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Potential role of an athlete-focused echocardiogram in sports eligibility

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World Journal of Cardiology 2021年第8期13卷 271-297页

作者： Stefano Palermi Alessandro Serio Marco Vecchiato Felice Sirico Francesco Gambardella Fabrizio Ricci Franco Iodice Juri Radmilovic vincenzo russo Antonello D'Andrea Department University of Naples Federico IINaples 80131Italy Sport and Exercise Medicine Division Department of MedicineUniversity Hospital of PadovaPadova 35128Italy Department of Neuroscience Imaging and Clinical Sciences“G.d’Annunzio”University of Chieti-PescaraChieti 66100Italy Department of Clinical Sciences Faculty of MedicineLund UniversityClinical Research CenterMalmö21428Sweden Casa di Cura Villa Serena Pescara 65013Italy Unit of Cardiology Department of Translational Medical SciencesUniversity of Campania“Luigi Vanvitelli”Monaldi HospitalNaples 80131Italy Unit of Cardiology and Intensive Coronary Care “Umberto I”HospitalNocera Inferiore 84014Italy

Sudden cardiac death(SCD)of an athlete is a rare but tragic event and sport activity might play a trigger role in athletes with underlying structural or electrical heart *** screenings(PPs)have been conceived for the potential to prevent SCD in young athletes by early identification of cardiac *** European Society of Cardiology protocol for PPs includes history collection,physical examination and baseline electrocardiogram,while further examinations are reserved to individuals with abnormalities at first-line ***,transthoracic echocardiography has been hypothesized to have a primary role in the *** review aims to describe how to approach an athlete-focused echocardiogram,highlighting what is crucial to focus on for the different diseases(cardiomyopathies,valvulopathies,congenital heart disease,myocarditis and pericarditis)and when is needed to pay attention to overlap diagnostic zone(“grey zone”)with the athlete's *** properly tested,focused echocardiography by sports medicine physicians may become standard practice in larger screening practices,potentially available during first-line evaluation.

关键词： Echocardiogram Athletes Sport eligibility Pre-participation screening Sudden cardiac death Sport cardiology

Alkoxylation for Surfactant Productions: towards the Continuous Reactors

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China Detergent & Cosmetics 2016年第4期1卷 38-42页

作者： vincenzo russo Riccardo Tesser Martino Di Serio Wieslaw Hreczuch Yongqiang Sun Department of Chemical Sciences University of Naples "Federico II" IT-80126 NapoliItaly MEXEO Institute of Technology Kedzierzyn-Kozle Poland China Research Institute of Daily Chemical Industry China

Introduction The alkoxylation reactions are generally performed in semibatch reactors,[1] also in series, in which the catalyst and the substrate （alkyl phenols, fatty alcohols or acids）are initially charged while epoxide （ethylene or propylene oxide） is added during the reaction course. This particular synthesis strategy is due to the high reactivity of alkoxides

关键词：烷氧基化反应反应器环氧化物催化剂

再发性低血糖对幼鼠脑内GLUT1及GLUT3表达的影响

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中国小儿急救医学 2006年第3期13卷 253-255页

作者：辛颖杜莉 George A Werther vincenzo C russo 中国医科大学附属第二医院儿科辽宁沈阳110004 澳大利亚皇家墨尔本儿童医院Murdoch儿童医学研究中心

目的观察再发性低血糖后脑内葡萄糖转运蛋白1(glucose transporter 1,GLUT1)及葡萄糖转运蛋白3(GLUT3)表达的变化,从而探讨无症状低血糖的发生机制。方法将80只15日龄野生型小鼠随机分为正常对照组及低血糖组,每组40只。低血糖组给予正... 详细信息

目的观察再发性低血糖后脑内葡萄糖转运蛋白1(glucose transporter 1,GLUT1)及葡萄糖转运蛋白3(GLUT3)表达的变化,从而探讨无症状低血糖的发生机制。方法将80只15日龄野生型小鼠随机分为正常对照组及低血糖组,每组40只。低血糖组给予正规胰岛素腹腔注射3次,每次剂量为5U/kg,对照组注射等体积生理盐水。两组分别在最后1次注射后12、24、48及72 h处死小鼠取脑组织(每组每时间点10只),应用免疫组化方法观察小鼠脑内GLUT1及GLUT3表达的变化。结果低血糖后脑内微血管上GLUT1表达有增加趋势,皮质增加高于海马,72 h皮质GLUT1表达显著高于对照组;低血糖后48、72 h皮质及海马GLUT3表达均显著高于相应对照组。结论再发性低血糖后脑内GLUT1及GLUT3适应性增高,这种适应既能节省神经元的能量代谢,但也能削减神经元对低血糖的反应。

关键词：葡萄糖转运蛋白低血糖症脑幼鼠

Neuroinflammation as a target for glaucoma therapy

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Neural Regeneration Research 2019年第3期14卷 391-394页

作者： Adornetto Annagrazia Rossella russo Parisi vincenzo Department of Pharmacy Health and Nutritional Sciences Section of Preclinical and Translational Pharmacology University of Calabria Visual Neurophysiology and Neurophthalmology Research Unit IRCCS G.B.Bietti Foundation

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation-involving the activation and proliferation of resident glial cells(astrocytes, Muller cells and microglia) and the release of a plethora of anti-and pro-inflammatory cytokines, chemokines and reactive oxygen species-has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. In view of this, therapies aimed at modulating the immune and inflammatory responses may represent a promising approach for limiting the optic nerve damage and the loss of retinal ganglion cells associated with glaucoma.

