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Neonatal opioid exposure:public health crisis and novel neuroinflammatory disease

Neural Regeneration Research 2021年第3期16卷 430-432页

作者： vikram vasan Yuma Kitase Jessie C.Newville Shenandoah Robinson Gwendolyn Gerner V.Joanna Burton Lauren L.Jantzie Department of Pediatrics Department of NeurologyJohns Hopkins University School of MedicineBaltimoreMDDepartment of NeurologyKennedy Krieger InstituteBaltimoreMDDepartment of PediatricsUniversity of New Mexico School of MedicineAlbuquerqueNMDepartment of NeurosciencesUniversity of New Mexico School of MedicineAlbuquerqueNMUSA

Substance use,specifically the use of prescription and non-prescription opioids among pregnant women,is a major public health issue and chief contributor to the opioid *** prevalence of Neonatal Opioid Withdrawal Syndrome has risen 5-fold in the past decade,and is a well-recognized consequence of perinatal opioid *** contrast,the long-term damage to the developing brain from opioid medications is just beginning to be recognized as a serious *** data suggest that opioid exposure commencing in utero negatively affects the maturation of the neural-immune system,and trajectory of central nervous system *** induces peripheral immune hyper-reactivity,lasting structural and microstructural brain injury,and significant deficits in executive function and cognitive control in adult animals following in utero ***,to address the cascading public health crisis stemming from the multitude of infants with in utero opioid exposure who will grow up with altered neurodevelopmental trajectories,rigorous preclinical,mechanistic studies are *** studies will define the long-term sequelae of prenatal opioid exposure in an effort to develop appropriate and targeted ***,the development of novel fluid,neuroimaging and biobehavioral biomarkers will be the most useful to aid in early identification and treatment of opioid exposed infants with the greatest risk of poor clinical *** studies will be essential to understand how in utero insults determine brain structure and function in adulthood,and what targeted interventions will be required to improve longterm outcomes in the countless children being born exposed to opioids each year.

关键词： biomarker buprenorphine cognition executive function magnetic resonance imaging methadone neonate

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Confinement effect on CO_(2)and CH_(4)permeability in shale

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Energy Geoscience 2024年第1期5卷 256-263页

作者： vikram Vishal Tuli Bakshi Computational and Experimental Geomechanics Laboratory Department of Earth SciencesIndian Institute of Technology BombayMumbai400076India National Centre of Excellence in Carbon Capture and Utilization Indian Institute of Technology BombayMumbai400076India

Gas flow in shales follows a number of physical mechanisms that include Knudsen diffusion,Darcy flow,and adsorption in the matrix and micro *** aim of the study is to resolve the interplay of gas transport in these media at increased effective stress as well as net pore *** this research,we investigated the nature of gas transport in the matrix of shale by sending He,CH_(4)and CO_(2)gases through a transient upstream pressure pulse decay instrument.A series of experiments were conducted at constant pore pressures and a gradually increasing confining *** same study was done in three different scenarios,injecting He,CO_(2)and CH_(4).At a constant pore pressure,gas permeability appears to decrease with an increasing confining pressure and effective *** increasing effective stress,the slip factor also decreases along with the *** decrease in slip could be attributed to prestressing,that is likely to create new *** the three purged gases,permeability of shale to CH_(4)is the highest,and that to CO_(2)is the lowest owing to its high *** permeability of CH_(4)against He,could be attributed to the dual transport mechanism.

关键词： Energy Porous media Gas transport Effective stress

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CuO–TiO_(2) based self-powered broad band photodetector

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Nano Materials Science 2024年第3期6卷 345-354页

作者： Chiranjib Ghosh Arka Dey Iman Biswas Rajeev Kumar Gupta vikram Singh Yadav Ashish Yadav Neha Yadav Hongyu Zheng Mohamed Henini Aniruddha Mondal Department of Physics National Institute of Technology DurgapurWest BengalIndia Department of Physics University of Petroleum&Energy Studies DehradunUttarakhandIndia Babasaheb Bhimrao Ambedkar University Lucknow226031India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China School of Physics and Astronomy University of NottinghamNottinghamNG72RDUnited Kingdom

An efficient room-temperature self-powered,broadband(300 nm–1100 nm)photodetector based on a CuO–TiO_(2)/TiO_(2)/p-Si(100)heterostructure is *** CuO–TiO_(2)nanocomposites were grown in a two-zone horizontal tube furnace on a 40 nm TiO_(2)thin film deposited on a p-type Si(100)*** CuO–TiO_(2)/TiO_(2)/p-Si(100)devices exhibited excellent rectification characteristics under dark and individual photoillumination *** devices showed remarkable photo-response under broadband(300–1100 nm)light illumination at zero bias voltage,indicating the achievement of highly sensitive self-powered photodetectors at visible and near-infrared light *** maximum response of the devices is observed at 300 nm for an illumination power of 10 *** response and recovery times were calculated as 86 ms and 78 ms,***,under a small bias,the devices showed a prompt binary response by altering the current from positive to negative under illumination *** main reason behind this binary response is the low turn-on voltage and photovoltaic characteristics of the *** illumination conditions,the generation of photocurrent is due to the separation of photogenerated electron-hole pairs within the built-in electric field at the CuO–TiO_(2)/TiO_(2)*** characteristics make the CuO–TiO_(2)/TiO_(2)broadband photodetectors suitable for applications that require high response speeds and self-sufficient functionality.

