stage grid ion thruster is a new type of electrostatic ion thruster,which can break through the limitations of traditional gridded ion thrusters,and greatly improve the specific *** high performance also makes the grid sensitive to operating *** this paper,the influence of grid parameters on xenon ion thruster’s performance in a wide range is systematically simulated,and the optimal operating condition is *** the over-focusing of the plume,and the transparency of the screen grid are improved,and the grid corrosion is reduced through simulation *** specific impulse under the given working conditions is 9877.24 s and the thrust is 7.28 *** on the simulation optimization,the limitation of the dual-stage grid is *** grid performs well under high voltage conditions(>3000 v)but not well under low voltage conditions(v).Finally,since argon is cheaper and more advantageous in future engineering applications,the plasma distribution and grid extraction ability under xenon and argon are analyzed and compared to study the flexibility of the dual-stage grid ion *** simulation results show that a set of optimal parameters is only applicable to the corresponding propellant,which needs to be optimized for different propellant types.

关键词： 3D modeling Dual-stage grid Ion thruster PIC/MCC method Plasma simulation

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沿阿穆尔板块西边界的活动断层(蒙古领土)

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地学前缘 2022年第1期29卷 245-265页

作者： vladimir A.SANKOv Anna v.PARFEEvETS Andrey I.MIROSHNITCHENKO Aleksey v.SANKOv Amgalan BAYASGALAN Sodnomsambuu DEMBEREL Institute of the Earth’s Crust Siberian Branch of the Russian Academy of SciencesIrkutsk 664033Russia Irkutsk State University Irkutsk 664003Russia Institute of Astronomy and Geophysics of the Mongolian Academy of Sciences Ulaanbaatar 51Mongolia

阿穆尔板块西部边界在蒙古境内的空间位置尚不清楚,并且活动断层构造及其沿线地壳的应力状态研究较少。本文在沿此边界的三个区域——杭爱—肯特构造鞍部、布尔古特地块(鄂尔浑—土拉交汇处)和色楞格地块(包括色楞格凹陷和布伦—努鲁隆... 详细信息

阿穆尔板块西部边界在蒙古境内的空间位置尚不清楚,并且活动断层构造及其沿线地壳的应力状态研究较少。本文在沿此边界的三个区域——杭爱—肯特构造鞍部、布尔古特地块(鄂尔浑—土拉交汇处)和色楞格地块(包括色楞格凹陷和布伦—努鲁隆起),利用空间图像解译、地形起伏度分析、地质构造资料以及构造压裂和沿裂缝位移资料重建构造古应力,对活动断层进行研究。研究表明,活动断裂继承了古生代和中生代古构造的非均质性。这些断层沿着板块边界并不是单一的带,而是成簇的。它们的运动取决于走向:亚纬向断层是具有一定逆分量的左旋走滑断层,北西向断层是逆断层或逆冲断层,通常具有右旋走滑分量,海底断层是右旋走滑断层,北东向断层是正断层。位于色楞格凹陷和杭爱东部的断裂构造的活动始于上新世。逆断层和走滑断层与上新世情况不符,但多与更新世地貌相符,表明其活动年代较晚,为更新世时期。利用构造断裂和沿断裂的位移,重建活动断裂带变形末阶段的应力应变状态,结果表明断裂在最大挤压轴的北北东和北东方向上以压缩和走滑为主。只有在色楞格凹陷内,以扩张和走滑类型的应力张量为主,且在最小挤压轴的北西走向尤为显著。在南部,杭爱东部(鄂尔浑地堑)内有1个以扩张机制为主的局部区域,说明蒙古中部断裂在更新世—全新世阶段的活动以及现代地震活动主要受与印度斯坦和欧亚大陆汇聚过程相关的东北方向的附加水平挤压的控制。使研究区地壳产生走滑变形、贝加尔湖裂谷发散活动以及阿穆尔板块东南运动的另一个因素是东南方向软流圈流动对岩石圈底部的影响。阿穆尔板块和蒙古地块之间的边界在构造结构上是零碎的,代表了覆盖整个蒙古西部变形带的边缘部分。

关键词：活动断层古应力状态断层运动学碰撞的远程效应阿穆乐板块蒙古

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Rapid Multi-Wavelength Optical Assessment of Circulating Blood volume Without a Priori Data

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Photonic Sensors 2016年第1期6卷 42-57页

作者： Ekaterina v. LOGINOvA Tatyana v. ZHIDKOvA Mikhail A. PROSKURNIN vladimir E ZHAROv M. v. Lomonosov Moscow State University Chemistry Department Moscow 119991 Russia Agilent Technologies Partner Laboratory / M.v. Lomonosov Moscow State University Analytical Center Moscow 119991 Russia philips Classic Laser Laboratories University of Arkansas for Medical Sciences Little Rock Arkansas 72205 USA