关键词： glaucoma retinal ganglion cells neuroinflammation neurodegeneration microglia oxidative stress inflammasome immune response

Stem cells sources for intervertebral disc regeneration

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World Journal of Stem Cells 2016年第5期8卷 185-201页

作者： Gianluca Vadalà Fabrizio russo Luca Ambrosio Mattia Loppini vincenzo Denaro Department of Orthopedic and Trauma Surgery University Campus Bio-Medico of Rome

Intervertebral disc regeneration field is rapidly growing since disc disorders represent a major health problem in industrialized countries with very few possible ***, current available therapies are symptomatic, and surgical procedures consist in disc removal and spinal fusion, which is not immune to regardable concerns about possible comorbidities, cost-effectiveness, secondary risks and long-lasting outcomes. This review paper aims to share recent advances in stem cell therapy for the treatment of intervertebral disc degeneration. In literature the potential use of different adult stem cells for intervertebral disc regeneration has already been reported. Bone marrow mesenchymal stromal/stem cells, adipose tissue derived stem cells, synovial stem cells, muscle-derived stem cells, olfactory neural stem cells, induced pluripotent stem cells, hematopoietic stem cells, disc stem cells, and embryonic stem cells have been studied for this purpose either in vitro or in vivo. Moreover, several engineered carriers(e.g., hydrogels), characterized by full biocompatibility and prompt biodegradation, have been designed and combined with different stem cell types in order to optimize the local and controlled delivery of cellular substrates in situ. The paper overviews the literature discussing the current status of our knowledge of the different stem cells types used as a cell-based therapy for disc regeneration.

关键词： Stem cells Intervertebral disc degeneration Spine Tissue engineering Cell therapy

Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure

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World Journal of Gastroenterology 2009年第45期15卷 5700-5705页

作者： Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi russo vincenzo Savarino Matteo Neri Enzo Grossi Rosario Cuomo Division of Gastroenterology Department of Clinical Sciences "L. Sacco" University HospitalVia G. B. Grassi 74-20157 MilanoItaly Gastroenterology Unit D.I.M.I University of GenovaViale Benedetto XV 6 16132 Genova Italy Gastroenterology Unit Dip. Med. Clin e Sper. AOU Federico ⅡVia S. Pansini 5 80131 Napoli Italy Department of Medicine and Aging Sciences and Ce.S.I "G. D'Annunzio" University & FoundationVia dei Vestini 31 66013 Chieti Italy Department of Medical Bracco Imaging SpAVia XXV Aprile 4 20097 San Donato Milanese Milano Italy

AIM： To assess the management and outcome of nonerosive gastro-esophageal reflux disease （NERD） patients who were identified retrospectively, after a 5-year follow-up. METHODS： We included patients with gastro-esophageal reflux disease （GERD） symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years （range 3.5-7 years） by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated endoscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis. RESULTS： 260 patients （137 women） were included. Predominant GERD symptoms were heartburn and regurgitation in 103/260 （40%）. 70% received a maintenance treatment, which was proton pump inhibitor （PPI） in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease （ERD） was found in 58/193 （30.0%） of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION： This study to ERD occurs in about 5% shows that progression of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression： smoking and absence of PPI therapy.

关键词： Esophagus Nonerosive gastro-esophageal reflux disease Gastro-esophageal reflux disease Epidemiology Acidity

3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior

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Bioactive Materials 2017年第3期2卷 138-145页

作者： Ugo D'Amora Teresa russo Antonio Gloria Virginia Rivieccio vincenzo D'Anto Giacomo Negri Luigi Ambrosio Roberto De Santis Institute of Polymers Composites and BiomaterialsNational Research CouncilNaplesItaly Villa Betania Evangelical Hospital NaplesItaly Department of Neuroscience Reproductive Sciences and Oral SciencesUniversity of Naples Federico IINaplesItaly Unit of Dentistry Bambino GesùChildren's HospitalIRCCSRomeItaly

Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable *** has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue *** aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds.

