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Postoperative complications of colectomy and J- pouch with ileostomy versus without ileostomy in children with inflammatory bowel diseases: a systematic review and meta- analysis

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World Journal of Pediatric Surgery 2022年第2期5卷 38-45页

作者： Irina Oltean Nicole Travis Manvinder Kaur viviane Grandpierre Lamia Hayawi Anne Tsampalieros Ahmed Nasr Department of Surgery Children's Hospital of Eastern OntarioOttawaOntarioCanada Children's Hospital of Eastern Ontario Research Institute Clinical Research UnitOttawaOntarioCanada University of Ottawa OttawaOntarioCanada

Background The efficacy of performing a restorative proctocolectomy and J-pouch ileoanal anastomosis without diverting ileostomy in children with inflammatory bowel disease has been a longstanding debate.A systematic review and meta-analysis is presented comparing the occurrence of postoperative complications in children who underwent either the pouch-anal anastomosis(IPAA)with ileostomy(diverted)versus the undiverted *** Records were sourced from CINAHL,CENTRAL,EMBASE and MEDLINE *** followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and compared postoperative complications in pediatric patients diagnosed with inflammatory diseases aged less than 18 years who underwent J-pouch with ileostomy versus without *** primary outcome was the occurrence of postoperative leaks,and the secondary outcomes were presence of postoperative small bowel obstruction(SBO),pouchitis,stricture and fistula complications.A random-effects meta-analysis was *** Twenty-three observational studies in the systematic review were included with 658 patients(83%diverted,17%undiverted).Pooled estimates showed no difference in occurrence of leaks in children who underwent J-pouch/IPAA with ileostomy versus without(odds ratio(OR)0.54,95%confidence interval(CI)0.17 to 1.64,I^(2)=16%).There was no difference in the occurrence of SBO,pouchitis or strictures in children who underwent J-pouch/IPAA with ileostomy versus without(SBO:OR 2.27,95%CI 0.52 to 9.92,I^(2)=0%,pouchitis:OR 1.76,95%CI 0.95 to 3.24,I^(2)=0%,strictures:OR 2.72,95%CI 0.44 to 16.69,I^(2)=66%).Conclusion The meta-analysis did not find differences in the occurrence of complications in pediatric patients who underwent the IPAA with ileostomy procedure versus without ileostomy.

关键词： complications bowel diseases

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Evolution of sexual size dimorphism and its relationship with sex ratio in carabid beetles of Genus Ceroglossus Solier

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Current Zoology 2013年第6期59卷 769-777页

作者： Hugo A. BENITEZ Jorge AVARIA-LLAUTUREO Cristian B.CANALES-AGUIRRE viviane JEREZ Luis E. PARRA Cristifin E.HERNANDEZ Faculty of Life Sciences University of Manchester Michael Smith Building Oxford Road Manchester M13 9PT UK Instituto de Alta Investigaci6n Universidad de Tarapaca Casilla 7-D Arica Chile Departamento de Zoologia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepcion Casilla 160-C Concepcion Chile Departamento de Oceanografia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepci6n Casilla 160-C Concepcion Chile

Although the degree of mate competition, given extreme differences in sex ratio, explains much of the pattern of male-biased size dimorphism among diverse taxa, it fails for some species which have potential for intense male competition for mates and yet exhibit little or no sexual size dimorphism （SSD）. This fact suggest that species with low SSD should be express the effect of evolutionary pressure in non-obvious geometrical shape promoted by sex ratio in an evolutionary time scale. To evaluate this hypothesis we used phylogenetic comparative method in a Bayesian framework to investigate the evolution of SSD and the role of sex ratio at inter-specific level in the species of Ceroglossus （Coleoptera： Carabidae）. In our results the proportion farthest from 1：1 is associated with more disparate body shape, even though the entire group has minimum variation in sex ratio, which is an intrinsic life history character of this group considering its phylogenetic conservatism or phylogenetic signal. We suggest that the sex ratio has determined the dimorphism degree during evolution of this group, since both traits have increased or decreased together during the species divergence （i.e. positive phylogenetic correlation： r2=0.85）. We suggest that morphological studies of SSD will benefit from using comparative method with Bayesian approaches to assess the effect of phylogenetic history and its uncertainty. Finally, this will be allow to researchers to quantify the uncertainty of specific evolutionary hypotheses accounting for observed sexual dimorphism patterns.