The measurement of circulating blood volume （CBv） is crucial in various medical conditions including surgery, iatrogenic problems, rapid fluid administration, transfusion of red blood ceils, or trauma with extensive blood loss including battlefield injuries and other emergencies. Currently, available commercial techniques are invasive and time-consuming for trauma situations. Recently, we have proposed high-speed multi-wavelength photoacoustic/photothermal （PA/PT） flow cytometry for in vivo CBv assessment with multiple dyes as PA contrast agents （labels）. As the first step, we have characterized the capability of this technique to monitor the clearance of three dyes （indocyanine green, methylene blue, and trypan blue） in an animal model. However, there are strong demands on improvements in PA/PT flow cytometry. As additional verification of our proof-of-concept of this technique, we performed optical photometric CBv measurements in vitro. Three label dyes--methylene blue, crystal violet simultaneous photometric determination of the and, partially, brilliant green--were selected for components of their two-dye mixtures in the circulating blood in vitro without any extra data （like hemoglobin absorption） known a priori. The tests of single dyes and their mixtures in a flow system simulating a blood transfusion system showed a negligible difference between the sensitivities of the determination of these dyes under batch and flow conditions. For individual dyes, the limits of detection of 3×10-6M-3×10-5M in blood were achieved, which provided their continuous determination at a level of 10-SM for the CBv assessment without a priori data on the matrix. The CBv assessment with errors no higher than 4% were obtained, and the possibility to apply the developed procedure for optical photometric （flow cytometry） with laser sources was shown.

关键词： Circulating blood volume assessment spectrophotometry methylene blue crystal violet

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Arrestins:structural disorder creates rich functionality

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Protein & Cell 2018年第12期9卷 986-1003页

作者： vsevolod v.Gurevich Eugenia v.Gurevich vladimir N.Uversky Department of Pharmacology Vanderbilt UniversityNashvilleTN 37232USA Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute Morsani College of Medicine University of South FloridaTampaFL 33612USA Institute for Biological Instrumentation Russian Academy of SciencesPushchinoMoscow RegionRussia 142290

Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence suggests that conformational flexibility in every functional state is the defining characteristic of arrestins. Flexibility, or plasticity, of proteins is often described as structural disorder, in contrast to the fixed conformational order observed in high-resolution crystal structures. However, protein-protein interactions often involve highly flexible elements that can assume many distinct conformations upon binding to different partners. Existing evidence suggests that arrestins are no exception to this rule: their flexibility is necessary for functional versatility. The data on arrestins and many other multi-functional proteins indicate that in many cases, "order" might be artificially imposed by highly non-physiological crystallization conditions and/or crystal packing forces. In contrast, conformational flexibility (and its extreme case, intrinsic disorder) is a more natural state of proteins, representing true biological order that underlies their physiologically relevant functions.

关键词： EPR GPCR NMR arrestin crystal structure disorder protein-protein interactions

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Sensing Characteristics of Mixed-Potential-Type YSZ-Based NO_x Sensor Using Au-Doped NiO Sensing Electrode

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稀有金属材料与工程 2006年第A3期35卷 36-39页

作者： vladimir v.Plashnitsa Taro Ueda Norio Miura Art Science and Technology Center for Cooperative ResearchKyushu UniversityKasuga-ShiFukuoka 816-8580Japan Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityKasuga-shiFukuoka 816-8580Japan

The nano-structured NiO powder obtained by sol-gel method was doped with 10 wt% gold in order to modify its morphology as well as its electrochemical catalytic *** NO_x sensing characteristics of mixed-potential-type YSZ-based planar sensors attached with each of the nano-NiO and the Au-doped nano-NiO materials as a sensing electrode SE) were examined at temperatures of 700℃～800℃.The Au-doped NiO-SE was found to give a large enhancement in the NO_2 sensitivity as well as the NO_2 selectivity at 800℃under wet condition,in comparison with the pure *** reason for the improvement in the NO_2 sensitivity was examined based on the data of polarization curves,impedance spectra and catalytic activity for the gas-phase NO_2 decomposition.

关键词： NO_x sensor mixed potential NiO nanostructure YSZ Au

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Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening

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World Journal of Gastroenterology 2007年第2期13卷 192-218页

作者： Ekaterina I Galanzha valery v Tuchin vladimir P Zharov Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States

Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed.

关键词：肠系膜血细胞计数显微术药物筛选

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