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Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure

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World Journal of Gastroenterology 2024年第34期30卷 3850-3855页

作者： Swati Katoch vikram Patial Division of Dietetics and Nutrition Technology Institute of Himalayan Bioresource TechnologyPalampur 176061Himachal PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

In this editorial,we comment on the article by Zhou et *** study reveals the connection between ferroptosis and pyroptosis and the effect of silent information regulator sirtuin 1(SIRT1)activation in acute liver failure(ALF).ALF is characterized by a sudden and severe liver injury resulting in significant hepatocyte damage,often posing a high risk of *** predominant form of hepatic cell death in ALF involves apoptosis,ferroptosis,autophagy,pyroptosis,and *** peroxidase 4(GPX4)inhibition sensitizes the cell to ferroptosis and triggers cell death,while Gasdermin D(GSDMD)is a mediator of *** study showed that ferroptosis and pyroptosis in ALF are regulated by blocking the p53/GPX4/GSDMD pathway,bridging the gap between the two *** inhibition of p53 elevates the levels of GPX4,reducing the levels of inflammatory and liver injury markers,ferroptotic events,and GSDMDN protein *** p53 expression and increased GPX4 on deletion of GSDMD indicated ferroptosis and pyroptosis ***1 is a NAD-dependent deacetylase,and its activation attenuates liver injury and inflammation,accompanied by reduced ferroptosis and pyroptosis-related proteins in ***1 activation also inhibits the p53/GPX4/GSDMD axis by inducing p53 acetylation,attenuating LPS/D-GalN-induced ALF.

关键词： Acute liver failure Ferroptosis Gasdermin D Pyroptosis p53 Silent information regulator sirtuin 1

Confinement effect on CO_(2)and CH_(4)permeability in shale

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Energy Geoscience 2024年第1期5卷 256-263页

作者： vikram Vishal Tuli Bakshi Computational and Experimental Geomechanics Laboratory Department of Earth SciencesIndian Institute of Technology BombayMumbai400076India National Centre of Excellence in Carbon Capture and Utilization Indian Institute of Technology BombayMumbai400076India

Gas flow in shales follows a number of physical mechanisms that include Knudsen diffusion,Darcy flow,and adsorption in the matrix and micro *** aim of the study is to resolve the interplay of gas transport in these media at increased effective stress as well as net pore *** this research,we investigated the nature of gas transport in the matrix of shale by sending He,CH_(4)and CO_(2)gases through a transient upstream pressure pulse decay instrument.A series of experiments were conducted at constant pore pressures and a gradually increasing confining *** same study was done in three different scenarios,injecting He,CO_(2)and CH_(4).At a constant pore pressure,gas permeability appears to decrease with an increasing confining pressure and effective *** increasing effective stress,the slip factor also decreases along with the *** decrease in slip could be attributed to prestressing,that is likely to create new *** the three purged gases,permeability of shale to CH_(4)is the highest,and that to CO_(2)is the lowest owing to its high *** permeability of CH_(4)against He,could be attributed to the dual transport mechanism.

关键词： Energy Porous media Gas transport Effective stress

CuO–TiO_(2) based self-powered broad band photodetector

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Nano Materials Science 2024年第3期6卷 345-354页

作者： Chiranjib Ghosh Arka Dey Iman Biswas Rajeev Kumar Gupta vikram Singh Yadav Ashish Yadav Neha Yadav Hongyu Zheng Mohamed Henini Aniruddha Mondal Department of Physics National Institute of Technology DurgapurWest BengalIndia Department of Physics University of Petroleum&Energy Studies DehradunUttarakhandIndia Babasaheb Bhimrao Ambedkar University Lucknow226031India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China School of Physics and Astronomy University of NottinghamNottinghamNG72RDUnited Kingdom

