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Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.Escaray Amelia Felipo-Benavent Cristian J.antonelli Begona Balaguer Maria Pilar Lopez-Gresa Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

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Gastrointestinal motility disorders in inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第1期20卷 37-44页

作者： Gabrio Bassotti Elisabetta antonelli Vincenzo Villanacci Marianna Salemme Manuela Coppola vito Annese Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineUniversity of Perugia06156 PerugiaItaly Second Pathology Section Spedali Civili of Brescia25100 BresciaItaly Gastroenterology Unit Careggi University Hospital50134 FlorenceItaly

The relationship between motility and inflammatory gastrointestinal disorders is at the same time complex and intriguing since these conditions might share some genetic, environmental, immunological and microbial predisposing factors. In addition, significant symptom overlapping may occur, muddling the waters within the clinical context. Although on one hand this represents a challenge for the clinician for a potential under- or over-treatment and diagnostic delay, on the other hand it possibly represents an opportunity for the researcher to better disclose the intimate relationship between chronic (often low-grade) inflammation, motor disorders and deranged sensory function. The best example is probably represented by Crohn’s disease and ulcerative colitis. In fact, a number of gastrointestinal motor disorders have been described in association with these diseases, disorders which span from the esophagus to the anorectum, and which will be extensively covered in this review. It is conceivable that at least part of this derangement is strictly related to inflammatory cytokine trafficking and neuromuscular changes; however, given the high prevalence of functional gastrointestinal disorders in the general population, this overlap might also be serendipitous. However, it is worth noting that literature data on this topic are relatively scarce, sometimes quite outdated, and mostly focused on the interplay between irritable bowel syndrome and inflammatory bowel disease. Nevertheless, both researchers and clinicians must be aware that symptoms related to gastrointestinal motility disorders may be highly prevalent in both active and inactive inflammatory bowel disease, correlate with greater psychological comorbidity and poorer quality of life, and may negatively influence the therapeutic approaches.

关键词： Crohn’ s disease, Gastrointestinal motility disorders, Gut, Inflammatory bowel diseases, Perception, Ulcerative colitis

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利用数字化技术提高硫回收装置生产效率

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硫酸工业 2024年第4期 38-43页

作者： Pasqualon E antonelli M Boni D Costantini A Romangnuolo S Maire集团公司意大利 NextChem有限公司意大利

出色的装置运行需要连续的过程监控以及对运行数据的收集和分析。数字过程监测器(DPM)提供了一个工艺过程数字化的孪生模型,该模型是一个精确的工艺过程数学模型,模型结合了技术许可方在硫回收技术方面的专业知识,让模型可以提供对工厂... 详细信息

出色的装置运行需要连续的过程监控以及对运行数据的收集和分析。数字过程监测器(DPM)提供了一个工艺过程数字化的孪生模型,该模型是一个精确的工艺过程数学模型,模型结合了技术许可方在硫回收技术方面的专业知识,让模型可以提供对工厂性能的持续监测。DPM系统的引入提升了硫回收装置(SRU)整体运行稳定性和效率。

关键词：数字化硫回收效率软测量

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The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： Francesco Chierigo Rocco Simone Flammia GabrieleSorce Benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian Fred Saad Marcus Graefen Michele Gallucci Alberto Briganti Francesco Montorsi Felix K.H.Chun Shahrokh F.Shariat Alessandro antonelli Giovanni Guano Guglielmo Mantica Marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz Department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San Martino GenovaItaly Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of Urology IRCCS Policlinico San MartinoGenovaItaly Department of Maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of Urology University Hospital FrankfurtFrankfurt am MainGermany Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

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Revisiting taxonomy,morphological evolution,and fossil calibration strategies in Chloranthaceae

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Journal of Systematics and Evolution 2011年第4期49卷 315-329页

作者： Alexandre antonelli Taylor S.FEILD Gothenburg Botanical Garden and Department of Plant and Environmental Sciences University of Gothenburg Department of Ecology and Evolutionary Biology University of Tennessee

