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Attempts to restore loss of.f.nction in damaged ACD cells open the way to non-mutational oncogenesis

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Genes & Diseases 2024年第3期11卷 5-6页

作者： vladimir f.Niculescu 86420 Diedorf Germany Kirschenweg

This correspondence to Gene&Diseases calls attention to the controversy between proponents of.genetic modif.cation in carcinogenesis and supporters of.non-mutational *** f.om molecular cancer research and f.ndings f.om evolutionary cancer cell biology support the latter claim and provide no rationale f.r the mutational origin of.sporadic *** is more conceivable that the general susceptibility of.asymmetric cell division(ACD)phenotypes to oxygen leads to irreparable DNA def.cts and dysregulated def.ctive symmetric cell division(DscD)phenotypes.

关键词： rational latter f.nding

Green synthesis of.biocompatible Gd^(3+)-doped ultrasmall carbon-based nanohybrids f.om cof.ee wastes

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Carbon Resources Conversion 2024年第2期7卷 64-73页

作者： Konstantin Paliienko Anna Topchylo Sergei Alekseev Alain Géloën Yurii Milovanov Tetiana Lysenko Valeriy Skryshevsky Tatiana Borisova vladimir Lysenko Department of.Neurochemistry Palladin Institute of BiochemistryNational Academy of Sciences of Ukraine9 Leontovicha strKyiv 01054Ukraine Corporation Science Park Taras Shevchenko University of Kyiv60 Volodymyrska Str.Kyiv 01033Ukraine Institute of.High Technologies Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine f.culty of.Chemistry Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine UMR Ecologie Microbienne Lyon(LEM) CNRS 5557INRAE 1418Claude Bernard University of LyonVetAgro SupResearch Team“Bacterial Opportunistic Pathogens and Environment”(BPOE)University of LyonF-69622 VilleurbanneFrance Light Matter Institute UMR-5306Claude Bernard University of Lyon/CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

A cheap method allowing f.brication of.biocompatible,ultra-small(2-10 nm)and f.uorescent(λ_(em)=425-500 nm)nanohybrids(NHs)f.om cof.ee wastes is *** gadolinium-doped nanohybrids(GDNHs)or gadolinium-f.ee carbon dots(Gf.Ds)can be synthesized in a domestic microwave oven according to green synthesis *** sizes,chemical composition,impact on proton magnetic resonance relaxation time and optical properties of.the GDNHs and Gf.Ds were studied in details and *** particular,doping of.the NHs with Gd^(3+)ions,up to 1.87%w/w of.gadolinium per particles’weight,will allow their application f.r magnetic resonance imaging(MRI).f.rthermore,cell culture tests on human adenocarcinomic alveolar basal epithelial cells line(A549)have shown high biocompatibility of.the GDNHs and in a wide concentration range 100-1000μg/ml.

关键词： Carbon dots f.om cof.ee waste Carbon dots f.r MRI Gadolinium-doped carbon dots Microwave-assisted synthesis

Hetero-integrated high-peak-optical-power laser source (940 nm) f.r time-of.f.ight sensors

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Chinese Optics Letters 2024年第7期22卷 81-85页

作者： Sergey Olegovich Slipchenko Aleksandr Aleksandrovich Podoskin Ilia Vasil'evich Shushkanov Marina Gennad'evna Rastegaeva Artem Eduardovich Rizaev Matvey Igorevich Kondratov Artem Evgen'evich Grishin Nikita Aleksandrovich Pikhtin Timur Anatol'evich Bagaev Maxim Anatol'evich Ladugin Aleksandr Anatol'evich Marmalyuk vladimir Aleksandrovich Simakov Iof.e Institut Russian Academy of SciencesSt.Petersburg 194021Russia Open Joint-Stock Company M.f.Stel’makh Polyus Research Institute Moscow 117342Russia RUDN University Moscow 117198Russia

The generation of.high-power laser pulses using a compact hetero-integrated assembly based on a semiconductor laser with a dual-element composite 2μm×100μm aperture and a compact heterothyristor switch is *** achieved peak optical power was 33 W with a pulse duration of.3 ns at a thyristor operating voltage of.55 *** leading edge of.the laser pulse turn-on was 50 ps to a power level of.24.7 W,and the turn-on delay between the elements of.the composite aperture was 160 ps.