An efficient room-temperature self-powered,broadband(300 nm–1100 nm)photodetector based on a CuO–TiO_(2)/TiO_(2)/p-Si(100)heterostructure is *** CuO–TiO_(2)nanocomposites were grown in a two-zone horizontal tube furnace on a 40 nm TiO_(2)thin film deposited on a p-type Si(100)*** CuO–TiO_(2)/TiO_(2)/p-Si(100)devices exhibited excellent rectification characteristics under dark and individual photoillumination *** devices showed remarkable photo-response under broadband(300–1100 nm)light illumination at zero bias voltage,indicating the achievement of highly sensitive self-powered photodetectors at visible and near-infrared light *** maximum response of the devices is observed at 300 nm for an illumination power of 10 *** response and recovery times were calculated as 86 ms and 78 ms,***,under a small bias,the devices showed a prompt binary response by altering the current from positive to negative under illumination *** main reason behind this binary response is the low turn-on voltage and photovoltaic characteristics of the *** illumination conditions,the generation of photocurrent is due to the separation of photogenerated electron-hole pairs within the built-in electric field at the CuO–TiO_(2)/TiO_(2)*** characteristics make the CuO–TiO_(2)/TiO_(2)broadband photodetectors suitable for applications that require high response speeds and self-sufficient functionality.

关键词： Self-powered CuO–TiO_(2) nanocomposite Broadband photodetector Two-zone horizontal tube furnace Responsivity

Assessing the Viability of Gandhar Field in India’s Cambay Basin for CO_(2) Storage

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哈尔滨工程大学学报（英文版） 2024年第3期23卷 529-543页

作者： vikram Vishal Somali Roy Yashvardhan Verma Bharath Shekar Department of Earth Sciences Indian Institute of Technology BombayMumbai 400076India National Centre of Excellence in Carbon Capture and Utilization Indian Institute of Technology BombayMumbai 400076India

Our research is centered on the Gandhar oil field, which was discovered in 1983, where daily oil production has declined significantly over the years. The primary objective was to evaluate the feasibility of carbon dioxide(CO_(2)) storage through its injection into the siliciclastic reservoirs of Ankleshwar Formation. We aimed to obtain high-resolution acoustic impedance data to estimate porosity employing model-based poststack seismic inversion. We conducted an analysis of the density and effective porosity in the target zone through geostatistical techniques and probabilistic neural networks. Simultaneously, the work also involved geomechanical analysis through the computation of pore pressure and fracture gradient using well-log data, geological information, and drilling events in the Gandhar field. Our investigation unveiled spatial variations in effective porosity within the Hazad Member of the Ankleshwar Formation, with an effective porosity exceeding 25% observed in several areas, which indicates the presence of well-connected pore spaces conducive to efficient CO_(2) migration. Geomechanical analysis showed that the vertical stress(Sv) ranged from 55 MPa to 57 MPa in Telwa and from 63.7 MPa to 67.7 MPa in Hazad Member. The pore pressure profile displayed variations along the stratigraphic sequence, with the shale zone, particularly in the Kanwa Formation, attaining the maximum pressure gradient(approximately 36 MPa). However, consistently low pore pressure values(30-34 MPa) considerably below the fracture gradient curves were observed in Hazad Member due to depletion. The results from our analysis provide valuable insights into shaping future field development strategies and exploration of the feasibility of CO_(2) sequestration in Gandhar Field.

关键词： Carbon capture and storage Reservoir characterization Seismic inversion Geomechanics CO_(2)storage CO_(2)enhancing oil recovery

Liver transplantation for hepatocellular carcinoma in India: Are we ready for 2040?

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World Journal of Transplantation 2024年第1期14卷 141-153页

作者： Hirak Pahari Amruth Raj Ambreen Sawant Dipak S Ahire Raosaheb Rathod Chetan Rathi Tushar Sankalecha Sachin Palnitkar vikram Raut Department of Liver Transplant and HPB Surgery Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Liver Transplant Anaesthesia Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210India Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsAurangabad 431003India Department of Gastroenterology and Hepatology Medicover HospitalsNashik 422009India Department of Gastroenterology and Hepatology Medicover HospitalsPune 411026India