关键词： Additive manufacturing Scaffold Magnetic field Cell-material interaction

3D Non-Fluoroscopic Cryoablation of Right-Sided Accessory Pathways in Children:Monocentric Study and Literature Review

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Congenital Heart Disease 2021年第6期16卷 561-572页

作者： Fabrizio Drago Irma Battipaglia Pietro Paolo Tamborrino Luigina Porco Camilla Calvieri Mario Salvatore russo vincenzo Pazzano Romolo Remoli Massimo Stefano Silvetti Pediatric Cardiology and Cardiac Arrhythmias Unit Department of Pediatric Cardiology and Cardiac SurgeryBambino GesùChildren’s HospitalIRCCSRomeItaly

Background:Cryoablation of accessory pathways(APs)is effective and very safe in children,as previously reported by our *** aim of this retrospective study was to evaluate the current efficacy of 3D non-fluoroscopic cryoablation of right sided APs in children,comparing results obtained with the Ensite VelocityTM and the more recent Ensite PrecisionTM 3D mapping *** and Results:From January 2016 to December 2019,102 pediatric patients[mean age 12.5±2.8,62 males(61%of total cohort)]with right APs underwent 3D non-fluoroscopic transcatheter cryoablation at our ***(14.7%)patients had previously undergone catheter *** procedural success rate was 95.1%(n=97).No significant differences were detected in acute success rates achieved with Ensite Velocity^(TM)or Ensite PrecisionTM systems nor between manifest(94%)and concealed APs(100%).No permanent complications *** follow-up(428±286 days,median 396 days[interquartile range 179-713]),19 patients(19.6%)had *** were more frequent for parahissian/anterior APs compared to midseptal/posterior and lateral APs(p=0.043).Recurrences were not related to the Ensite system used.A redo ablation procedure was attempted in 13 cases,11 cryoablation and 2 radiofrequency ablations:the former was successful in 10 cases out of 11(90.9%).Conclusion:3D cryoablation of right-sided APs is associated with a very high acute success rate with limited use of fluoroscopy,resulting in great benefit to the *** rates are not high and patients can be retreated with cryo-energy with higher success rates.

关键词： 3D Mapping accessory pathway children cryoablation pediatric tachyarrhythmias

Effects of viremia and CD4 recovery on gut“microbiome-immunity”axis in treatment-na?ve HIV-1-infected patients undergoing antiretroviral therapy

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World Journal of Gastroenterology 2022年第6期28卷 635-652页

作者： Edda russo Giulia Nannini Gaetana Sterrantino Seble Tekle Kiros vincenzo Di Pilato Marco Coppi Simone Baldi Elena Niccolai Federica Ricci Matteo Ramazzotti Marco Pallecchi Filippo Lagi Gian Maria Rossolini Alessandro Bartoloni Gianluca Bartolucci Amedeo Amedei Department of Clinical and Experimental Medicine University of FlorenceFlorence 50134Italy Department of Surgical Sciences and Integrated Diagnostics University of GenoaGenoa 16126Italy Department of Biomedical Experimental and Clinical"Mario Serio"University of FlorenceFlorence 50134Italy Microbiology and Virology Unit Florence Careggi University HospitalUniversity of FlorenceFlorence 50134Italy Department of Neurosciences PsychologyDrug Research and Child HealthUniversity of FlorenceFlorence 50019Italy

BACKGROUND Human immunodeficiency virus type 1(HIV-1)infection is characterized by persistent systemic inflammation and immune activation,even in patients receiving effective antiretroviral therapy(ART).Converging data from many cross-sectional studies suggest that gut microbiota(GM)changes can occur throughout including human immunodeficiency virus(HIV)infection,treated by ART;however,the results are *** the first time,we compared the fecal microbial composition,serum and fecal microbial metabolites,and serum cytokine profile of treatment-na?ve patients before starting ART and after reaching virological suppression,after 24 wk of ART *** addition,we compared the microbiota composition,microbial metabolites,and cytokine profile of patients with CD4/CD8 ratio1(immunological responders[IRs]),after 24 wk of ART *** To compare for the first time the fecal microbial composition,serum and fecal microbial metabolites,and serum cytokine profile of treatment-na?ve patients before starting ART and after reaching virological suppression(HIV RNA<50 copies/m L)after 24 wk of *** We enrolled 12 treatment-na?ve HIV-infected patients receiving ART(mainly based on integrase inhibitors).Fecal microbiota composition was assessed through next generation *** addition,a comprehensive analysis of a blood broad-spectrum cytokine panel was performed through a multiplex *** the same time,serum free fatty acid(FFA)and fecal short chain fatty acid levels were obtained through gas chromatography-mass *** We first compared microbiota signatures,FFA levels,and cytokine profile before starting ART and after reaching virological *** alterations were observed in microbiota composition,in particular in the viral suppression condition,we detected an increase of Ruminococcus and Succinivibrio and a decrease of ***,in the same condition,we also obser

关键词： HIV Antiretroviral therapy Microbiome-immunity axis Microbiota Cytokines Short chain fatty acid Inflammation Immunological responders Viremia