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中国蜂业 2024年第5期75卷 49-51页

作者：罗照明(编译) 孟丽峰(编译) 中国蜂产品协会北京100050 中国农业科学院蜜蜂研究所北京100093

一、引言过去几年,由于消费者需求旺盛,基于蜂胶的新专利和天然产品逐步增加。目前,全球各大洲已有超过4500项注册的蜂胶专利。对于一个天然产品来说,这是相当大量的专利,尤其是考虑到全球范围内对此类专利的激励措施直到上世纪90年代... 详细信息

一、引言过去几年,由于消费者需求旺盛,基于蜂胶的新专利和天然产品逐步增加。目前,全球各大洲已有超过4500项注册的蜂胶专利。对于一个天然产品来说,这是相当大量的专利,尤其是考虑到全球范围内对此类专利的激励措施直到上世纪90年代末才开始出现。涉及蜂胶专利数量之多,不仅是因为市场增长所致,还与对这种天然产品的研究增加、生产和技术进步有关。

关键词：蜂胶激励措施专利分布全球范围专利数量消费者市场

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Brazilian adolescents’lifestyle in the COVID‑19 pandemic:a mixed‑methods study

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World Journal of Pediatrics 2022年第8期18卷 553-557页

作者： Caroline lima Fonseca Carolina Ferreira Peterle Bruna Hinnah Borges Martins de Freitas Maria Aparecida Munhoz Gaíva Paula Manuela Jorge Diogo Juliano Bortolini Federal University of Mato Grosso 2367 Fernando Corrêa da Costa AvBoa EsperançaCuiabáMT 78060-900Brazil Lisbon College of Nursing LisbonPortugal

The COVID-19 pandemic has forced the health authorities and governments worldwide to engage in a battle against the disease,adopting several mitigation strategies[1].Since then,the world population has been afected by various changes in its *** imposed by the COVID-19 pandemic are believed to have had an impact on adolescents'lifestyle(LS)[2].The LS is determined by discernible behavior patterns that can trigger efects on adolescents'health and is related to countless aspects that refect attitudes,values and life opportunities[3].Therefore,LS can be observed from the habits,behaviors and activities performed by people in their daily lives[4].

关键词： has routine COV

An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros lima Wu Hong Kwong Antonio José Goncalves Cruz Chemical Engineering Graduate Program Federal University of Sao Carlos department of Chemical Engineering department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

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Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

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Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz Henrique Medeiros Geraldo Tania Cristina Leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina Carvalho da Fonseca Celina Garcia Fabio de Almeida Mendes Catarina Freitas Marcos Fabio dosSantos Flavia Regina Souza lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro Paulo Niemeyer-Secretaria de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

Osmoregulators in Hymenaea courbaril and Hymenaea stigonocarpa under water stress and rehydration

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Journal of Forestry Research 2018年第6期29卷 1475-1479页

作者： Luma Castro de Souza Luana Moraes da Luz Je′ssica Taynara da Silva Martins Candido Ferreira de Oliveira Neto Juscelino Goncalves Palheta Tamires Borges de Oliveira Ediane Conceicao Alves Risely Ferraz de Almeida Raimundo Leonardo lima de Oliveira Roberto Cezar Lobo da Costa Nariane Quaresma Vilhena Universidade estadual paulista ju′lio de mesquita filho JaboticabalSP 14884-900Brazil Universidade Federal Rural da Amazonia(UFRA) Campus CapanemaCapanema 68700-030Brazil Universidade Federal Rural da Amazonia Campus BelemBelem 66077-830Brazil Universidade Federal de Vicosa(UFV) Vicosa 36570-900Brazil Universidade Estadual Paulista Ju′lio de Mesquita Fiho(UNESP) Jaboticabal 14884-900Brazil Universidade do Estado do Para′(UEPA) Bele′m 66113-200Brazil

The objective of this work was to evaluate the effect of different water deficiency and rehydration levels on the concentrations of osmoregulators in two plant species（Hymenaea courbaril and H. Stigonocarpa） in the Amazon. We adopted a 2×5×5 factorial system,referring to 2 species（H. courbaril and H. stigonocarpa）and 5 stages of hydration and rehydration. The five hydration and rehydration stages were established in:（1）Control treatment E0;（2） Plants with 13 days of stress after incubation—E13;（3） Plants with 26 days of stress E26;（4）The plants that were established after 26 days after incubation and rehydrated for two days（RD2）;（5） rehydrated for two days（RD4）. The plants that were established after 26 days after incubation and rehydrated for four days. The experiment totaled fifty young plants with five *** measurements were performed at the beginning of the experiment（E0） at 13（E13） and 26（E26） days after the water stress, in which the plants were rehydrated,repeating the analyses after two（RD2） and four（RD4）days. Both species increased the sucrose concentration by18%, with a decrease of 52% in starch content. The RD4 time presented the highest mean starch concentration(0.19 mmol g-1 of the residue for H. courbaril and0.27 mmol g;of residue for H. stigonocarpa). Increased proline concentrations were recorded for controls until RD2 for both species. For glycine betaine, the highest increases in treatments E26 and RD2 were observed for the H. courbaril species. Our rehydration period was not sufficient for total recovery of pre-stress concentrations of all studied solutes.