Chloranthaceae is one of the earliest diverging angiosperm families and is comprised of approximately 75 species in four genera (Chloranthus,Sarcandra,Ascarina,and Hedyosmum).This family has received considerable attention because of its seemingly primitive morphology,disjunct tropical distribution in Asia and America,and extensive fossil record from the Early *** the present study,we reconstructed the phylogeny of Chloran- thaceae based on a combined dataset of three plastid DNA regions and 56 *** then estimated divergence times in the family using two relaxed molecular clock methods (BEAST and penalized likelihood).We focused on testing the influence of fossil taxa in calibrating the molecular phylogeny,and on assessing the current taxonomy of the family in light of the phylogenetic *** results indicate that most intrageneric divisions within Asca-rina and Hedyosmum are not *** results from the dating analysis suggest that the Hedyosmum-like fossil Asteropollis represents a stem lineage of Hedyosmum,as has been suggested previously from morphological *** contrast,our results indicate that the Chloranthus-like fossil Chloranthistemon,previously suggested on morphological grounds to be a stem relative of Chloranthus,may,instead,belong to the branch leading to the clade Chloranthus + *** median crown ages of Chloranthus,Sarcandra,Ascarina,and Hedyosmum estimated in the BEAST analysis were 26.3,9.5,31.0 and 45.8 million years ago (Ma),respectively,whereas the divergence between Chloranthus and Sarcandra,the splitting of Ascarina with the former two genera,and Hedyos- mum separating from the three genera were estimated to 63.8,95.7 and 111.1 *** present study sheds further light on the temporal evolution of Chloranthaceae and exemplifies how molecular dating analyses may be used to explore alternative phylogenetic placements of fossil taxa.

关键词： angiosperm evolution Asteropollis Chloranthaceae Chloranthistemon molecular dating phylogeny.

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Intravascular contrast agents in diagnostic applications： Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents

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Nano Research 2017年第3期10卷 731-766页

作者： Antonella antonelli Carla Sfara Mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biology Section University of Urbino 'Carlo Bo' Via Saffi 2 61029Urbino (PU) Italy

In medicine, discrimination between pathologies and normal areas is of great importance, and in most cases, such discrimination is made possible by novel imaging technologies. Numerous modalities have been developed to visualize tissue vascularization in cardiovascular diseases or during angiogenic and vasculogenic processes. Here, we report the recent advances in vasculature imaging, providing an overview of the current non-invasive approaches in biomedical diagnostics and potential future strategies for prognostic assessment of vessel diseases, such as aneurysms and coronary artery occlusion leading to myocardial infarction. There are several contrast agents （CAs） available to improve the visibility of specific tissues at the early stage of diseases, allowing for rapid treatment. However, CAs are also hampered by numerous limitations, including rapid diffusion from blood vessels into the interstitial space, toxicity, and low sensitivity. Extravasation from blood vessels leads to a rapid loss of the image. If the contrast medium can fully be confined to the vascular space, high-resolution structural and functional vascular imaging could be obtained. Many scientists have contributed new materials and/or new carrier systems. For example, the use of red blood cells （RBCs） as CA-delivery systems appears to provide a scalable alternative to current procedures that allows adequate vascular imaging. Recognition and removal of CAs from the circulation can be prevented and/or delayed by using RBCs as biomimetic CA-carriers, and this technology should be clinically validated.