关键词： Self-powered CuO–TiO_(2) nanocomposite Broadband photodetector Two-zone horizontal tube furnace Responsivity

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Liver transplantation for hepatocellular carcinoma in India: Are we ready for 2040?

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World Journal of Transplantation 2024年第1期14卷 141-153页

作者： Hirak Pahari Amruth Raj Ambreen Sawant Dipak S Ahire Raosaheb Rathod Chetan Rathi Tushar Sankalecha Sachin Palnitkar vikram Raut Department of Liver Transplant and HPB Surgery Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Liver Transplant Anaesthesia Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210India Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsAurangabad 431003India Department of Gastroenterology and Hepatology Medicover HospitalsNashik 422009India Department of Gastroenterology and Hepatology Medicover HospitalsPune 411026India

BACKGROUND Liver transplantation(LT)for hepatocellular carcinoma(HCC)has been widely researched and is well established *** cornerstone of this treatment lies in the various criteria formulated by expert consensus and *** variations among the criteria are staggering,and the short-and long-term outcomes are *** To study the differences in the current practices of LT for HCC at different centers in India and discuss their clinical implications in the *** We conducted a survey of major centers in India that performed LT in December 2022.A total of 23 responses were *** centers were classified as high-and low-volume,and the current trend of care for patients undergoing LT for HCC was *** Of the 23 centers,35%were high volume center(>500 Liver transplants)while 52%were high-volume centers that performed more than 50 transplants/*** 39%of centers had performed>50 LT for HCC while the percent distribution for HCC in LT patients was 5%–15%in approximately 73%of the *** a few,most centers were divided equally between University of California,San Francisco(UCSF)and center-specific criteria when choosing patients with HCC for LT,and most(65%)did not have separate transplant criteria for deceased donor LT and living donor LT(LDLT).Most centers(56%)preferred surgical resection over LT for a Child A cirrhosis patient with a resectable 4 cm HCC ***-emission tomography-computed tomography(CT)was the modality of choice for metastatic workup in the majority of centers(74%).Downstaging was the preferred option for over 90%of the centers and included transarterial chemoembolization,transarterial radioembolization,stereotactic body radiotherapy and atezolizumab/bevacizumab with varied *** alphafetoprotein(AFP)cut-off was used by 74%of centers to decide on transplantation as well as to downstage tumors,even if they met the *** criteria for successful downstaging v

关键词： Hepatocellular carcinoma Liver transplant India Downstaging Survey Milan University of California,San Francisco Portal vein tumor thrombus Expanded criteria

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Nitrosamines crisis in pharmaceuticals Insights on toxicological implications, root causes and risk assessment: A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

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Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

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Cervical cancer:a tale from HPV infection to PARP inhibitors

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Genes & Diseases 2023年第4期10卷 1445-1456页

作者： Minakshi Mann vikram Pratap Singh Lalit Kumar Department of Medical Oncology Dr.B.R.A.Institute Rotary Cancer HospitalAll India Institute of Medical SciencesNew Delhi 110029India Department of Oncoanaesthesia and Palliative Medicine Dr.B.R.A.Institute Rotary Cancer HospitalAll India Institute of Medical SciencesNew Delhi 110029India Epigenetics Section Mouse Cancer Genetics ProgramCenter for Cancer ResearchNational Cancer InstituteFrederickMD 21702USA

Globally,cervical cancer(CxCa)ranks 4th common cancer among females and led to 569,847 incidences and 311,365 deaths in 2018.80%of CxCa cases occur due to persistent infection with a high-risk subtype of human papillomavirus(HPV-16 and 18).Smoking,high par-ity,and co-infection with type 2 herpes simplex or HIV are other known risk factors for *** histological subtypes are squamous(70%)and adenocarcinoma(25%).Presently,concur-rent radiation plus cisplatin(CDDP)-based chemotherapy is the standard treatment for CxCa ***,CDDP resistance and toxic side effects limit its efficacy,leading to a poorer response rate and an expected overall survival ranging from 10 to 17.5 *** drug uptake,increased DNA damage repair,increased CDDP inactivation,and overexpressed Bcl-2 or caspase inhibition,are primarily accountable mechanisms for CDDP resistance and improving CDDP’s efficacy remains the major ***(ADP-ribosyl)polymerase-1,an effective mediator of nucleotide excision repair pathway,is involved in DNA repair as well as maintaining genomic stability and is significantly expressed in malignant lymphomas,hepa-tocellular-,cervical-and colorectal carcinoma,which has been approved effective in mainte-nance therapy and may serve as an effective target to enhance CDDP sensitivity in ***,we summarize the etiology and epidemiology of and treatment for CxCa,the mechanism responsible for chemotherapy resistance,PARP inhibitor as a possible therapy for CxCa,and other possible chemotherapeutic options for CxCa treatment.