关键词： hetero-integrated assembly semiconductor lasers thyristor switches LIDAR gain-switching mode laser heterostructure

A comment on the article of.Zoran Ivanovic and Marija Vlaski-Laf.rge(2022):On cancer,stemness and deep evolutionary homologies

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Genes & Diseases 2023年第4期10卷 1139-1140页

作者： vladimir f.Niculescu Kirschenweg 1 Diedorf 86420Germany

The comment of.Ivanovic and Vlaski-Laf.rge on my article“Cancer genes and cancer stem cells in tumorigenesis:Evolutionary deep homology and controversies”opens up a welcome discussion on the evolutionary history of.*** authors have appreciative words about my work,f.r which I am very *** this point,I would like to contribute a f.w words on polyploidy,cancer genes,age,and colonial organization.

关键词： cancer Cancer evolutionary

Cancer genes and cancer stem cells in tumorigenesis:Evolutionary deep homology and controversies

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Genes & Diseases 2022年第5期9卷 1234-1247页

作者： vladimir f.Niculescu Kirschenweg 1 Diedorf 86420Germany

In the past,contradictory statements have been made about the age of.cancer *** phylostratigraphic studies suggest that cancer genes emerged during the transitional period f.om unicellularians(UC)to early metazoans(EM),lif. cycle studies suggest that they arose *** controversy could not be *** methods use data f.om somatic tumor gene collections containing or lacking polyploidy genes(PGCC genes)and compare them to genes f.om evolutionary node taxa.I analyze whether the selected taxa are suitable to resolve the above contradiction or *** cancer and amoebae lif. cycles have a reproductive asexual germline that produces germline stem cells(GSCs)and somatic cell lines that *** the germline loses its reproductive f.nction,the soma-to-germ transition f.rms a new reproductive *** reproductive polyploidy of.cancer is homologous to the reproductive polyploidy of.unicellular *** repair DNA def.cts,reorganize the involved genome architecture and produce new *** present study ref.tes the dogma of.the early metazoan origin of.*** has a unicellular lif. cycle that was adopted by early metazoans to rescue themselves f.om evolutionary dead *** metazoans controlled the unicellular lif. cycle through suppressor and anti-suppressor genes that could suspend or reactivate *** are the archetypes of.tumor suppressor genes and *** of.mammalians and humans that reach a similar impasse as early metazoans can reactivate the conserved lif. cycle of.unicellularians.

关键词： Cancer Entamoeba Gene age Lif. cycle Polyploidy CSCs EMT PGCC

Cancer exploits a late premetazoan gene module conserved in the human genome

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Genes & Diseases 2023年第4期10卷 1136-1138页

作者： vladimir f.Niculescu Kirschenweg 1 Diedorf 86420Germany

f.om an evolutionary perspective,the human cancer genome is based on an ancient gene module developed by the common ancestor of.the Amoebozoa,Metazoa,and f.ngi(AMf..^(1)The transition phase to multicellularity(premetazoan period)was a rather long period of.evolu-tionary attempts and *** this time,suppressor genes were evolved to deactivate the G+S cell system inherited f.om the AMf.ancestor.

关键词： ancient evolved Cancer

Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of.Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev vladimir A.Chernyshev Aleksandr S.Aleksandrovsky Alexander S.Krylov Svetlana N.Krylova Nikolai P.Shestakov Dmitriy A.Velikanov Alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Saf.n Laboratory of.Theory and Optimization of.Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of.Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of.Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of.Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of.Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of.Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute f.r Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientif.c and Educational and Innovation Center f.r Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of.Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the f.brication of.which has been a challenge until this *** structure of.the reported selenide was elucidated f.om the powder X-ray dif.raction data,which revealed the f.rmation of.EuCeCuSe3with excellent yield(96.7%)accompanied with a minor f.action of.CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of.the title compound completes the row of.the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of.which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of.the CuSe4polyhedron was compared f.r the whole series of.EuRECuSe3compounds using theτ4-descriptor f.r f.ur coordinated ions,which revealed the highest degree of.distortion f.r the Ce3+-containing selenide,f.llowed by the La3+-based ***,the crystallographic and geometrical parameters of.the reported selenide were discussed in comparison to the Ce3+-based sulf.des SrCeCuS3and *** initio calculations of.the crystal structure,a phonon spectrum and elastic constants f.r the crystal of.EuCeCuSe3were also *** types and wavenumbers of.f.ndame ntal modes were determined and the involvement of.ions participating in the phonon modes was *** experimental IR spectrum of.the reported selenide was interpreted and f.und to be in agreement with the calculated *** experimental direct band gap of.EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of.its origin due to interband transitions between orbitals emerging mainly f.om 4f.valence band)and 5d(conduction band)levels of.the Eu2+*** dependence of.the Young’s modulus on the direction demonstrates the anisotropy of.the elastic properties,while the Vickers hardness f.r EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

