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Candida Colonization among Neonates with Low Birth Weight: There Is Much More to Explore

Open Journal of Pediatrics 2020年第4期10卷 626-634页

作者： Wilhelmina Mussa Benard Modest Adolfine Hokororo Florentina Mashuda vitus silago Stephen E. Mshana Martha F. Mushi Department of Pediatrics and Child Health Weill Bugando School of Medicine Catholic University of Health and Allied Sci-ences Mwanza Tanzania Department of Microbiology and Immunology Weill Bugando School of Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania

Background and Objectives: Candida colonization in neonates with low birth weight is reported to be the first step for invasive candidiasis. This study was designed to describe the patterns of Candida spp. colonizing neonates with low birth weight in Mwanza, Tanzania to provide baseline information for future studies in this field. Methodology: The hospital based cross sectional study was conducted between January 2019 and April 2019 among neonates with low birth weight. Clinical and social demographic data were collected using interview guide questionnaire. Oral and umbilical rectal swabs were collected on the first and seventh day of life to assess Candida spp. colonization status. Data were analyzed using STATA version 13 following the study objectives. Results: A total of 320 neonates with median body weight of 1600 [IQR 1000 - 2000] grams were enrolled. Prevalence of Candida spp. colonization on either ora

关键词： Candida Colonization C. albicans C. glabrata Oral

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Hepatitis B and Hepatitis C among Human Immunodeficiency Virus Infected Patients at a District Hospital in Mwanza, Tanzania

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World Journal of AIDS 2019年第1期9卷 1-10页

作者： Mariam M. Mirambo Benson R. Kidenya vitus silago Emmanuel Mkumbo Awadh Mujuni Kennedy J. Mmanga Japhet J. Mwihambi Shimba Henerico Carolyne A. Minja Stephen E. Mshana Department of Microbiology and Immunology Weill Bugando School of Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania Department of Biochemistry and Molecular Biology Weill Bugando School of Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania Bugando Medical Centre Mwanza Tanzania

Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections have been a major public health problem. HIV patients with HBV and HCV infection are at high risk of liver diseases which is associated with increased mortality. This study aims at determining the prevalence of hepatitis B surface antigen (HBsAg), HCV antibodies and HBV antibodies (anti-HBsAg) among HIV seropositive adults attending care and treatment clinic at Sengerema district hospital in Mwanza, Tanzania. A cross-sectional hospital based study was conducted between February and March 2017 among 243 HIV adult patients at Sengerema designated district hospital, Mwanza, Tanzania. Socio-demographic and other relevant information were collected using pre-tested questionnaires. Detection of HBsAg and HCV antibodies was done by commercial rapid immunochromatographic test while the detection of anti-HBsAg was done using enzyme linked immunosorbent assay. Data were analyzed by using STATA version 13. The median age of the study participants was 43, interquartile range (IQR): 37 - 51 years. The majority 172 (70.8) of study participants were female and the majority (88%) of participants had CD4 count of greater than 200 counts/μl. The prevalence of HBsAg, HCV antibodies and anti-HBsAg were 26/243 (10.7%, 95% confidence interval [CI]: 7 - 14), 20/243 (8.2%, 95% CI: 4.7 - 11.6) and (100/243) 41.2%, 95% CI: 35 - 47, respectively. Co-infection with HCV (OR: 4.45, 95% CI: 1.51 - 13.21, P = 0.007) was independenlty found to predict HbsAg positivity. History of blood transfusion (OR: 2.34, 95% CI: 1.08 - 5.06, P = 0.028) was significantly associated with anti-HBsAg among HIV infected individuals while, the rate of anti-HBsAg was found to decrease by 2.02 IU/L in a year increase in age. About one tenth of HIV infected individuals are co-infected with HCV and HBV with more than one third being positive for anti-HBsAg. There is a paramount need to emphasize the need for regular screeni

关键词： Hepatitis B Hepatitis C HIV Sengerema Tanzania

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Candida Colonization among Neonates with Low Birth Weight: There Is Much More to Explore

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Open Journal of Pediatrics（儿科学期刊） 2020年第4期

作者： Wilhelmina Mussa Benard Modest Adolfine Hokororo Florentina Mashuda vitus silago Stephen E. Mshana Martha F. Mushi

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