关键词： Macroevolution Geometric Morphometrics Bayesian approach Sexual Dimorphism Sex Ratio Ceroglossus

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A NEW REGULARITY CLASS FOR THE NAVIER-STOKES EQUATIONS IN IR^n

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Chinese Annals of Mathematics,Series B 1995年第4期16卷 407-412页

作者： H. BEIRaO DA veiga (Department of Mathematics, Pisa University, Pisa, Italy) Pisa University 意大利

Consider the Navier-Stokes equations in IRn×(0, T), for n≥3. Let 1 < a≤min{2, n/(n-2)} and define β by (2/a)+ (n/β) = 2. Set α′= α/(α-1). It is proved that Dv belongs to C(0, T; Lα′) ∩ Lα′ (0, T; L2β/(n-2)) whenever Dv ∈ Lα(0, T; Lβ). In pwticular, v is a regular solution. This results is the natural extensinn to α ∈ (1, 2] of the classical sufficient condition that establishes that Lα(0, T; Lγ) is a regularity class if (2/α)+(n/γ) = 1. Even the borderline case α = 2 is significat. In fact, this result states that L2(0, T; W1,n) is a regularity class if n≤ 4. Since W1,n→L∞ is false, this result does not follow from the classical one that states that L2(0, T; L∞) is a regularity class.

关键词： Navies-Stokes equation Regularity of solution Extension.

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Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

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Journal of Pharmaceutical Analysis 2019年第3期9卷 143-155页

作者： A.R. Pinho A. Fortuna A. Falcao A.C. Santos R. Seia C. Estevens F. veiga A.J. Ribeiro Laboratory of Pharmaceutical Technology Faculty of Pharmacy University of Coimbra Polo das Ci^encias da Saúde Azinhaga de Santa Comba 3000-548 Coimbra Portugal Laboratory of Pharmacology Faculty of Pharmacy University of Coimbra Polo das Ci^encias da Saúde Azinhaga de Santa Comba 3000-548 Coimbra Portugal CNC e Centre for Neuroscience and Cell Biology University of Coimbra 3004-517 Coimbra Portugal REQUIMTE/LAQV Group of Pharmaceutical Technology Faculty of Pharmacy University of Coimbra Polo das Ci^encias da Saúde Azinhaga de Santa Comba 3000-548 Coimbra Portugal Laboratory of Physiology IBILI Faculty of Medicine University of Coimbra Polo das Ci^enicas da Saúde Azinhaga de Sante Comba 300-548 Coimbra Portugal Pharmaceutical Development TECNIMEDE S. A. Quinta da Cerca Caixaria 2565-187 Dois Portos Portugal I3S Instituto de Investiga鐍ao e Inova鐍ao em Sa鷇e Group Genetics of Cognitive Dysfunction IBMC e Instituto de Biologia Molecular e Celular Rua do Campo Alegre 823 4150-180 Porto Portugal

The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse effects or toxicity. Therefore, it is required to develop several quantification methods for GLP-1 analogs products, in order to achieve the therapeutic goals, among which ELISA and HPLC arise. These methods are developed, optimized and validated in order to determine GLP-1 analogs, not only in final formulation of the active pharmaceutical ingredient, but also during preclinical and clinical trials assessment. This review highlights the role of ELISA and HPLC methods that have been used during the assessment for GLP-1 analogs, especially for exenatide.

关键词： Type 2 diabetes Exenatide Therapeutic drug monitoring ELISA HPLC

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Radiographic and tomographic description of marlin sucker Remora osteochir, Pisces: Echeneidae—preliminary data of one specimen

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Marine Life Science & Technology 2020年第3期2卷 246-251页

作者： AndréLuiz veiga Conrado Renata Stecca lunes Carlos Eduardo Malavasi Bruno Aline Tiemi Shiraishi Rocha JoséRoberto Machado Cunha da Silva Laboratory of Evolutive Histophysiology Department of Cell and Developmental BiologyInstitute of Biomedical SciencesUniversity of Sao PauloAvenida ProfLineu Prestes1524Cidade UniversitariaSao Paulo 05508-000Brazil Laboratory of Immunological Techniques Applied to Morphophysiology School of Veterinary Medicine and Animal ScienceDepartment of SurgeryUniversity of Sao PauloAvenida Prof.Di.Orlando Marques de Paiva87.Cidade UniversitariaSao Paulo 05508-270Brazil

Remoras are commensal fish of various marine species,such as sharks,swordfishes,turtles,dolphins,manta rays and *** specimen of marlin sucker Remora osteochir was evaluated using computed tomography for skeletal digital reconstruction,digital radiology for general evaluation and bone counting,and the double contrast technique to distinguish coelomic *** radiographic images,it was possible to observe otoliths in the center of the neurocranium,to count 27 vertebrae,nine pairs of ribs,and to detect the presence of the hipural and epural bones near of the caudal *** double contrast images,it was possible to visualize the swim bladder,gills,heart,liver,stomach and *** the tomographic images and reconstructions,it was possible to identify the intercalar bones of the cephalic disc;the spine with vertebral bodies composed of neural arches and ventral ribs;and the pectoral girdle formed by posttemporal,cleithrum and scapulocoracoid *** was concluded that digital radiology and computed tomography were able to describe anatomical structures of marlin sucker *** without the need for dissection.