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中红外大模场单模全固态硫系光子晶体光纤

中国激光 2024年第17期 248-256页

作者：李宁哲贾金升张敏王煜泽肖峰黄庆白胜闯 vladimir Shiryaev 戴世勋聂秋华王训四宁波大学信息科学与工程学院高等技术研究院红外材料与器件实验室浙江省光电探测材料及器件重点实验室俄罗斯科学院高纯物质化学研究所宁波海洋研究院

针对当前硫系光纤难以同时实现高功率传输与高光束质量的问题，通过COMSOL软件仿真模拟光纤性质，设计出了满足单模传输需要且具有大模场面积的光子晶体光纤（PCf.的结构参数。所设计的光纤在1.5～10μm的波长范围内满足高阶模(LP11)... 详细信息

针对当前硫系光纤难以同时实现高功率传输与高光束质量的问题，通过COMSOL软件仿真模拟光纤性质，设计出了满足单模传输需要且具有大模场面积的光子晶体光纤（PCf.的结构参数。所设计的光纤在1.5～10μm的波长范围内满足高阶模(LP11)与基模(LP01)的限制损耗比大于10～2的单模条件，且光纤基模的有效模面积在波长2μm处约为5362μm2。根据仿真模拟的结构参数，探索出新型动、静态蒸馏相结合的技术，制备出高纯硫系玻璃，结合新型的挤压-堆积法，制备出基于全硫系玻璃的全固态大模场单模光子晶体光纤。该光纤在波长1.55μm处的近高斯光能量分布特征验证了其单模特性；同时在弯曲半径为14 cm的1.5 m长的光纤中观察到低弯曲损耗为1 dB，与仿真结果基本一致，表明此全固态光子晶体光纤具有出色的单模传输和抗弯性能，在中红外高能激光传输方面具备一定的应用潜能。

关键词：光纤光学中红外全固态光子晶体光纤硫系玻璃大模场面积单模传输

20%PEG胁迫下评价引进哈萨克斯坦不同春小麦种质苗期的抗旱性

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新疆农业科学 2024年第6期61卷 1352-1360页

作者：王一钊杨其志刘玉秀阿拉依·努尔卡马力 vladimir Shvidchenko 张正茂西北农林科技大学农学院陕西杨凌712100 哈萨克斯坦赛福林农业技术大学阿斯塔纳010000

【目的】研究引进哈萨克斯坦不同春小麦种质的萌发和生理特性,为选育适宜我国西北旱区春小麦品种提供亲本材料。【方法】采用20%聚乙二醇(polyethylene glycol,PEG)高渗溶液模拟干旱胁迫条件,比较分析28份小麦种质(其中引进哈萨克斯坦... 详细信息

【目的】研究引进哈萨克斯坦不同春小麦种质的萌发和生理特性,为选育适宜我国西北旱区春小麦品种提供亲本材料。【方法】采用20%聚乙二醇(polyethylene glycol,PEG)高渗溶液模拟干旱胁迫条件,比较分析28份小麦种质(其中引进哈萨克斯坦春小麦种质25份)苗期的根长、苗长、根鲜/干重、苗鲜/干重、发芽率、发芽势及发芽指数的变化,利用隶属函数、主成分分析综合评价不同春小麦种质苗期抗旱性。【结果】与对照相比,干旱胁迫显著降低种质苗期的根长、苗长、根鲜重、苗鲜/干重、发芽势和发芽率(P<0.05),降低幅度为18.29%~52.17%;显著增加根干重(P<0.05),平均增加了66.67%。各性状间存在不同程度的相关性,大多数性状抗旱系数间存在显著或极显著相关。9个小麦苗期抗旱相关指标可转换为4个(苗鲜/干重、苗长和发芽率)独立的综合指标可作为哈萨克斯坦春小麦苗期耐旱性评价的主效指标。28份供试材料的加权抗旱指数进行聚类分析,5份为抗旱性强种质,17份为抗旱性种质,6份为抗旱性弱种质。【结论】25份引进哈萨克斯坦春小麦种质中有5份种质,苗期具有较强的萌发特性和抗旱能力,适宜在我国西北旱区春小麦育种中提供抗旱亲本材料。

关键词：春小麦引种种质苗期抗旱性隶属函数