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study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma science and Technology 2024年第4期26卷 94-100页

作者： sunil KANCHI Rohit sHUKLA Archana sharma Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

Assessing the Viability of Gandhar Field in India’s Cambay Basin for CO_(2) storage

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哈尔滨工程大学学报（英文版） 2024年第3期23卷 529-543页

作者： Vikram vishal somali Roy Yashvardhan Verma Bharath shekar Department of Earth sciences Indian Institute of Technology BombayMumbai 400076India National Centre of Excellence in Carbon Capture and Utilization Indian Institute of Technology BombayMumbai 400076India

Our research is centered on the Gandhar oil field, which was discovered in 1983, where daily oil production has declined significantly over the years. The primary objective was to evaluate the feasibility of carbon dioxide(CO_(2)) storage through its injection into the siliciclastic reservoirs of Ankleshwar Formation. We aimed to obtain high-resolution acoustic impedance data to estimate porosity employing model-based poststack seismic inversion. We conducted an analysis of the density and effective porosity in the target zone through geostatistical techniques and probabilistic neural networks. simultaneously, the work also involved geomechanical analysis through the computation of pore pressure and fracture gradient using well-log data, geological information, and drilling events in the Gandhar field. Our investigation unveiled spatial variations in effective porosity within the Hazad Member of the Ankleshwar Formation, with an effective porosity exceeding 25% observed in several areas, which indicates the presence of well-connected pore spaces conducive to efficient CO_(2) migration. Geomechanical analysis showed that the vertical stress(sv) ranged from 55 MPa to 57 MPa in Telwa and from 63.7 MPa to 67.7 MPa in Hazad Member. The pore pressure profile displayed variations along the stratigraphic sequence, with the shale zone, particularly in the Kanwa Formation, attaining the maximum pressure gradient(approximately 36 MPa). However, consistently low pore pressure values(30-34 MPa) considerably below the fracture gradient curves were observed in Hazad Member due to depletion. The results from our analysis provide valuable insights into shaping future field development strategies and exploration of the feasibility of CO_(2) sequestration in Gandhar Field.

关键词： Carbon capture and storage Reservoir characterization seismic inversion Geomechanics CO_(2)storage CO_(2)enhancing oil recovery

Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire:An observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 33-39页

作者： Neha Jindal Anuraag Jena Krishan Kumar Bijaya K Padhi Rajni sharma Vaneet Jearth Usha Dutta vishal sharma Department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Psychiatry Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Community Medicine and school of Public Health Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Advanced Pediatric Centre Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India

BACKGROUND The gastrointestinal symptom rating scale(GsRs)is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome(IBs)and peptic ulcer *** validated scale has questions on around 15 items and has been validated in patients with dyspepsia and *** To translate and validate the English version of the GsRs questionnaire to the Hindi *** The purpose of the present work was to create a Hindi version of this questionnaire for use in the Indian *** process involved various steps as per the World Health Organization methodology including initial forward translation,backward translation,and assessment by an expert *** pilot testing was followed by testing in healthy and diseased *** The Hindi translation was pilot tested in 20 individuals and further validated in healthy controls(n=30,15 females)and diseased individuals(n=72,27 females).The diseased group included patients with functional dyspepsia and ***'s alpha for internal consistency on the final translated GsRs questionnaire was 0.715 which is considered *** questions significantly differentiated the diseased population from the healthy population(P valueslated Hindi version of the *** The translated Hindi GsRs can be used to evaluate gastrointestinal function in clinical trials and community surveys in Hindi speaking populations.

关键词： Irritable bowel syndrome Gut health Dyspepsia symptoms Pain Constipation Diarrhoea

Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer

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World Journal of Gastroenterology 2024年第26期30卷 3257-3260页

作者： Naresh singh samantha sharma Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States

Over the years immunotherapy has demonstrably improved the field of cancer ***,achieving long-term survival for colorectal cancer(CRC)patients remains a significant unmet *** immunotherapies incor-porating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative ***,substantial gaps remain in the current therapeutic armamentarium for *** recent years,there has been a surge of interest in exploring novel treatment strategies,including the application of light-activated drugs in conjunction with optical *** approach holds promise for achie-ving localized and targeted delivery of cytotoxic agents,such as microtubule-targeting drugs,directly to cancerous cells within the colon.

Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury

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World Journal of stem Cells 2024年第7期16卷 742-759页

作者： Prashasti sharma Dharmendra Kumar Maurya Life sciences Homi Bhabha National InstituteMumbai 400094MaharashtraIndia Radiation Biology&Health sciences Division Bhabha Atomic Research CentreMumbai 400085MaharashtraIndia

Wharton’s jelly mesenchymal stem cells(WJ-MsCs)are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation ***-MsCs are more naïve and have a better safety profile,making them suitable for both autologous and allogeneic *** review highlights the regenerative potential of WJ-MsCs and their clinical applications in mitigating various types of radiation *** this review,we will also describe why WJ-MsCs will become one of the most probable stem cells for future regenerative medicine along with a balanced view on their strengths and ***,the most updated literature related to both preclinical and clinical usage of WJ-MsCs for their potential application in the regeneration of tissues and organs will also be compiled.