BACKGROUND Liver transplantation(LT)for hepatocellular carcinoma(HCC)has been widely researched and is well established *** cornerstone of this treatment lies in the various criteria formulated by expert consensus and *** variations among the criteria are staggering,and the short-and long-term outcomes are *** To study the differences in the current practices of LT for HCC at different centers in India and discuss their clinical implications in the *** We conducted a survey of major centers in India that performed LT in December 2022.A total of 23 responses were *** centers were classified as high-and low-volume,and the current trend of care for patients undergoing LT for HCC was *** Of the 23 centers,35%were high volume center(>500 Liver transplants)while 52%were high-volume centers that performed more than 50 transplants/*** 39%of centers had performed>50 LT for HCC while the percent distribution for HCC in LT patients was 5%–15%in approximately 73%of the *** a few,most centers were divided equally between University of California,San Francisco(UCSF)and center-specific criteria when choosing patients with HCC for LT,and most(65%)did not have separate transplant criteria for deceased donor LT and living donor LT(LDLT).Most centers(56%)preferred surgical resection over LT for a Child A cirrhosis patient with a resectable 4 cm HCC ***-emission tomography-computed tomography(CT)was the modality of choice for metastatic workup in the majority of centers(74%).Downstaging was the preferred option for over 90%of the centers and included transarterial chemoembolization,transarterial radioembolization,stereotactic body radiotherapy and atezolizumab/bevacizumab with varied *** alphafetoprotein(AFP)cut-off was used by 74%of centers to decide on transplantation as well as to downstage tumors,even if they met the *** criteria for successful downstaging v

关键词： Hepatocellular carcinoma Liver transplant India Downstaging Survey Milan University of California,San Francisco Portal vein tumor thrombus Expanded criteria

Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

Beneficial effects of splenectomy on liver regeneration in a rat model of massive hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 60-65页

作者： vikram Raut Department of Breast Surgery Graduate School of MedicineKyoto University

BACKGROUND: Small-for-size syndrome is a widely recognized clinical complication after living donor liver transplantation or extended hepatectomy due to inadequate liver mass. The purpose of this study was to investigate the role of splenectomy in rats after massive hepatectomy, a surrogate model of small-for-size graft. METHODS: Rats were divided into eight groups, each with 20 animals: 50% hepatectomy (50% Hx), 50% hepatectomy+ splenectomy (50% Hx+Sp), 60% Hx, 60% Hx+Sp, 70% Hx, 70% Hx+Sp, 90% Hx and 90% Hx+Sp. The following parameters were evaluated: liver function tests (ALT, AST and TBIL), liver regeneration ratio, DNA synthesis, proliferation cell nuclear antigen, hepatic oxygen delivery (HDO(2)) and hepatic oxygen consumption (HVO(2)). RESULTS: The liver regeneration ratio was enhanced in the Hx+Sp groups (P < 0.05). In addition, compared with the Hx groups, the Hx+Sp groups had better liver functions (P < 0.05). DNA synthesis and proliferation cell nuclear antigen were also increased in the Hx+Sp groups compared with the Hx groups (P < 0.05). Furthermore, in the Hx+Sp groups, HDO(2) and HVO(2) were increased over those in the Hx groups (P < 0.05), and were positively correlated with the liver regeneration ratio. CONCLUSIONS: Splenectomy significantly improved liver function, and enhanced DNA synthesis and proliferation cell nuclear antigen after massive hepatectomy in rats. This operation could be mediated through increased HDO(2), and HVO(2) which facilitate liver regeneration. (Hepatobiliary Pancreat Dis Int 2012;11:60-65)

关键词： liver regeneration splenectomy hepatic oxygen delivery hepatic oxygen consumption

Geriatric oncology: problems with under-treatment within this population

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Cancer Biology & Medicine 2015年第4期12卷 275-283页

作者： Divya Swaminathan vikram Swaminathan Norwich Medical School University of East Anglia Health Education North West

We are currently faced with an aging population, which is rapidly growing worldwide. Two thirds of cancer occurs in the over 65-year age group. Societal conceptions from the past have created ageist stereotypes; old age is associated with frailty and the elderly are perceived to be destined for deterioration and loss of independence. Cancer within the elderly is also subject to these stereotypes, with elderly cancer patients considered by some not as likely to recover as younger patients with cancer. We summarise and review the current concerns regarding elderly management and treatments utilised for the management of oncological disease in the elderly, and discuss the impact of under-treatment within this population.

关键词： Cancer elderly management geriatric oncology