关键词： diagnostic applications magnetic resonanceimaging (MRI) vascular contrast agents red blood cells medical imaging new tomography

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Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus

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Neural Regeneration Research 2019年第1期14卷 59-61页

作者： Francesca antonelli Arianna Casciati Simonetta Pazzaglia Laboratory of Biomedical Technologies Agenzia Nazionale per le Nuove Tecnologie l'Energia e lo Sviluppo Economico Sostenibile(ENEA)

The morphogen Sonic Hedgehog(Shh)plays a critical role in the development of different tissues,both in invertebrates and *** mediates its action via a receptor complex associating two transmembrane proteins:Patched1(Ptch1)and Smoothened(Smo).The repression exerted by Ptch1 on Smo is relieved when Shh,the ligand,binds to Ptch1,which leads to a complex signaling cascade involving the transcription factors of the Gli family and finally,to

关键词：神经发生信号刺猬声音无脊椎动物回转牙齿控制

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Novel oral-targeted therapies for mucosal healing in ulcerative colitis

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World Journal of Gastroenterology 2018年第47期24卷 5322-5330页

作者： Elisabetta antonelli Vincenzo Villanacci Gabrio Bassotti Gastroenterology Section Perugia General Hospital Pathology Unit ASST Spedali Civili Department of Medicine Gastroenterology and Hepatology Section University of Perugia Medical School

Ulcerative colitis(UC), a chronic, relapsing, remitting disease of the colon and rectum, is characterized by inflammatory ulceration of the mucosa. Current UC therapy relies on controlling acute episodes and preventing relapse. To predict modifications in the natural course of UC, mucosal healing(MH) has emerged as a major treatment goal. Endoscopic evaluation is considered the gold standard for assessing MH, which can be achieved by conventional drugs and biologics in many, but not all, patients. Consequently, interest is focusing on the development of new substances for UC therapy, and new oral agents are in the pipeline. This review will focus on the ability of newly developed oral drugs to induce and maintain MH in UC patients.

关键词： Mucosal healing New oral treatments Ozanimod Peficitinib Tofacitinib Ulcerative colitis

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National botanical gardens at the forefront of global plant conservation

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The Innovation 2023年第5期4卷 1-2页

作者： Hai Ren Alexandre antonelli South China Botanical Garden of the Chinese Academy of Sciences Guangzhou 510650China South China National Botanical Garden Guangzhou 510650China Royal Botanic Gardens KewRichmondLondonTW93AE SurreyUK Gothenburg Global Biodiversity Center Department of Biological and Environmental SciencesUniversity of GothenburgBox 46140530 GoteborgSweden|

Global changes in land use driven by demands on food,energy,and other resources in response to a rapidly increasing human population have collectively led to escalating environmental challenges,including biodiversity loss,global warming,environmental pollution,and ecosystem *** present,biodiversity is seriously threatened at global,regional,and local scales,which,in turn,threatens our own *** is a global asset of immense material and non-material value,providing us with food,medicine,building materials,fiber,and the ecological environment required for our well-being and health.

关键词： collective pollution seriously

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Efficacy of Prucalopride in bowel cleansing before colonoscopy:Results of a pilot study

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World Journal of Gastrointestinal Endoscopy 2017年第11期9卷 558-560页

作者： vito Domenico Corleto Giulio antonelli Chiara Coluccio Lucia D'Alba Emilio di Giulio Department of Digestive Endoscopy School of Medicine and Psychology 'Sapienza' University of Rome Sant’ Andrea Hospital Gastroenterology and Digestive Endoscopy San Giovanni-Addolorata Hospital

Colonoscopy is a crucial diagnostic instrument for colorectal cancer screening and an adequate bowel preparation is definitely decisive for the success of the procedure. Especially in elderly patients, bowel cleansing is considered a big issue, because it is often poorly tolerated for many reasons(like inability to swallow large volume of liquids or unlikable taste); this can cause a suboptimal preparation that may lead to miss a neoplastic lesion. There is relatively little data about how to improve preparation tolerability. The purpose of our pilot study was to analyze the effect of prucalopride(Resolor~?), a highly selective serotonin 5HT4 receptor agonist used for chronic constipation for its ability to stimulate gastrointestinal peristalsis, undertaken the day before colonoscopy, followed by half volume of polyethylene glycol solution. We found that this can be a good and safe method to achieve an adequate and better-tolerated colon cleansing.

关键词： Bowel cleansing Colonoscopy Prucalopride Screening Colorectal cancer

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