关键词： Cervical cancer Chemotherapy Cisplatin Disease etiology and histology PARP inhibitors Resistance

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Machine learning assisted derivation of minimal low-energy models for metallic magnets

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npj Computational Materials 2023年第1期9卷 353-364页

作者： vikram Sharma Zhentao Wang Cristian D.Batista Department of Physics and Astronomy The University of TennesseeKnoxvilleTN 37996USA School of Physics and Astronomy University of MinnesotaMinneapolisMN 55455USA Quantum Condensed Matter Division and Shull-Wollan Center Oak Ridge National LaboratoryOak RidgeTN 37831USA Present address:Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China

We consider the problem of extracting a low-energy spin Hamiltonian from a triangular Kondo Lattice Model(KLM).The non-analytic dependence of the effective spin-spin interactions on the Kondo exchange excludes the use of perturbation theory beyond the second *** then introduce a Machine Learning(ML)assisted protocol to extract effective two-and four-spin *** resulting spin model reproduces the phase diagram of the original KLM as a function of magnetic field and single-ion anisotropy and reveals the effective four-spin interactions that stabilize the field-induced skyrmion crystal ***,this model enables the computation of static and dynamical properties with a much lower numerical cost relative to the original KLM.A comparison of the dynamical spin structure factor in the fully polarized phase computed with both models reveals a good agreement for the magnon dispersion even though this information was not included in the training data set.

关键词： Kondo dynamical derivation

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Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma:Experimental and clinical scenarios

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World Journal of Gastroenterology 2022年第28期28卷 3535-3554页

作者： Swati Katoch Vinesh Sharma vikram Patial Division of Dietetics and Nutrition Technology Institute of Himalayan Bioresource TechnologyPalampur 176061Himachal PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002UPIndia

Hepatocellular carcinoma(HCC)is the most common type of liver cancer *** hepatitis is a significant risk factor for HCC,although metabolic syndrome and diabetes are more frequently associated with the *** increasing prevalence,there is expected to be>1 million cases annually by ***,there is an urgent need to establish potential therapeutic targets to cure this ***-proliferator-activated receptor gamma(PPARγ)is a ligand-activated transcription factor that plays a crucial role in the pathophysiology of *** synthetic agonists of PPARγsuppress HCC in experimental studies and clinical *** synthetic agonists have shown promising results by inducing cell cycle arrest and apoptosis in HCC cells and preventing the invasion and metastasis of ***,some synthetic agonists also pose severe side effects in addition to their therapeutic *** natural PPARγagonists can be an alternative to exploit this potential target for HCC *** this review,the regulatory role of PPARγin the pathogenesis of HCC is ***,the experimental and clinical scenario of both synthetic and natural PPARγagonists against HCC is *** of the available literature advocates PPARγas a potential therapeutic target for the treatment of HCC.

关键词： Anticancer Hepatocellular carcinoma Natural agonists Peroxisome proliferator-activated receptor-γ Thiazolidinediones

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文摘

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上海广播电视研究 2024年第3期 21-23页

作者：方世忠阎建钢魏克然上海广播电视台(上海文广集团)党委白玉兰奖电视剧类别评委会白玉兰奖纪录片类评委会华纳兄弟探索集团华纳兄弟探索集团大中华区和东南亚区

拥抱AIGC科技变革锻造媒体新质生产力。科技创新是培育新质生产力的核心要素。当前,新一轮科技革命和产业变革深入发展,不断突破人类认知的边界,特别是5G、大数据、区块链、人工智能等前沿科技迅猛发展,对媒体格局、舆论生态、传播方式... 详细信息

拥抱AIGC科技变革锻造媒体新质生产力。科技创新是培育新质生产力的核心要素。当前,新一轮科技革命和产业变革深入发展,不断突破人类认知的边界,特别是5G、大数据、区块链、人工智能等前沿科技迅猛发展,对媒体格局、舆论生态、传播方式均产生了深刻影响。

关键词：产业变革前沿科技科技变革人工智能区块链大数据媒体格局舆论生态

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