关键词： stem cells Wharton’s jelly mesenchymal stem cells Radiotherapy Xerostomia Lung fibrosis

Role of social Capital in Determining Happiness and Life satisfaction:Mediation of self-reported Health Using Path Analysis

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Fudan Journal of the Humanities and social sciences 2024年第2期17卷 211-242页

作者： suraj sharma Department of Economics S.M.(P.G.)CollegeChandausiM.J.P.Rohilkhand UniversityBareilly243006India

This study links social capital with people’s health and well-being using data from the seventh wave of the World Value survey,logistic regression,and path *** study’s findings show that happiness and life satisfaction are two different measures of the same construct,or *** determinants of each are also characterised differently:while life satisfaction is more of a stable and relative measure and is more strongly influenced by civic cooperation,social participation,and educational attainment,happiness is more of an unstable measure and is more strongly influenced by community belonging,trust and confidence aggregates,including employment and location of residence of an ***,freedom of choice,financial satisfaction or social comparison,and state of health were the most important factors influencing happiness and life *** findings also show that self-reported health(sRH)has a greater impact on happiness than a measure of life *** analysis shows out of the three other components of social capital—community belonging,civic engagement,and social participation—trust and confidence aggregates are the ones that have the biggest impact on increased social *** both well-being measures,sRH mediated the *** life satisfaction measure had a higher level of mediation of sRH than happiness,but social capital had a smaller direct impact on life satisfaction than on *** was found to be partially mediating this relationship for both happiness and life satisfaction measures,which means that people with higher social capital reported feeling better off.

关键词： Happiness Health Life satisfaction Path analysis social capital

Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： vishal singh Arnab Choudhury Hyung Jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

Covalent Bond Based Android Malware Detection Using Permission and system Call Pairs

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Computers, Materials & Continua 2024年第3期78卷 4283-4301页

作者： Rahul Gupta Kapil sharma R.K.Garg Department of Information Technology Delhi Technological UniversityNew Delhi110042India Department of Mechanical Engineering Deenbandhu Chhotu Ram University of Science and TechnologyMurthal131039India

The prevalence of smartphones is deeply embedded in modern society,impacting various aspects of our *** versatility and functionalities have fundamentally changed how we communicate,work,seek entertainment,and access *** the many smartphones available,those operating on the Android platform dominate,being the most widely used *** widespread adoption of the Android Os has significantly contributed to increased malware attacks targeting the Android ecosystem in recent ***,there is an urgent need to develop new methods for detecting Android *** literature contains numerous works related to Android malware *** far as our understanding extends,we are the first ones to identify dangerous combinations of permissions and system calls to uncover malicious behavior in Android *** introduce a novel methodology that pairs permissions and system calls to distinguish between benign and malicious *** approach combines the advantages of static and dynamic analysis,offering a more comprehensive understanding of an application’s *** establish covalent bonds between permissions and system calls to assess their combined *** introduce a novel technique to determine these pairs’Covalent Bond strength *** pair is assigned two scores,one for malicious behavior and another for benign *** scores serve as the basis for classifying applications as benign or *** correlating permissions with system calls,the study enables a detailed examination of how an app utilizes its requested permissions,aiding in differentiating legitimate and potentially harmful *** comprehensive analysis provides a robust framework for Android malware detection,marking a significant contribution to the *** results of our experiments demonstrate a remarkable overall accuracy of 97.5%,surpassing various state-of-the-art detection techniques proposed in the current literature.

关键词： Android malware android security hybrid analysis permission and system call pairs

Clinical use of donor-derived cell-free DNA in kidney transplantation

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World Journal of Transplantation 2024年第4期14卷 61-66页

作者： vishal Jaikaransingh Bhaktidevi Makadia Hafiz s Khan Irtiza Hasan Department of Medicine Divison of NephrologyUniversity of Florida College of Medicine-JacksonvilleJacksonvilleFL 32209United States

Traditional monitoring of kidney transplant recipients for allograft dysfunction caused by rejection involves serial checks of serum creatinine with biopsy of the renal allograft if dysfunction is *** approach is labor-intensive,invasive and *** addition,because this approach relies on a rise in serum creatinine above historical baselines,injury to the allograft can be extensive before this rise *** an effort to address this,donor-derived cell-free DNA(dd-cf DNA)is being used with increasing frequency in the clinical setting as a means of diagnosing a rejection of the renal allograft early in the *** can poten-tially allow for early intervention to minimize not only injury,but the intensity of antirejection therapy needed and the avoidance of side ***,we will review the available methodology for the determination and quantification of dd-cf DNA,the data supporting its use in clinical practice and the limitations of this technology.

关键词： Kidney Transplant Donor-derived cell-free DNA Transplant rejection Biomarker