关键词： Teleost fish Double contrast Computed tomography Digital radiology Skeleton

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Pd-TiO_(2)/C催化剂中TiO_(2)对直接碱性燃料电池中丙三醇氧化的影响

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燃料化学学报 2022年第4期50卷 474-483页

作者： viviane Santos Pereira Júlio Nandenha Andrezza Ramos Almir Oliveira Neto Instituto de Pesquisas Energéticas e Nucleares-IPEN-CNEN/SP Centro de Células a Combustível e Hidrogênio-CECCO Cidade UniversitáriaSão Paulo-SP 05508-000Brasil

以Vulcan XC-72炭为载体,采用硼氢化钠还原法制备了Pd-TiO_(2)/C电催化剂用于直接丙三醇燃料电池阳极材料,并用能量色散谱(EDX)、X射线衍射(XRD)、透射电子显微镜(TEM)、循环伏安法(CV)、计时电流法(I-t)和全反射-傅里叶变换红外光谱(AT... 详细信息

以Vulcan XC-72炭为载体,采用硼氢化钠还原法制备了Pd-TiO_(2)/C电催化剂用于直接丙三醇燃料电池阳极材料,并用能量色散谱(EDX)、X射线衍射(XRD)、透射电子显微镜(TEM)、循环伏安法(CV)、计时电流法(I-t)和全反射-傅里叶变换红外光谱(ATR-FTIR)对催化剂进行了表征。EDX结果表明,Pd-TiO_(2)/C中Pd和Ti含量接近名义原子比。Pd-TiO_(2)的X射线衍射结果表明,Pd具有面心立方fcc结构,同时TiO_(2)展现出四方结构的锐钛矿相的峰特征。TEM图像显示Pd和TiO_(2)纳米颗粒在碳载体中分布均匀并存在一些簇状区域,纳米颗粒大小为7.0-8.0 nm。循环伏安显示在1 mol/L KOH电解液中催化剂Pd-TiO_(2)/C在约-0.7 V vs Ag/AgCl有明显的析氢行为和电容增加现象,表明催化剂在TiO_(2)修饰后活性明显增加。通过循环伏安对碱性体系的丙三醇电催化氧化表明,Pd-TiO_(2)/C(70∶30)显示了非常好的催化活性:起始氧化电位也变得更负达到-0.4V vs Ag/AgCl,氧化电流达到14.91 mA/cm,优于Pd-TiO_(2)/C(90∶10)的9.37 mA/cm和Pd-TiO_(2)/C(50∶50)的4.88 mA/cm,明显高于Pd/C和TiO_(2)/C的1.88和0.55 mA/cm。I-t实验表明1000 s之前Pd-TiO_(2)/C展现出最高的电流密度,但在1000 s后电流密度有一定程度的下降,表明催化剂的催化活性很高但长期稳定性方面需要进一步提升。在碱性直接丙三醇燃料电池中进行的实验表明,所制备的Pd-TiO_(2)/C(50∶50)、Pd-TiO_(2)/C(70∶30)和Pd-TiO_(2)/C(90∶10)对甘油的电化学氧化性能均优于Pd/C电催化剂,其中,Pd-TiO_(2)/C(70∶30)的催化活性最好:开路电压达到817 mV,最大功率密度达到12.5mW/cm,高于Pd-TiO_(2)/C(50∶50)的12.4mW/cm、Pd-TiO_(2)/C(90∶10)的7.9mW/cm、Pd/C的3.7mW/cm以及TiO_(2)/C的2.25 mW/cm,这表明,TiO_(2)对Pd/C催化剂有很好的促进作用,这种协同效应可以归因为TiO_(2)对Pd的电子效应和双功能机理,同时Pd和TiO_(2)比例为70∶30时,其催化性能达到最优。ATR-FTIR结果表明,反应后所有Pd-TiO_(2)/C电催化剂表面均有甘油醛、羟丙酮酸、甲酸等高附加值产物生成,为直接丙三醇燃料电池电-化学品联产提供一定的依据。

关键词：丙三醇氧化 Pd-TiO_(2)电催化剂原位ATR-FTIR 循环伏安碱性燃料电池

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Time-dependent impact of a high-fat diet on the intestinal barrier of male mice

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World Journal of Methodology 2024年第1期14卷 114-123页