关键词： Amazonia Water stress Osmotic adjustment Proline Sucrose

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Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros lima Antonio Jose Goncalves Cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

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Vibration Control of a Gym Floor Using Tuned Mass Dampers: A Numerical Analysis

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Modern Mechanical Engineering 2013年第3期3卷 9-16页

作者： Marcos Daniel Souza dos Santos Daniel Valenca Fiuza lima Jorge Eliécer Campuzano Carmona Suzana moreira Avila Graciela Nora Doz de Carvalho departamento de Engenharia Civil e Ambiental Faculdade de TecnologiaUniversidade de BrasiliaBrasiliaBrasil

This work presents a study on excessive vibration problem occurring on concrete slabs, usually used on residential and commercial building floors. Even well designed slabs, according to ultimate and serviceability limit states criteria, can be vulnerable to undesirable vibrations that lead to user discomfort. A gym floor, that presented real excessive vibrations, located in a commercial building situated in the city of Brasilia,Brazil, was analyzed via Finite Element Method using ANSYS software. The first step in this analysis was to obtain natural frequencies and vibration modes, the structure presented low natural frequencies representing its flexible behavior. Then it was simulated a dynamic loading of people jumping, characteristic of this type of building occupation. Since it was observed the occurrence of excessive vibrations also in the numerical analysis, a Tuned Mass Damper (TMD) control system was proposed, looking for the best set of dampers to improve the control performance. The parameters for the best vibration reduction were obtained via a parametric study considering four different slabs varying dimensions and support conditions. Different models considering one and more TMDs, varying its placements and parameters, besides the frequency reference value to tune the damper were considered. An efficient control solution to this practical problem is presented to reduce its undesirable vibrations.

关键词： Structural Dynamics Structural Control Concrete Slabs Tuned Mass Damper

Tertiary peritonitis: A disease that should not be ignored

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World Journal of Clinical Cases 2021年第10期9卷 2160-2169页

作者： Hanna Santos Marques Glauber Rocha lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Paulo Victor Dias Versiani Jaqueline Silva Caires Thiago de Carvalho Milet Fabrício Freire de Melo Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil department of Surgery Hospital Geral de Vitória da ConquistaVitória da Conquista 45029-094BahiaBrazil

Intra-abdominal infections can be classified into uncomplicated or complicated(peritonitis). Peritonitis is divided into primary, secondary, and tertiary. Tertiaryperitonitis is the less common but the most severe among peritonitisstratifications, being defined as a recurrent intra-abdominal infection that occurs48 h after a well-succeeded control of a secondary peritonitis. This disease has acomplex pathogenesis that is closely related to the capacity of the peritonealcavity to activate immunological processes. Patients who progress to persistentperitonitis are at an increased risk of developing several infectious complicationssuch as sepsis and multiple organ failure syndrome. Moreover, tertiary peritonitisremains an important cause of hospital death mainly among patients withassociated risk factors. The microbiological profile of organisms causing tertiaryperitonitis is often different from that observed in other types of peritonitis. Inaddition, there is a high prevalence of multidrug-resistant pathogens causing thiscondition, and an appropriate and successful clinical management depends on anearly diagnosis, which can be made easier with the use of clinical scorespresenting a good prediction value during the intensive care unit ***, immediate therapy should be performed to control theinfectious focus and to prevent new recurrences. In this sense, the treatment isbased on initial antimicrobial therapy and well-performed peritoneal drainage.

关键词： Tertiary peritonitis Pathogenesis Clinical manifestation Diagnosis Treatment Prognosis

Self-Care Practice of Patients with Mechanical Heart Valve Prosthesis Accompanied in Nursing Consultation

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Health 2015年第10期7卷 1387-1395页

作者： Lidia Stella Teixeira de Meneses Francisca Elisangela Teixeira lima Sherida Karanini Paz de Oliveira Francisca Jane Gomes Oliveira Maira di Ciero Miranda Vieira Paulo Cesar Almeida viviane Martins da Silva Federal University of Ceará Fortaleza Brazil department of Nursing Federal University of Ceará Fortaleza Brazil State University of Ceará Fortaleza Brazil

The objective was to evaluate the practice of self-care of patients with mechanical heart valve prosthesis. A descriptive, cross-sectional study developed in two outpatient valvopathies of teaching hospitals of Fortaleza/CE, from October 2013 to January 2014. The sample consisted of 127 patients with mechanical heart valve prosthesis. It was held an interview using instrument based on the Theory of Orem’s Self-Care and Brazilian Guidelines for Valvular Heart Diseases. The data were presented in tables and charts. Results: Universal self-care practices of larger adhesion: body hygiene (97.6% washed-haired, daily-bath 92.1%);oral hygiene (brushing teeth before sleeping, 87.4%);fluid intake (drinking-water 95.2%);food intake (salt intake ≤ 2 g/day, 92.1%, fruit and vegetable consumption 79.5%);intestinal eliminations (without blood or mucus—96%, non-parasitic 94.4%);urinary elimination (no blood nor pus-96.8%, urination 4 to 6 times a day, 96%). As self-care developmental requirements predominated: never used illegal drugs, tobacco, alcohol, or stopped at the discovery of the disease (70%). As self-care health deviation requirements we have: making use of certain medication at the right dose (95.2%);attending medical appointments (cardiologist—92.1%;nursing—84.2%);INR control (identifies signs of bleeding— 85.8%). We conclude that patients did not perform all recommended self-care practices, being necessary to establish strategies to reduce the self-care deficit.

关键词： Nursing Self-Care Heart Valve