作者： Carolline Santos Miranda Daiana Araujo Santana-Oliveira Isabela Lopes Vasques-Monteiro Nathan Soares Dantas-Miranda Jade Sancha de Oliveira Glauser Flavia Maria Silva-veiga Vanessa Souza-Mello Department of Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil

BACKGROUND Excessive saturated fat intake compromises the integrity of the intestinal mucosa,leading to low-grade inflammation,impaired mucosal integrity,and increased intestinal permeability,resulting in the migration of lipopolysaccharide(LPS)to other *** To evaluate the chronic effects(at 10 and 16 wk)of a high-fat diet(HFD)(with 50%energy as fat)on the phylogenetic gut microbiota distribution and intestinal barrier structure and protection in C57BL/6 *** Forty adult male mice were divided into four nutritional groups,where the letters refer to the type of diet(control and HFD or HF)and the numbers refer to the period(in weeks)of diet administration:Control diet for 10 wk,HFD for 10 wk,control diet for 16 wk,and HFD for 16 *** sacrifice,biochemical,molecular,and stereological analyses were *** The HF groups were overweight,had gut dysbiosis,had a progressive decrease in occludin immunostaining,and had increased LPS *** progression reduced the number of goblet cells per large intestine area and Mucin2 expression in the HF16 group,consistent with a completely disarranged intestinal ultrastructure after 16 wk of HFD *** Chronic HFD intake causes overweight,gut dysbiosis,and morphological and functional alterations of the intestinal barrier after 10 or 16 ***-dependent reductions in goblet cell numerical density and mucus production have emerged as targets for countering obesity-driven intestinal damage.

关键词： High-fat diet Intestine Ultrastructure Goblet cells Gut microbiota

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Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study

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Neural Regeneration Research 2021年第5期16卷 805-812页

作者： viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da Silva ThaynáWeiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio Curso de Fisioterapia do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of ***,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these *** exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different ***,little is reported on this in post-stroke *** purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke *** this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and *** intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone *** was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES *** intervention,a better cognitive performance was found in both groups compared with before the *** intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone *** addition,the intervention induced lower levels of lipid *** intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the

关键词： cognition epigenetic exercise functional electrical stimulation functional mobility oxidative stress stroke WalkAide

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New flavan and unusual chalcone glycosides from Drypetes parvifolia

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Chinese Chemical Letters 2008年第8期19卷 943-946页

作者： viviane Nadège Nenkep Jovita Chi Shirri Hanh Trinh Van-Dufat Falindor Sipepnou Philippe Vérité Elisabeth Seguin Francois Tillequin Jean Wandji Department of Organic Chemistry University of Yaounde-1Faculty of ScienceP.O.Box 812YaoundeCameroon Laboratoire de Pharmacognosie de l'Université Paris Descartes UMR/CNRS N 8638Faculté des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance Laboratoire de Chimie Analytique UFR de Médecine Pharmacie Rouen22-Bid Gambetta76183 Rouen Cedex 1France Laboratoire de Pharmacognosie UFR de Médecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

Two new compounds 7-hydroxy-5-O-（β-D-glucopyranoside） flavan （1） and （Z）-4＇,6＇-dihydroxy-2＇-O-（β-D-glucopyranoside） chalcone （2）, along with eight known compounds, were isolated from the stem bark of Drypetes parvifolia （Euphorbiaceae）. Their structures were established on the basis of spectroscopic analysis and chemical evidence.

关键词： Drypetes parvifolia Flavonoid glycosides 7-Hydroxy-5-O-(β-D-glucopyranoside) flavan (Z)-4',6'-Dihydroxy-2'-O-(β-D-glucopyr-anoside) chalcone

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CONCERNING TIME-PERIODIC SOLUTIONS OF THE NAVIER-STOKES EQUATIONS IN CYLINDRICAL DOMAINS UNDER NAVIER BOUNDARY CONDITIONS

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Journal of Partial Differential Equations 2006年第4期19卷 369-376页

作者： H. Beirāo da veiga Department of Applied Mathematics The University of Pisa Italy

The problem of the existence of time-periodic flows in infinite cylindrical pipes in correspondence to any given, time-periodic, total flux, was solved only quite recently in [1]. In this last reference we solved the above problem for flows under the non-slip boundary condition as a corollary of a more general result. Here we want to show that the abstract theorem proved in [1] applies as well to the solutions of the well known slip （or Navier） boundary condition （1.7） or to the mixed boundary condition （1.14）. Actually, the argument applies for solutions of many other boundary value problems. This paper is a continuation of reference [1], to which the reader is referred for some notation and results.

关键词： Flows in pipes time-periodic poiseuiUe slip boundary conditions.

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